Month: December 2022

Choi, Jong-Won published the artcileOrganic acid-based linear free energy relationship models for green leaching of strategic metals from spent lithium-ion batteries and improvement of leaching performance, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is Journal of Hazardous Materials (2022), 423(Part_B), 127214, database is CAplus and MEDLINE.

Water-soluble organic acids (e.g., acetic acid, acrylic acid, and ascorbic acid), as green leachants, have been applied to leach strategic metals (Ni, Li, Mn, and Co) from spent lithium-ion batteries (LIBs). Organic acid-based linear free energy relationship models were developed and simulated to predict the feasibility of the leaching efficiency for each of the strategic metals based on in silico calculated descriptors. The developed models, with accuracy (R2) of 0.747-0.831, reveal that hydrogen bond acidity of organic acids promotes the leaching efficiency, whereas mol. volume or excess molar refraction inhibits the efficiency. Furthermore, toxicity (LD 50%) of organic acids was discussed along with the predicted leaching efficiency to explore more green and efficient organic acids. Considering both toxicity and leaching efficiency, citric acid was selected as a green and efficient leachant. To more improve the leaching performance (rate and efficiency) of citric acid, glucose as a green reductant and microwave treatment were addnl. applied. Under the selected conditions, the leaching efficiencies after 1 h for Ni, Li, Mn, and Co were enhanced up to 98.3%, 99.1%, 98.7%, and 97.7%, resp.

Journal of Hazardous Materials published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yongchen published the artcileSynthesis of the C50 diastereomers of the C33-C51 fragment of stambomycin D, HPLC of Formula: 57044-25-4, the publication is Organic Chemistry Frontiers (2022), 9(2), 445-449, database is CAplus.

Herein, syntheses of the two C50 diastereomers of the C33-C51 region of the stambomycins I and II, which support the polyketide synthase-based configurational assignment were described, and established a strategy suitable for access to the extended stambomycin framework.

Organic Chemistry Frontiers published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C33H22N4, HPLC of Formula: 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xiaoping published the artcileOn the chemistry of 1-pyrroline in solution and in the gas phase, HPLC of Formula: 6346-09-4, the publication is Scientific Reports (2017), 7(1), 1-8, database is CAplus and MEDLINE.

1-Pyrroline has a highly characteristic odor, which is employed by living organisms for chem. signaling and other purposes, but the mechanism whereby this odor is formed remains poorly understood. Here we used a combination of ambient mass spectrometry (AMS) and NMR (NMR) spectroscopy to exptl. address the mechanistic aspects of 1-pyrroline volatility and other controversies regarding the chem. of this compound Our results indicate that in solution the volatility of the monomer species is significantly higher than that of the trimer species, and 1-pyrroline is evaporated mainly in its monomer state. Neat 1-pyrroline is essentially the pure trimer and displays ca. 100-fold lower evaporation rate than the monomer state in solution In the gas-phase the trimer species is irreversibly decomposed into monomer species. Under equilibrium conditions the vapor of 1-pyrroline entirely consists of monomer species. The evaporation rate of 1-pyrroline in water has a step-wise dependence on the solution pH, the abrupt increase in volatility (>1,000-fold) occurring around the pKa value of 1-pyrroline (6.8). The pronounced step-wise dependence of 1-pyrroline volatility around neutral pH may also be an important evolutionary factor allowing living systems to regulate the odor strength from very weak to very strong with minimal efforts.

Scientific Reports published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C7H5ClN2S, HPLC of Formula: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arima, Hidetoshi published the artcileEnhancement of gene transfer activity mediated by mannosylated dendrimer/α-cyclodextrin conjugate (generation 3, G3), Product Details of C13H15NO6S, the publication is Journal of Controlled Release (2006), 116(1), 64-74, database is CAplus and MEDLINE.

To enhance gene transfer activity of dendrimers, we prepared its conjugate (generation 3, G3) with α-cyclodextrin bearing mannose (Man-α-CDE conjugates) with various degrees of substitution of the mannose moiety (DSM5, 10, 13, 20) and compared their cytotoxicity and gene transfer activity, and elucidated the enhancing mechanism for the activity. Of the various carriers used here, Man-α-CDE conjugate (G3, DSM10) provided the highest gene transfer activity in NR8383, A549, NIH3T3 and HepG2 cells, being independent of the expression of mannose receptors. Gene transfer activity of Man-α-CDE conjugate (G3, DSM10) was not decreased by the addition of 10% serum in A549 cells. Cytotoxicity of the polyplex with Man-α-CDE conjugates (G3, DSM10) was not observed in A549 and NIH3T3 cells up to the charge ratio of 200/1 (carrier/pDNA). The gel mobility and particle size of polyplex with Man-α-CDE conjugate (G3, DSM10) were relevant to those with α-CDE conjugate (G3), but ζ-potential, DNase I stability, pDNA condensation of the former polyplex were somewhat different from those of the latter one. Cellular association of polyplex with Man-α-CDE conjugate (G3, DSM10) was almost comparable to that with dendrimer (G3) complex and α-CDE conjugate (G3). The addition of mannan and mannose attenuated gene transfer activity of Man-α-CDE conjugate (G3, DSM10) in A549 cells. Alexa-pDNA complex with TRITC-Man-α-CDE conjugate (G3, DSM10), but not the complex with TRITC-α-CDE conjugate (G3), was found to translocate to nucleus at 24 h after incubation in A549 cells. HVJ-E vector including mannan, but neither the vector alone nor the vector including dextran, suppressed the nuclear localization of TRITC-Man-α-CDE conjugate (G3, DSM10) to a striking degree after 24 h incubation in A549 cells. These results suggest that Man-α-CDE conjugate (G3, DSM10) has less cytotoxicity and prominent gene transfer activity through not only its serum resistant and endosome-escaping abilities but also nuclear localization ability.

Journal of Controlled Release published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Product Details of C13H15NO6S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Knight, Zachary A. published the artcileIsoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold, Recommanded Product: 3-Morpholinophenol, the publication is Bioorganic & Medicinal Chemistry (2004), 12(17), 4749-4759, database is CAplus and MEDLINE.

Phosphoinositide 3-kinases (PI3-Ks) are an ubiquitous class of signaling enzymes that regulate diverse cellular processes including growth, differentiation, and motility. Physiol. roles of PI3-Ks have traditionally been assigned using two pharmacol. inhibitors, LY294002 and wortmannin. Although these compounds are broadly specific for the PI3-K family, they show little selectivity among family members, and the development of isoform-specific inhibitors of these enzymes has been long anticipated. Herein, the preparation of two classes of arylmorpholine PI3-K inhibitors and the characterization of their specificity against a comprehensive panel of targets within the PI3-K family are reported. Multiplex inhibitors that potently inhibit distinct subsets of PI3-K isoforms, including the first selective inhibitor of p110β/p110δ (IC₅₀ p110β = 0.13 μM, p110δ = 0.63 μM), were identified. Trends that suggest certain PI3-K isoforms may be more sensitive to potent inhibition by arylmorpholines, thereby guiding future drug design based on this pharmacophore, were also identified.

Bioorganic & Medicinal Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Natarajan, P. N. published the artcileSynthesis and pharmacological evaluation of N-alkylamino butanol esters of 3,4,5-trimethoxybenzoic acid as potential hypotensive agents, HPLC of Formula: 4543-95-7, the publication is Canadian Journal of Pharmaceutical Sciences (1973), 8(2), 61-3, database is CAplus.

The title esters I (R = Me, Et, Pr, Me2CH, Bu) were prepared by condensing γ-butyrolactone with RNH2, reducing the resulting HO(CH2)3CONHR with LiAlH4, and esterifying the hydrochlorides of the amines formed with 3,4,5-(MeO)3C6H2COCl in C6H6 at ∼70° under N for 15-20 hr. Evaluation of I, for hypotensive activity in normotensive rats and for central nervous system activity in mice showed that I did not have any reserpine-like activity.

Canadian Journal of Pharmaceutical Sciences published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, HPLC of Formula: 4543-95-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jahng, Wan Jin published the artcileLecithin retinol acyltransferase forms functional homodimers. [Erratum to document cited in CA137:59457], COA of Formula: C18H20N2O12, the publication is Biochemistry (2002), 41(23), 7528, database is CAplus.

In the legend of Figure 2, all millimolar (mM) concentrations should be micromolar (μM). In the legend of Figure 4, the concentrations of RPE and BMH in lane 3 should be 10 μM and those of RPE and BMH in lane 4 should be 50 μM. In footnote c of Table 1, C# is carbamidomethylated cysteine.

Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, COA of Formula: C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jahng, Wan Jin published the artcileLecithin Retinol Acyltransferase Forms Functional Homodimers, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Biochemistry (2002), 41(20), 6311-6319, database is CAplus and MEDLINE.

Membrane-bound lecithin retinol acyltransferase (LRAT), an essential enzyme in vitamin A processing, catalyzes the formation of retinyl esters from vitamin A and lecithin. Cloned and expressed LRAT has a mol. mass of 25.3 kDa. The enzyme is not homologous to known enzymes and is, therefore, of substantial interest mechanistically. Along these lines, the functional protomeric state of LRAT is of importance. Gel electrophoretic studies on LRAT in the presence of SDS and disulfide reducing agents show the expected 25 kDa monomer. However, gel electrophoresis in the absence of a reducing agent and/or strong denaturing conditions reveals substantial dimer formation. LRAT monomers can be efficiently and irreversibly cross-linked by thiol reactive bismaleimides in retinal pigment epithelial (RPE) membranes generating LRAT homodimers. Cross-linked LRAT homodimers are fully active catalytically. The experiments suggest that LRAT monomers interact in membranes and form functional homodimers through protein-protein interactions and disulfide bond formation.

Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chutia, Rituparna published the artcileAn efficient base and H₂O₂ free protocol for the synthesis of phenols in water and oxygen using spinel CuFe₂O₄ magnetic nanoparticles, Application In Synthesis of 17236-59-8, the publication is Journal of Coordination Chemistry (2020), 73(13), 1925-1936, database is CAplus.

An efficient base and H₂O₂ free protocol was used for the synthesis of phenols from boronic acids using biogenic CuFe₂O₄ magnetic nanoparticles as catalyst at room temperature in water and oxygen. The catalyst was prepared using the flowers of Lantana camara. The size of the nanoparticles was 4.27 nm. Base free and ligand free protocol, less time, excellent yields, room temperature, biogenic synthesis of the catalyst, use of O₂ as an environmentally friendly oxidant are the advantages of the present protocol. The recyclability of the catalyst was for 5 cycles without loss of magnetic property or catalytic activity.

Journal of Coordination Chemistry published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Application In Synthesis of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Xu published the artcileIron-Catalyzed, Markovnikov-Selective Hydroboration of Styrenes, Quality Control of 608534-44-7, the publication is Organic Letters (2017), 19(5), 969-971, database is CAplus and MEDLINE.

A highly Markovnikov-selective, iron-catalyzed hydroboration of styrenes is reported using available oxazolinylphenyl picolinamide as the ligand to afford the branched hydroboration products with up to >50/1 b/l. This reaction is operationally simple and could be carried out in gram scale.

Organic Letters published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Quality Control of 608534-44-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts