Month: December 2022

Aubineau, Thomas published the artcileA One-Pot Reaction toward the Diastereoselective Synthesis of Substituted Morpholines, SDS of cas: 96-20-8, the publication is Organic Letters (2018), 20(23), 7419-7423, database is CAplus and MEDLINE.

The diastereoselective synthesis of various substituted morpholines has been achieved from vinyloxiranes and amino-alcs. under sequential Pd(0)-catalyzed Tsuji-Trost/Fe(III)-catalyzed heterocyclization. Using the same strategy, 2,6-, 2,5-, and 2,3-disubstituted as well as 2,5,6- and 2,3,5-trisubstituted morpholines were obtained in good to excellent yields and diastereoselectivities.

Organic Letters published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, SDS of cas: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rosenbaum, Anton I. published the artcileThiadiazole Carbamates: Potent Inhibitors of Lysosomal Acid Lipase and Potential Niemann-Pick Type C Disease Therapeutics, HPLC of Formula: 30165-97-0, the publication is Journal of Medicinal Chemistry (2010), 53(14), 5281-5289, database is CAplus and MEDLINE.

Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized at the cellular level by abnormal accumulation of cholesterol and other lipids in lysosomal storage organelles. Lysosomal acid lipase (LAL) has been recently identified as a potential therapeutic target for NPC. LAL can be specifically inhibited by a variety of 3,4-disubstituted thiadiazole carbamates. An efficient synthesis of the C(3) oxygenated/C(4) aminated analogs has been developed that furnishes the products in high yields and high degrees of purity. Common intermediates can also be used for the synthesis of the C(3) carbon substituted derivatives Herein we tested various thiadiazole carbamates, amides, esters, and ketones for inhibition of LAL. In addition, we tested a diverse selection of com. available non-thiadiazole carbamates. Our studies show that, among the compounds examined herein, only thiadiazole carbamates are effective inhibitors of LAL. We present a mechanism for LAL inhibition by these compounds whereby LAL transiently carbamoylates the enzyme similarly to previously described inhibition of acetylcholinesterase by rivastigmine and other carbamates as well as acylation of various lipases by orlistat.

Journal of Medicinal Chemistry published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, HPLC of Formula: 30165-97-0.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Delgado, Jose A. C. published the artcileBiocompatible photoinduced alkylation of dehydroalanine for the synthesis of unnatural α-amino acids, Category: alcohols-buliding-blocks, the publication is Organic Letters (2021), 23(13), 5251-5255, database is CAplus and MEDLINE.

A site-selective alkylation of dehydroalanine to access protected unnatural amino acids is described. The protocol is characterized by the wide nature of alkyl radicals employed, mild conditions, and functional group compatibility. This protocol is further extended to access peptides, late-stage functionalization of pharmaceuticals, and enantioenriched amino acids.

Organic Letters published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Malheiros, Jessica Moraes published the artcileComparative untargeted metabolome analysis of ruminal fluid and feces of Nelore steers (Bos indicus), Recommanded Product: 3-Hydroxyphenylacetic acid, the publication is Scientific Reports (2021), 11(1), 12752, database is CAplus and MEDLINE.

We conducted a study to identify the fecal metabolite profile and its proximity to the ruminal metabolism of Nelore steers based on an untargeted metabolomic approach. Twenty-six Nelore were feedlot with same diet during 105 d. Feces and rumen fluid were collected before and at slaughter, resp. The metabolomics anal. indicated 49 common polar metabolites in the rumen and feces. Acetate, propionate, and butyrate were the most abundant polar metabolites in both bio-samples. The rumen presented significantly higher concentrations of the polar compounds when compared to feces (P < 0.05); even though, fecal metabolites presented an accentuated representability of the ruminal fluid metabolites. All fatty acids present in the ruminal fluid were also observed in the feces, except for C20:2n6 and C20:4n6. The identified metabolites offer information on the main metabolic pathways (higher impact factor and P < 0.05), as synthesis and degradation of ketone bodies; the alanine, aspartate and glutamate metabolisms, the glycine, serine; and threonine metabolism and the pyruvate metabolism The findings reported herein on the close relationship between the ruminal fluid and feces metabolic profiles may offer new metabolic information, in addition to facilitating the sampling for metabolism investigation in animal production and health routines.

Scientific Reports published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vaillant, Fabrice published the artcilePlasma Metabolome Profiling by High-Performance Chemical Isotope-Labelling LC-MS after Acute and Medium-Term Intervention with Golden Berry Fruit (Physalis peruviana L.), Confirming Its Impact on Insulin-Associated Signaling Pathways, Application of 3-Hydroxyphenylacetic acid, the publication is Nutrients (2021), 13(9), 3125, database is CAplus and MEDLINE.

Golden berry (Physalis peruviana L.) is an exotic fruit exported from Colombia to different countries around the world. A review of the literature tends to demonstrate a hypoglycemic effect with an improvement in insulin sensitivity after oral ingestion of fruit extracts in animal models. However, little is known about their potential effects in humans, and very little is known about the mechanisms involved. This study aimed at identifying discriminant metabolites after acute and chronic intake of golden berry. An untargeted metabolomics strategy using high-performance chem. isotope-labeling LC-MS was applied. The blood samples of eighteen healthy adults were analyzed at baseline, at 6 h after the intake of 250 g of golden berry (acute intervention), and after 19 days of daily consumption of 150 g (medium-term intervention). Forty-nine and 36 discriminant metabolites were identified with high confidence, resp., after the acute and medium-term interventions. Taking into account up- and downregulated metabolites, three biol. networks mainly involving insulin, epidermal growth factor receptor (EGFR), and the phosphatidylinositol 3-kinase pathway (PI3K/Akt/mTOR) were identified. The biol. intracellular networks identified are highly interconnected with the insulin signalling pathway, showing that berry intake may be associated with insulin signalling, which could reduce some risk factors related to metabolic syndrome. Primary registry of WHO.

Nutrients published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C7H10O4, Application of 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kaya, S. Irem published the artcileSimple preparation of surface molecularly imprinted polymer based on silica particles for trace level assay of bisphenol F, Application In Synthesis of 80-09-1, the publication is Analytical and Bioanalytical Chemistry (2022), 414(19), 5793-5803, database is CAplus and MEDLINE.

A new electrochem. sensor based on molecularly imprinted tetra-Et orthosilicate (TEOS)-based porous interface was developed for selective recognition of bisphenol F (BPF) in this study. The sensor was prepared by depositing the solution containing TEOS and L-tryptophan (L-Trp) in the presence of cetyltrimethylammonium bromide (CTAB) as a pore-maker via hydrolysis/condensation reaction on the glassy carbon electrode (GCE). While the surface morphol. and structure characterization were carried out using Fourier transform IR spectroscopy (FTIR) and SEM (SEM), electrochem. characterization was performed through electrochem. impedance spectroscopy (EIS) and cyclic voltammetry (CV). The resulted MIP(TEOS:L-Trp)@GCE achieved a wide linear range of 1 x 10^-15-1 x 10^-14 M for BPF detection with an excellent detection limit of 0.291 fM. Furthermore, the recovery of BPF from spiked bottled water and serum samples varied between 98.83 and 101.03%. These results demonstrate that MIP(TEOS:L-Trp)@GCE was found to be a simple, sensitive, and selective smart interface to detect trace pollution even from complicated samples.

Analytical and Bioanalytical Chemistry published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Application In Synthesis of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Botubol-Ares, Jose Manuel published the artcileMethylene-Linked Bis-NHC Half-Sandwich Ruthenium Complexes: Binding of Small Molecules and Catalysis toward Ketone Transfer Hydrogenation, Formula: C10H12ClNO, the publication is Organometallics (2021), 40(6), 792-803, database is CAplus.

[Cp^*RuCl(COD)] reacts with LH₂Cl₂ (L = methanebis(3-methylimidazol-2-ylidene)) and LiBu in THF at 65° furnishing the bis-carbene derivative [Cp^*RuCl(L)] (2). This compound reacts with NaBPh₄ in MeOH under dinitrogen to yield the labile dinitrogen-bridged complex [{Cp^*Ru(L)}₂(μ-N₂)][BPh₄]₂ (4). The dinitrogen ligand in 4 is readily replaced by donor mols. leading to the corresponding cationic complexes [Cp^*Ru(X)(L)][BPh₄] (X = MeCN 3, H₂ (6), C₂H₄ (8a), CH₂CHCOOMe 8b, CHPh 9). Attempts to recrystallize 4 from MeNO₂/EtOH solutions gave the nitrosyl derivative [Cp^*Ru(NO)(L)][BPh₄]₂ (5), which was structurally characterized. The allenylidene complex [Cp^*Ru:C:C:CPh₂(L)][BPh₄] (10) was also obtained, and it was prepared by reaction of 2 with HCCC(OH)Ph₂ and NaBPh₄ in MeOH at 60°. 3, 4, And 6 are efficient catalyst precursors for the transfer hydrogenation of a broad range of ketones. The dihydrogen complex 6 proved particularly effective, reaching TOF values up to 455 h^-1 at catalyst loadings of 0.1% mol., with a high functional group tolerance on the reduction of a broad scope of aryl and aliphatic ketones to yield the corresponding alcs.

Organometallics published new progress about 1310357-40-4. 1310357-40-4 belongs to alcohols-buliding-blocks, auxiliary class Benzenes, name is 7-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-ol, and the molecular formula is C10H12ClNO, Formula: C10H12ClNO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Amery, G. W. published the artcileSynthesis and identification of some N-methylated aminonitrophenols, Application In Synthesis of 14703-69-6, the publication is Journal of the Chemical Society [Section] C: Organic (1967), 1053-7, database is CAplus.

The synthesis of a number of new N-methyl and N,N-dimethylaminonitrophenols is described. Spectroscopy assisted in deducing the orientation of these compounds In particular, the position of the nitro group, relative to the OH group, can be clearly discerned by comparison of the spectrum of the hydroxynitroanilinium ion with those of the 3 nitrophenols. 26 references.

Journal of the Chemical Society [Section] C: Organic published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Application In Synthesis of 14703-69-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Siezen, Roland J. published the artcilePermanent suppression of phase separation cataract in calf lens using amine modification agents, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Biochemical and Biophysical Research Communications (1985), 133(1), 239-47, database is CAplus and MEDLINE.

Low-temperature-induced opacification (cold cataract) of the nucleus of young mammalian lenses was associated with a phase separation of proteins in the lens cell cytoplasm. Calf lenses were treated with a variety of imidoesters and N-hydroxysuccinimide esters, which react specifically with amino groups. Many potent inhibitors of phase-separation cataract were identified which lower the opacification temperature by ≥6°. Lenses generally remained clear, colorless and soft. Furthermore, suppression of the cold-cataract temperature was permanent upon removal of excess reagent.

Biochemical and Biophysical Research Communications published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C7H14N4, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Watts, Norman R. M. published the artcileStructure of the bacteriophage T4 baseplate as determined by chemical cross-linking, Application of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Journal of Virology (1990), 64(1), 143-54, database is CAplus and MEDLINE.

A series of reversible chem. crosslinking experiments using the reagent ethylene glycol-bis(succinimidylsuccinate) were carried out to determine the 3-dimensional structure of the bacteriophage T4 baseplate. In a previous report, near-neighbor contacts in baseplate precursors and substructures were examined (Watts, N. R. M.; Coombs, J. 1989). Finished baseplates and tails were also examined Most of the previous contacts were confirmed, and several new contacts, including those within the central hub (gp5-gptd₂, gp26-gptd), between the hub and the outer wedges (gp6-gp27₂), between baseplate and sheath (gp54-gp18), and between sheath and core (gp19-gp18) are reported. On the basis of this and other available information, a partial 3-dimensional model of the baseplate is proposed.

Journal of Virology published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C14H26O2, Application of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts