Month: December 2022

Vaid, Arvind published the artcileA randomized controlled trial of prophylactic sublingual misoprostol versus intramuscular methyl-ergometrine versus intramuscular 15-methyl PGF2α in active management of third stage of labor, Related Products of alcohols-buliding-blocks, the publication is Archives of Gynecology and Obstetrics (2009), 280(6), 893-897, database is CAplus and MEDLINE.

Objective: To compare the efficacy and side effects of 0.2 mg methyl-ergometrine IM, 400 μg misoprostol sublingual and 125 μg 15 Me PGF2α IM in active management of third stage of labor. Method: Two hundred low risk pregnant women with induced or spontaneous labor were randomized to receive either 400 μg misoprostol sublingually or 0.2 mg methyl-ergometrine i.m. or 125 μg 15-Me PGF2α i.m., after the delivery of anterior shoulder of baby. The main outcome measures were: blood loss more than 500 mL, need for addnl. oxytoxic drug, change in Hb level and side effects due to drugs. Results: The median estimated blood loss, blood loss more than 500 mL, need for addnl. oxytocic drug and change in Hb levels were similar in all three groups. The significant side effects in the misoprostol group were shivering, pyrexia (temperature > 38°C) and vomiting, which were self-limiting. Diarrhea was significantly more in the 15 Me PGF2α group. Three women in methyl-ergometrine group underwent manual removal of placenta. One woman in misoprostol group received blood transfusion. Conclusion: Sublingual misoprostol appears to be as effective as i.m. methyl-ergometrine and i.m. 15-Me PGF2α in the prevention of postpartum hemorrhage. It can be a good alternative in resource poor setting.

Archives of Gynecology and Obstetrics published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C5H7BO2S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Naeimi, Hossein published the artcileFacile sonochemical heterocyclization of 2,5-dimethoxy tetrahydrofuran with primary amines using sulfonated MWCNTs as a recyclable catalyst in aqueous media, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Green Chemistry Letters and Reviews (2017), 10(4), 412-419, database is CAplus.

A set of N-substituted pyrrole derivatives was designed and synthesized using sulfonated multi-walled carbon nanotubes as a recyclable heterogeneous catalyst under ultrasound irradiation This reaction was carried out between 2,5-dimethoxy THF and primary amines in water under green conditions. This method has some advantages such as: short reaction times, excellent product yields, simplicity of the procedure, easy work-up and high purity of products.

Green Chemistry Letters and Reviews published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Naeimi, Hossein published the artcileEfficient and green synthesis of N-aryl pyrroles catalyzed by ionic liquid [H-NMP] [HSO₄] in Water at room temperature, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Journal of the Chinese Chemical Society (Weinheim, Germany) (2014), 61(10), 1127-1132, database is CAplus.

A suitable and efficient method for the synthesis of N-aryl pyrroles I [Ar = C₆H₅, 4-CH₃C₆H₄, 4-OHC₆H₄, etc.] by using 2,5-dimethoxy THF and several primary aromatic amines in the presence of the catalytic amount of [H-NMP][HSO₄] under room temperature was described. This method has the advantages such as; easy reaction workup, absolutely separated of catalyst from the reaction mixture and smoothly recyclability of catalyst. The compound I were obtained as desired products in excellent yields and short reaction times via green and one-pot procedure.

Journal of the Chinese Chemical Society (Weinheim, Germany) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Naeimi, Hossein published the artcileFunctionalized multi-walled carbon nanotubes as an efficient reusable heterogeneous catalyst for green synthesis of N-substituted pyrroles in water, Computed Properties of 23351-09-9, the publication is RSC Advances (2015), 5(93), 76221-76228, database is CAplus.

In this protocol, the functionalization of multiwalled carbon nanotubes (MWCNTs) was carried out and the resulting sulfonated MWCNTs were characterized by FT-IR, XRD, SEM, BET, EDX, XPS and Raman spectroscopy that are each discussed sep. in the text. Then, the MWCNT-SO₃H composite was applied as an efficient, recyclable heterogeneous catalyst for the synthesis of N-substituted pyrroles via the reaction of 2,5-dimethoxy THF with primary amines under clean and mild conditions. In this reaction, the N-substituted pyrroles were obtained as beneficial and significant products in short reaction times (30-65 min) and good to excellent yields (40-92%) with high purity. The products were obtained through a simple work up procedure and characterized by FT-IR, ¹H NMR and ¹³C NMR. After the end of the reaction, the nanocatalyst was recovered and reused several times without efficient loss of its activity for the preparation of N-substituted pyrroles.

RSC Advances published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Computed Properties of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Acimovic, Milica G. published the artcileBiological activity and profiling of Salvia sclarea essential oil obtained by steam and hydrodistillation extraction methods via chemometrics tools, SDS of cas: 106-25-2, the publication is Flavour and Fragrance Journal (2022), 37(1), 20-32, database is CAplus.

Salvia sclarea L. or clary sage is cultivated worldwide in temperate and sub-tropical climates, as an ornamental and essential oil (EO) bearing plant. EO is obtained from fresh spikes in full flowering stage and is recognized as an important com. product for food, beverage and cosmetic industries. This study investigated the EO composition of S. sclarea grown in Serbia (Southeast Europe) obtained by two different methods, steam (SD) and hydrodistillation (HD). GC-MS anal. identified oxygenated monoterpenes as the main class of compounds for all EOs (between 81.8% and 88.2% depending on the distillation process). The most abundant oxygenated monoterpenes were linalyl acetate and linalool. In addition, in vitro antimicrobial (modified resazurin microtitre-plate assay) and antioxidant activities (DPPH· assay) and total polyphenol content of obtained EOs were also evaluated. According to the assay used for the evaluation of the antibacterial activity, Gram-neg. bacteria were more sensitive to S. sclarea EO in comparison to Gram-pos. bacteria. EOs exhibited low antioxidant capacity, below 3% neutralized DPPH· radicals, reaching up to approx. 400 μg AAE mL-1. This study also investigated a possibility for predicting retention indexes (RIs) of compounds isolated from EOs. In total, 78 exptl. obtained RIs were applied to construct the prediction model. The quant. structure-chromatog. retention relationship (QSRR) model was used to anticipate the exptl. obtained RIs. Five mol. descriptors were selected by factor anal. and genetic algorithm to predict RIs. The obtained accuracy of the QSRR model reached r2 = .912, which showed that these models might be applied for predicting retention indexes.

Flavour and Fragrance Journal published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, SDS of cas: 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bosca, F. published the artcilePhotochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensitizing platelet antiaggregant drug triflusal, HPLC of Formula: 328-90-5, the publication is Photochemistry and Photobiology (2001), 73(5), 463-468, database is CAplus.

Triflusal is a platelet antiaggregant drug with photoallergic side effects. However, it is considered a prodrug since it is metabolized to 2-hydroxy-4-trifluoromethyl-benzoic acid (HTB)-the pharmacol. active form. HTB was found to be photolabile under various conditions. Its major photodegradation pathway appears to be the nucleophilic attack at the trifluoromethyl moiety. The involvement of the triplet state in the photodegradation has been unequivocally proved by direct detection of this transient in laser flash photolysis and by quenching experiments with oxygen, cyclohexadiene and naphthalene. Finally, the photobinding of HTB to proteins such as bovine serum albumin has been demonstrated using UV-visible (UV-Vis) and fluorescence spectroscopy. Nucleophilic groups present in the protein appear to be responsible for the formation of covalent drug photoadducts, which is the first step involved in the photoallergy shown by triflusal.

Photochemistry and Photobiology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boscá, F published the artcilePhotochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensitizing platelet antiaggregant drug triflusal., COA of Formula: C8H5F3O3, the publication is Photochemistry and photobiology (2001), 73(5), 463-8, database is MEDLINE.

Triflusal is a platelet antiaggregant drug with photoallergic side effects. However, it is considered a prodrug since it is metabolized to 2-hydroxy-4-trifluoromethylbenzoic acid (HTB)–the pharmacologically active form. HTB was found to be photolabile under various conditions. Its major photodegradation pathway appears to be the nucleophilic attack at the trifluoromethyl moiety. The involvement of the triplet state in the photodegradation has been unequivocally proved by direct detection of this transient in laser flash photolysis and by quenching experiments with oxygen, cyclohexadiene and naphthalene. Finally, the photobinding of HTB to proteins such as bovine serum albumin has been demonstrated using ultraviolet-visible (UV-Vis) and fluorescence spectroscopy. Nucleophilic groups present in the protein appear to be responsible for the formation of covalent drug photoadducts, which is the first step involved in the photoallergy shown by triflusal.

Photochemistry and photobiology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, COA of Formula: C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xianjin published the artcileCatalytic Boration of Alkyl Halides with Borane without Hydrodehalogenation Enabled by Titanium Catalyst, Application of 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Angewandte Chemie, International Edition (2021), 60(22), 12298-12303, database is CAplus and MEDLINE.

An unprecedented and general Ti-catalyzed boration of alkyl (pseudo)halides (alkyl-X, X = I, Br, Cl, OMs) with borane (HBpin, HBcat) is reported. The use of Ti catalyst can successfully suppress the undesired hydrodehalogenation products that prevail using other transition-metal catalysts. Synthetically useful alkyl boronate esters are readily obtained from various (primary, secondary, and tertiary) alkyl electrophiles, including unactivated alkyl chlorides, with tolerance of other reducing functional groups such as ester, alkene, and carbamate. Preliminary studies on the mechanism revealed a possible radical reaction pathway. Further extension of the authors’ strategy to aryl bromides is also demonstrated.

Angewandte Chemie, International Edition published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C22H12F6O6S2, Application of 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Jingchen published the artcileOptimization of synthesis process for sodium ascorbate, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2012), 550-553(Pt. 1), 10-15, database is CAplus.

With 2-keto-L-gulonic acid(2KLG) and methanol as raw materials, 98% concentrated sulfuric acid as catalyst, the Me esterification reaction is occurred. Then with sodium carbonate as a transforming agent, through a conversion reaction sodium carbonate is obtained. In this experiment, the effects of reaction time, reaction temperature and reactant ratio on conversion rate of sodium ascorbate were studied. The results showed that sodium carbonate as the reactant of lactonization reaction can effectively shorten the reaction time and improve reaction yield. By experiment under the optimum process conditions: the reaction temperature is 65 °C, reaction time is 150 min and the molar ratio of 2-keto-L-gu Me to sodium carbonate is 1:0.6, the conversion rate reaches 98 % and the effect is better than with sodium bicarbonate as transforming agent.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C8H10N2O2, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Zhen-Yuan published the artcileEfficient synthesis and activity of beneficial intestinal flora of two lactulose-derived oligosaccharides, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is European Journal of Medicinal Chemistry (2016), 8-13, database is CAplus and MEDLINE.

Lactulose is considered as a prebiotic because it promotes the intestinal proliferation of Lactobacillus acidophilus which is added to various milk products. Moreover, lactulose is used in pharmaceuticals as a gentle laxative and to treat hyperammonemia. This study was aimed at the total synthesis of two Lactulose-derived oligosaccharides: one is 3-O-β-D-galactopyranosyl-D-fructose, D-fructose and β-D-galactose bounded together with β-1,3-glycosidic bound, the other is 1-O-β-D-galactopyranosyl-D-fructose, D-fructose and β-D-galactose bounded together with β-1,1-glycosidic bound, which were accomplished in seven steps from D-fructose and β-D-galactose and every step of yield above 75%. This synthetic route provided a practical and effective synthetic strategy for galacto-oligosaccharides, starting from com. available monosaccharides. Then we evaluated on their prebiotic properties in the search for potential agents of regulating and improving the intestinal flora of human. The result showed that the prebiotic properties of Lactulose-derived oligosaccharides was much better than Lactulose. Among them, 3-O-β-D-galactopyranosyl-D-fructose displayed the most potent activity of proliferation of L. acidophilus.

European Journal of Medicinal Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C7H8FNO2S, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts