Month: December 2022

Tian, Guangming published the artcileA polycaprolactone/polydopamine nanocomposite with sunlight-induced shape memory effect and solid state plasticity, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is polydopamine doped polycaprolactone diol acrylate thiol shape memory elasticity.

A facile photo-cured polycaprolactone (PCL)/polydopamine (PDA) nanocomposite is prepared via thiol-ene reaction. Owing to favorable light-to-thermal transfer of doped polydopamine nanoparticles (PDAPs) in composites, active photo-thermal actuation of the composite is achieved when subjected to simulated sunlight irradiation, the effects of sunlight intensity and PDAPs concentration on the composite’s surface temperature are studied systematically. Solid state plasticity is also achieved by activating the dynamic transesterification reaction within the same polymer network. More importantly, the composite also features sunlight-induced plasticity under a light intensity of 960 mW cm-2. Macroscopically, the flat permanent shape can be reconfigured to a new 3D permanent shape via simulated sunlight, and the reconfigured shape still exhibits excellent elasticity-based shape memory behaviors even after seven cycles of testing. Based on these special properties, the PCL/PDAPs composite is further used in the field of electronic devices. It is expected that the design of PCL-PDAPs composite can pave a simple pathway for the simplification of complex shapes and can be extended to fabricate light-operated actuators.

Smart Materials and Structures published new progress about Actuators. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiang, Yaoyao published the artcileA High-Fidelity Preparation Method for Liquid Crystal Elastomer Actuators, Name: Pentaerythritol tetra(3-mercaptopropionate), the main research area is fidelity liquid crystal elastomer actuator.

Three-dimensional (3D) structural actuators based on monodomain liquid crystal elastomers (mLCEs) show a wide range of potential applications. A direct ink writing technique has been developed to print LCE structures. It is still a challenge to print high-precision 3D-mLCE actuators. Here, a method of wet 3D printing combined with freeze-drying is proposed. The coagulation bath is designed to restrain the nascent fiber disturbance of the capillary wave and weight by adjusting the ink viscosity and printing speed to control the LC mol. order, enabling uniform (B = 1.02) fibers with a high degree of orientational alignment (S = 0.45) of the mesogens. Furthermore, dynamic disulfide bond formation was used as the crosslinking point, which can allow the LCE network structure to be continuously cured to ensure adjacent layers are effectively bonded and, in combination with freeze-drying, produce the 3D-mLCE actuators of fidelity architecture (98.37 volume %) by printing. The actuators have excellent actuating strain (45.12%), and the dynamic disulfide bond makes them programmable. Finally, a printed bionic starfish and a printed bionic hand can easily grab regular and irregular objects. This work provides a feasible scheme for fabricating complex 3D-mLCEs with reversible changes in shape.

Langmuir published new progress about Actuators. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Name: Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Jianheng published the artcileDesign, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFRL858R/T790M inhibitors, Application In Synthesis of 505-10-2, the main research area is cyclopropylindolyl anilinopyrimidine preparation EGFR inhibitor structure activity; pyrimidine antitumor EGFR inhibition SAR docking apoptosis induction pharmacokinetic; Anti-proliferation; Anti-tumor efficacy in vivo; Epidermal growth factor receptor; L858R/T790M double mutants; Non-small cell lung cancer (NSCLC).

A new series of 2,4-diarylpyrimidine derivatives containing a cyclopropyl moiety, I [R = N(Me)(CH2)2OH, thiomorpholino, O(CH2)3SMe, etc., X = H; R = S(CH2)2NMe2, S(O)(CH2)2NMe2, X = Cl], were designed, synthesized and evaluated as novel selective EGFRL858R/T790M inhibitors. The most promising compound, I [R = S(:O)CH2CH2NMe2] (II), demonstrated excellent kinase inhibitory activity against EGFR double mutation with IC50 value of 0.26 nM. Moreover, II provided strong activity against H1975 cells with IC50 value of 0.008μM and exhibited little toxicity toward four non-tumorigenic cell lines. Furthermore, II showed potent antitumor efficacy in a murine EGFRL858R/T790M-driven H1975 xenograft model. These results indicated that II may be a promising drug candidate for further study.

European Journal of Medicinal Chemistry published new progress about Aminopyrimidines Role: ADV (Adverse Effect, Including Toxicity), PAC (Pharmacological Activity), PKT (Pharmacokinetics), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Application In Synthesis of 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Yu-Ya A. published the artcileOlefin Cross-Metathesis on Proteins: Investigation of Allylic Chalcogen Effects and Guiding Principles in Metathesis Partner Selection, Synthetic Route of 2595-07-5, the main research area is olefin cross metathesis protein allylic chalcogen.

Olefin metathesis has recently emerged as a viable reaction for chem. protein modification. The scope and limitations of olefin metathesis in bioconjugation, however, remain unclear. Herein the authors report an assessment of various factors that contribute to productive cross-metathesis on protein substrates. Sterics, substrate scope, and linker selection are all considered. It was discovered during this investigation that allyl chalcogenides generally enhance the rate of alkene metathesis reactions. Allyl selenides were exceptionally reactive olefin metathesis substrates, enabling a broad range of protein modifications not previously possible. The principles considered in this report are important not only for expanding the repertoire of bioconjugation but also for the application of olefin metathesis in general synthetic endeavors.

Journal of the American Chemical Society published new progress about Bacillus lentus. 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Synthetic Route of 2595-07-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kooij, Stefan published the artcileExplosive fragmentation of Prince Rupert’s drops leads to well-defined fragment sizes, Application In Synthesis of 64519-82-0, the main research area is explosive fragmentation glass fragment size.

Abstract: Anyone who has ever broken a dish or a glass knows that the resulting fragments range from roughly the size of the object all the way down to indiscernibly small pieces: typical fragment size distributions of broken brittle materials follow a power law, and therefore lack a characteristic length scale. The origin of this power-law behavior is still unclear, especially why it is such an universal feature. Here we study the explosive fragmentation of glass Prince Rupert’s drops, and uncover a fundamentally different breakup mechanism. The Prince Rupert’s drops explode due to their large internal stresses resulting in an exponential fragment size distribution with a well-defined fragment size. We demonstrate that generically two distinct breakup processes exist, random and hierarchical, that allows us to fully explain why fragment size distributions are power-law in most cases but exponential in others. We show exptl. that one can even break the same material in different ways to obtain either random or hierarchical breakup, giving exponential and power-law distributed fragment sizes resp. That a random breakup process leads to well-defined fragment sizes is surprising and is potentially useful to control fragmentation of brittle solids.

Nature Communications published new progress about Crack (fracture). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application In Synthesis of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Matsuda, Takeshi published the artcileRelease behavior of pH sensitive microcapsules containing corrosion inhibitor, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is core shell pH sensitive microcapsules release behavior corrosion inhibitor.

A pH sensitive microcapsule (pH-MC) which can be decomposed in corrosive environments on metal substrates was synthesized and its release behavior was investigated. Ester chains which can be hydrolyzed under both alk. and acidic conditions were successfully introduced into the shell wall of the pH-MC. In sep. sets of experiments, cerium nitrate was encapsulated as a corrosion inhibitor, whereas aluminum nitrate was used to investigate the release property due its amphoteric nature. Study of the release behavior with the aluminum nitrate-containing pH-MC (Al-MC) demonstrated that the Al-MCs are sensitive to acidic and basic environments and are inactive in neutral environments. It was also found that hydrolysis of the ester chains occurred prior to release of the core materials. When immersed in an electrolyte with the cerium nitrate-containing pH-MC (Ce-MC), the open circuit potential (OCP) of a steel substrate showed a nobler potential than when immersed in an electrolyte without Ce-MC.

Progress in Organic Coatings published new progress about Corrosion inhibitors. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lunyera, Joseph published the artcileUrine tricarboxylic acid cycle signatures of early-stage diabetic kidney disease, Related Products of alcohols-buliding-blocks, the publication is Metabolomics (2022), 18(1), 5, database is CAplus and MEDLINE.

Urine tricarboxylic acid (TCA) cycle organic anions (OAs) are elevated in diabetes and may be biomarkers for diabetic kidney disease (DKD) progression. We assessed associations of 10 urine TCA cycle OAs with estimated glomerular filtration rate (eGFR) and eGFR slope. This study is ancillary to the Simultaneous Risk Factor Control Using Telehealth to SlOw Progression of Diabetic Kidney Disease (STOP-DKD) Trial-a randomized trial of pharmacist-led medication and behavior management in 281 patients with early to moderate DKD at Duke from 2014 to 2015. We used linear mixed models to assess associations of urine TCA cycle OAs with outcomes and modelled TCA cycle OAs as: (1) the average of z-scores for each OA; and (2) principal component (PC) scores derived by principal component anal. (PCA). Untargeted urine metabolomics were added for addnl. discovery. Among 132 participants with 24 h urine samples (50% men; 58% Black; mean age 64 years [SD 9]; mean eGFR 74 mL/min/1.73m² [SD 21] and median urine albumin-to-creatinine [UACR] 20 mg/g [IQR 8-95]), PCA identified 3 OA metabolite PCs. Malate, fumarate, pyruvate, α-ketoglutarate, lactate, succinate and citrate/isocitrate loaded pos. on PC1; methylsuccinate, ethylmalonate and succinate loaded pos. on PC2; and methylmalonate, ethylmalonate and citrate/isocitrate loaded neg. on PC3. Over a median follow-up of 1.8 years (IQR, 1.2 to 2.2), higher average OA z-score was strongly associated with higher eGFR after covariate adjustment (p = 0.01), but not with eGFR slope (p = 0.9). Higher PC3, but not other PCs, was associated with lower eGFR (p < 0.001). Conditional random forests and smooth clipped absolute deviation models confirmed methylmalonate, citrate/isocitrate, and ethylmalonate, and added lactate as top ranked metabolites in models of baseline eGFR (R-squared 0.32 and 0.33, resp.). Untargeted urine metabolites confirmed association of urine TCA cycle OAs with kidney function. Thus, lower urine TCA cycle OAs, most notably lower methylmalonate, ethylmalonate and citrate/isocitrate, are potential indicators of kidney impairment in early stage DKD.

Metabolomics published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fanfoni, Lidia published the artcileEfficient synthesis of new fluorinated building blocks by means of hydroformylation, Quality Control of 83706-94-9, the publication is Chimia (2014), 68(6), 371-377, database is CAplus and MEDLINE.

The hydroformylation reactions of fluorinated olefins were reviewed and added new results from the research group. The particular attention is paid to the remarkable influence of organofluorine substituents on catalyst activity, regio- and stereoselectivity of the hydroformylation reaction.

Chimia published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Quality Control of 83706-94-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tribet, C. published the artcileThermodynamic Characterization of the Exchange of Detergents and Amphipols at the Surfaces of Integral Membrane Proteins, Quality Control of 85618-21-9, the publication is Langmuir (2009), 25(21), 12623-12634, database is CAplus and MEDLINE.

The aggregation of integral membrane proteins (IMPs) in aqueous media is a significant concern for mechanistic investigations and pharmaceutical applications of this important class of proteins. Complexation of IMPs with amphiphiles, either detergents or short amphiphilic polymers known as amphipols (APols), renders IMPs water-soluble It is common knowledge that IMP-detergent complexes are labile, while IMP-APol complexes are exceptionally stable and do not dissociate even under conditions of extreme dilution To understand the thermodn. origin of this difference in stability and to guide the design of new APols, the authors have studied by isothermal titration calorimetry (ITC) the heat exchanges during two reciprocal processes, the “trapping” of detergent-solubilized IMPs in APols and the “stripping” of IMP-APol complexes by detergents, using two IMPs (the transmembrane domain of porin OmpA from Escherichia coli and bacteriorhodopsin from Halobacterium salinarium), two APols [an anionic polymer derived from acrylic acid (A8-35) and a cationic phosphorylcholine-based polymer (C22-43)], and two neutral detergents [n-octyl thioglucoside (OTG) and n-octyltetraethylene glycol (C₈E₄)]. In the presence of detergent, free APols and IMP-APol complexes form mixed particles, APol-detergent and IMP-APol-detergent, resp., according to the regular mixing model. Diluting IMP-APol-detergent complexes below the critical micellar concentration (CMC) of the detergent triggers the dispersion of detergent mols. as monomers, a process characterized by an enthalpy of demicellization. The enthalpy of APol ↔ detergent exchange on the hydrophobic surface of IMPs is negligibly small, an indication of the similarity of the mol. interactions of IMPs with the two types of amphiphiles. The enhanced stability against dilution of IMP-APol complexes, compared to IMP-detergent ones, originates from the difference in entropy gain achieved upon release in water of a few APol mols. (in the case of IMP-APol complexes) or several hundred detergent mols. (in the case of IMP-detergent complexes). The data account both for the stability of IMP-APols complexes in the absence of detergent and for the ease with which detergents displace APols from the surface of proteins.

Langmuir published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C18H34N4O5S, Quality Control of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Wen-hua published the artcileApplication of carboprost tromethamine and improved B-Lynch suture in postnatal hemorrhage of cesarean section, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Zhongguo Fuyou Baojian (2013), 28(22), 3710-3711, database is CAplus.

The objective of this paper is to investigate carboprost tromethamine and uterine Modified B-Lynch suture in the treatment of intractable postpartum hemorrhage in cesarean. Here, 36 patients treated by general application can not stop the bleeding maternal carboprost tromethamine and modified B-Lynch suture. The results shows, 30 cases of postpartum hemorrhage were stopped, the bleeding rate was 83.33%. Carboprost tromethamine and modified B-Lynch suture in the treatment of uterine cesarean intractable postpartum hemorrhage is certainly worthy of promotion.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application of 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts