Month: December 2022

Faltracco, Matteo published the artcileDiastereoselective Synthesis of β-Lactams by Ligand-Controlled Stereodivergent Intramolecular Tsuji-Trost Allylation, Computed Properties of 22483-09-6, the main research area is diastereoselective intramol Tsuji Trost allylation ligand controlled stereodivergent; beta lactam stereoselective preparation.

The diastereoselective synthesis of highly substituted β-lactams by intramol. Tsuji-Trost allylation is reported. Judicious selection of the ligand on palladium allows selective access to either the trans isomer (in generally good to excellent yield with very high diastereomeric excess) or cis isomer (with yields and diastereoselectivity ranging from modest to excellent depending on the substrate). The reaction proceeds under exceedingly mild conditions (rt, no additives) with a broad range of substrates, which are readily accessible by the Ugi reaction.

Journal of Organic Chemistry published new progress about Diastereoselective synthesis. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Computed Properties of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rouchaud, Anne published the artcileA new and efficient synthesis of derivatives of octahydro-4H-pyrrolo[1,2-c]pyrido[1′,2′-a]imidazole, Computed Properties of 87905-98-4, the main research area is octahydropyrrolopyridoimidazole preparation.

When di-Et malonate was added to a solution of Δ1-piperideine, generated in situ by oxidative desamination and decarboxylation of L-lysine by N-bromosuccinimide (NBS), formation of the unexpected tricyclic compound I was observed The structure of I was deduced from anal. of its spectroscopic data and was confirmed both by chem. degradation and by total synthesis. We proved that 3-bromo-1-piperideine was implicated in its formation. Moreover, based on this feature, a new and efficient synthesis of I was developed. The elaborated pathway was adapted to access derivatives related to I that differed in their C-4 substituent.

European Journal of Organic Chemistry published new progress about Michael reaction. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Computed Properties of 87905-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Snyder, Brittany L. published the artcileDrug Delivery and Drug Efficacy from Amorphous Poly(thioether anhydrides), Product Details of C17H28O8S4, the main research area is polythioether anhydride drug delivery efficacy; drug delivery; lidocaine; poly(thioether anhydride); surface erosion.

The correlation between erosion and drug (lidocaine and 6-mercaptopurine, 6-MP) release from amorphous poly(thioether anhydrides), which are synthesized using radical-mediated thiol-ene polymerization, is reported. Cytotoxicity studies of the polymer toward human fibroblast human dermal fibroblasts adult, melanoma A-375, and breast cancer MCF-7 cells are conducted, and drug efficacy of a cancer and autoimmune disease drug (6-MP) when released from the poly(thioether anhydrides) is examined against two cancerous cell types (A-375 and MCF-7). Erosion and drug release studies reveal that lidocaine release is governed by network erosion whereas 6-MP is released by a combination of erosion and diffusion. The cytotoxicity studies show that all three cell types demonstrate high viability, thus cytocompatibility, to poly(thioether anhydrides). Toxicity to the material is dose dependent and comparable to other polyanhydride systems. The 6-MP cancer drug is shown to remain bioactive after encapsulation in the poly(thioether anhydride) matrix and the polymer does not appear to modify the efficacy of the drug.

Macromolecular Bioscience published new progress about Biocompatibility, cytocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Product Details of C17H28O8S4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

von Poser, Gilsane L. published the artcileEssential Oil Composition and Allelopathic Effect of the Brazilian Lamiaceae Hesperozygis ringens (Benth.) Epling and Hesperozygis rhododon Epling, Computed Properties of 42822-86-6, the main research area is Hesperozygis oil composition; terpene Hesperozygis oil.

Samples of Hesperozygis ringens (Benth.) Epling and Hesperozygis rhododon Epling essential oils were analyzed by a combination of anal. techniques: capillary gas chromatog., liquid/solid chromatog., GC/MS coupling, and NMR spectroscopy. Twenty-four components have been identified representing altogether more than 95% of the oil content. The oil of H. ringens is constituted mainly by pulegone (79.2%) accompanied by several oxygenated derivatives (pulegone oxides, 1.2%; 8-hydroxy-p-menth-3-one, 1.3%; and 8-hydroxy-p-menth-4-en-3-one, 3.7%); that of H. rhododon contains menthone and pulegone as main compounds in almost comparable amounts (43.4% and 29.6%, resp.). Tests carried out on lettuce seeds using alc. extracts of the two species showed significant antigerminating properties mainly for H. ringens. The same activity was observed with its essential oil.

Journal of Agricultural and Food Chemistry published new progress about. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Computed Properties of 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kong, Ying-Ying published the artcileIridium-Catalyzed α-Alkylation of Arylacetonitriles Using Secondary and Primary Alcohols, SDS of cas: 584-02-1, the main research area is alkylated arylacetonitrile green preparation; alc arylacetonitrile alpha alkylation iridium catalyst.

In the presence of NaOtBu, [Cp*IrCl2]2-catalyzed reaction of arylacetonitriles with alcs. was performed to yield α-monoalkylation products of arylacetonitriles such as I [R1 = (CH2)2CH3, (CH2)4CH3, CH2(CH2)2Ph, etc .; R2 = H, Ph; R1 = R2 = Me, Et; R1R2 = CH2(CH2)2CH2, CH2(CH2)3CH2, CH2(CH2)5CH2, etc.; Ar = Ph, 4-PhC6H4, 2-naphthyl, etc.]. The catalyst and conditions also suited for the α-monoalkylation of arylacetonitriles with primary alcs.

Asian Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, SDS of cas: 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fellechner, Oliver published the artcileLong-Chain Alcohol-Modified Micellar Systems and Their Application in a Continuous Extraction Process, Quality Control of 111-87-5, the main research area is long chain alc micellar extraction micelle surfactant purification.

The integration of an in situ extraction into biocatalytic processes is often limited by the toxicity of organic solvents. Therefore, it is desirable to use water-based extraction systems (for example, aqueous micellar two-phase systems). They can be used, for instance, for the extraction of valuable products from microalgae cultures. Recently, the nonionic surfactant ROKAnol NL5 was identified as a suitable surfactant for this purpose, since it forms an upper micellar phase, enabling an easy separation of whole-cell biocatalysts. However, its application at temperatures below 45 °C is limited by unstable phase boundaries, whereas the maximal temperature to ensure the vitality of the most microalgae cultures is ∼40 °C. To overcome this problem, the addition of long-chain alcs. to the surfactant-water mixture during extraction is suggested in this work. Using 1-hexanol, a continuous extraction process with the model solute trans-cinnamic acid at 40 °C in a stirred column could be realized. The results of a new suggested water/ROKAnol NL5/1-hexanol system at 40 °C (extraction yield, Ycont = 97.67% ± 0.14%; enrichment factor, log10TCA = 2.42 ± 0.03; number of theor. stages, Ntheo = 4.45 ± 0.16) are comparable to those of the water/ROKAnol NL5 system at 45 °C (Ycont = 99.26% ± 0.24%, log10TCA = 2.60 ± 0.10, Ntheo = 5.88 ± 0.67), ensuring, however, no damage of microalgae.

Industrial & Engineering Chemistry Research published new progress about Micellar extraction. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Quality Control of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zheng, Yuzhu published the artcileDirect activation of alcohols via perrhenate ester formation for an intramolecular dehydrative Friedel-Crafts reaction, Related Products of alcohols-buliding-blocks, the main research area is silica supported rhenium oxide preparation; tetrahydronaphthalene derivative preparation; aryl alc intramol dehydrative Friedel Crafts rhenium oxide catalyst.

A general method for synthesis of tetrahydronaphthalene derivatives I [R = Ph, 4-MeC6H4, 2-BrC6H4, etc.; R1 = H, Me; R2 = H, 5-Me, 7-Br, etc.; X = CH2, O, NTs; Y = CH2, O, NTs] via Re2O7 catalyzed intramol. dehydrative Friedel-Crafts reaction of alcs. in hexafluoroisopropanol (HFIP) was reported. The potential application of this methodol. was exemplified by the formal or total synthesis of several com. available drugs or biol. relevant mols., including sertraline, nafenopin, etc. DFT calculations showed the preference for the activation of hydroxyl groups by Re2O7 via perrhenate ester formation followed by heterolytic C-O bond cleavage over Bronsted acid-catalyzed dehydration.

Organic Chemistry Frontiers published new progress about Free energy. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adebomi, Victor published the artcileMetal-free selective modification of secondary amides: Application in late-stage diversification of peptides, Formula: C4H11NO2, the main research area is peptide solid phase synthesis twisted amide diversification metal free; carbon nitrogen bond activation DFT ground state rotational energy; transamidation esterification thiocarbonyl insertion reaction thiocarbonylation solid support; mol structure twisted amino acid.

Here we solve a long-standing challenge of the site-selective modification of secondary amides and present a simple two-step, metal-free approach to selectively modify a particular secondary amide in mols. containing multiple primary and secondary amides. D. functional theory (DFT) provides insight into the activation of C-N bonds. This study encompasses distinct chem. advances for late-stage modification of peptides thus harnessing the amides for the incorporation of various functional groups into natural and synthetic mols.

Organic Letters published new progress about Amino acids Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Formula: C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Long, Christopher P. published the artcileHigh-resolution 13C metabolic flux analysis, Synthetic Route of 97-67-6, the main research area is Escherichia 13C metabolic flux analysis glycogen glucose ribose.

Precise quantification of metabolic pathway fluxes in biol. systems is of major importance in guiding efforts in metabolic engineering, biotechnol., microbiol., human health, and cell culture. 13C metabolic flux anal. (13C-MFA) is the predominant technique used for determining intracellular fluxes. Here, we present a protocol for 13C-MFA that incorporates recent advances in parallel labeling experiments, isotopic labeling measurements, and statistical anal., as well as best practices developed through decades of experience. The protocol is based on growing microbes in two (or more) parallel cultures with 13C-labeled glucose tracers, followed by gas chromatog.-mass spectrometry measurements of isotopic labeling of protein-bound amino acids, glycogen-bound glucose, and RNA-bound ribose. Fluxes are then estimated using software for 13C-MFA, such as Metran, followed by comprehensive statistical anal. to determine the goodness of fit and calculate confidence intervals of fluxes. The presented protocol can be completed in 4 d and quantifies metabolic fluxes with a standard deviation of =2%, a substantial improvement over previous implementations. The presented protocol is exemplified using an Escherichia coli ΔtpiA case study with full supporting data, providing a hands-on opportunity to step through a complex troubleshooting scenario. This protocol can be easily adjusted for application to eukaryotic organisms.

Nature Protocols published new progress about Computer program (Metran). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Synthetic Route of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Qian published the artcileTriptycene-based dicationic guanidinium ionic liquid: A novel stationary phase of high selectivity towards a wide range of positional and structural isomers, Product Details of C5H12O, the main research area is triptycene derivative dicationic guanidinium ionic liquid stationary GC isomer; Aromatic and aliphatic isomers; Dicationic guanidinium ionic liquid, gas chromatography; Essential oil; Separation performance; Triptycene-based stationary phase.

This work presents a new triptycene-based dicationic guanidinium ionic liquid (TPG) as the stationary phase for gas chromatog. (GC). To knowledge, this is the 1st example of employing a dicationic guanidinium ionic liquid (GIL) for chromatog. analyses. As a result, the TPG column exhibited moderate polarity and column efficiency of 3840 plates/m and 3120 plates/m measured by naphthalene and 1-octanol at 120°, resp. Particularly, the TPG column exhibited distinctly advantageous performance for the challenging Grob test mixture and the isomer mixture of phenols and anilines over the monocationic GIL and its counterpart with dicationic immidazolium units (TP-2IL). Also, it showed higher selectivity towards the isomers of alkanes, alcs., diethylbenzenes, bromotoluenes, bromonitrobenzenes than the com. DB-35MS column. Also, the TPG column achieved improved thermal stability over the GIL column and excellent repeatability with the relative standard deviation values of 0.01-0.05% for run-to-run, 0.11-0.24% for day-to-day and 2.4-4.1% for column-to-column. Its application to GC-MS anal. of the essential oil of Mentha haplocalyx proved its good potential for anal. of complex samples.

Journal of Chromatography A published new progress about Alkanes Role: ANT (Analyte), PEP (Physical, Engineering or Chemical Process), PRP (Properties), ANST (Analytical Study), PROC (Process). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Product Details of C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts