Month: December 2022

Chardon, Fabien published the artcileNatural variation in the long-distance transport of nutrients and photoassimilates in response to N availability, Application of (S)-2-hydroxysuccinic acid, the main research area is nitrogen nutrient transport phloem xylem natural variation Arabidopsis; Allocation; Pipecolate; Raffinose; Succinate; Sucrose; Transport.

Phloem and xylem tissues are necessary for the allocation of nutrients and photoassimilates. However, how the long-distance transport of carbon (C) and nitrogen (N) is coordinated with the central metabolism is largely unknown. To better understand how the genetic and environmental factors influence C and N transport, we analyzed the metabolite profiles of phloem exudates and xylem saps of five Arabidopsis thaliana accessions grown in low or non-limiting N supply. We observed that xylem saps were composed of 46 or 56% carbohydrates, 27 or 45% amino acids, and 5 or 13% organic acids in low or non-limiting N supply, resp. In contrast, phloem exudates were composed of 76 or 86% carbohydrates, 7 or 18% amino acids, and 5 or 6% organic acids. Variation in N supply impacted amino acid, organic acid and sugar contents. When comparing low N and non-limiting N, the most striking differences were variations of glutamine, aspartate, and succinate abundance in the xylem saps and citrate and fumarate abundance in phloem exudates. In addition, we observed a substantial variation of metabolite content between genotypes, particularly under high N. The content of several organic acids, such as malate, citrate, fumarate, and succinate was affected by the genotype alone or by the interaction between genotype and N supply. This study confirmed that the response of the of nutrients in the phloem and the xylem to N availability is associated with the regulation of the central metabolism and could be an adaptive trait.

Journal of Plant Physiology published new progress about Arabidopsis thaliana. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Application of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rubio, Bernadette published the artcileMetabolic profile discriminates and predicts Arabidopsis susceptibility to virus under field conditions, HPLC of Formula: 97-67-6, the main research area is Arabidopsis Turnip mosaic virus; Arabidopsis thaliana; Turnip mosaic virus; central metabolism; field conditions; growth; specialized metabolism; trade-off.

As obligatory parasites, plant viruses alter host cellular metabolism There is a lack of information on the variability of virus-induced metabolic responses among genetically diverse plants in a natural context with daily changing conditions. To decipher the metabolic landscape of plant-virus interactions in a natural setting, twenty-six and ten accessions of Arabidopsis thaliana were inoculated with Turnip mosaic virus (TuMV), in two field experiments over 2 years. The accessions were measured for viral accumulation, above-ground biomass, targeted and untargeted metabolic profiles. The phenotypes of the accessions ranged from susceptibility to resistance. Susceptible and resistant accessions were shown to have different metabolic routes after inoculation. Susceptible genotypes accumulate primary and secondary metabolites upon infection, at the cost of hindered growth. Twenty-one metabolic signatures significantly accumulated in resistant accessions whereas they maintained their growth as mock-inoculated plants without biomass penalty. Metabolic content was demonstrated to discriminate and be highly predictive of the susceptibility of inoculated Arabidopsis. This study is the first to describe the metabolic landscape of plant-virus interactions in a natural setting and its predictive link to susceptibility. It provides new insights on plant-virus interactions. In this undomesticated species and in ecol. realistic conditions, growth and resistance are in a permanent conversation.

Metabolites published new progress about Arabidopsis thaliana. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, HPLC of Formula: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Zhengwei published the artcileEffect of package oxygen on color, color-related compounds, and volatile composition of Chinese bayberry wine after bottling, Quality Control of 584-02-1, the main research area is Myrica wine oxygen color bottling.

Package oxygen is an important factor for the wine quality during storage. However, its role in Chinese bayberry wine remains unclear. This study aimed to investigate the effect of package oxygen on color and volatile composition of Chinese bayberry wine. Wines with different package oxygen were anal. monitored (color parameters, pigments, non-volatile monomeric phenols, acetaldehyde, 5-hydroxymethylfurfural and volatile composition) during 90 days of accelerated storage at 37°C in dark. The result showed that high package oxygen accelerated the color deterioration, anthocyanin degradation, polymeric pigments formation, and acetaldehyde production The molar ratio of produced protocatechuic acid to degraded anthocyanin after storage increased from 5.08% to 25.14% as package oxygen increased. As the package oxygen increased, the concentration of total volatile esters and acids increased by up to 19.74% and 41.03%, resp. However, no significant effect of package oxygen was found on total volatile alcs., carbonyl compounds, and terpenes. The results suggest that package oxygen probably enhanced the scission more than the condensation of anthocyanin. Low package oxygen is beneficial to the color and some volatile compounds of Chinese bayberry wine.

LWT–Food Science and Technology published new progress about Bottling. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Quality Control of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cabal, Luis Felipe Rodriguez published the artcileDetermination of ring-substituted amphetamines through automated online hollow fiber liquid-phase microextraction-liquid chromatography, Application of n-Octanol, the main research area is forensic ring substituted amphetamine hollow liquid microextraction chromatog; Automation; Liquid chromatography; Mass spectrometry; Microextraction; Sample preparation.

The present paper describes an original method for the online preconcentration and anal. of ring-substituted amphetamines in urine samples, used on the integration of robot-assisted hollow fiber liquid-phase microextraction (HF-LPME), high-performance liquid chromatog. (HPLC), and fluorescence detection (FLD). A laboratory-made autosampler, actuating a 100-μL syringe and equipped with a three-way solenoid microvalve, allowed the acceptor phase to flow through and be withdrawn from the lumen fiber, enabling the automated online transference of the enriched acceptor phase for chromatog. anal., through a six-port switching valve. The developed online HF-LPME-LC/FLD method demonstrated high anal. throughput and confidence, facilitating the efficient extraction and determination of the target analytes, with minimal solvent consumption and sample manipulation, in a straightforward way. Sample cleanup, analyte uptake, and anal. were carried out in 14.5 min. Under optimal conditions, automated online HF-LPME showed excellent linearity, precision, and trueness, obtaining intraday RSDs between 2.9 and 9.2% (n = 6) and interday RSDs between 5.3 and 9.3% (n = 6). Enrichment factors (EFs) ranged between 14.2 and 15.7, extraction recoveries (ERs) ranged between 17.7 and 19.5%, and the limits of detection (S/N = 3) were 2.0, 3.0, and 3.0 μg L-1 for MDA, MDMA, and MDEA, resp. The method proved to be an effortless, rapid, reliable, and environment-friendly approach for the determination of drug abuse in urine samples.

Analytical and Bioanalytical Chemistry published new progress about Automated analysis. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liao, Lan-Shan published the artcileOne-pot synthesis of oxoaporphines as potent antitumor agents and investigation of their mechanisms of actions, HPLC of Formula: 22483-09-6, the main research area is oxoporphine derivative preparation antitumor agents; Antitumor activity; Apoptosis; Cell cycle; Oxoaporphine.

An efficient one-pot reaction for the synthesis of oxoaporphine alkaloids has been developed. Twenty-three compounds of oxoaporphine alkaloids were prepared and assessed for their antitumor activities. Most compounds inhibited the growth of T-24 tumor cells in vitro. Particularly, I displayed the most potent activity with an IC50 value of 0.5μM, which was 19-fold more potent than the parent compound 4. The substitution at C3-position of oxoaporphine core by -NO2 significantly enhanced the anticancer activity. Mechanism studies indicated that II and I induced cell cycle arrest at G2/M phase; in contrast, III induced cell cycle arrest at the S phase. Increase of mitochondrial ROS/Ca2+ and decrease of MMP, accompanied by activation of caspase-3/9, were observed in T-24 cells after exposure to compounds I, II and III, suggesting that the mitochondrial pathway was involved in the induced apoptosis. Moreover, compound I effectively inhibited tumor growth in a mouse xenograft model bearing T-24.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, HPLC of Formula: 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jung, Mun Yhung published the artcileAn unattended HS-SPME-GC-MS/MS combined with a novel sample preparation strategy for the reliable quantitation of C8 volatiles in mushrooms: A sample preparation strategy to fully control the volatile emission, Recommanded Product: n-Octanol, the main research area is mushroom volatile HSSPMEGCMS freeze drying rehydration; Automation; Beech; Button; C8 volatiles; Gas chromatography; Headspace-solid phasemicroextraction; Mass spectrometry; Mushrooms; Quantitative analysis; Shiitake.

Eight carbon (C8) compounds are the key characteristic flavors of mushrooms. The quant. anal. of the volatiles in mushrooms is challenging especially with the unattended HS-SPME-GC-MS. An unattended HS-SPME-GC-MS/MS in combination with novel sample preparation of the complete control of volatile emissions was developed for the quantitation of the C8 volatiles in mushrooms. The sample preparation strategy was composed of freeze-drying, rehydration, and the addition of a 15% citric acid solution With this strategy, the volatile emission from mushroom was fully controlled at a certain time point. This method was found to be highly reliable, sensitive, precise, and accurate. This method was successfully applied to measure the contents of the C8 volatiles in the beech, button, and shiitake mushrooms. 1-Octene-3-ol was the most predominant compound in the mushrooms, representing 62.4, 69.0, and 89.2% of the total C8 volatiles in the beech, button, and shiitake mushrooms, resp.

Food Chemistry published new progress about Adsorption. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wilson, Tyler M. published the artcileEssential Oil Composition and Stable Isotope Profile of Cultivated Ocimum campechianum Mill. (Lamiaceae) from Peru, Quality Control of 124-76-5, the main research area is Ocimum Lamiaceae essential oil stable isotope Peru; Ocimum campechianum; Peruvian basil; chemotype; essential oil; stable isotope; yield.

Ocimum campechianum Mill. (Peruvian basil) is an essential oil-bearing plant of the Lamiaceae family. Volatile oil produced through steam distillation of Peruvian basil was examined to establish the aromatic and stable isotope profiles of samples (n = 9) from three different cultivated plots in Peru. The resulting essential oils were analyzed by GC/FID, GC/MS, and GC/IRMS. In accordance with findings from other researchers, multiple chemotypes, defined by the most abundant aromatic compounds, exist within these populations. Overall, 55% of samples are the eugenol chemotype (values ranging 15.4-30.2%), 33% are the Me eugenol chemotype (values ranging 68.1-68.7%), and a single sample is a mixture of both chemotypes, containing high levels of both eugenol (38.1%) and Me eugenol (8.6%). Stable isotope ratios, δ2H and δ13C, performed on prominent compounds provide supporting data for distinguishing chemotypes. Complete aromatic profiles, stable isotope ratios, and essential oil yield are established for each sample. This study confirms the existence of multiple chemotypes and, for the first time, to the author’s best knowledge, establishes stable isotope ratios for O. campechianum essential oil, which proves a useful tool in further investigating plant metabolism and determining essential oil authenticity.

Molecules published new progress about Flower. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Quality Control of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Jie published the artcileMetal-Organic Framework Based on Heptanuclear Cu-O Clusters and Its Application as a Recyclable Photocatalyst for Stepwise Selective Catalysis, COA of Formula: C5H12O, the main research area is preparation polynuclear copper disulfobiphenyldicarboxylate bipyridine phenanthroline MOF cluster; crystal structure polynuclear copper disulfobiphenyldicarboxylate bipyridine phenanthroline MOF cluster; thermal decomposition polynuclear copper disulfobiphenyldicarboxylate bipyridine phenanthroline MOF cluster; recyclable photocatalyst polynuclear copper disulfobiphenyldicarboxylate bipyridine phenanthroline MOF cluster.

Visible-light driven photoreactions using metal-organic frameworks (MOFs) as catalysts are promising with regard to their environmental friendly features such as the use of renewable and sustainable energy of visible light and potential catalyst recyclability. To develop potential heterogeneous photocatalysts, a family of three copper(II) coordination polymers bearing different Cu-O assemblies were synthesized with the ligand 4,4′-disulfo-[1,1′-biphenyl]-2,2′-dicarboxylate acid (H4DSDC), namely, {[Cu7(DSDC)2(OH)6(H2O)10]·xH2O}n (1), {[Cu4(DSDC)(4,4′-bpy)2(OH)4]·2H2O}n (2), and {Cu2(DSDC)(phen)2(H2O)2}n (3) (4,4′-bpy = 4,4′-bipyridine and phen = 1,10-phenanthroline). Complex 1 represents a metal-organic framework featuring a NbO type topol. constructed from the infinite linkage of heptanuclear [Cu7(μ3-OH)6(H2O)10]8+ clusters by deprotonated DSDC4- ligands, comprising one-dimensional hexagonal channels of a diameter around 11 Å that are filled with water mols. The infinite waving {[Cu2(OH)2]2+}n ladderlike chains in complex 2 are bridged by DSDC4- and 4,4′-bpy ligands into a three-dimensional framework. A two-dimensional layered structure is formed in complex 3 due to the existence of terminal phenanthroline ligands. All of the coordination polymers 1-3 are able to catalyze the visible-light driven oxidation of alcs. at mild conditions using hydrogen peroxide as an oxidant, in which complex 1 demonstrates satisfactory efficiency. Significantly for this photoreaction catalyzed by 1, the extent of oxidation over aryl primary alcs. is fully controllable with time-resolved product selectivity, giving either corresponding aldehydes or carboxylate acids in good yields. It is also remarkable that the photocatalyst could be recovered almost quant. on completion of the catalytic cycle without any structure change, and could be recycled for catalytic use for at least five cycles with constant efficiency. This photocatalyst with time-resolved selectivity for different products may provide new insight into the design and development of novel catalytic systems. A metal-organic framework featuring a NbO type topol. constructed from infinite linkage of heptanuclear [Cu7(μ3-OH)6(H2O)10]8+ clusters was fabricated, which can catalyze visible-light driven oxidation of alcs. at mild conditions, demonstrating satisfactory efficiency. The extent of oxidation over aryl primary alcs. is fully controllable with time-resolved product selectivity, giving either corresponding aldehydes or carboxylate acids in good yields. The photocatalyst can be recovered quant. on completion of the catalytic cycle and can be reused for at least five catalytic cycles with constant efficiency.

Inorganic Chemistry published new progress about Crystal structure. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, COA of Formula: C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Long, Nguyen Phuoc published the artcileIsolation and Metabolic Assessment of Cancer Cell Mitochondria, Category: alcohols-buliding-blocks, the main research area is metabolism cancer cell mitochondria.

Mitochondrial metabolism plays an essential role in various biol. processes of cancer cells. Herein, the authors established an exptl. procedure for the metabolic assessment of mitochondria in cancer cells. The authors examined procedures for mitochondrial isolation coupled with various mitochondrial extraction buffers in three major cancer cell lines (PANC1, A549, and MDA-MB-231) and identified a potentially optimal and generalized approach. The purity of the mitochondrial fraction isolated by the selected protocol was verified using specific protein markers of cellular components, and the ultrastructure of the isolated mitochondria was also analyzed by TEM. The isolation procedure, involving a bead beater for cell lysis, a modified sucrose buffer, and differential centrifugation, appeared to be a suitable method for the extraction of mitochondria from cancer cells. Electron micrographs indicated an intact two-layer membrane and inner structures of mitochondria isolated by this procedure. Metabolomic and lipidomic analyses were conducted to examine the metabolic phenotypes of the mitochondria-enriched fractions and associated bulk cancer cells. A total of 44 metabolites, including malate and succinate, occurred at significantly higher levels in the mitochondrial fractions, whereas 51 metabolites, including citrate, oxaloacetate, and fumarate of the Krebs cycle and the oncometabolites glutamine and glutamate, were reduced in mitochondria compared to that in the corresponding bulk cells of PANC1. Similar patterns were observed in mitochondria and bulk cells of MDA-MB-231 and A549 cell lines. A clear difference between the lipid profiles of bulk PANC1, MDA-MB-231, and A549 and corresponding mitochondrial fractions of these cell lines was detected by principal component anal. In conclusion, the authors developed an exptl. procedure for a large-scale metabolic assessment for suborganelle metabolic profiling and multiple omics data integration in cancer cells with broad applications.

ACS Omega published new progress about Biomarkers. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Beyer, Valentin Peter published the artcileThiol-Bromo Click Reaction for One-Pot Synthesis of Star-Shaped Polymers, Product Details of C17H28O8S4, the main research area is thiol bromo click star shaped polymer; Cu-mediated RDRP; Star polymers; click reactions; one pot reactions; thiol-bromo.

Star-shaped polymers have unique phys. properties and they are sought after materials in industry. However, the ease of synthesis is essential for translation of these materials into large-scale applications. Herein, a highly efficient synthetic method to prepare star-shaped polymers by combination of Cu-mediated reversible deactivation radical polymerization (Cu-RDRP) and thiol-bromo click reaction is described. Well-defined linear and block polymers with a very high bromine chain end fidelity are obtained via Cu-RDRP and subsequently react with multi-functional thiol compounds High coupling efficiencies of larger than 90% are obtained owing to the quick and efficient reaction between thiols and alkyl bromides. Moreover, the arms of the obtained star-shaped polymers are linked via thioether bonds to the core, making them susceptible for oxidative degradation

Macromolecular Rapid Communications published new progress about Click chemistry. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Product Details of C17H28O8S4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts