Month: December 2022

Farag, Mohamed A. published the artcileComparative Metabolite Profiling and Fingerprinting of Medicinal Cinnamon Bark and Its Commercial Preparations via a Multiplex Approach of GC-MS, UV, and NMR Techniques, Category: alcohols-buliding-blocks, the main research area is Cinnamomum metabolite profiling fingerprinting gas chromatog mass spectrometry; NMR; SPME/GC–MS; UV/Vis; chemometrics; cinnamaldehyde; cinnamon; metabolomics.

Various species of cinnamon (Cinnamomum sp.) are consumed as traditional medicine and popular spice worldwide. The current research aimed to provide the first comparative metabolomics study in nine cinnamon drugs and their different com. preparations based on three anal. platforms, i.e., solid-phase microextraction coupled to gas chromatog.-mass spectrometry method (SPME/GC-MS), NMR (NMR), and UV-visible spectrophotometry (UV/Vis) targeting its metabolome. SPME/GC-MS of cinnamon aroma compounds showed a total of 126 peaks, where (E)-cinnamaldehyde was the major volatile detected at 4.2-60.9% and 6.3-64.5% in authenticated and com. preparations, resp. Asides, modeling of the GC/MS dataset could relate the com. products CP-1 and CP-3 to C. cassia attributed to their higher coumarin and low (E)-cinnamaldehyde content. In contrast, NMR fingerprinting identified (E)-methoxy cinnamaldehyde and coumarin as alternative markers for C. verum and C. iners, resp. Addnl., quant. NMR (qNMR) standardized cinnamon extracts based on major metabolites. UV/Vis showed to be of low discrimination power, but its orthogonal projections to latent structures discriminant anal. (OPLS-DA) S-plot showed that C. iners was more abundant in cinnamic acid compared to other samples. Results of this study provide potential insights into cinnamon drugs QC anal. and identify alternative markers for their discrimination.

Metabolites published new progress about Cinnamomum cassia. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Montemurro, Marco published the artcileSelection of non-Lactobacillus strains to be used as starters for sourdough fermentation, Formula: C4H10OS, the main research area is Enterococcus Leuconostoc Weissella Pediococcus sourdough fermentation; Lactic acid bacteria; Leuconostoc; Non-Lactobacillus strains; Pediococcus; Sourdough; Starter selection.

The suitability of forty-one non-Lactobacillus strains to be used as selected starters for sourdough fermentation was evaluated. According to the data collected, Pediococcus pentosaceus OA1 and S3N3 and Leuconostoc citreum PRO17 were selected based on the optimal acidification and growth performances and the intense proteolytic activity (increase of TFFA up to 80%) on whole wheat flour doughs. A relevant degradation of phytic acid (up to 58%) and the increase of phenols content and scavenging activity (4- and 2-folds, resp.) were also observed The technol. performances were compared to two representative Lactobacillus strains (Lactobacillus plantarum and Lactobacillus sanfranciscensis). The investigation of the robustness of the selected strains during the propagation (back-slopping procedure) showed their long-term dominance only when singly-inoculated; while Leuc. citreum PRO17 dominated the fermentation when the strains were co-inoculated. The sourdoughs obtained by the non-Lactobacillus selected strains (singly or pooled) were used for breadmaking. Selected sourdoughs allowed the production of breads characterized by in-vitro protein digestibility (IVPD) higher than that of breads obtained with Lactobacillus strains or bakers yeast. The aroma profile, estimated by GC/MS, was complex and characterized by high concentration of the typical compounds (hexanol, 3-methylbutanol and 2-pentylfuran) of sourdough bread.

Food Microbiology published new progress about Bread. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Formula: C4H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kumar, Shreemoyee published the artcileRu(II)-catalyzed allenylation and sequential annulation of N-tosylbenzamides with propargyl alcohols, Recommanded Product: 3,5-Dimethylhex-1-yn-3-ol, the main research area is allenylamide isoquinolone preparation; tosylbenzamide propargyl alc allenylation sequential annulation ruthenium catalyst.

Here Ru(II)-catalyzed C(sp2)-H allenylation of N-tosylbenzamides to access multi-substituted allenylamides has been reported. Furthermore, the allenylamides were converted to the corresponding isoquinolone derivatives via base mediated annulation. The current protocol features low catalyst loading, mild reaction conditions, high functional group compatibility and desired scalability. The unique functionality of the afforded allenes allowed further transformations to expand the practicality of the protocol.

Chemical Communications (Cambridge, United Kingdom) published new progress about Allenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, Recommanded Product: 3,5-Dimethylhex-1-yn-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Luo, Yi published the artcileFormation of diversified spiro-[imidazole-indene] derivatives from 2H-imidazoles: based on versatile propargyl alcohols, COA of Formula: C8H14O, the main research area is phenylimidazole aryl propargyl alc rhodium catalyst regioselective tandem spirocyclization; aryl spiro imidazole indene preparation.

Rh(III)-catalyzed efficient cascade annulation for the regioselective construction of various spiro[imidazole-indene] derivatives were reported by utilizing versatile propargyl alcs. as coupling partners. The type of propargyl alc. played a key role in tuning the combination state and controlling formation of different products.

Organic Chemistry Frontiers published new progress about Alkenylation. 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, COA of Formula: C8H14O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aubineau, Thomas published the artcileIron-Catalyzed Diastereoselective Synthesis of Disubstituted Morpholines via C-O or C-N Bond Formation, Name: 2,2-Dimethoxyethanamine, the main research area is hydroxybutenyl hydroxyethyl methylbenzenesulfonamide iron chloride catalyst diastereoselective heterocyclization; tosylmorpholine preparation green chem; butenyhydroxy oxyethyl methylbenzenesulfonamide iron chloride catalyst diastereoselective heterocyclization; styryl tosylmorpholine preparation green chem.

The diastereoselective synthesis of 2,6- and 3,5-disubstituted morpholines was achieved from 1,2-amino ethers and 1,2-hydroxy amines substituted by an allylic alc. using an iron(III) catalyst. The morpholines were obtained either by C-O or C-N bond formation. A plausible mechanism was suggested, involving a thermodn. equilibrium to explain the formation of the cis diastereoisomer as the major product.

Synlett published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Name: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schuetz, Ramona published the artcileA versatile approach to 1-oxo-, 1-oxo-3,4-dihydro- and 1,3,4-trioxo isoquinoline alkaloids and first total synthesis of the dimeric 1-oxoisoquinoline alkaloids berbanine and berbidine, Recommanded Product: 2,2-Dimethoxyethanamine, the main research area is isoquinoline alkaloid preparation one pot Suzuki coupling cyclization; berbanine total synthesis; berbidine total synthesis.

We have worked out a very short approach to 1-oxoisoquinoline alkaloids starting from readily available 2-bromobenzamides utilizing a 2-ethoxyvinylboronate as a C2 building block for introduction of the C-3,C-4 unit of the isoquinoline core. TFA-mediated cyclization of crude ortho-ethoxyvinyl benzamides gave 1-oxoisoquinolines in one single operation. Further modifications of these compounds opened an access to the other chemotypes. In total, 14 alkaloids from four chemotypes (five 1-oxoisoquinolines, six 1-oxo-3,4-dihydroisoquinolines, one 1,3,4-trioxoisoquinoline, and two dimeric isoquinoline alkaloids) were obtained in this investigation. With this approach we improved the total syntheses of the monomeric oxoisoquinolines, and worked out the first total syntheses of the dimeric alkaloids berbanine (I) and berbidine (II).

Tetrahedron published new progress about Cyclization. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Recommanded Product: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Hong-Yan published the artcileThe chemical, sensory, and volatile characteristics of instant sweet tea (Lithocarpus litseifolius [Hance] Chun) using electronic nose and GC-MS-based metabolomics analysis, Synthetic Route of 124-76-5, the main research area is Lithocarpus litseifolius chem sensory volatile electronic nose GCMS metabolomics.

This study aims to investigate the effect of instant tea processing on the chem., sensory, and volatile profiles of sweet tea. Young leaves of Lithocarpus litseifolius [Hance] Chun were extracted and dried with freeze-drying and spray-drying, resp. The contents of proteins, polysaccharides, total phenolics, total flavonoids, and free amino acids in instant teas were found to be higher than those in sweet tea. A total of 268 volatiles were identified by HS-SPME-GC-MS, and 88 compounds showed significant differences among different samples, and most of volatile compounds showed lower concentrations in instant tea powder than sweet tea powder. Nine aroma attributes were evaluated through descriptive sensory anal. Sweet tea had a higher intensity of woody, green, floral, fruity, and sweet descriptor, while the instant sweet teas demonstrated the higher intensity of caramel-like attribute. Our study emphasized the nutritive value of instant sweet tea, while the aroma needs to be improved further.

LWT–Food Science and Technology published new progress about Flavonoids Role: ANT (Analyte), FFD (Food or Feed Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Synthetic Route of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Friese, Florian W. published the artcileDeoxygenative Borylation of Secondary and Tertiary Alcohols, HPLC of Formula: 124-76-5, the main research area is deoxygenative borylation secondary tertiary alc xanthate oxalate; boronic acid ester preparation; alcohols; borylation; deoxygenation; photoredox catalysis; radical reactions.

Two different approaches for the deoxygenative radical borylation of secondary and tertiary alcs. are presented. These transformations either proceed through a metal-free silyl-radical-mediated pathway or utilize visible-light photoredox catalysis. Readily available xanthates or Me oxalates are used as radical precursors. The reactions show broad substrate scope and high functional-group tolerance, and are conducted under mild and practical conditions.

Angewandte Chemie, International Edition published new progress about Borylation. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, HPLC of Formula: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Mingming published the artcileBase-Mediated Radical Borylation of Alkyl Sulfones, COA of Formula: C5H12O, the main research area is borylation alkylsulfone preparation boronate neopentyl ester base catalyst; boron; boronate; boronic acid; metal-free; radical.

A practical and direct method was developed for the production of versatile alkyl boronate esters via transition metal-free borylation of primary and secondary alkyl sulfones. The key to the success of the strategy is the use of bis(neopentyl glycolato) diboron (B2neop2), with a stoichiometric amount of base as a promoter. The practicality and industrial potential of this protocol are highlighted by its wide functional group tolerance, the late-stage modification of complex compounds, no need for further transesterification, and operational simplicity. Radical clock, radical trap experiments, and EPR studies were conducted which show that the borylation process involves radical intermediates.

Chemistry – A European Journal published new progress about Borylation. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, COA of Formula: C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Yangyang published the artcileNickel-catalyzed migratory alkyl-alkyl cross-coupling reaction, Related Products of alcohols-buliding-blocks, the main research area is alkyl halide migratory cross coupling bond formation nickel catalyst.

A migratory cross-coupling strategy, which can overcome this obstacle to access the desired cross-coupling products ArCH(R)(CH2)nCR1R2R3 (Ar = Ph, 4-fluorophenyl, indol-3-yl, etc.; R = cyclopentyl, cyclohexyl, cycloheptyl, N-benzyl-piperidin-4-yl, 2-methyl-propan-1-yl; R1 = H, D; R2 = H, D; R3 = H; n = 0-3, 5), 1-cyclopentyl-indan, 1-cycloheptyl-indan, (1-cyclopentyl-3-methyl-pentyl)benzene was described. Accordingly, a selective migratory cross-coupling of two alkyl electrophiles (RBr, ArCH(R)(CH2)nCR1R2R3 (R3 = Br or Cl), 2-bromoindan, (5-bromo-1-cyclopentyl-3-methyl-pentyl)benzene) has been accomplished by nickel catalysis. Remarkably, this alkyl-alkyl cross-coupling reaction provides a platform to prepare 2°-2° carbon-carbon bonds from 1° and 2° carbon coupling partners. Preliminary mechanistic studies suggest that chain-walking occurs at both alkyl halides in this reaction, thus a catalytic cycle with the key step involving two alkylnickel(II) species is proposed for this transformation.

Chemical Science published new progress about C-C bond formation. 93427-13-5 belongs to class alcohols-buliding-blocks, name is 2-(3,5-Dichlorophenyl)ethanol, and the molecular formula is C8H8Cl2O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts