Month: December 2022

Karlinskii, Bogdan Ya. published the artcileSynthesis of 2-Azidomethyl-5-ethynylfuran: A New Bio-Derived Self-Clickable Building Block, Computed Properties of 107-54-0, the main research area is azidomethylfurancarboxaldehyde preparation azide alkyne cycloaddition; triazolylmethylfurancarboxaldehyde preparation; azidomethylethynylfuran preparation polymerization copper catalyzed azide alkyne cycloaddition; biomass derived azide containing alkyne preparation polymerization; safety toxicity sodium azide.

Furanylmethyl azide I was prepared in three steps from D-fructose or cellulose; copper-catalyzed azide-alkyne cycloaddition of I with terminal alkynes and diynes yielded triazolylmethylfurancarboxaldehydes such as II [R = Me2C(OH), Ph, BuCH2, BuCH2CCCH2, MeO2C, NC(CH2)3, HO(CH2)4, BocNHCH2, HOCH2, 3-quinolinyl, MeOCH2, t-Bu, cyclopropyl, i-PrCH2CMe(OH), t-BuCMe(OH)]. 2-Azidomethyl-5-ethynylfuran III was prepared as a monomer; in the presence of CuBr and pentamethyldiethylenetriamine, it underwent polymerization to form oligomer with MN = 4100 g/mol. Sodium azide is toxic and should be handled with care.

Synthesis published new progress about Azide-alkyne 1,3-dipolar cycloaddition reaction. 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, Computed Properties of 107-54-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghahremani, Pantea published the artcileCerium containing pH-responsive microcapsule for smart coating application: Characterization and corrosion study, Formula: C17H28O8S4, the main research area is cerium nitrate melamine formaldehyde microcapsule epoxy coating pH corrosion.

In the following paper first, novel pH-sensitive melamine-formaldehyde microcapsules containing ethylene glycol with three concentrations of cerium nitrate were synthesized. Then, three different quantities of the microcapsules were introduced to the epoxy coatings and applied on the AA2024-T3 substrate to meet the increasing demands for self-healing coatings. The characteristics of microcapsules were studied by scanning electron microscope, transmission electron microscope, Fourier transform IR, and dynamic light scattering. The UV-Vis spectroscopy was accomplished to the appraise pH-triggered release of the microcapsules. The salt spray test along with electrochem. impedance spectroscopy was conducted for studying the anti-corrosion and self-healing proficiency of microcapsule-based coatings. The UV-Vis spectroscopy outcomes showed that the synthesized microcapsules are responsive to alk. pH and the release rate of microcapsules in the basic medium rises with increasing the pH values. Moreover, the EIS and salt spray results indicated that incorporation of 10 wt% of the microcapsules into the epoxy coating not only improved the anti-corrosion strength of the aluminum substrate compared to neat epoxy coating remarkably but also, provided active corrosion protection of the substrate through the self-healing action of cerium ions. Also, the attendance of cerium cations in the scratch surface was confirmed by field emission SEM and energy-dispersive X-ray map.

Surface and Coatings Technology published new progress about Anticorrosive coating materials. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Formula: C17H28O8S4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Roberts, Dean D. published the artcileRegioselective Synthesis of Multifunctional Allylic Amines; Access to Ambiphilic Aziridine Scaffolds, SDS of cas: 107-54-0, the main research area is allylic amine ambiphilic aziridine preparation regioselective; propargylic amine dimethylphenylsilane hydrosilylation platinum chloride XantPhos catalyst.

A highly regioselective hydrosilylation of propargylic amines has been described here for the first time. The reaction utilizes a PtCl2/XantPhos catalyst system to deliver hydrosilanes across the alkyne to afford multifunctional allylic amines in high yields. The reaction is tolerant to a wide variety of functional groups and provides high value intermediates with two distinct functional handles. The synthetic applicability of the reaction has been shown through the synthesis of diverse ambiphilic aziridines.

Organic Letters published new progress about Amines, propargyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, SDS of cas: 107-54-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ji, Xiang published the artcileSynthesis of 1,2-Dihydroisoquinolines by a Modified Pomeranz-Fritsch Cyclization, Name: 2,2-Dimethoxyethanamine, the main research area is trifluoromethanesulfonamide trimethylsilyl triflate regioselective Pomeranz Fritsch cyclization; dihydroisoquinoline preparation.

Isoquinolines (IQs) and their derivatives are present in many natural products and biol. active small mols. Herein, we report a modified procedure for the classical Pomeranz-Fritsch protocol, which expands the scope of 1,2-dihydroisoquinoline (DHIQ) products. 1,2-DHIQs are an attractive branch point for the synthesis of IQs, but because of their innate reactivity, they have remained difficult to prepare We demonstrate that the Fujioka/Kita conditions, combining trimethylsilyl triflate (TMSOTf) and an amine base, activate dimethylacetals required for Pomeranz-Fritsch cyclization under sufficiently mild conditions to prepare a broad range of 1,2-DHIQ products. We also demonstrate the synthetic value of these DHIQs by further functionalization to either reduced tetrahydroisoquinoline (THIQ) or fully aromatized IQ natural products.

Journal of Organic Chemistry published new progress about Pomeranz-Fritsch cyclization (regioselective). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Name: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Krylov, Vadim B. published the artcilePyranoside-into-Furanoside Rearrangement: New Reaction in Carbohydrate Chemistry and Its Application in Oligosaccharide Synthesis, Safety of (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, the main research area is disaccharide enzymic UDP galactopyranose mutase rearrangement uronate; pyranoside furanoside rearrangement oligosaccharide synthesis sulfation acid catalyst; carbohydrates; furanoside; glycosylation; rearrangement; sulfation.

Great interest in natural furanoside-containing compounds has challenged the development of preparative methods for their synthesis. Herein a novel reaction in carbohydrate chem., namely a pyranoside-into-furanoside (PIF) rearrangement permitting the transformation of selectively O-substituted pyranosides into the corresponding furanosides is reported. The discovered process includes acid-promoted sulfation accompanied by rearrangement of the pyranoside ring into a furanoside ring followed by solvolytic O-desulfation. This process, which has no analogy in organic chem., was shown to be a very useful tool for the synthesis of furanoside-containing complex oligosaccharides, which was demonstrated by synthesizing disaccharide derivatives α-D-Galp-(1→3)-β-D-Galf-OPr, 3-O-s-lactyl-β-D-Galf-(1→3)-β-D-Glcp-OPr, and α-L-Fucf-(1→4)-β-D-GlcpA-OPr related to polysaccharides from the bacteria Klebsiella pneumoniae and Enterococcus faecalis and the brown seaweed Chordaria flagelliformis.

Chemistry – A European Journal published new progress about Oligosaccharides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Safety of (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Shuang published the artcileCharacterization of polysaccharide from Helicteres angustifolia L. and its immunomodulatory activities on macrophages RAW264.7, Application In Synthesis of 59-23-4, the main research area is Helicteres polysaccharide immunomodulatory agent macrophage; Helicteres angustifolia L.; Immunomodulatory activity; Macrophages; Polysaccharide.

Helicteres angustifolia L. (H. angustifolia) has been widely used as a remedy against various types of illness relating to immune response, such as inflammations and fever. In order to characterize the structure and identify the immunomodulatory activity of polysaccharide from H. angustifolia, a polysaccharide fraction (SPF3-1) was purified from H. angustifolia by using DEAE Sepharose Fast Flow and Sephacry S-400 chromatog., successively. Physicochem. anal. demonstrated that SPF3-1 is an acidic heteropolysaccharide with a mol. weight of about 13.36 kDa; in vitro immunomodulatory assay reflects that SPF3-1 could significantly (p < 0.05) enhance the proliferation of macrophages, stimulate the macrophages phagocytic capacity, as well as induce NO and immunomodulatory cytokines generation. All the results suggest that SPF3-1 from H. angustifolia possesses potent immunomodulatory activity and could be further developed as new products for medicines or functional foods. Biomedicine & Pharmacotherapy published new progress about Cell proliferation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gonnissen, Y. published the artcileDevelopment of directly compressible powders via co-spray drying, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is carbohydrate excipient compression spray drying tablet.

Continuous production of directly compressible powders was achieved by coprocessing acetaminophen and carbohydrates via spray drying. Binary and ternary powder mixtures containing drug substance and carbohydrates were prepared by co-spray drying and evaluated on spray drying processibility, powder hygroscopicity, flowability, and compactability. The influence of process parameters during spray drying on the compaction behavior of drug/excipient mixtures was investigated via Heckel anal. Erythritol, lactose, maltodextrin, and mannitol were efficient in co-spray drying with acetaminophen. However, lactose mixtures showed poor flowability. Spray dried mixtures containing mannitol and erythritol were characterized as non-hygroscopic, highly dense, and good flowing powders. Mannitol increased tablet tensile strength in contrast with the poor compactability of erythritol. Maltodextrin was selected for further experiments because it provided excellent tablet tensile strength. The use of erythritol, maltodextrin and mannitol in binary drug/excipient mixtures resulted in high process yields. Compacts of erythritol, mannitol, and maltodextrin were characterized by higher tablet tensile strength at higher spray drying temperatures due to the increased particle fragmentation of erythritol and mannitol mixtures and to the increased plastic deformation of maltodextrin formulations. A combination of erythritol, maltodextrin, and mannitol was selected for further formulation and process optimization of co-spray dried powders for direct compression.

European Journal of Pharmaceutics and Biopharmaceutics published new progress about Compaction. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zha, Gao-Feng published the artcileSO2F2-Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes, Application of 2-(3,5-Dichlorophenyl)ethanol, the main research area is alkyne chemoselective preparation; phenyltriazole phenylacetylene preparation; sulfuryl fluoride DMSO mediated oxidative dehydrogenation elimination alc; beta hydroxy amide secondary alc oxidative elimination sulfuryl fluoride; sequential oxidative elimination primary alc azide alkyne cycloaddition azidobenzene; oxidative elimination primary alc Sonogashira coupling iodobenzene.

Terminal and internal alkynes were prepared directly from primary alcs. and secondary alcs. and β-hydroxyamides by oxidative dehydrogenation and dehydration using sulfuryl fluoride as the leaving group source and DMSO as oxidant; the method does not require transition metal reagents or catalysts. The method was used in one-pot preparations of phenyltriazoles and phenylacetylenes using the oxidative dehydrogenation/elimination reaction in sequence with azide-alkyne cycloaddition with Ph azide and Sonogashira coupling with iodobenzene.

Journal of the American Chemical Society published new progress about Alkynes, internal Role: SPN (Synthetic Preparation), PREP (Preparation). 93427-13-5 belongs to class alcohols-buliding-blocks, name is 2-(3,5-Dichlorophenyl)ethanol, and the molecular formula is C8H8Cl2O, Application of 2-(3,5-Dichlorophenyl)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Chi published the artcileLithium Salt-Induced In Situ Polymerizations Enable Double Network Polymer Electrolytes, Quality Control of 7575-23-7, the main research area is lithium salt induced polymer electrolytes radical polymerization battery; double networks; in situ polymerization; lithium-ion batteries; polymer electrolytes.

Structural design is an intriguing strategy to improve the phys. and electrochem. performance of polymer electrolytes (PEs) for lithium-ion batteries. However, the complex synthetic process and introduction of nonelectrolyte composition severely limit the development and practical application of PEs. Here, a facile method is reported for the fabrication of a double network polymer electrolyte (DN-PE) through combining the lithium salt-accelerated thiol-Michael addition and lithium salt-catalyzed radical polymerization By adjusting the reaction temperature, the double network with the crosslinking structure can be in situ formed step by step at room temperature and 80°C. Notably, using lithium salt as the accelerator and catalyst avoids the addition of extra species and the related side reactions in the electrolyte system. Compared with single network polymer electrolyte (SN-PE), DN-PE has a distinctly improved mech. strength and a better interfacial compatibility with the electrode, which leads to a stable cycling of the sym. Li|DN-PE|Li cell over 1000 h at a c.d. of 0.05 mA cm-2. In addition, the Li|DN-PE|LiFePO4 cell shows a high discharge specific capacity of 150.3 mAh g-1 at 0.1 C and coulomb efficiency of 99%.

Macromolecular Rapid Communications published new progress about Battery capacity. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Quality Control of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thiyagarajan, Subramanian published the artcileRuthenium-Catalyzed α-Alkylation of Ketones Using Secondary Alcohols to β-Disubstituted Ketones, Application In Synthesis of 584-02-1, the main research area is Ruthenium pincer catalyzed alkylation ketone secondary alc.

An assortment of aromatic ketones was successfully functionalized with a variety of unactivated secondary alcs. that serve as alkylating agents, providing β-disubstituted ketone products in good to excellent yields. Remarkably, challenging substrates such as simple acetophenone derivatives are effectively alkylated under this ruthenium catalysis. The substituted cyclohexanol compounds displayed product-induced diastereoselectivity. Mechanistic studies indicate the involvement of the hydrogen-borrowing pathway in these alkylation reactions. Notably, this selective and catalytic C-C bond-forming reaction requires only a minimal load of catalyst and base and produces H2O as the only byproduct, making this protocol attractive and environmentally benign.

Organic Letters published new progress about Alkylation catalysts. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Application In Synthesis of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts