Month: December 2022

Pardatscher, Lorenz published the artcileHighly Efficient Abnormal NHC Ruthenium Catalyst for Oppenauer-Type Oxidation and Transfer Hydrogenation Reactions, SDS of cas: 584-02-1, the main research area is cationic ruthenium phosphinoethylimidazolylidene carbene complex preparation catalyst transfer hydrogenation; crystal structure cationic ruthenium phosphinoethylimidazolylidene carbene complex; mol structure cationic ruthenium phosphinoethylimidazolylidene carbene complex; oxidation catalyst cationic ruthenium phosphinoethylimidazolylidene carbene complex.

The Ru complex [Ru(OAc)(a-PC)2]Br (3) containing two abnormal NHC ligands was obtained by reaction of Ru(OAc)2(PPh3)2 (1) with 1-(2-diphenylphosphinoethyl)-3-mesitylimidazolium bromide in the presence of NaOAc. Complex 3 catalyzes the Oppenauer-type oxidation of a number of alcs. at unrivalled reaction rates reaching TOFs up to 550,000 h-1, at low catalyst loadings (S/C >10,000) and using acetone in stoichiometric amounts Complex 3 is also highly active in the reverse transfer hydrogenation of several ketones with iso-PrOH, displaying TOFs up to 600,000 h-1.

ACS Catalysis published new progress about Crystal structure. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, SDS of cas: 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pardatscher, Lorenz published the artcileHighly Efficient Abnormal NHC Ruthenium Catalyst for Oppenauer-Type Oxidation and Transfer Hydrogenation Reactions, Category: alcohols-buliding-blocks, the main research area is cationic ruthenium phosphinoethylimidazolylidene carbene complex preparation catalyst transfer hydrogenation; crystal structure cationic ruthenium phosphinoethylimidazolylidene carbene complex; mol structure cationic ruthenium phosphinoethylimidazolylidene carbene complex; oxidation catalyst cationic ruthenium phosphinoethylimidazolylidene carbene complex.

The Ru complex [Ru(OAc)(a-PC)2]Br (3) containing two abnormal NHC ligands was obtained by reaction of Ru(OAc)2(PPh3)2 (1) with 1-(2-diphenylphosphinoethyl)-3-mesitylimidazolium bromide in the presence of NaOAc. Complex 3 catalyzes the Oppenauer-type oxidation of a number of alcs. at unrivalled reaction rates reaching TOFs up to 550,000 h-1, at low catalyst loadings (S/C >10,000) and using acetone in stoichiometric amounts Complex 3 is also highly active in the reverse transfer hydrogenation of several ketones with iso-PrOH, displaying TOFs up to 600,000 h-1.

ACS Catalysis published new progress about Crystal structure. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sadier, Achraf published the artcileEffect of carbon chain length on catalytic C-O bond cleavage of polyols over Rh-ReOx/ZrO2 in aqueous phase, Formula: C5H12O, the main research area is polyol carbon oxygen bond cleavage rhenium rhodium bimetallic catalyst.

Production of linear deoxygenated C4 (butanetriols, -diols, and butanols), C5 (pentanetetraols, -triols, -diols, and pentanols), and C6 products (hexanepentaols, -tetraols, -triols, -diols, and hexanols) is achievable by hydrogenolysis of erythritol, xylitol, and sorbitol over supported-bimetallic Rh-ReOx (Re/Rh molar ratio 0.5) catalyst, resp. After validation of the anal. methodol., the effect of some reaction parameters was studied. In addition to C-O bond cleavage by hydrogenolysis, these polyols can undergo parallel reactions such as epimerization, cyclic dehydration, and C-C bond cleavage. The time courses of each family of linear deoxygenated C4, C5, and C6 products confirmed that the sequence of appearance of the different categories of deoxygenated products followed a multiple sequential deoxygenation pathway. The highest selectivity to a mixture of linear deoxygenated C4, C5, and C6 products at 80% conversion was favored under high pressure in the presence of 3.7wt.%Rh-3.5wt.%ReOx/ZrO2 catalysts (54-71% under 80 bar) at 200 °C.

Applied Catalysis, A: General published new progress about C-O bond cleavage (catalysts). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Formula: C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abdul Waseem, Malik published the artcileCatalyst Free Selective Monobenzoylation of Diols with Benzoyl Cyanide: A Robust and Regioselective Strategy, COA of Formula: C8H9BrO2, the main research area is diol polyol benzoyl cyanide regioselective chemoselective monobenzoylation catalyst free.

A general and robust strategy for regio- and chemoselective benzoylation of diols and polyols was developed under catalyst-free reaction conditions. This approach is highly flexible in generating a diverse range of 1,2-, 1,3-, and 1,4-monobenzoylated-adducts in excellent yields without the involvement of expensive catalysts. Collectively, these results have implications in reducing the burden of cost and toxicity associated with the catalysts used in earlier methods.

ChemistrySelect published new progress about Benzoylation, regioselective. 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, COA of Formula: C8H9BrO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gao, Han published the artcileTransition Metal-Free Radical α-Oxy C-H Cyclobutylation via Photoinduced Hydrogen Atom Transfer, Recommanded Product: 3-Pentanol, the main research area is oxyalkane arylsulfonyl bicyclobutane regioselective quinuclidine photocatalyst ring opening; arylsulfonyl cyclobutane preparation.

A transition-metal-free photoinduced radical-mediated α-oxy C-H cyclobutylation reaction of bicyclo[1.1.0]butane (BCB) compounds was described. In this protocol, α-oxy C(sp3)-H motifs including ethers and alcs. were activated via photocatalytic conditions, releasing the ring strain of BCBs and generating 1,3-disubstituted cyclobutanes in 40-80% yields. Control experiments and Stern-Volmer quenching experiments indicated that the reaction proceeded through the generation of α-oxy carbon-centered radical intermediates by photoinduced hydrogen atom transfer (HAT) process.

Advanced Synthesis & Catalysis published new progress about Aromatic compounds, sulfones Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Fang published the artcileDirect Benzylic C(sp3)-O Coupling with Alcohol via Site-Selective C(sp3)-H Cleavage at Room Temperature through a Remote Directing Group-Enabled Radical Relay Strategy, Quality Control of 584-02-1, the main research area is benzylic carbon oxygen coupling alc regioselective copper catalyst; alkyl aryl carbamate carbon hydrogen bond cleavage.

Employing a low loading of the terminal oxidant, a remote directing group-enabled radical relay strategy for benzylic direct C(sp3)-H alkoxylation with alcs. at room temperature is developed. Satisfactory site-selectivity, chemoselectivity, and reaction scope are achieved under simple and mild conditions, and no ligand or additive is required. Mechanistic studies, ready conversions of the directing group, and other benzylic functionalizations currently under development in laboratory further indicate the promising potentials of this remote directing group-enabled radical relay strategy.

Journal of Organic Chemistry published new progress about Alkoxylation. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Quality Control of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Jiadi published the artcileSelf-photocatalyzed regulable alkylation of 2H-benzothiazoles with diverse aliphatic C-H donors, Quality Control of 584-02-1, the main research area is benzothiazole alc photochem alkylation; alkyl hydroxy benzothiazole preparation; amide benzothiazole photochem alkylation; amido alkyl benzothiazole preparation; alc benzothiazole photochem alkylation; alkylbenzothiazole preparation.

Here, a mild and efficient method that combines self-photoredox catalysis and hydrogen atom transfer to achieve the alkylation of 2H-benzothiazoles with alcs., ethers, lactams, amides and alkane, which features broad substrate scope and excellent functional group compatibility was reported. Notably, alcs. can be used not only as hydroxyalkylating reagents, but also as dehydroxyalkylating reagents in this regulable alkylation protocol. The previous elusive self-photocatalytic mechanism was investigated and preliminary results on this catalytic alkylation were reported.

Green Chemistry published new progress about Alkanes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Quality Control of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chang, Chun-Wei published the artcileAutomated Quantification of Hydroxyl Reactivities: Prediction of Glycosylation Reactions, Quality Control of 87905-98-4, the main research area is predictive stereoselective glycosylation automated quantification hydroxyl group reactivity; carbohydrates; diastereoselectivity; glycosylation; hydroxyl; predictive algorithms.

The stereoselectivity and yield in glycosylation reactions are paramount but unpredictable. We have developed a database of acceptor nucleophilic constants (Aka) to quantify the nucleophilicity of hydroxyl groups in glycosylation influenced by the steric, electronic and structural effects, providing a connection between experiments and computer algorithms. The subtle reactivity differences among the hydroxyl groups on various carbohydrate mols. can be defined by Aka, which is easily accessible by a simple and convenient automation system to assure high reproducibility and accuracy. A diverse range of glycosylation donors and acceptors with well-defined reactivity and promoters were organized and processed by the designed software program “”GlycoComputer”” for prediction of glycosylation reactions without involving sophisticated computational processing. The importance of Aka was further verified by random forest algorithm, and the applicability was tested by the synthesis of a Lewis A skeleton to show that the stereoselectivity and yield can be accurately estimated

Angewandte Chemie, International Edition published new progress about Algorithm. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Quality Control of 87905-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Isaacs-Ten, Anna published the artcileMetabolic Regulation of Macrophages by SIRT1 Determines Activation During Cholestatic Liver Disease in Mice, Synthetic Route of 97-67-6, the main research area is cholestatic liver disease autophagy SIRT1 macrophage metabolic regulation; Cholestasis; Inflammasome; Macrophages; Metabolism; SIRT1.

Inflammation is the hallmark of chronic liver disease. Metabolism is a key determinant to regulate the activation of immune cells. Here, we define the role of sirtuin 1 (SIRT1), a main metabolic regulator, in controlling the activation of macrophages during cholestatic liver disease and in response to endotoxin. We have used mice overexpressing SIRT1, which we treated with i.p. lipopolysaccharides or induced cholestasis by bile duct ligation. Bone marrow-derived macrophages were used for mechanistic in vitro studies. Finally, PEPC-Boy mice were used for adoptive transfer experiments to elucidate the impact of SIRT1-overexpressing macrophages in contributing to cholestatic liver disease. We found that SIRT1 overexpression promotes increased liver inflammation and liver injury after lipopolysaccharide/GalN and bile duct ligation; this was associated with an increased activation of the inflammasome in macrophages. Mechanistically, SIRT1 overexpression associated with the activation of the mammalian target of rapamycin (mTOR) pathway that led to increased activation of macrophages, which showed metabolic rewiring with increased glycolysis and broken tricarboxylic acid cycle in response to endotoxin in vitro. Activation of the SIRT1/mTOR axis in macrophages associated with the activation of the inflammasome and the attenuation of autophagy. Ultimately, in an in vivo model of cholestatic disease, the transplantation of SIRT1-overexpressing myeloid cells contributed to liver injury and fibrosis. Our study provides novel mechanistic insights into the regulation of macrophages during cholestatic disease and the response to endotoxin, in which the SIRT1/mTOR crosstalk regulates macrophage activation controlling the inflammasome, autophagy and metabolic rewiring.

Cellular and Molecular Gastroenterology and Hepatology published new progress about Apoptosis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Synthetic Route of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Deppermann, Carsten published the artcileMacrophage galactose lectin is critical for Kupffer cells to clear aged platelets, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is AMR galactose lectin hepatocyte macrophage platelet Kupffer cell interaction.

Every day, megakaryocytes produce billions of platelets that circulate for several days and eventually are cleared by the liver. The exact removal mechanism, however, remains unclear. Loss of sialic acid residues is thought to feature in the aging and clearance of platelets. Using state-of-the-art spinning disk intravital microscopy to delineate the different compartments and cells of the mouse liver, we observed rapid accumulation of desialylated platelets predominantly on Kupffer cells, with only a few on endothelial cells and none on hepatocytes. Kupffer cell depletion prevented the removal of aged platelets from circulation. Ashwell-Morell receptor (AMR) deficiency alone had little effect on platelet uptake. Macrophage galactose lectin (MGL) together with AMR mediated clearance of desialylated or cold-stored platelets by Kupffer cells. Effective clearance is critical, as mice with an aged platelet population displayed a bleeding phenotype. Our data provide evidence that the MGL of Kupffer cells plays a significant role in the removal of desialylated platelets through a collaboration with the AMR, thereby maintaining a healthy and functional platelet compartment.

Journal of Experimental Medicine published new progress about Aging, animal. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts