Month: December 2022

Di Maio, Ernesto published the artcileScaffolds with tubular/isotropic Bi-modal pore structures by gas foaming and fiber templating, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is tissue scaffold polycaprolactone gas foaming and fiber templating pore.

The aim of this study was to engineer a scaffold for tissue engineering with double shape pore architecture, with tubular and isotropic pores. A novel method is herein proposed, based on the combination of gas foaming and fiber templating. In particular, the tubular pores have been obtained by leaching of melt-spun saccharide fibers (cotton candy) within CO2-foamed poly(ε-caprolactone). The optimization of the scaffold has been conducted via the selection of the proper saccharide, its thermal treatment to stabilize the spun fiber (crystallization), the formation of the polymer-fiber composite, the selection of the proper gas-foaming processing parameter and the final leaching in water.

Materials Letters published new progress about Composites. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fall, Fanta published the artcileMetabolic reprograming of LPS-stimulated human lung macrophages involves tryptophan metabolism and the aspartate-arginosuccinate shunt, Category: alcohols-buliding-blocks, the main research area is LM tryptophan metabolism lipopolysaccharide aspartate arginosuccinate metabolic reprogramming.

The objective of the present work was to characterize the metabolic alterations occurring during the exptl. M1 LM polarization. Human LM were obtained from resected lungs and cultured for 24 h in medium alone or with 10 ng.mL-1 lipopolysaccharide. Cells and culture supernatants were subjected to extraction for metabolomic anal. with high-resolution LC-MS (HILIC and reverse phase -RP- chromatog. in both neg. and pos. ionization modes) and GC-MS. The data were analyzed with R and the Worklow4Metabolomics and MetaboAnalyst online infrastructures. A total of 8,741 and 4,356 features were detected in the intracellular and extracellular content, resp., after the filtering steps. Pathway anal. showed involvement of arachidonic acid metabolism, tryptophan metabolism and Krebs cycle in the response of LM to LPS, which was confirmed by the specific quantitation of selected compounds This refined anal. highlighted a regulation of the kynurenin pathway as well as the serotonin biosynthesis pathway, and an involvement of aspartate-arginosuccinate shunt in the malate production Macrophages M1 polarization is accompanied by changes in the cell metabolome, with the differential expression of metabolites involved in the promotion and regulation of inflammation and antimicrobial activity. The anal. of this macrophage immunometabolome may be of interest for the understanding of the pathophysiol. of lung inflammatory disesases.

PLoS One published new progress about Homo sapiens. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nakamura, Shinji published the artcileDiscovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers, Category: alcohols-buliding-blocks, the main research area is trifluoromethyl phenyl oxazolyl propanoic acid preparation RBP4 reducer SAR; pyrrolidinyloxy acetic acid trifluoromethyl phenyl preparation RBP4 reducer SAR; Age-related macular degeneration (AMD); Diabetes; Protein–protein interaction (PPI); Retinol-binding protein 4 (RBP4); Transthyretin (TTR).

Retinol-binding protein 4 (RBP4) is a potential drug target for metabolic and ophthalmol. diseases. A high-throughput screening of compound library has identified a small-mol. RBP4 reducer compound I, as a hit compound Aiming to provide a suitable tool for investigating the pharmacol. effects of RBP4 reducers, we conducted a structure-activity relationship study of compound I. Exploration of the aryl head, oxazole core, and propanoic acid tail of compound I resulted in the discovery of novel, potent, and orally available phenylpyrrolidine derivatives ({(3S)-1-[3,5-bis(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid and ({(3R)-1-[3,5-bis(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid. Compound ({(3S)-1-[3,5-bis(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid had a potent and long-lasting blood RBP4-level-reducing effect when orally administered to mice at a dose as low as 0.3 mg/kg.

Bioorganic & Medicinal Chemistry published new progress about Eye disease. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aravamudhan, Sriram published the artcilePhosphoproteomics of the developing heart identifies PERM1 – An outer mitochondrial membrane protein, Quality Control of 97-67-6, the main research area is heart phosphoproteomics mitochondrial membrane protein; Heart development; Lipid metabolism; Mitochondria; PERM1; Phosphoproteomics; SILAC.

Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that were assigned to different pathways. Anal. of mitochondrial proteins led to the identification of PGC-1- and ERR-induced regulator in muscle 1 (PERM1), which is specifically expressed in skeletal muscle and heart tissue and associates with the outer mitochondrial membrane. We demonstrate PERM1 is subject to rapid changes mediated by the UPS through phosphorylation of its PEST motif by casein kinase 2. Ablation of Perm1 in mice results in reduced protein expression of lipin-1 accompanied by accumulation of specific phospholipid species. Isolation of Perm1-deficient mitochondria revealed significant downregulation of mitochondrial transport proteins for amino acids and carnitines, including SLC25A12/13/29/34 and CPT2. Consistently, we observed altered levels of various lipid species, amino acids, and acylcarnitines in Perm1-/- mitochondria. We conclude that the outer mitochondrial membrane protein PERM1 regulates homeostasis of lipid and amino acid metabolites in mitochondria.

Journal of Molecular and Cellular Cardiology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Quality Control of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Colombo Dugoni, Greta published the artcileDeep eutectic solvents: promising co-solvents to improve the extraction kinetics of CyMe4-BTBP, Application of 2,2′-Oxydiacetic acid, the main research area is deep eutectic solvent cosolvent extraction SANEX fuel reprocessing actinide.

In this communication, the authors report on the use of deep eutectic solvents (DESs) for processing nuclear waste, with a view to selectively recovering minor actinides (MA) from highly active raffinate solutions DESs are an interesting new class of green and eco-sustainable solvents. Here, a representative family of DES was tested as a co-solvent for MA/lanthanides partitioning based on Selective ActiNide Extraction (SANEX)-like hydrometallurgical processes. The reference system exploits the CyMe4-BTBP lipophilic extractant for selective MA recovery, but the slow kinetics is the main limitation toward the industrial implementation. A selection of hydrophilic DESs has been proposed as a phase transfer catalyst and tested to improve the process performances. In this work, the radiochem. stability and the extraction behavior of these DESs have been ascertained. Moreover, a preliminary optimization of system composition has been achieved. This study underlines a catalytic effect of DES that can be proficiently exploited to enhance CyMe4-BTBP extraction and selectivity.

ACS Omega published new progress about Chemical stability (radiochem.). 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Application of 2,2′-Oxydiacetic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kononenko, Veno published the artcileGrouping of poorly soluble low (cyto)toxic particles: example with 15 selected nanoparticles and A549 human lung cells, Safety of (S)-2-hydroxysuccinic acid, the main research area is lung cell soluble cytotoxic nanoparticle; alveolar type II cells; biopersistent particles; endo-lysosomal organelles; fast screening tools; poorly soluble low toxicity particles (PSLTs).

Poorly soluble, low (cyto)toxic particles (PSLTs) are often regarded as one group, but it is important that these particles can be further differentiated based on their bioactivity. Currently, there are no biol. endpoint based groupings for inhaled nanoparticles (NPs) that would allow us to subgroup PSLTs based on their mode of action. The aim of this study was to group NPs based on their cytotoxicity and by using the in vitro response of the endo-lysosomal system as a biol. endpoint. The endo-lysosomal system is a main cellular loading site for NPs. An impaired endo-lysosomal system in alveolar type II cells may have serious adverse effects on the maintenance of pulmonary surfactant homeostasis. The 15 different NPs were tested with human lung adenocarcinoma (A549) cells. The highly soluble NPs were most cytotoxic. With respect to PSLTs, only three NPs increased the cellular load of acid and phospholipid rich organelles indicating particle biopersistence. All the rest PSLTs could be regarded as low hazardous. The presented in vitro test system could serve as a fast screening tool to group particles according to their ability to interfere with lung surfactant metabolism We discuss the applicability of the suggested test system for bringing together substances with similar modes-of-action on lung epithelium. In addition, we discuss this approach as a benchmark test for the comparative assessment of biopersistence of PSLTs.

Nanomaterials published new progress about Carboxyl group. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Safety of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cannon, Robert J. published the artcileIdentification, Synthesis, and Characterization of Novel Sulfur-Containing Volatile Compounds from the In-Depth Analysis of Lisbon Lemon Peels (Citrus limon L. Burm. f. cv. Lisbon), HPLC of Formula: 42822-86-6, the main research area is lemon peel flavor aroma volatile sulfur compound; GC-MS; GC-O; lemons; volatile sulfur compounds.

Lemons (Citrus limon) are a desirable citrus fruit grown and used globally in a wide range of applications. The main constituents of this sour-tasting fruit have been well quantitated and characterized. However, addnl. research is still necessary to better understand the trace volatile compounds that may contribute to the overall aroma of the fruit. In this study, Lisbon lemons (C. limon L. Burm. f. cv. Lisbon) were purchased from a grove in California, USA, and extracted by liquid-liquid extraction Fractionation and multidimensional gas chromatog.-mass spectrometry were utilized to sep., focus, and enhance unidentified compounds In addition, these methods were employed to more accurately assign flavor dilution factors by aroma extract dilution anal. Numerous compounds were identified for the first time in lemons, including a series of branched aliphatic aldehydes and several novel sulfur-containing structures. Rarely reported in citrus peels, sulfur compounds are known to contribute significantly to the aroma profile of the fruit and were found to be aroma-active in this particular study on lemons. The identification, synthesis, and organoleptic properties of these novel volatile sulfur compounds are discussed.

Journal of Agricultural and Food Chemistry published new progress about Citrus limon. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, HPLC of Formula: 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saavedra Moreno, Yesenia published the artcileFoam stability of flotation frothers under dynamic and static conditions, Recommanded Product: 3-Pentanol, the main research area is foam stability flotation frother dynamic static condition.

The objective of this paper is to provide a detailed understanding of the relation between frother type and foam stability under dynamic and static conditions. The dynamic foam stability for eighteen non-ionic frothers from different frother families was assessed using foaminess, which quantified the ratio of foam height to the gas superficial velocity. For all tested frothers, the foaminess increased as the concentration was increased. The static foam stability was assessed by measuring the half-life and the decay rate of the foams at different superficial gas velocities and concentrations The foam stability results showed that for aliphatic alcs., the greater the number of hydrocarbon groups, the more stable the foam was under dynamic and static conditions. For polypropylene glycols, increasing the number of propylene oxide groups increased foaminess and half-life, however, a further increase in the number of propylene oxide groups (m > 7) led to a decrease in foaminess. There was not a clear relation between the number of propylene oxide groups and the maximum foam half-life. Interestingly, the foam decay rate coefficient increased by increasing the number of propylene oxide groups. For propylene glycol Me ethers, foaminess, foam half-life and decay rate coefficient increased with an increase in the number of propylene oxide groups.

Separation and Purification Technology published new progress about Foam stability. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kurnia, Irwan published the artcileSynthesis of p-menthane-3,8-diol from citronellal over lignin-derived carbon acid catalysts, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is menthanediol citronellal lignin carbon acid catalyst.

P-Menthane-3,8-diol (PMD) is receiving growing attention as a natural mosquito repellent with lower toxicity compared to the widely-used N,N-di-Et m-toluamide (DEET). In this study, sustainable carbon acid catalysts derived from alk. lignin (AL) were prepared for synthesizing PMD from a popular chem. (±)-citronellal in an environmentally friendly solvent of water. The catalytic performances of the AL-derived carbon acid catalysts prepared at different pyrolysis temperatures were better than those of other catalysts such as carbon black and H-USY. In particular, when the AL pyrolyzed at 500°C was used as the carbon acid catalyst, the conversion of (±)-citronellal was as high as 97% with a high PMD yield of 86%, indicating that waste alk. lignin from pulp and paper industries can be used as a source of acid catalysts. It is found that the formation of PMD is preferred over catalysts with weaker acid sites, whereas isopulegol was more easily formed over stronger acid sites. Moreover, the reaction route of the citronellal cyclization-hydration reaction was more dominant via the carbocation-hydration pathway rather than the isopulegol hydration route on the weaker carbon acid catalyst.

New Journal of Chemistry published new progress about Carbon black Role: CAT (Catalyst Use), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation) (Vulcan XC 72C). 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Xingguo published the artcileHighly selective membrane for efficient separation of environmental determinands: Enhanced molecular imprinting in polydopamine-embedded porous sleeve, SDS of cas: 7575-23-7, the main research area is polydopamine embedded molecularly imprinted membrane selective separation environmental.

The molecularly imprinted membrane has shown irreplaceable superiority in advanced water treatment, biochem. purification, and in most cases, pretreatment of environmental determinands. However, effective and controllable construction of imprinted sites in membrane-based interpenetrating pores is as yet the significant bottleneck. Herein, the authors proposed a thermally induced strategy on the polydopamine-embedded molecularly imprinted membrane (DEMIM) for enhanced selective separation of Ciprofloxacin (CIP). The porous sleeve was constructed with polyvinylidene fluoride (PVDF), together with the integrated β-cyclodextrin (β-CD) for hydrophilicity and anti-fouling requirements. Based on the thermally induced operation, polydopamine (PDA) embedded in the membrane matrix acted as a secondary reaction platform, effectively improving the interpenetrating-bicontinuous porous morphol. and enhancing the availability of imprinted sites in microchannels. The imprinting polymerization was carried out by the efficient thiol-ene click reaction, which was investigated in depth by d. functional theory (DFT) calculations The impressive relative separation factor (2.33-4.59) and permselectivity (9.50-12.50) indicated the superior availability of DEMIM for the selective separation The remarkable regeneration performance (fluctuation in 8.4%∼10.8%) demonstrated the feasibility of the porous membrane-based sleeve for regeneration of mol. imprinting. The approach and methodologies achieved in this work will potentially promote the development of novel molecularly imprinted membranes for advanced applications.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Density functional theory. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, SDS of cas: 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts