Month: December 2022

Cheng, Tik-Chee published the artcileEstrogen receptor-α prevents right ventricular diastolic dysfunction and fibrosis in female rats, Safety of (S)-2-hydroxysuccinic acid, the main research area is estrogen receptor alpha ventricular diastolic dysfunction fibrosis mouse; adverse remodeling; estrogen receptor-α; pressure overload; right ventricle.

Although women are more susceptible to pulmonary arterial hypertension (PAH) than men, their right ventricular (RV) function is better preserved. Estrogen receptor-α (ERα) has been identified as a likely mediator for estrogen protection in the RV. However, the role of ERα in preserving RV function and remodeling during pressure overload remains poorly understood. We hypothesized that loss of functional ERα removes female protection from adverse remodeling and is permissive for the development of a maladapted RV phenotype. Male and female rats with a loss-of-function mutation in ERα (ERαMut) and wild-type (WT) littermates underwent RV pressure overload by pulmonary artery banding (PAB). At 10 wk post-PAB, WT and ERαMut demonstrated RV hypertrophy. Anal. of RV pressure waveforms demonstrated RV-pulmonary vascular uncoupling and diastolic dysfunction in female, but not male, ERαMut PAB rats. Similarly, female, but not male, ERαMut exhibited increased RV fibrosis, comprised primarily of thick collagen fibers. There was an increased protein expression ratio of TIMP metallopeptidase inhibitor 1 (Timp1) to matrix metalloproteinase 9 (Mmp9) in female ERαMut compared with WT PAB rats, suggesting less collagen degradation RNA-sequencing in female WT and ERαMut RV revealed kallikrein-related peptidase 10 (Klk10) and Jun Proto-Oncogene (Jun) as possible mediators of female RV protection during PAB. In summary, ERα in females is protective against RV-pulmonary vascular uncoupling, diastolic dysfunction, and fibrosis in response to pressure overload. ERα appears to be dispensable for RV adaptation in males. ERα may be a mediator of superior RV adaptation in female patients with PAH.

American Journal of Physiology published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Cbr1). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Safety of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Waris, Muhammad Irfan published the artcileMolecular and in vitro biochemical assessment of chemosensory protein 10 from brown planthopper Nilaparvata lugens at acidic pH, Computed Properties of 124-76-5, the main research area is mol in vitro biochem assessment chemosensory protein; Nilaparvata lugens acidic pH.

Chemosensory proteins (CSPs) are important mol. components of the insect olfactory system, which are involved in capturing, binding, and transporting hydrophobic odor mols. across the sensillum in sensillar lymph in regulating insect behavior. This protein family (CSPs) is also involved in many other systems that are not linked to olfactory receptors in olfactory sensilla. The brown planthopper (BPH) is a monophagous pest of rice that causes damage by sucking phloem sap and transmitting a number of diseases caused by viruses. In this study, fluorescence competitive binding assay and fluorescence quenching assay at acidic pH were performed as well as homol. modeling to describe the binding affinity of NlugCSP10. Fluorescence competitive binding assay (FCBA) demonstrated that NlugCSP10 bound strongly to nonadecane, farnesene, and 2-tridecanone at acidic pH. The results of FCBA indicated that NlugCSP10 bound different ligands at the physiol. pH (5.0) of the bulk sensillum lymph. Fluorescence quenching assay demonstrated that NlugCSP10 generated a stable complex with 2-tridecanone, while two ligands nonadecane and farnesene collided due to mol. collisions. The interaction of selected ligands with the modeled structure of NlugCSP10 was also analyzed, which found the key amino acids (Gln23, Gln24, Gln25, Asn27, Met33, Ser34, Ile35, Tyr36, Asn42, Met43, Val45, Asn46, Asn93, Arg96, Ala97, Lys99, and Ala100) in NlugCSP10 that were involved in binding of volatile compounds The present study contributes to the binding profile of NlugCSP10 that promotes the development of behaviorally active ligands based on BPH olfactory system.

Journal of Integrative Agriculture published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Ala97). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Waris, Muhammad Irfan published the artcileMolecular and in vitro biochemical assessment of chemosensory protein 10 from brown planthopper Nilaparvata lugens at acidic pH, Synthetic Route of 584-02-1, the main research area is mol in vitro biochem assessment chemosensory protein; Nilaparvata lugens acidic pH.

Chemosensory proteins (CSPs) are important mol. components of the insect olfactory system, which are involved in capturing, binding, and transporting hydrophobic odor mols. across the sensillum in sensillar lymph in regulating insect behavior. This protein family (CSPs) is also involved in many other systems that are not linked to olfactory receptors in olfactory sensilla. The brown planthopper (BPH) is a monophagous pest of rice that causes damage by sucking phloem sap and transmitting a number of diseases caused by viruses. In this study, fluorescence competitive binding assay and fluorescence quenching assay at acidic pH were performed as well as homol. modeling to describe the binding affinity of NlugCSP10. Fluorescence competitive binding assay (FCBA) demonstrated that NlugCSP10 bound strongly to nonadecane, farnesene, and 2-tridecanone at acidic pH. The results of FCBA indicated that NlugCSP10 bound different ligands at the physiol. pH (5.0) of the bulk sensillum lymph. Fluorescence quenching assay demonstrated that NlugCSP10 generated a stable complex with 2-tridecanone, while two ligands nonadecane and farnesene collided due to mol. collisions. The interaction of selected ligands with the modeled structure of NlugCSP10 was also analyzed, which found the key amino acids (Gln23, Gln24, Gln25, Asn27, Met33, Ser34, Ile35, Tyr36, Asn42, Met43, Val45, Asn46, Asn93, Arg96, Ala97, Lys99, and Ala100) in NlugCSP10 that were involved in binding of volatile compounds The present study contributes to the binding profile of NlugCSP10 that promotes the development of behaviorally active ligands based on BPH olfactory system.

Journal of Integrative Agriculture published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Ala97). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Synthetic Route of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Jin published the artcileElectrochemical Hydrogenation with Gaseous Ammonia, Formula: C4H10OS, the main research area is gaseous ammonia electrochem hydrogenation; ammonia; electrochemistry; hydrogen-storage material; hydrogenation; sustainable chemistry.

As a carbon-free and sustainable fuel, ammonia serves as high-energy-d. hydrogen-storage material. It is important to develop new reactions able to utilize ammonia as a hydrogen source directly. Herein, we report an electrochem. hydrogenation of alkenes, alkynes, and ketones using ammonia as the hydrogen source and carbon electrodes. A variety of heterocycles and functional groups, including for example sulfide, benzyl, benzyl carbamate, and allyl carbamate were well tolerated. Fast stepwise electron transfer and proton transfer processes were proposed to account for the transformation.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent) (electrochem. hydrogenation of). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Formula: C4H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xia, Guoqin published the artcileReversing conventional site-selectivity in C(sp3)-H bond activation, SDS of cas: 584-02-1, the main research area is directing group regioselective carbon hydrogen bond activation.

One of the core barriers to developing C-H activation reactions is the ability to distinguish between multiple C-H bonds that are nearly identical in terms of electronic properties and bond strengths. Through recognition of distance and mol. geometry, remote C(sp2)-H bonds have been selectively activated in the presence of proximate ones. Yet achieving such unconventional site selectivity with C(sp3)-H bonds remains a paramount challenge. Here we report a combination of a simple pyruvic acid-derived directing group and a 2-pyridone ligand that enables the preferential activation of the distal γ-C(sp3)-H bond over the proximate β-C(sp3)-H bonds for a wide range of alc.-derived substrates [e.g., I + Me 4-iodobenzoate → II (52%, + 23% diarylated, after esterification)]. A competition experiment between the five- and six-membered cyclopalladation step, as well as kinetic experiments, demonstrate the feasibility of using geometric strain to reverse the conventional site selectivity in C(sp3)-H activation.

Nature Chemistry published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, SDS of cas: 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sole, Aran published the artcileStability of sugar alcohols as PCM for thermal energy storage, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is sugar alc phase change material thermal energy storage stability.

Sugar alcs. as phase change materials (PCM) are very promising due to their high storage capacity, safety and economic reasons. Their phase change temperatures make them suitable for medium temperature storage, which is needed for solar process heat or waste heat recovery applications. To guarantee a long PCM working lifetime they should be tested under a repeated number of freezing/melting cycles to check whether the thermophys. properties remain constant or not. The cycling stability of D-mannitol, myo-inositol and galactitol has been studied with DSC and the chem. stability with FT-IR. Myo-inositol shows a good cycling stability under the chosen measuring parameters. The cycling and chem. stability of D-mannitol up to 20 cycles can be achieved by controlling some parameters. The variable affecting it the most is the amount of oxygen in contact with it. Hence, in the storage unit this could be prevented with an inert or vacuum atm.

Solar Energy Materials & Solar Cells published new progress about Fusion enthalpy. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Recommanded Product: (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Palomo Del Barrio, Elena published the artcileNew sugar alcohols mixtures for long-term thermal energy storage applications at temperatures between 70 °C and 100 °C, Product Details of C12H24O11, the main research area is sugar alc mixture temperature thermal energy storage.

Sugar alcs. (SA) are attractive phase change materials for long-term thermal energy storage (TES) applications at low-to-medium temperatures, as i.e. solar seasonal energy storage. Most of them undergo severe undercooling, thus allowing energy storage at temperatures far below the m.p. with thermal losses reduction Besides, some of them could provide very high volumetric energy d. at affordable cost. However, sugar alcs. with high latent heat of fusion often exhibit melting temperatures above 100 °C. The objective of this work was to found out new sugar alc. eutectic mixtures that display lower temperatures without significant reduction of the latent heat. A comprehensive anal. of SA relevant properties for TES has been carried out in order to select the most appropriate single SA for mixtures anal. Sixteen SA-based binary systems have been investigated. Their corresponding phase diagrams have been exptl. and theor. established. Four eutectic mixtures with potential for long-term TES at temperature around 80 °C have been identified. They are: (1) adonitol-erythritol at 30 mol% of erythritol, with melting temperature of 87 °C and latent heat of fusion of 254 J/g; (2) arabitol-erythritol at 40 mol% of erythritol, with melting temperature of 86 °C and latent heat of fusion of 225 J/g; (3) xylitol-erythritol at 36 mol% of erythritol, with melting temperature of 82 °C and latent heat of fusion of 270 J/g; and (4) arabitol-xylitol at 56 mol% of xylitol, with melting temperature of 77 °C and latent heat of fusion of 243 J/g.

Solar Energy Materials & Solar Cells published new progress about Binary systems. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Product Details of C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Tiejun published the artcileHydrothermal conversion of biomass to higher alcohol fuels for compression ignition engine, Safety of 3-Pentanol, the main research area is alc fuel compression ignition engine biomass hydrothermal conversion.

Higher alc. (C5/C6 alc.) blended with diesel or bio-diesel is a promising alternative clean fuel for the compression ignition engine. The most important puzzle is the technol. development of biomass to higher alc. fuels. In this paper, a novel approach of hydrothermal conversion of biomass into C5/C6 higher alc. fuels was proposed. High yield of higher alc. fuels was obtained from the real biomass with the C5/C6 alc. selectivity of 77% under the mild hydrothermal conditions. The properties of the produced higher alc. fuels are similar to that of 0# diesel. The exhaust emission of compression ignition engine decreased vigorously by blending the higher alc. fuels with diesel at weight ratio of 20/80.

Energy Procedia published new progress about Bagasse. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Safety of 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ponomarev, A. V. published the artcileEffect of Boiling on the Radiolysis of 1-Propanol, Related Products of alcohols-buliding-blocks, the main research area is propanol radiolysis boiling.

The radiolysis of 1-propanol without heating and in a boiling state under the action of accelerated (8-MeV electrons) was investigated. At room temperature, aldehydes dominated among mol. products. Unlike γ-radiolysis, monohydric alcs. were the second most important fraction. The yields of formation of aldehydes, monohydric alcs., and diols in boiling 1-propanol were approx. equal. Boiling increased the weight fraction of products heavier than 1-propanol to 74%, whereas this fraction was 57% at room temperature As follows from the anal. of products, boiling accelerated the dissociation of radicals and radical cations and facilitated radical exchange and combinations processes. The yields of 1-propanol degradation were 10.1 ± 0.9 and 13.3 ± 0.9 mol./100 eV at room temperature and in a boiling state, resp.

High Energy Chemistry published new progress about Aldehydes Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Silva, Weliton D. published the artcile3-Hydroxyhexan-2-one and 3-Methylthiopropan-1-ol as Pheromone Candidates for the South American Cerambycid Beetles Stizocera phtisica and Chydarteres dimidiatus dimidiatus, and Six Related Species, Computed Properties of 505-10-2, the main research area is Stizocera phtisica hydroxyhexan pheromone candidate; Aggregation-sex pheromone; Coleoptera; Hydroxyketone; Longhorned beetles; Monitoring; Semiochemistry; Structural motifs; Traps.

Here, we study the pheromone chem. of two South American cerambycid beetle species, and their behavioral responses to candidate pheromone components. Adult males of Stizocera phtisica Gounelle (subfamily Cerambycinae: tribe Elaphidiini) produced a sex-specific blend of (R)-3-hydroxyhexan-2-one with lesser amounts of 3-methylthiopropan-1-ol. In field bioassays, traps baited with racemic 3-hydroxyhexan-2-one and 3-methylthiopropan-1-ol did not catch conspecific beetles, but did catch both sexes of a sympatric species, Chydarteres dimidiatus dimidiatus (F.) (Cerambycinae: Trachyderini). We found that males of this species also produce (R)-3-hydroxyhexan-2-one and 3-methylthiopropan-1-ol, and small amounts of 2-phenylethanol. Subsequent bioassays with these compounds showed that a blend of 3-hydroxyhexan-2-one and 3-methylthiopropan-1-ol constitutes the aggregation-sex pheromone of C. d. dimidiatus, with 2-phenylethanol not influencing the attraction of conspecifics. During the field bioassays, six other species in the Cerambycinae also were caught in significant numbers, including Aglaoschema ventrale (Germar) (tribe Compsocerini), congeners Chrysoprasis aurigena (Germar), Chrysoprasis linearis Bates, and an unidentified Chrysoprasis species (Dichophyiini), and Cotyclytus curvatus (Germar) and Itaclytus olivaceus (Laporte & Gory) (both Clytini), suggesting that one or more of the compounds tested are also pheromone components for these species.

Journal of Chemical Ecology published new progress about Carpophilus dimidiatus. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Computed Properties of 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts