Month: December 2022

Neelakandan, Poovarasan published the artcileVolatile 1-octanol of tea (Camellia sinensis L.) fuels cell division and indole-3-acetic acid production in phylloplane isolate Pseudomonas sp. NEEL19, SDS of cas: 111-87-5, the main research area is Camellia sinensis Pseudomonas octanol indole acetic acid production; phylloplane fuel cell division production.

Tea leaves possess numerous volatile organic compounds (VOC) that contribute to tea’s characteristic aroma. Some components of tea VOC were known to exhibit antimicrobial activity; however, their impact on bacteria remains elusive. Here, we showed that the VOC of fresh aqueous tea leaf extract, recovered through hydrodistillation, promoted cell division and tryptophan-dependent indole-3-acetic acid (IAA) production in Pseudomonas sp. NEEL19, a solvent-tolerant isolate of the tea phylloplane. 1-octanol was identified as one of the responsible volatiles stimulating cell division, metabolic change, swimming motility, putative pili/nanowire formation and IAA production, through gas chromatog.-mass spectrometry, microscopy and partition petri dish culture anal. The bacterial metabolic responses including IAA production increased under 1-octanol vapor in a dose-dependent manner, whereas direct-contact in liquid culture failed to elicit such response. Thus, volatile 1-octanol emitting from tea leaves is a potential modulator of cell division, colonization and phytohormone production in NEEL19, possibly influencing the tea aroma.

Scientific Reports published new progress about Alkalinization. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cordes, Thekla published the artcileItaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury, Category: alcohols-buliding-blocks, the main research area is ischemia reperfusion injury tricarboxylic acid metabolism itaconate; Brain injury; Cerebral ischemia/reperfusion (IR); Itaconate; Mitochondrial metabolism; Redox stress; Succinate dehydrogenase (SDH).

We conducted metabolic flux and bioenergetic studies in response to exogenous itaconate treatment in cultures of primary rat cortical neurons and astrocytes. We administered itaconate to mouse models of cerebral reperfusion injury with ischemia or traumatic brain injury followed by hemorrhagic shock resuscitation. We quant. characterized metabolite levels, neurol. behavior, markers of redox stress, leukocyte adhesion, arterial blood flow, and arteriolar diameter in brains of treated/untreated mice. We demonstrate that “”immunometabolite”” itaconate slowed TCA cycle metabolism and buffered redox imbalance via succinate dehydrogenase inhibition and induction of anti-oxidative stress response in primary cultures of astrocytes and neurons. Addition of itaconate to reperfusion fluids after mouse cerebral IR injury increased glutathione levels and ROS/RNS to improve neurol. function. Plasma organic acids increased post-reperfusion injury, while administration of itaconate normalized these metabolites. In mouse cranial window models, itaconate significantly improved hemodynamics while reducing leukocyte adhesion. Itaconate supplementation increased survival in mice experiencing traumatic brain injury and hemorrhagic shock. Itaconate transiently inhibits SDH to gradually “”awaken”” mitochondrial function upon reperfusion that minimizes ROS and tissue damage. Itaconate acts as mitochondrial regulator that controls redox metabolism to improve physiol. outcomes associated with IR injury.

Molecular Metabolism published new progress about Antioxidants. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Yuqing published the artcileChemical structure and anti-inflammatory activity of a branched polysaccharide isolated from Phellinus baumii, HPLC of Formula: 59-23-4, the main research area is Phellinus fruit extract SHPS1 branched polysaccharide structure antiinflammatory; Anti-inflammatory activity; Inflammatory bowel disease; Phellinus baumii; Polysaccharide; Structure.

Phellinus baumii is used to treat inflammatory bowel disease (IBD) and gastroenteritis. In this study, a 46 kDa heteropolysaccharide SHPS-1 was isolated from fruiting bodies of P. baumii. SHPS-1 consisted of arabinose, mannose, glucose, and galactose at a molar ratio of 2.2:15.7:49.3:32.8. SHPS-1 had a backbone containing 1,3-linked β-D-Glcp and 1,6-linked α-D-Galp residues, and Araf, Manp and Galp units were attached as oligosaccharidic side chains to the backbone at C-6 of some glucopyranoses. SHPS-1 decreased phosphorylation level of STAT-1 and expression levels of STAT-1 targeted genes such as iNOS and TNF-α in lipopolysaccharide-stimulated macrophage RAW 264.7 cells. Furthermore, SHPS-1 promoted the expression of IL-10 and macrophage mannose receptor CD 206, markers of tissue repairing macrophages. SHPS-1 alleviated ulcerative colitis in mice by decreasing pro-inflammatory genes and increasing anti-inflammatory and tissue repairing genes. Collectively, SHPS-1 polysaccharide from P. baumii had anti-inflammatory activity and can potentially treat IBD.

Carbohydrate Polymers published new progress about Anti-inflammatory agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Choung, Wonken published the artcileIdentification of BR101549 as a lead candidate of non-TZD PPARγ agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR, Synthetic Route of 584-02-1, the main research area is drug discovery antidiabetics PPARgamma agonist SAR type 2 diabetes; Antidiabetics; Drug discovery; PPARgamma agonist.

The new class of PPARgamma non-TZD agonist originally derived from the backbone of anti-hypertensive Fimasartan, BR101549, was identified as a potential lead for anti-diabetic drug development. The X-ray crystallog. of BR101549(I) with PPARgamma ligand binding domain (LBD) revealed unique binding characteristics vs. traditional TZD full agonists. The lead candidate, BR101549, has been found activating PPARgamma to the level of Pioglitazone in vitro and indeed has demonstrated its effects on blood glucose control in mouse proof-of-concept evaluation. The attempts to improve its metabolic stability profile through follow-up SAR including deuterium incorporation have been also described.

Bioorganic & Medicinal Chemistry Letters published new progress about Adiponectins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Synthetic Route of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kang, Jingtian published the artcileControllable bistable smart composite structures driven by liquid crystal elastomer, Formula: C17H28O8S4, the main research area is liquid crystal elastomer smart composite simulation.

In this article, we proposed a new way to achieve monostable and bistable characteristics of composite layers based on liquid crystal elastomer (LCE). A smart trilayer composite structure is fabricated using LCE and acrylic elastomer, which can have several morphologies. It keeps flat at room temperature and can deform into a monostable saddle or bistable cylinder surface in response to simple temperature changes. The reversible deformation can be controlled through two parameters including geometrical size and actuation strain. The LCE can be programmed to generate different actuation strains by different formulas during synthesis or different mech. stretches during UV radiation. The deformed morphol. for different sample sizes and actuation strain is calculated using Finite element simulation. By comparison with the exptl. results, we confirm that the phenomena can be captured through numerical simulations. Furthermore, to have a quant. understanding, we use numerical simulation to calculate the deformation of the composite structure by tuning these two parameters and give a morphol. portrait illustrating the relationship between the deformed shape and control parameters.

Smart Materials and Structures published new progress about Deformation (mechanical). 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Formula: C17H28O8S4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Voce, Sabrina published the artcileCompositional characterization of commercial sparkling wines from cv. Ribolla Gialla produced in Friuli Venezia Giulia, Application of 3-(Methylthio)propan-1-ol, the main research area is Ribolla Gialla sparkling wine terpene norisoprenoid lipid.

Ribolla Gialla (RG) is a white grape variety used in the production of high-quality sparkling wines. It is cultivated in a limited area between Friuli Venezia Giulia (FVG-Northeast Italy) and Slovenia; for this reason, there is little information about the composition and chem. characteristics of the sparkling wines produced. This work used different anal. approaches (FTIR spectroscopy, UHPLC-MS/MS, liquid-liquid extraction, SPE and SPME-GC-MS) to characterize thirty-three com. sparkling RG wines from different areas of FVG. The characteristics included the overall volatile profile and content of terpenes, C13-norisoprenoids, lipids, and metabolites of aromatic amino acids. The aroma profile of RG wines was mainly characterized by fermentative esters and β-damascenone, whereas other norisoprenoids and varietal aromas were below the odor threshold. Appreciable amounts of certain fatty acids were found (e.g., palmitic acid), which could be potentially correlated with greater foam stability. However, high concentrations of aromatic amino acids metabolites highlighted a higher risk of developing atypical aging defects.

European Food Research and Technology published new progress about Esters Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Application of 3-(Methylthio)propan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Yannan published the artcileMalate Circulation: Linking Chloroplast Metabolism to Mitochondrial ROS, Computed Properties of 97-67-6, the main research area is review Arabidopsis chloroplast NADH malate mitochondria reactive oxygen species; chloroplast-to-mitochondrion communication; malate circulation; malate valve; programmed cell death; reactive oxygen species; reducing power.

In photosynthetic cells, chloroplasts and mitochondria are the sites of the core redox reactions underpinning energy metabolism Such reactions generate reactive oxygen species (ROS) when oxygen is partially reduced. ROS signaling leads to responses by cells which enable them to adjust to changes in redox status. Recent studies in Arabidopsis thaliana reveal that chloroplast NADH can be used to generate malate which is exported to the mitochondrion where its oxidation regenerates NADH. Oxidation of this NADH produces mitochondrial ROS (mROS) which can activate signaling systems to modulate energy metabolism, and in certain cases can lead to programmed cell death (PCD). We propose the term ‘malate circulation’ to describe such redistribution of reducing equivalent to mediate energy homeostasis in the cell.

Trends in Plant Science published new progress about Chloroplast Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Computed Properties of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Savchenko, Tatyana V. published the artcileJasmonates-mediated rewiring of central metabolism regulates adaptive responses, Quality Control of 97-67-6, the main research area is review Arabidopsis jasmonate metabolism adaptive response plant growth; Adaptive responses; Allene oxide synthase; Central metabolism; Growth; Jasmonates; Resource allocation.

The lipid-derived hormones jasmonates (JAs) play key functions in a wide range of physiol. and developmental processes that regulate growth, secondary metabolism and defense against biotic and abiotic stresses. In this connection, biosynthesis, tissue-specific distribution, metabolism, perception, signaling of JAs have been the target of extensive studies. In recent years, the involvement of JAs signaling pathway in the regulation of growth and adaptive responses to environmental challenges has been further examined However, JAs-mediated mechanisms underlying the transition from ‘growth mode’ to ‘adaptive mode’ remain ambiguous. Combined anal. of transgenic lines deficient in JAs signaling in conjunction with the data from JAstreated plants revealed the function of these hormones in rewiring of centralmetabolism. The collective data illustrate JAs-mediated decrease in the levels of metabolites associated with active growth such as sucrose, raffinose, orotate, citrate, malate, and an increase in phosphorylated hexoses, responsible for the suppression of growth and photosynthesis, concurrent with the induction of protective metabolites, such as aromatic and branched-chain amino acids, and aspartate family of metabolites. This finding provides an insight into the function of JAs in shifting the central metabolism from the production of growth-promoting metabolites to protective compounds and expands our understanding of the role of JAs in resource allocation in response to environmental challenges.

Plant and Cell Physiology published new progress about Aromatic amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Quality Control of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tremblay-Laganiere, Camille published the artcilePolychlorinated biphenyl 126 exposure in rats alters skeletal muscle mitochondrial function, Formula: C4H6O5, the main research area is polychlorinated biphenyl skeletal muscle mitochondrial disease; Electron transport chain; Oxidative phosphorylation; Oxidative stress; Polychlorinated biphenyls; Skeletal muscle metabolism.

In the past few years, polychlorinated biphenyls (PCBs), a class of environmental pollutants, have been associated with metabolism dysregulation. Muscle is one of the key regulators of metabolism because of its mass and its important role in terms of glucose consumption and glucose storage. It has been shown that muscle alterations, such as oxidative stress and mitochondrial dysfunction, contribute significantly to the development of metabolic diseases. No study has yet investigated the toxicol. effect of PCBs on muscle mitochondrial function and oxidative stress in vivo. The aim of this study was to assess the effect of PCB126 in vivo exposure (single dose of 1.05 μmol/kg) on muscle mitochondrial function and oxidative stress in rats. PCB126-treated rats showed a marked increase in Cyp1a1 mRNA levels in skeletal muscles in association with a 40% reduction in state 3 oxygen consumption rate measured with complex I substrates in permeabilized muscle fibers. Furthermore, PCB126 exposure altered the expression of some enzymes involved in ROS detoxification such as catalase and glutaredoxin 2. Our results highlight for the first time a toxic effect of coplanar PCBs on skeletal muscle mitochondrial function and oxidative stress. This suggests that acute PCB exposure, by affecting muscle metabolism, could contribute to the development of metabolic disorders. Studies are needed to determine if lower-level but longer-term PCB exposure exhibits the same effect.

Environmental Science and Pollution Research published new progress about Glutaredoxins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Youxia published the artcileComprehensive analysis of aberrantly expressed profiles of mRNA and its relationship with serum galactose-deficient IgA1 level in IgA nephropathy, COA of Formula: C6H12O6, the main research area is gene expression galactose IgA1 IgA nephropathy; Differential gene expression; Galactose-deficient IgA1; IgA nephropathy; RNA-deep sequencing; mRNA microarray.

IgA nephropathy (IgAN) is the leading cause of end-stage kidney disease. Previous mRNA microarray profiling studies of IgAN revealed inconsistent data. We sought to identify the aberrantly expressed genes and biol. pathways by integrating IgAN gene expression datasets in blood cells and performing systematically exptl. validation. We also explored the relationship between target genes and galactose-deficient IgA1 (Gd-IgA1) in IgAN. We retrieved Gene Expression Omnibus (GEO) datasets of IgAN. Gene Ontol. (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used for functional anal. Deep sequencing on RNA isolated from B cells was used for microarray validation. The relationship between target mRNA expressions and Gd-IgA1 levels in serum were also studied. Three studies with microarray expression profiling datasets met our inclusion criteria. We identified 655 dyregulated genes, including 319 up-regulated and 336 down-regulated genes in three GEO datasets with a total of 35 patients of IgAN and 19 healthy controls. Based on biol. process in GO term, these dyregulated genes are mainly related to pentose-phosphate shunt, non-oxidative branch, post-embryonic camera-type eye development and leukocyte activation. KEGG pathway anal. of microarray data revealed that these aberrantly expressed genes were enriched in human T-cell leukemia virus 1 infection, proteoglycans in cancer, intestinal immune network for IgA production and autophagy. We further performed deep sequencing on mRNAs isolated from B cells of an independent set of five patients with IgAN and three healthy persons with the same clin. and demog. characteristics. Seventy-seven genes overlapped with 655 differentially regulated genes mentioned above, including 43 up-regulated and thirty-four down-regulated genes. We next investigated whether these genes expression correlated with Gd-IgA1 levels in IgAN patients. Pearson correlation analyses showed PTEN (phosphatase and tensin homolog) was the most powerful gene neg. correlated with Gd-IgA1 levels. These results demonstrated that dyregulated genes in patients with IgAN were enriched in intestinal immune network for IgA production and autophagy process, and PTEN in B cells might be involved in the mechanism of Gd-IgA1 production

Journal of Translational Medicine published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (DEF8). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts