Month: December 2022

Guo, M.-Z. published the artcileStructure characterization, physicochemical property and immunomodulatory activity on RAW264.7 cells of a novel triple-helix polysaccharide from Craterellus cornucopioides, Synthetic Route of 59-23-4, the main research area is Craterellus macrophage immunomodulation polysaccharide; Chemical structure; Craterellus cornucopioides; Polysaccharide; Stability immunomodulatory activity.

In the study, a new triple-helix polysaccharide with favorable stability was purified from C. cornucopioides. Its structural characterization, stability and solution behavior were investigated by the GC-MS, periodate oxidation-smith degradation, FT-IR, 1D and 2D NMR spectroscopy, methylation anal., Scanning electron microscope, Congo-red, CD, TGA and DSC anal. The results showed that Craterellus cornucopioide polysaccharide (CCP) possessed the mol. weight of 1.97 × 103 kDa, is mainly composed of mannose (48.73%), galactose (17.37%), glucose (15.97%) and xylose (17.93%), resp. It was a heteroglycan with (1 → 3)-linked-β-D-Manp-(1 → 6)-linked a-D-Galp backbone distributed by (1 → 4)-linked-a-D-Xylp-t-a-D-Manp and t-β-D-Glup units at O-6. The result of TGA and DSC assay indicated that CCP has a favorable thermal stability. MTT and Scanning electro microscopy (SEM) assay showed that CCP could significantly improve the proliferation activity and induce cells activation of RAW264.7 in a certain range of concentrations and period.

International Journal of Biological Macromolecules published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shakhmatov, Evgeny G. published the artcileStructural studies of biologically active pectin-containing polysaccharides of pomegranate Punica granatum, Computed Properties of 59-23-4, the main research area is Punica fruit feel membrane pectin polysaccharide structural property; Arabinan; NMR; Pectic polysaccharides; Pomegranate wastes; Punica granatum; Structural analysis.

The polysaccharide PGW was isolated from peels and membranes of fruits of pomegranate P. granatum by hot water extraction The methods of ion exchange chromatog., partial acid hydrolysis, enzymic hydrolysis and NMR spectroscopy were employed to establish the major elements of its structure. It was shown that this polysaccharide contained polymers with different structures, the main components among which were pectic polysaccharides, represented mainly by highly methyl-esterified and lowly acetylated 1,4-α-D-galactopyranosyluronan and a minor amount of partially 2-O- and/or 3-O-acetylated RG-I. The side carbohydrate chains of the branched region of RG-I were mainly represented by terminal, 5-O-, 3-O-, 2,5-di-O-, 3,5-di-O- and 2,3,5-tri-O-substituted α-L-Araf residues indicating the presence of branched 1,5-α-L-arabinan and minor regions of 1,4-β-D-galactan or arabinogalactan type I. The degree of methylation of the isolated pectins varied depending on the method of treatment. As a result, peels and membranes of pomegranate fruits can be recommended as a source of highly and lowly methyl-esterified pectic polysaccharides.

International Journal of Biological Macromolecules published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Conte, Federica published the artcileGalactose in human metabolism, glycosylation and congenital metabolic diseases: Time for a closer look, Category: alcohols-buliding-blocks, the main research area is review galactose human metabolism glycosylation congenital metabolic disease; Collagen glycosylation; Congenital disorders of glycosylation; Galactose; Galactosemia; Keratan sulfate; Lysosomal disorders.

Galactose is an essential carbohydrate for cellular metabolism, as it contributes to energy production and storage in several human tissues while also being a precursor for glycosylation. Galactosylated glycoconjugates, such as glycoproteins, keratan sulfate-containing proteoglycans and glycolipids, exert a plethora of biol. functions, including structural support, cellular adhesion, intracellular signaling and many more. The biol. relevance of galactose is further entailed by the number of pathogenic conditions consequent to defects in galactosylation and galactose homeostasis. The growing number of rare congenital disorders involving galactose along with its recent therapeutical applications are drawing increasing attention to galactose metabolism In this review, we aim to draw a comprehensive overview of the biol. functions of galactose in human cells, including its metabolism and its role in glycosylation, and to provide a systematic description of all known congenital metabolic disorders resulting from alterations of its homeostasis.

Biochimica et Biophysica Acta, General Subjects published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nopianti, R. published the artcileCryoprotective effect of low-sweetness additives on protein denaturation of threadfin bream surimi (Nemipterus spp.) during frozen storage, Formula: C12H24O11, the main research area is lactitol maltodextrin polydextrose trehalose Nemipterus protein denaturation frozen storage.

The cryoprotective effects of lactitol, maltodextrin, palatinit, polydextrose, trehalose on the protein denaturation of threadfin bream surimi during six months of frozen storage were investigated. The characteristics analyzed were Ca2+-ATPase activity, protein solubility, sulfhydryl (SH) content, electrophoresis, surface morphol., and thermal stability. The effectiveness of all cryoprotectants generally decreased as the storage time increased. Polydextrose was able to maintain Ca2+-ATPase activity, protein solubility, and SH content of 33.5%, 71.3%, 71.8%, resp. Sucrose was able to maintain Ca2+-ATPase activity, protein solubility, and SH content of 32.4%, 68.1%, 75.6%, resp. Electrophoresis showed that the myosin heavy chain (MHC) and actin band intensity almost disappeared by the end of storage. Anal. by SEM (SEM) demonstrated that the number of pores formed increased after storage. Thermal stability anal. showed a decrease in myosin but no significant change in actin content. This study suggests that polydextrose as a cryoprotectant is able to maintain protein from denaturation as the same as sucrose.

CyTA–Journal of Food published new progress about Calcium pumps Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Shijun published the artcileInvestigation of vaping fluids recovered from New York State e-cigarette or vaping product use-associated lung injury patients, Quality Control of 124-76-5, the main research area is electronic cigarette vaping fluid product human lung injury; EVALI; cannabis; diluents; electronic cigarettes; pesticides; terpenes; vaping fluid; vitamin E acetate.

E-cigarette or vaping product use-associated lung injury (EVALI) is a serious pulmonary condition that is associated with the extended use of certain vaping products. EVALI was first characterized in the summer of 2019 and has since been reported in all 50 U.S. states. From August 2019 through June 2021, the New York State Department of Health has reported more than 197 confirmed cases emanating from all regions of the state. The Wadsworth Center at the New York State Department of Heath received vaping cartridges recovered from EVALI patients for chem. anal. of their contents. Untargeted anal. methods using gas chromatog.-mass spectrometry and liquid chromatog.-high-resolution mass spectrometry as well as targeted analyses for a variety of analytes including cannabinoids, pesticides, vitamin E acetate (VEA) and mycotoxins were used to characterize the composition of the vaping fluids and several com. vaping fluid additives. From the analyses of the 284 e-cigarette devices recovered from patients, 82 were found to be nicotine-containing pods, and 202 devices containing cannabis oil, apparently from unauthorized or black-market dealers. The fluids from the cannabis-oil cartridges tended to have lower levels of THCs (Δ9-tetrahydrocannabinol + Δ8-tetrahydrocannabinol) and total cannabinoids compared with those of com. produced formulations and contained significant levels of diluents including VEA, medium-chain triglycerides, polyethylene glycol, and castor oil. VEA was the diluent most frequently detected, which was present in 132 (65.3%) of the vaping fluids that contained cannabis oil. When present, VEA ranged from 2.0 to 67.8% of the total mass of the oil with a mean content of 37.0%. In some cases, two or three diluents were detected in the same sample. The ratio of VEA to THCs varied widely, from 0.07 to 5.34. VEA and specifically the high ratios of VEA to THCs in black-market vaping fluids may be causative in EVALI. The safety of addnl. components and additives that are present in vaping fluids are likewise of concern.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Benzoic acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Quality Control of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ayestaran, Belen published the artcileEffect of the winemaking process on the volatile composition and aromatic profile of Tempranillo Blanco wines, SDS of cas: 505-10-2, the main research area is volatile wine aromatic; Carbonic maceration; PLS; Sensory properties; Tempranillo Blanco wine; Volatile compounds.

The effects of the carbonic maceration and conventional winemaking on the volatile composition and aromatic sensory characteristics of Tempranillo Blanco wines were studied for the first time, during three consecutive vintages. Relationships between instrumental (volatiles) and sensory variables were analyzed applying partial least squares regression (PLS). Carbonic macerated wines had higher contents of alcs. and carbonyl compounds, yet lower concentrations of C6 alcs. and volatile acids than wines conventionally produced. The Odor Activity Values (OAV) exhibited an increase in wines when carbonic maceration was applied. According to the geometric mean (% GM) obtained from aroma descriptors the effect of the winemaking process was significant for seed fruit, ripe fruit and floral notes. When subjected to PLS the data from the instrumental anal. yielded a satisfactory model for the prediction of aroma descriptors in this set of wines.

Food Chemistry published new progress about Aromatic compounds Role: ANT (Analyte), PRP (Properties), ANST (Analytical Study). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, SDS of cas: 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Jie published the artcilePeroxide-Driven Hydroxylation of Small Alkanes Catalyzed by an Artificial P450BM3 Peroxygenase System, Related Products of alcohols-buliding-blocks, the main research area is alkane hydroxylation P450BM3 peroxygenase hydrogen peroxide protein engineering.

We report the selective hydroxylation of small alkanes with H2O2 catalyzed by an artificial P 450 peroxygenase system generated from engineered cytochrome P450BM3 variants in assistance with dual-functional small mol. (DFSM), in which DFSM acts as a general acid-base co-catalyst for activating H2O2. This peroxygenase system exhibited comparable catalytic turnover number (TON) to the fungal peroxygenase AaeUPO, the only known H2O2-dependent natural alkane hydroxylase. Moreover, when compared with evolved/engineered NADPH-dependent P 450 variants, the current system yielded similar or even better product formation rates (PFRs) but lower total TONs. The substitution of the highly conserved T268 with amino acids having hydrophobic side chains was identified to play critical roles in improving the hydroxylation activity of the DFSM-facilitated P450BM3 peroxygenase system, which is distinct from NADPH-dependent P 450 enzymes. These results offer useful insights into how to tune the catalytic functions and chem. of P 450 peroxygenases.

ACS Catalysis published new progress about Alkanes, C3-6 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tanimoto, Toshiko published the artcileRetention behavior of positional isomers of disubstituted cyclomalto-oligosaccharide (cyclodextrin) derivatives on an ODS column, Formula: C13H28O, the main research area is disubstituted cyclomalto oligosaccharide retention liquid chromatog; HPLC disubstituted cyclomalto oligosaccharide ODS column; cyclodextrin derivative positional isomer ODS column liquid chromatog.

The correlation between hydrophobic effects and structures of three and four positional isomers of 61,6n-di-O-triphenylmethyl (trityl)- or 61,6n-di-O-tert.- butyldimethylsilyl (tert.-BuMe2Si)-cyclomaltohexaoses (cG6s, α-cyclodextrin) (n = 2-4), -cyclomaltoheptaoses (cG7s, β-cyclodextrin) (n = 2-4), and -cyclomaltooctaoses (cG8s, γ-cyclodextrin) (n = 2-5) on an ODS column are discussed. Cyclodextrins with two hydrophobic-substituted groups bonded to hydroxyl groups tended to show low retention of positional isomers in which the binding positions of the two substituted groups on the cyclodextrin ring were far apart from each other.

Journal of Chromatography A published new progress about Aliphatic alcohols Role: ANT (Analyte), PRP (Properties), ANST (Analytical Study). 58783-82-7 belongs to class alcohols-buliding-blocks, name is 5-Tridecanol, and the molecular formula is C13H28O, Formula: C13H28O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cavaglia, Julieta published the artcileATR-MIR spectroscopy and multivariate analysis in alcoholic fermentation monitoring and lactic acid bacteria spoilage detection, Safety of (S)-2-hydroxysuccinic acid, the main research area is Lactobacillus Oenococcus contamination alc fermentation ATR MIR spectroscopy.

Wine production processes still rely on post-production evaluation and off-site laboratory analyses to ensure the quality of the final product. Here we propose an at-line methodol. that combines a portable ATR-MIR spectrometer and multivariate anal. to control the alc. fermentation process and to detect wine fermentation problems. In total, 36 microvinifications were conducted, 14 in normal fermentation conditions (NFC) and 22 intentionally contaminated fermentations (ICF) with different lactic acid bacteria (LAB) concentrations ATR-MIR measurements were collected during alc. and malolactic fermentations and relative d., pH, and L-malic acid were analyzed by traditional methods. Partial Least Squares Regression could suitably predict d. and pH in fermenting samples (root mean squared errors of prediction of 0.0014 g mL-1 and 0.06 resp.). With regard to ICF, LAB contamination was detected by multivariate discriminant anal. when the difference in L-malic acid concentration between NFC and ICF was in the order of 0.7-0.8 g L-1, before the end of malolactic fermentation This methodol. shows great potential as a fast and simple at-line anal. tool for detecting fermentation problems at an early stage.

Food Control published new progress about Alcohols Role: BCP (Biochemical Process), BIOL (Biological Study), PROC (Process). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Safety of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sathyan, Ashlin published the artcileRing-Opening Polymerization of Allyl-Functionalized Lactams, COA of Formula: C17H28O8S4, the main research area is ring opening polymerization allyl functionalized lactam.

Aliphatic polyamides containing pendent allyl groups were prepared by anionic ring-opening copolymerization of ε-caprolactam with substituted lactam 3-(3-propenyl)-2-azepanone (1). Copolymerization experiments revealed that up to 11 mol % of 1 was integrated successfully into these novel polyamides, which ranged in mol. weight from 27 to 72 kDa. Relative to the well-known com. polyamide-6 (PA-6), the degree of crystallinity of the copolymers decreased with incorporation of functional monomer. Moreover, the pendent allyl groups afforded rapid access to numerous functional aliphatic polyamides, using photoinitiated thiol-ene chem., providing a pathway to cross-linked polyamide films and gels.

Macromolecules (Washington, DC, United States) published new progress about Polyamides Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, COA of Formula: C17H28O8S4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts