Month: December 2022

Ding, Meng published the artcileOrderly MOF-Assembled Hybrid Monolithic Stationary Phases for Nano-Flow HPLC, Category: alcohols-buliding-blocks, the main research area is MOF assembled hybrid monolithic stationary phasesnano flow HPLC.

We report an approach that polymerizable handle-modified nanosized metal organic frameworks (MOFs) are used as independent monomers to be covalently organized by crosslinking mols. (CLMs) into an orderly MOF-assembled hybrid monolithic stationary phase, overcoming the resp. problems of previously reported MOF-mixed or embedded stationary phases so far. It has a hierarchical micro-, meso-, and macropore structure throughout the monolithic matrix that is donated from MOF themselves, formed via CLM crosslinking in-between MOFs and expended by porogenic solvents, and a tunable surface chem. derived inherently from MOFs, regulated by CLMs and initiated by the mobile phases as well. Such a pore structure and surface chem. display multiplex interactions of sieving and electrostatic repulsion in addition to the polarity-based interactions that synergistically govern the partitioning way and degree of target mols. between the stationary and mobile phases, thus offering the ability to simultaneously sep. small and large mols. during one chromatog. run on a nano-flow capillary high-performance liquid chromatog. platform. A baseline mutual separation with the HETP and Rs of, for example, 9.2 μm butylbenzene and 4.56 (butylbenzene and pentylbenzene), 7.9 μm (phenylalanine) and 3.50 (tryptophan and phenylalanine), and 7.0 μm (myoglobin) and 1.91 (bovine serum albumin and myoglobin) was achieved when UiO-66/NH-methacrylate was exemplified as a model of MOFs and 1,6-hexanediol dimethacrylate and stearyl methacrylate together as CLMs. Not limited to the MOFs and CLMs demonstrated here, other available MOFs and CLMs or newly designed and synthesized ones are expected to be used for constructing one′s own desired monolithic stationary phases toward her/his particular purposes.

Analytical Chemistry (Washington, DC, United States) published new progress about Bovine serum albumin Role: ANT (Analyte), ANST (Analytical Study). 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kochansky, Jan published the artcileSubstituent effects on chemosterilant activity of 2,4-di-tert-butyl-6-(4′-substituted benzyl)phenols in the house fly (Musca domestica L.), Recommanded Product: (4-Butoxyphenyl)methanol, the main research area is chemosterilant butylbenzylphenol fly structure; Musca chemosterilant butylbenzylphenol structure.

A series of 2,4-di-tert-butyl-6-(4′-X-benzyl)phenols was prepared, analogous to the compound Jurd 2644 (X = OMe) in an attempt to establish a Hammett relationship between the 4′-substituent and the chemosterilant activity of the compounds after oral administration to adult Musca domestica. Fourteen compounds of this type were prepared, 12 of them new. Jurd 2419 (X = H) was found to be as active in our bioassay as Jurd 2644, as were four new compounds [X = N(CH3)2, CH3, SCH3, Cl]. All prevented successful reproduction at 30 mg/kg of diet. There was no correlation between Hammett σ and activity. Active compounds all had small substituents and mol. weights below 350. The activity seemed to be determined by the bulk of X rather than by its electronic properties.

Journal of Agricultural and Food Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Recommanded Product: (4-Butoxyphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

He, Xiaochun published the artcileSynthesis of Unsymmetrical N-Heterocyclic Carbene-Nitrogen-Phosphine Chelated Ruthenium(II) Complexes and Their Reactivity in Acceptorless Dehydrogenative Coupling of Alcohols to Esters, Formula: C8H18O, the main research area is tridentate phosphinophenyliminoimidazolylidene chelated ruthenacycle preparation catalyst dehydrogenative coupling alc; crystal structure tridentate phosphinophenyliminoimidazolylidene chelated ruthenacycle; mol structure tridentate phosphinophenyliminoimidazolylidene chelated ruthenacycle; ester preparation.

Two novel Ru complexes RuH(CO)Cl(PPh3)(κ2-CP) (1) and [fac-RuH(CO)(PPh3)(κ3-CNP)]Cl (2) bearing unsym. N-heterocyclic carbene-N-phosphine (CNP) were synthesized and characterized with 1H NMR, 31P NMR, and HRMS. The structure of complex 2 was further confirmed by single-crystal x-ray diffraction. An anion exchange experiment proved that complex 2 could transform into complex 1 in solution The two complexes exhibited a highly catalytic performance in acceptorless dehydrogenative coupling of alcs. to esters, and the excellent isolated yields of esters were given in a catalyst loading of 1% for para- and meta-substituted benzyl alcs. and long-chain primary alcs. Although some ortho-substituted benzyl alcs. displayed a relatively low reactivity due to the steric hindrance and the coordination of electron donor with the Ru center, the good product yields were still obtained by prolonging the reaction time. Especially, this system successfully realized the dehydrogenative cross-coupling to esters between two different primary alcs.

Organometallics published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hikawa, Hidemasa published the artcileA Borrowing Hydrogen Strategy for Dehydrative Coupling of Aminoisoquinolines with Benzyl Alcohols in Water, Category: alcohols-buliding-blocks, the main research area is borrowing hydrogen strategy dehydrative coupling aminoisoquinoline benzylic alc.

We report a borrowing hydrogen strategy for a palladium-catalyzed dehydrative coupling of aminoisoquinolines with benzylic alcs. in water. This cascade reaction using the π-benzylpalladium system can be achieved in an atom-economic process without the need for base or other additives, furnishing the N-benzylated aminoisoquinolines in moderate to excellent yields along with water as the sole co-product. The crossover experiment using [D7]benzyl alc. and 4-methoxybenzyl alc. afforded H/D scrambled products. KIE experiments showed that benzylic C-H bond cleavage of benzyl alc. was involved in the turnover limiting step (KIE = 4.4). The coupling reaction was found to be first order in benzyl alc. with a kinetic solvent isotope effect (KSIE) of 1.6. These exptl. results are consistent with a borrowing hydrogen mechanism in water. Notably, the water-soluble Pd0/TPPMS system can be applied to the more challenging catalytic benzylic amination with aminoisoquinoline nucleophiles despite the possible deactivation of PdII species.

European Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hikawa, Hidemasa published the artcilePalladium-Catalyzed Benzylic C-H Benzylation via Bis-Benzylpalladium(II) Complexes in Water: An Effective Pathway for the Direct Construction of N-(1,2-Diphenylethyl)anilines, Computed Properties of 6214-45-5, the main research area is aniline diphenylethyl preparation; benzyl alc aniline benzylation palladium catalyst.

A strategy for the N-benzylation/benzylic C-H benzylation cascade of anilines by the π-benzylpalladium system using a water-soluble palladium(0)/sodium diphenylphosphinobenzene-3-sulfonate (TPPMS) catalyst and benzyl alc. in water has been developed. The nucleophilic ν1-σ-benzyl anion ligand attacks the electrophilic ν3-π-benzyl ligand to give a dibenzylated product. The intermol. competition between mono-N-benzylaniline and its monodeuterated form (monodeuterated at the benzylic group) with benzyl alc. gave a KIE = 4.6, suggesting that C-H bond cleavage was involved in the rate-determining step. Hammett studies on the rate constants of benzylation by various substituted anthranilic acids and mono-N-benzylanilines show a good correlation between the log(kX/kH) and the σ values of the resp. substituents. From the slope, neg. ρ values were obtained, suggesting that there is a build-up of pos. charge in the transition state. The reaction of anilines R1C6H4NH2 (R1 = 4-Me, 3-COOEt, 2-OPh, etc.) with electron-donating and electron-withdrawing groups R2C6H4CH2 (R2 = H, 4-MeO, 3-Me, etc.) afforded the corresponding N-(1,2-diphenylethyl)anilines I in moderate to good yields (54-86%). Interestingly, the reaction of anthranilic acids R3C6H3(COOH)NH2 (R3 = 6-Me, 5-NHAc, H, etc.) with benzylic alcs. R4CH2OH (R4 = Ph, naphthyl, 4-MeC6H4, 3-MeC6H4) proceeded smoothly to give only the corresponding dibenzylated products II in good to excellent yields (70-87%) in which carboxyl group of the anthranilic acids acts as a directing group.

Advanced Synthesis & Catalysis published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Computed Properties of 6214-45-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fillery, Shaun M. published the artcileExpeditious Access to Functionalized Tricyclic Pyrrolo-Pyridones via Tandem or Sequential C-N/C-C Bond Formations, Computed Properties of 22483-09-6, the main research area is tricyclic pyrrolopyridone preparation; bromopyridone bromoaniline cyclic ketone Buchwald Hartwig Heck Fischer indole.

The facile synthesis of both saturated and unsaturated tricyclic pyrrolo-pyridones starting from a single readily available, common monocyclic reagent has been developed. An intermol. annulation via a tandem Buchwald-Hartwig/Heck reaction led to the synthesis of β-carbolinones. The analogous semisatd. tricyclic pyrrolo-pyridones were prepared in good to excellent yields by sequential Buchwald-Hartwig and Fischer indole reactions. The methods feature mild reaction conditions and good functional group tolerance.

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (bromo). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Computed Properties of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jin, Lele published the artcileCatalytic conversion of cellulose to C5/C6 alkanes over Ir-VOx/SO2 combined with HZSM-5 in n-dodecane/water system, Application In Synthesis of 584-02-1, the main research area is catalytic conversion C5 C6 alkane liquid fuel.

The liquid fuel (made of C5/C6 alkanes) was obtained directly from the hydrogenolysis of microcrystalline cellulose (MCC) with Ir-VOx/SiO2 combined with HZSM-5 as the composite catalyst in a biphasic system (n-dodecane + H2O). The performance of the catalyst was investigated by carrying out a series of experiments using various V/Ir molar ratios, catalyst dosages, reaction temperatures, reaction time, hydrogen pressure and substrates. At the optimized conditions, the cellulose was almost completely converted, and at the same time, a high C5/C6 yield of 85.1% was obtained at 210° for 24 h and 6 MPa with the V/Ir molar ratio being 0.13. These results not only proved that Ir-VOx/SiO2 (V/Ir = 0.13) has excellent performance for the hydrogenolysis of MCC to liquid alkanes, but also indicated that vanadium is a good metal promoter for iridium. In addition, it was proven the C5/C6 alkanes were obtained via sorbitol through the combined effect of Ir-VOx/SiO2 and HZSM-5.

Fuel Processing Technology published new progress about Alkanes, C5 Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Application In Synthesis of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bai, Xishan published the artcileHydrogen-Borrowing Amination of Secondary Alcohols Promoted by a (Cyclopentadienone)iron Complex, Formula: C5H12O, the main research area is hydrogen borrowing amination secondary alc cyclopentadienone iron complex catalyst.

Thanks to a highly active catalyst, the scope of the (cyclopentadienone)iron complex-promoted ‘hydrogen-borrowing’ (HB) amination has been expanded to secondary alcs., which had previously been reported to react only in the presence of large amounts of co-catalysts [e.g., p-anisidine + 1-phenylethanol â†?N-(4-methoxyphenyl)-1-phenylethylamine (89% conversion) in presence of mol. sieves with amine:alc. stoichiometry of 4:1 at 150° in toluene]. A range of cyclic and acyclic secondary alcs. were reacted with aromatic and aliphatic amines giving fair to excellent yields of the substitution products. The catalyst was also able to promote the cyclization of diols bearing a secondary alc. group with primary amines to generate saturated N-heterocycles.

Synthesis published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Formula: C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ofner, Alessandro published the artcileControlled Massive Encapsulation via Tandem Step Emulsification in Glass, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is encapsulation tandem step emulsification glass.

Controlled encapsulation is important in pharmaceutics, agriculture, food products, and in emerging materials applications. Microfluidics offers a compelling approach to create controlled emulsions and microcapsules for these applications, but upscaling of this technol. for the robust encapsulation of chem. diverse active ingredients is not yet demonstrated. Microfluidic step emulsification can be exploited in upscaled glass devices to robustly produce monodisperse double emulsions and functional microcapsules in tandem at high throughput rates. The effect of geometrical parameters of the devices and the operating flow rates on the morphol., dimensions, and structure of monodisperse double emulsions is investigated and quantified using simple quant. models. Using such double emulsions as templates, mechanoresponsive microcapsules that can be embedded in a soft matrix to generate damage-reporting polymer parts that change color in areas subjected to excessive mech. loads are created. Thanks to the chem. versatility and mech. robustness of glass, this platform should enable the high-throughput encapsulation of a wide variety of chems. while providing the exquisite control achievable through microfluidics.

Advanced Functional Materials published new progress about Acrylic polymers Role: RCT (Reactant), RACT (Reactant or Reagent). 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kurandina, Daria published the artcileTransition-Metal- and Light-Free Directed Amination of Remote Unactivated C(sp3)-H Bonds of Alcohols, Product Details of C5H12O, the main research area is directed remote amination aliphatic alc diazonium salt.

Due to the great value of amino alcs., new methods for their synthesis are in high demand. Abundant aliphatic alcs. represent the ideal feedstock for the method development toward this important motif. To date, transition-metal-catalyzed approaches for the directed remote amination of alcs. have been well established. Yet, they have certain disadvantages such as the use of expensive catalysts and limited scope. Very recently, transition-metal-free visible-light-induced radical approaches have emerged as new powerful tools for directed remote amination of alcs. Relying on 1,5-HAT reactivity, these methods are limited to β- or δ-amination only. Herein, we report a novel transition-metal- and visible-light-free room-temperature radical approach for remote β-, γ-, and δ-C(sp3)-N bond formation in aliphatic alcs. using mild basic conditions and readily available diazonium salt reagents. Thus, e.g., reaction of silylmethyl iodide I with PhN2.BF4- afforded II (76%, GC-MS yield) in presence of HCO2Li.H2O as base and reducing agent in DMA/MeOH mixed solvent.

Journal of the American Chemical Society published new progress about Abstraction reaction (iodine abstraction from silylmethyl iodide). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Product Details of C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts