Month: December 2022

Nilsson, Kurt G. I. published the artcileA simple strategy for changing the regioselectivity of glycosidase-catalyzed formation of disaccharides. Part II. Enzymic synthesis in situ of various acceptor glycosides, Application In Synthesis of 2595-07-5, the main research area is galactopyranoside acceptor preparation; transglycosidation lactose galactosidase; raffinose transglycosidation; galactopyranosylgalactopyranoside disaccharide.

β-D-Galactosidase induced the formation of allyl, benzyl, and trimethylsilylethyl β-D-galactopyranosides on a 1-20 g scale from lactose and allyl alc., benzyl alc., and trimethylsilylethanol. Similarly, α-D-galactosidase catalyzed the formation of allyl α-D-galactopyranoside from raffinose and allyl alc. The galactosides were used as acceptors for the preparation of several galactopyranosylgalactopyranoside disaccharides.

Carbohydrate Research published new progress about Glycosides Role: SPN (Synthetic Preparation), PREP (Preparation). 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Application In Synthesis of 2595-07-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ziegler, Thomas published the artcileSynthesis of the 5-aminopentyl glycoside of β-D-Galp-(1→4)-β-D-GlcpNAc-(1→3)-L-Fucp and fragments thereof related to glycopeptides of human Christmas factor and the marine sponge Microciona prolifera, Synthetic Route of 87905-98-4, the main research area is aminopentyl glycoside acetamidodeoxy oligosaccharide; glycopeptide christmas factor acetamidodeoxy oligosaccharide; marine sponge Microciona prolifera oligosaccharide.

The marine sponge Microciona prolifera and human coagulation factor IX (Christmas factor)-related mono- to tri-saccharide 5-aminopentyl glycosides β-D-Galp-R, β-D-GlcpNAc-R (16), β-D-Galp-(1→4)-β-D-GlcpNAc-R, β-D-GlcpNAc-(1→3)-β-L-Fucp-R, β-D-GlcpNAc-(1→3)-α-L-Fucp-R, β-D-Galp-(1→4)-β-D-GlcpNAc-(1→3)- β-L-Fucp-R, and β-D-Galp-(1→4)-β-D-GlcpNAc-(1→3)- α-L-Fucp-R, where R is a 5-aminopentyloxy spacer moiety, which allowed the construction of glycoconjugates, were prepared

Carbohydrate Research published new progress about Glycosides Role: SPN (Synthetic Preparation), PREP (Preparation). 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Synthetic Route of 87905-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, Reiko T. published the artcileSynthesis of 3-(2-aminoethylthio)propyl glycosides, HPLC of Formula: 2595-07-5, the main research area is allyl alc glycoside addition; ethylthiopropyl glycoside; glucopyranoside ethylthiopropyl; galactopyranoside ethylthiopropyl.

Anomeric pairs of 3-(2-aminoethylthio)propyl D-galactopyranoside D-glucopyranoside and 2-acetamido-2-deoxy-D-glucopyranoside were prepared by addition of H2N(CH2)2SH to the corresponding anomeric allyl glycosides. The allyl α-glycosides were prepared by refluxing the sugars with allyl alc. in the presence of an acid catalyst; the allyl β-glycosides were prepared by the reaction of acetylated glycosyl bromides with allyl alc. in the presence of Hg(CN)2 followed by O-deacetylation. The rate of thiol addition to the allylic group was different for each glycoside.

Carbohydrate Research published new progress about Glycosides Role: SPN (Synthetic Preparation), PREP (Preparation). 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, HPLC of Formula: 2595-07-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hang, Zhaojun published the artcileA practical method for N-cyanation of secondary amines and sulfonamides, HPLC of Formula: 22483-09-6, the main research area is cyanamide preparation; secondary amine sulfonamide CBX cyanation alk condition.

Cyanamides are an important class of mols. This work describes a facile synthesis of disubstituted cyanamides. Here, readily accessible 1-cyano-1,2-benziodoxol-3-(1H)-one (CBX) was applied as a stable electrophilic cyanation reagent. Diverse secondary amines were effectively cyanated. Moreover, secondary sulfonamides proved to be suitable substrates and were readily converted to N-alkyl(aryl)-N-arylsulfonyl-cyanamides, as the significant building blocks of the organic transformation.

Tetrahedron Letters published new progress about Cyanamides Role: SPN (Synthetic Preparation), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, HPLC of Formula: 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Russo, Laura published the artcileThiol-ene Mediated Neoglycosylation of Collagen Patches: A Preliminary Study, COA of Formula: C9H16O6, the main research area is thiol ene neoglycosylation collagen patch surface treatment.

Despite the relevance of carbohydrates as cues in eliciting specific biol. responses, the covalent surface modification of collagen-based matrixes with small carbohydrate epitopes has been scarcely investigated. We report thereby the development of an efficient procedure for the chemoselective neoglycosylation of collagen matrixes (patches) via a thiol-ene approach, between alkene-derived monosaccharides and the thiol-functionalized material surface. Synchrotron radiation-induced XPS (SR-XPS), Fourier transform-IR (FT-IR), and enzyme-linked lectin assay (ELLA) confirmed the effectiveness of the collagen neoglycosylation. Preliminary biol. evaluation in osteoarthritic models is reported. The proposed methodol. can be extended to any thiolated surface for the development of smart biomaterials for innovative approaches in regenerative medicine.

Langmuir published new progress about Collagen type I Role: RCT (Reactant), RACT (Reactant or Reagent). 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, COA of Formula: C9H16O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yuanze published the artcileDiverse Isoquinoline Scaffolds by Ugi/Pomeranz-Fritsch and Ugi/Schlittler-Mueller Reactions, Quality Control of 22483-09-6, the main research area is isoquinoline scaffold preparation Ugi Pomeranz Fritsch Schlittler Mueller.

The Pomeranz-Fritsch reaction and its Schlittler-Mueller modification were successfully applied in the Ugi postcyclization strategy by using orthogonally protected aminoacetaldehyde di-Et acetal and complementary electron rich building blocks. Several scaffolds, including isoquinolines, carboline, alkaloid-like tetrazole-fused tetracyclic compounds, and benzo[d]azepinone scaffolds, were synthesized in generally moderate to good yield. All the authors’ syntheses provide a short MCR-based sequence to novel or otherwise difficult to access scaffolds. Hence, the authors foresee multiple applications of these synthesis technologies.

Organic Letters published new progress about Carbolines Role: SPN (Synthetic Preparation), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Quality Control of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guan, Zhipeng published the artcileElectrochemical Oxidative Carbon-Atom Difunctionalization: Towards Multisubstituted Imino Sulfide Ethers, COA of Formula: C4H10OS, the main research area is electrochem oxidative difunctionalization isocyanide imino sulfide ether stereoselective synthesis; electrochemistry; ethers; isocyanides; radicals; synthetic methods.

Ethers (C-O/S) are ubiquitously found in a wide array of functional mols. and natural products. Nonetheless, the synthesis of imino sulfide ethers, containing an N(sp2)=C(sp2)-O/S fragment, still remains a challenge because of its sensitivity to acid. Developed here in is an unprecedented electrochem. oxidative carbon-atom difunctionalization of isocyanides, providing a series of novel multisubstituted imino sulfide ethers. Under metal-free and external oxidant-free conditions, isocyanides react smoothly with simple and readily available mercaptans and alcs. [e.g., 4-fluorobenzenethiol + Et isocyanoacetate + methanol �(Z)-I (80% isolated)]. Importantly, the procedure exhibited high stereoselectivities, excellent functional-group tolerance, and good efficiency on large-scale synthesis, as well as further derivatization of the products.

Angewandte Chemie, International Edition published new progress about Aromatic thiols Role: RCT (Reactant), RACT (Reactant or Reagent). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, COA of Formula: C4H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xie, Ya-Fei published the artcileBifunctional organocatalysts for the conversion of CO2, epoxides and aryl amines to 3-aryl-2-oxazolidinones, Related Products of alcohols-buliding-blocks, the main research area is aryl oxazolidinone preparation; epoxide carbon dioxide aryl amine regioselective ring opening cycloaddition.

A route to synthesize 3-aryl-2-oxazolidinones I (R1 = Me, H2C:CHCH2OCH2, Ph, 4-FC6H4, etc.; R2 = Ph, 1-naphthyl, 2-pyridyl, etc.) through a three-component reaction between CO2, aryl amines R2NH2, and the corresponding 2-R1-substituted epoxides with a binary organocatalytic system composed of organocatalysts II (R3 = R4 = Me; R3 = H, R4 = Me, i-Pr, MeSCH2, Ph, 4-HOC6H4; X = I, Br, Cl) and DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) was developed. The method allows wide scopes of epoxide and aryl amine substrates with various functional groups under mild reaction conditions. The control experiments indicate that a cyclic carbonate is formed via cycloaddition of epoxides with CO2, which further reacts with the β-amino alc. originating from epoxides and aryl amines, resulting in the formation of 3-aryl-2-oxazolidinones.

Organic & Biomolecular Chemistry published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adib, Mehdi published the artcileTBHP/n-Bu4PBr-Promoted Oxidative Cross-Dehydrogenative Coupling of Aryl Methanols: A Facile Synthesis of Symmetrical Carboxylic Anhydride Derivatives, Category: alcohols-buliding-blocks, the main research area is carboxylic anhydride preparation aryl methanol oxidative dehydrogenative coupling.

A transition-metal-free oxidative cross-dehydrogenative coupling reaction was developed for the preparation of sym. carboxylic anhydrides through self-coupling dual C-O bond formations of aryl methanols. In the presence of a catalytic amount of tetrabutylphosphonium bromide (TBPB) as transfer agent and aqueous tert-Bu hydroperoxide (TBHP) as oxidant and reactant, methylene groups of aryl methanols were efficiently oxidized to C:O and coupled with the peroxide oxygen from TBHP to form a diverse array of sym. carboxylic anhydride derivatives

Synlett published new progress about Anhydrides Role: SPN (Synthetic Preparation), PREP (Preparation). 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghandi, Mehdi published the artcileA combined multicomponent-acid catalyzed cyclization reaction as an efficient route to novel tricyclic pyrrolo[2,1-a]isoquinoline derivatives, SDS of cas: 22483-09-6, the main research area is tricyclic pyrroloisoquinoline preparation; polysubstituted pyrrole preparation heterocyclization sulfuric acid catalyst; arylglyoxal cyclic dicarbonyl dimethoxyethanamine keto ester four component Knoevenagel.

A simple, new two-step procedure for the synthesis of novel tricyclic pyrrolo[2,1-a]isoquinoline derivatives I (R = H, Me, Cl, Ph; R1 = 2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl, 2-hydroxy-6-oxocyclohex-1-en-1-yl, 4-hydroxy-2-oxo-2H-chromen-3-yl; R2 = Me, Et) is described. The initially prepared polysubstituted pyrroles II via the four-component condensation of arylglyoxals 4-RC6H4C(O)CHO, cyclic 1,3-dicarbonyls such as 1,3-cyclohexanedione, 5,5-dimethyl-1,3-cyclohexanedione, 4-hydroxy-2H-chromen-2-one, aminoacetaldehyde di-Me acetal and β-keto esters R2OC(O)CH2C(O)CH3 subsequently underwent intramol. acid-catalyzed cyclization to give the desired products in moderate to good yields I.

Journal of Heterocyclic Chemistry published new progress about Cyclic diketones Role: RCT (Reactant), RACT (Reactant or Reagent). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, SDS of cas: 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts