Month: December 2022

Srinivasachary, K. published the artcilePractical and Efficient Route to Dolutegravir Sodium via One-Pot Synthesis of Key Intermediate with Controlled Formation of Impurities, COA of Formula: C4H11NO2, the main research area is dolutegravir sodium preparation green chem.

An efficient, cost effective and com. viable synthesis of dolutegravir sodium has been developed from com. available I as the key intermediate. The key features of the synthesis are lower number of synthetic steps and the use of eco-friendly and inexpensive reagents. The process has been demonstrated to meet ICH requirements on scaling up.

Russian Journal of Organic Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, COA of Formula: C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Shan-Shui published the artcileAerobic oxidation of alcohols with air catalyzed by decacarbonyldimanganese, Application of 1-(4-Bromophenyl)ethane-1,2-diol, the main research area is manganese catalyzed aerobic oxidation functionalized alc.

The oxidation of alcs. to carbonyl compounds using air as the terminal oxidant is highly desirable. As described in previous reports, the abstraction of α-H of the alc. is the most important step, and it typically requires not only a metal catalyst but also complex ligands, co-catalysts and bases. Herein, we report a practical and efficient method for the oxidation of primary alcs., secondary alcs., 1,2-diols, 1,2-amino alcs., and other α-functionalized alcs. using a com. available catalyst, Mn2(CO)10, and no additives. Preliminary mechanistic studies indicated that an alkoxyl radical intermediate existed in our system, and a plausible mechanism consistent with the exptl. results and literature was proposed.

Green Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Application of 1-(4-Bromophenyl)ethane-1,2-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kaur, Nirmaljeet published the artcileSynthesis and Application of (S)-Nicotine-Based Chiral Ionic Liquids in Enantiomeric Recognition by Using Fluorescence Spectroscopy, Related Products of alcohols-buliding-blocks, the main research area is nicotine enantiomeric recognition fluorescence spectroscopy synthesis.

The present report discusses the synthesis, characterization and application of novel chiral ionic liquids (CILs) derived from an enantiopure alkaloid (S)-nicotine. The synthesis of the CILs was initiated by the preparation of (-)-bornyl chloroacetate from (-)-borneol and monochloroacetic acid and then used for the quaternization of (S)-nicotine. The derivatives of the parent CIL were obtained via anion-metathesis reactions with sodium salts of dicyanamide and dioctyl sulfosuccinate. The synthesis of the resp. compounds was confirmed through NMR (1H,13C) spectroscopy, mass spectrometry, and FTIR. The thermal stability and optical activity of the CILs were analyzed through TGA, DTG and polarimetry. All the CILs obtained were liquid at room temperature and exhibited thermal stability up to 150 °C. The potential of chiral ionic liquids as enantiomeric recognizing agents for six amino acids (phenylalanine, proline, valine, alanine, leucine, histidine) was determined through fluorescence spectroscopy. CILs performed well against enantiomers of all amino-acid with maximum selectivity 1.22 (phenylalanine) and fluorescence enhancement 24.90 : 23.79 (ID/Io : IL/Io) for enantiomers of leucine.

ChemistrySelect published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lagerspets, Emi published the artcileSchiff base Cu(I) catalyst for aerobic oxidation of primary alcohols, Application of n-Octanol, the main research area is copper Schiff base complex catalyst preparation; aldehyde preparation; alc aerobic oxidation copper Schiff base complex catalyst.

New copper(I)-Schiff base complexes were reported for the selective aerobic oxidation of primary alcs. to aldehydes RCHO [R = (CH2)6, Ph, (CH2)2Ph, etc.] under ambient conditions. Particularly, the copper(I) complex bearing N-(4-fluorophenyl)-1-(furan-2-yl)methanimine showed high activity in the series and gave near- quant. yields in the oxidations of benzyl alc. (99% yield in 1 h) and 1-octanol (96% yield in 24 h). Based on the X-ray structure determination, the complex had a square pyramidal coordination accomplished by two N-(4-fluorophenyl)-1-(furan-2-yl)methanimine ligands and bromide as a counter anion. The oxidation reactions were monitored with UV-vis and in situ ATR-IR spectroscopy to study the changes in the catalytic structure and to elucidate the catalytic properties and the mechanistic details. Accordingly, detachment of one of the N-(4-fluorophenyl)-1-(furan-2-yl)methanimine ligands from the complexes was related to the oxidation activity.

Molecular Catalysis published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lagerspets, Emi published the artcileSchiff base Cu(I) catalyst for aerobic oxidation of primary alcohols, Name: 3-(Methylthio)propan-1-ol, the main research area is copper Schiff base complex catalyst preparation; aldehyde preparation; alc aerobic oxidation copper Schiff base complex catalyst.

New copper(I)-Schiff base complexes were reported for the selective aerobic oxidation of primary alcs. to aldehydes RCHO [R = (CH2)6, Ph, (CH2)2Ph, etc.] under ambient conditions. Particularly, the copper(I) complex bearing N-(4-fluorophenyl)-1-(furan-2-yl)methanimine showed high activity in the series and gave near- quant. yields in the oxidations of benzyl alc. (99% yield in 1 h) and 1-octanol (96% yield in 24 h). Based on the X-ray structure determination, the complex had a square pyramidal coordination accomplished by two N-(4-fluorophenyl)-1-(furan-2-yl)methanimine ligands and bromide as a counter anion. The oxidation reactions were monitored with UV-vis and in situ ATR-IR spectroscopy to study the changes in the catalytic structure and to elucidate the catalytic properties and the mechanistic details. Accordingly, detachment of one of the N-(4-fluorophenyl)-1-(furan-2-yl)methanimine ligands from the complexes was related to the oxidation activity.

Molecular Catalysis published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Name: 3-(Methylthio)propan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moore, Peter W. published the artcileHydrogen-Bonding Interactions in the Ley-Griffith Oxidation: Practical Considerations for the Synthetic Chemist, HPLC of Formula: 111-87-5, the main research area is aldehyde preparation hydrogen bonding Ley Griffith oxidation primary alc.

The Ley-Griffith oxidation, which is catalyzed by tetra-n-propylammonium perruthenate (TPAP, nPr4N[RuO4]), is a popular method for not only controlled oxidation of primary alcs. to aldehydes, but also a host of other synthetically useful transformations. While the fundamental reaction mechanism has recently been elucidated, several key hydrogen-bonding interactions between the reagents were implicated but not investigated. Herein the prevalence of H-bonding between the co-oxidant N-methylmorpholine N-oxide (NMO), the alc. substrate, water and the perruthenate catalyst is established. These observations help to rationalize the importance of drying the reagents and lead to several practical suggestions.

European Journal of Organic Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, HPLC of Formula: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Man published the artcileMerging N-Hydroxyphthalimide into Metal-Organic Frameworks for Highly Efficient and Environmentally Benign Aerobic Oxidation, Safety of 3-Pentanol, the main research area is hydroxyphthalimide metal organic framework green oxidation catalyst; N-hydroxyphthalimide; aerobic oxidation; heterogeneous catalysis; metal-organic frameworks; nitroxyl radicals.

Two highly efficient metal-organic framework catalysts TJU-68-NHPI and TJU-68-NDHPI have been successfully synthesized through solvothermal reactions of which the frameworks are merged with N-hydroxyphthalimide (NHPI) units, resulting in the decoration of pore surfaces with highly active nitroxyl catalytic sites. When t-Bu nitrite (TBN) is used as co-catalyst, the as-synthesized MOFs are demonstrated to be highly efficient and recyclable catalysts for a novel three-phase heterogeneous oxidation of activated C-H bond of primary and secondary alcs., and benzyl compounds under mild conditions. Based on the high efficiency and selectivity, an environmentally benign system with good sustainability, mild conditions, simple work-up procedure has been established for practical oxidation of a wide range of substrates.

Chemistry – A European Journal published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Safety of 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Azhong published the artcilePalladium-Catalyzed Direct Oxidation of Alkenes with Molecular Oxygen: General and Practical Methods for the Preparation of 1,2-Diols, Aldehydes, and Ketones, Related Products of alcohols-buliding-blocks, the main research area is terminal disubstituted olefin oxygen base palladium dihydroxylation; diol preparation; oxygen terminal disubstituted olefin PTSA palladium oxidative cleavage; aldehyde Ketone preparation green chem reaction mechanism; dihydroxylation oxidative cleavage catalyst palladium.

Novel and environmentally benign methods for palladium-catalyzed dihydroxylation and oxidative cleavage of olefins with oxygen as sole oxidant are presented. The cleavage reactions were performed with acid as additive in aqueous solution, whereas 1,2-diols were formed in the presence of base. A broad substrate scope has been demonstrated allowing monosubstituted aromatic and aliphatic terminal alkenes, 1,2-disubstituted, and 1,1-disubstituted olefins. The cleavage reactions of dioxo-PdII complexes implicate 1,2-diol might act as a key intermediate of olefin cleavage.

Journal of Organic Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Ji published the artcileDirect synthesis of adipic acid esters via palladium-catalyzed carbonylation of 1,3-dienes, Recommanded Product: 3-Pentanol, the main research area is palladium pyridyl bidentate phosphine ligand catalyzed carbonylation diene alc; adipic acid ester green preparation carbonylation diene alc.

The direct carbonylation of 1,3-butadiene offers the potential for a more cost-efficient and environmentally benign route to industrially important adipic acid derivatives However, owing to the complex reaction network of regioisomeric carbonylation and isomerization pathways, a selective practical catalyst for this process has thus far proven elusive. Here, we report the design of a pyridyl-substituted bidentate phosphine ligand (HeMaRaphos) that, upon coordination to palladium, catalyzes adipate diester formation from 1,3-butadiene, carbon monoxide, and butanol with 97% selectivity and 100% atom-economy under industrially viable and scalable conditions (turnover number > 60,000). This catalyst system also affords access to a variety of other di- and triesters from 1,2- and 1,3-dienes.

Science (Washington, DC, United States) published new progress about 1,3-Alkadienes Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Farsang, Evelin published the artcileAnalysis of non-ionic surfactant triton X-100 using hydrophilic interaction liquid chromatography and mass spectrometry, Related Products of alcohols-buliding-blocks, the main research area is Triton X 100 hydrophilic interaction liquid chromatog mass spectrometry; gradient optimization; hydrophilic interaction liquid chromatography; non-ionic surfactant; octylphenol–polyethoxylate.

It is well known that surfactants increase the solubility of hydrophobic organic compounds and cause adverse environmental effects. The removal of these compounds from the contaminated soil or ground-water is particularly difficult due to their water soluble feature. In this work, an ultra-high performance hydrophilic interaction liquid chromatog. method was developed for the separation of oligomers of Triton X-100 octylphenol-polyethoxylate non-ionic surfactant. Liquid chromatog.-mass spectrometry (LC-MS) was used to identify the Triton X-100 compounds There was a 44 mass unit difference between two adjacent peaks that is the molar mass of one ethylene oxide group (-CH2CH2O-). A quadratic retention model was applied for the estimation of retention of the examined non-ionic surfactant and the optimization of gradient elution conditions. The optimized method was suitable for the baseline separation of 28 Triton X-100 oligomers in five minutes.

Molecules published new progress about Hydrophilic interaction liquid chromatographic stationary phases. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts