Month: December 2022

Bole, Leonie J. published the artcileUntangling the Complexity of Mixed Lithium/Magnesium Alkyl/Alkoxy Combinations Utilised in Bromine/Magnesium Exchange Reactions, Quality Control of 2212-32-0, the main research area is lithium magnesium alkyl alkoxy bromine exchange reaction reactivity substitution; crystal structure mol lithium magnesium alkyl alkoxy complex preparation; alkoxides; bromine/magnesium exchange; lithium; magnesium; mixed-aggregates.

While it is known that the addition of Group 1 alkoxides to s-block organometallics can have an activating effect on reactivity, the exact nature of this effect is not that well understood. Here we describe the activation of sBu2Mg towards substituted bromoarenes by adding one equivalent of LiOR (R = 2-ethylhexyl), where unusually both sBu groups can undergo efficient Br/Mg exchange. Depending on the substitution pattern on the bromoarene two different types of organometallic intermediates have been isolated, either a mixed aryl/alkoxide [{LiMg(2-FG-C6H4)2(OR)}2] (FG = OMe; NMe2) or a homoaryl [(THF)4Li2Mg(4-FG-C6H4)4] (FG = OMe, F). Detailed NMR spectroscopic studies have revealed that these exchange reactions and the formation of their intermediates are controlled by a new type of bimetallic Schlenk-type equilibrium between heteroleptic [LiMgsBu2(OR)], alkyl rich [Li2MgsBu4] and Mg(OR)2, with [Li2MgsBu4] being the active species performing the Br/Mg exchange process.

Angewandte Chemie, International Edition published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, Quality Control of 2212-32-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kaur, Tejinder published the artcileComparison of glycoprofiles of rituximab versions licensed for sale in India and an analytical approach for quality assessment, Synthetic Route of 59-23-4, the main research area is glycoprofile rituximab analytical approach quality assessment; Biosimilars; Glycosylation; Monoclonal antibodies; N-Glycans; Rituximab.

Glycosylation affects clin. efficacy and safety; therefore, is a critical quality attribute of therapeutic monoclonal antibodies. Glycans are often labile and complex in patterns, giving rise to macro- and micro-heterogeneity. Recombinant production, diverse geog. locations, associated transportation and storage conditions further compound the problem. Two-way studies comparing glycoprofile of the originator and its given biosimilar are aplenty. However, the extent of anal. variation and similarity in glycoprofile across all approved versions of a drug is hardly explored. Using UHPLC and mass spectrometry, we compared the glycoprofiles of eight rituximab drug samples licensed for sale in India. While the types of glycans were found identical, the abundance of some glycans varied significantly within the tested population. The quality range of glycosylation parameters of the tested sample population differed significantly from the previously established values for US/EU licensed rituximab. As the mean abundance of the 90% of identified glycans falls within ±3SD, the extent of mutual variations amongst tested lots is less significant compared to the extreme deviation from previously established QR limits. Thus, we propose this approach as an orthogonal method to capture glycan variations in licensed versions of mAbs for quality surveillance and in cases where originator samples′ are limiting. As fluctuation in glycosylation may be of clin. significance, we identify that a one-to-one comparison with originator alone is insufficient in sensing the extent of variations in glycosylation parameters in licensed biosimilars of a given therapeutic mAb. Here we propose that future biosimilarity anal. may include an orthogonal approach of generating an addnl. combined QR range representing variations across the originator and its biosimilars. The glycosylation profiles of eight rituximab drug samples of different make obtained from the point of sale in India were found identical amongst the tested rituximab versions. However, the QR limits corresponding to important glycosylation parameters differed significantly across all tested samples from the previously established QR limits of US- and EU-licensed rituximab in statistical terms. Such an approach may be useful in defining the true range of glycan variations in licensed versions of therapeutic mAbs.

Journal of Proteomics published new progress about Antibody mimetics Role: ANT (Analyte), ANST (Analytical Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ramesh, Madhan published the artcileHalf-Sandwich η6-p-Cymene) Ruthenium(II) complexes bearing 5-Amino-1-Methyl-3-Phenylpyrazole Schiff base ligands: Synthesis, structure and catalytic transfer hydrogenation of ketones, Related Products of alcohols-buliding-blocks, the main research area is ruthenium Schiff base complex preparation; alc preparation; ketone transfer hydrogenation ruthenium catalyst.

New (η6-p-cymene)ruthenium(II) complexes containing Schiff base ligands of the general composition [RuCl(η-p-cymene)(L)] were synthesized and screened for their efficiency as catalysts in the transfer hydrogenation of various ketones to alcs. RCH(OH)R1 [R = Et, Ph, 4-ClC6H4, etc.; R1 = Me, Et, Ph; RR1 = (CH2)4, (CH2)5] showing excellent conversion up to 99%. The complexes were characterized by anal. and spectral (FT-IR, UV-Vis, 1H NMR and 13C NMR) methods and the mol. structure of complex I was determined by single crystal X-ray diffraction studies, revealing a pseudo-octahedral piano stool geometry around ruthenium(II) ion. Under the optimized conditions, the influence of base, reaction temperature and substrate scope was also reported.

Journal of Organometallic Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Onisuru, Oluwatayo Racheal published the artcileTransfer hydrogenation of ketone; an in situ approach toward an eco-friendly reduction, SDS of cas: 584-02-1, the main research area is silica supported palladium particle preparation; ketone transfer hydrogenation green chem.

The use of water as a solvent in chem. reactions has recently been brought to public attention, especially in the exploration of eco-friendly procedures. It is readily available, abundantly accessible, non-toxic, non-flammable, and at a low cost. As opposed to the previous limitation of reactant solubilities associated with aqueous media, a hydrogel such as a hydroxypropyl methylcellulose (HPMC) solution can significantly improve the reactant solubility This investigation employed water and HPMC as the reaction solvent, and the reaction medium viscosity was impressively enhanced. Silica-supported Pd particles (Pd@SiO2) were synthesized and effectively catalyzed the reduction of acetophenone in the presence of sodium borohydride (NaBH4) as the hydrogen source. The conversion of acetophenone to 1-Ph ethanol remained at a very high value of >99.34% with 100% selectivity towards 1-Ph ethanol.

RSC Advances published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, SDS of cas: 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Wenjun published the artcileBasic Promotors Impact Thermodynamics and Catalyst Speciation in Homogeneous Carbonyl Hydrogenation, Recommanded Product: n-Octanol, the main research area is promotor thermodn homogeneous catalyst carbonyl hydrogenation.

Homogeneously catalyzed reactions often make use of additives and promotors that affect reactivity patterns and improve catalytic performance. While the role of reaction promotors is often discussed in view of their chem. reactivity, we demonstrate that they can be involved in catalysis indirectly. In particular, we demonstrate that promotors can adjust the thermodn. of key transformations in homogeneous hydrogenation catalysis and enable reactions that would be unfavorable otherwise. We identified this phenomenon in a set of well-established and new Mn pincer catalysts that suffer from persistent product inhibition in ester hydrogenation. Although alkoxide base additives do not directly participate in inhibitory transformations, they can affect the equilibrium constants of these processes. Exptl., we confirm that by varying the base promotor concentration one can control catalyst speciation and inflict substantial changes to the standard free energies of the key steps in the catalytic cycle. Despite the fact that the latter are universally assumed to be constant, we demonstrate that reaction thermodn. and catalyst state are subject to external control. These results suggest that reaction promotors can be viewed as an integral component of the reaction medium, on its own capable of improving the catalytic performance and reshaping the seemingly rigid thermodn. landscape of the catalytic transformation.

Journal of the American Chemical Society published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghosh, Rahul published the artcileTransfer Hydrogenation of Aldehydes and Ketones in Air with Methanol and Ethanol by an Air-Stable Ruthenium-Triazole Complex, Name: 3-Pentanol, the main research area is alc preparation chemoselective green chem; aldehyde ketone methanol ethanol transfer hydrogenation ruthenium triazole catalyst; ruthenium triazole catalyst preparation.

Coordination of 1,4-disubstituted 1,2,3-triazoles with [(p-cymene)RuCl2]2 followed by dehydrochlorination in the presence of a base resulted in the formation of ruthenium complexes, resp. Both were tested for the transfer hydrogenation of aldehydes and ketones in air using ecol. benign and cheap ethanol as the hydrogen source in the presence of a catalytic amount of a base. Air-stable ruthenium complex was proved to be an active catalyst for the transfer hydrogenation of a wide variety of aromatic and aliphatic aldehydes and ketones bearing various functionalities. Catalyst ruthenium complex was also effective for the transfer hydrogenation of carbonyls using the simplest primary alc., methanol, under aerobic conditions. Under the present catalytic protocol, labile or reducible functionalities such as nitro, cyano, and ester groups were tolerated. Good selectivity was also observed for acyclic α,β-unsaturated carbonyls. However, this catalytic protocol was not selective for 2-cyclohexen-1-one as both alkene and keto moieties were reduced. The transfer hydrogenations are believed to proceed via a ruthenium-hydride intermediate. Finally, transfer hydrogenation of acetophenone using isopropanol as a commonly used hydrogen source was also performed and the sustainable and green credentials of these catalytic protocols utilizing methanol, ethanol, and isopropanol were compared with the help of the CHEM21 green metrics toolkit.

ACS Sustainable Chemistry & Engineering published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Name: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bettoni, Leo published the artcileIron-Catalyzed α-Alkylation of Ketones with Secondary Alcohols: Access to β-Disubstituted Carbonyl Compounds, Recommanded Product: 3-Pentanol, the main research area is iron catalyzed alkylation ketone secondary alc borrowing hydrogen.

An iron-catalyzed borrowing hydrogen strategy has been applied in the synthesis of β-branched carbonyl compounds Various secondary benzylic and aliphatic alcs. have been used as alkylating reagents under mild reaction conditions. The ketones have been isolated in good to excellent yield. Deuterium labeling experiments provide evidence that the alc. is the hydride source in this reaction and that no reversible step or hydrogen/deuterium scrambling takes place during the process.

Organic Letters published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Panda, Surajit published the artcileEfficient α-Alkylation of Arylacetonitriles with Secondary Alcohols Catalyzed by a Phosphine-Free Air-Stable Iridium(III) Complex, Category: alcohols-buliding-blocks, the main research area is iridium complex catalyzed alkylation arylacetonitrile secondary alc.

A well-defined and readily available air-stable dimeric iridium(III) complex catalyzed α-alkylation of arylacetonitriles using secondary alcs. with the liberation of water as the only byproduct is reported. The α-alkylations were efficiently performed at 120°C under solvent-free conditions with very low (0.1-0.01 mol %) catalyst loading. Various secondary alcs. including cyclic and acyclic alcs. and a wide variety of arylacetonitriles bearing different functional groups were converted into the corresponding α-alkylated products in good yields. Mechanistic study revealed that the reaction proceeds via alc. activation by metal-ligand cooperation with the formation of reactive iridium-hydride species.

Journal of Organic Chemistry published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Yiwei published the artcilePrognostic effects of glycometabolism changes in lung adenocarcinoma: a prospective observational study, Quality Control of 97-67-6, the main research area is human lung adenocarcinoma glycometabolism prognostic effect; Lung adenocarcinoma; Warburg effect; clinicopathological characteristics; glycometabolism changes; prognosis.

Changes in glycometabolism of cancer cells provides cancer cells with growth advantages, which are also of great value in the prognosis prediction of the patients with lung adenocarcinoma. However, currently available studies are controversial. We successively collected 100 paired surgical specimens from patients with lung adenocarcinoma. The content of glycometabolic intermediates in tissues was tested by liquid chromatog.-mass spectrometry. Follow-up was conducted every 6 mo for patients enrolled in this study. There were significant differences in the contents of six intermediates, including glucose (P<0.0001), pyruvate (P = 0.0009), lactate (P<0.0001), citrate (P = 0.0001), α-ketoglutarate (P = 0.0002), and fumarate (P = 0.0096). For different TNM stages, the pyruvate content (P<0.001) and lactate content (P<0.001) in the II/III/IV stage cancer tissues were significantly higher than those in the stage I cancer tissues. The overall survival (OS) of patients with high levels of glucose (P = 0.0034), pyruvate (P<0.0001), lactate (P = 0.049), and citrate (P = 0.024) in cancer tissues was significantly worse than that of patients with low levels. N stage (P<0.001) and the contents of pyruvate (P = 0.033) were independent prognostic factors for the OS. The contents of glucose, pyruvate, lactate, and citrate in cancer tissues are higher than that in para-carcinoma tissues, and the long-term survival decrease in patients with higher glucose, pyruvate, lactate, and citrate. Translational Lung Cancer Research published new progress about Carbohydrate metabolism disorders Role: BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Quality Control of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Shengdong published the artcileSilver-Catalyzed Hydrogenation of Ketones under Mild Conditions, Computed Properties of 124-76-5, the main research area is silver catalyst hydrogenation ketone aliphatic aromatic; alc preparation.

The silver-catalyzed hydrogenation of ketones using H2 as hydrogen source is reported. Silver nanoparticles are generated from simple silver (I) salts and operate at 25 °C under 20 bar of hydrogen pressure. Various aliphatic and aromatic ketones, including natural products were reduced into the corresponding alcs. in high yields. This silver catalyst allows for the selective hydrogenation of ketones in the presence of other functional groups.

Advanced Synthesis & Catalysis published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts