Month: December 2022

Yin, Fucheng published the artcileAryl Halides as Halogenation Reagents in the Bromination and Iodination of Arene-Tethered Diols, Recommanded Product: 1-(4-Bromophenyl)ethane-1,2-diol, the main research area is dioxolanyl halide preparation green chem; arene tether diol aryl halide halogenation palladium catalyst.

The demonstrate usage of aryl bromides (Me 2-bromobenzoate) and aryl iodides (such as 1-iodo-2-nitrobenzene, Me 2-iodobenzoate, 2-iodo-benzenesulfinic acid, etc.) in C-Br or C-I bond formation were described. Me 2-bromobenzoate and 2-nitrophenyl iodides were developed as mild and effective bromination and iodination reagents for functionalization of arene-tethered diols I (R = Ph, naphthalen-2-yl, 3,4-dichlorophenyl, etc.). This efficient cascaded catalysis can be applied to the total syntheses of natural product Mafaicheenamine A and Claulamine A.

Organic Letters published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Recommanded Product: 1-(4-Bromophenyl)ethane-1,2-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gao, Xiaofang published the artcileIodine-Initiated Dioxygenation of Aryl Alkenes Using tert-Butylhydroperoxides and Water: A Route to Vicinal Diols and Bisperoxides, Application of 1-(4-Bromophenyl)ethane-1,2-diol, the main research area is vicinal diol green preparation; aryl alkene dioxygenation iodine catalyst; bisperoxide green preparation; alkene aryl dioxygenation iodine catalyst.

An environment-friendly and efficient dioxygenation of aryl alkenes for the construction of vicinal diols ArCH(OH)CH(OH)R [Ar = Ph, 2-MeC6H4, 4-MeC6H4, etc.; R = H, Br, Me, etc.] was developed in water with iodine as the catalyst and tert-butylhydroperoxides (TBHPs) as the oxidant. The protocol was efficient, sustainable, and operationally simple. Detailed mechanistic studies indicated that one of the hydroxyl groups was derived from water and the other one was derived from TBHP. Addnl., the bisperoxides ArCH(OOtBu)CH(OOtBu)R [Ar = Ph, 4-MeC6H4, 3-FC6H4, etc.] could be obtained in good yields with iodine as the catalyst, Na2CO3 as the additive, and propylene carbonate as the solvent, instead.

Journal of Organic Chemistry published new progress about Aryl alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Application of 1-(4-Bromophenyl)ethane-1,2-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bag, Raghunath published the artcileK2S2O8-Mediated Dioxygenation of Aryl Alkenes Using N-Hydroxylamines and Air, SDS of cas: 92093-23-7, the main research area is diol preparation; aryl alkene hydroxylamine dioxygenation potassium persulfate air.

The vicinal dioxygenation of aryl alkenes is reported using N-hydroxylamines and air in the presence of potassium persulfate (K2S2O8). The alkene is first oxidized to β-aminoxy alkyl hydroperoxide, which is in situ reduced to the diol e.g., I using molybdenum hexacarbonyl [Mo(CO)6] and base. Metal-free, aerobic conditions and the substrate scope are the important practical features.

ChemistrySelect published new progress about Aryl alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, SDS of cas: 92093-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Weber, Stefan published the artcileRethinking Basic Concepts-Hydrogenation of Alkenes Catalyzed by Bench-Stable Alkyl Mn(I) Complexes, Recommanded Product: 3-Pentanol, the main research area is alkene hydrogenation alkyl manganese complex catalyst.

An efficient additive-free manganese-catalyzed hydrogenation of alkenes to alkanes with mol. hydrogen is described. This reaction is atom economic, implementing an inexpensive, earth-abundant nonprecious metal catalyst. The most efficient precatalyst is the bench-stable alkyl bisphosphine Mn(I) complex fac-[Mn(dippe)(CO)3CH2CH2CH3Pr]. The catalytic process is initiated by migratory insertion of a CO ligand into the Mn-alkyl bond to yield an acyl intermediate which undergoes rapid hydrogenolysis to form the active 16e Mn(I) hydride catalyst [Mn(dippe)(CO)2(H)]. A range of mono- and disubstituted alkenes were efficiently converted into alkanes in good to excellent yields. The hydrogenation of 1-alkenes and 1,1-disubstituted alkenes proceeds at 25°, while 1,2-disubstituted alkenes require a reaction temperature of 60°. In all cases, a catalyst loading of 2 mol % and a hydrogen pressure of 50 bar were applied. A mechanism based on DFT calculations is presented, which is supported by preliminary exptl. studies.

ACS Catalysis published new progress about Alkanes Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Liangkun published the artcileLewis Base Catalyzed Dioxygenation of Olefins with Hypervalent Iodine Reagents, Formula: C8H9BrO2, the main research area is diol preparation; acetal regioselective preparation; alkene dioxygenation catalyst phenyliodine bis trifluoroacetate.

1,2-Diols were extremely useful building blocks in organic synthesis. Hypervalent iodine reagents were useful for the vicinal dihydroxylation of olefins to gave 1,2-diols under metal-free conditions, but strongly acidic promoters were often required. Herein, synthesis of 1,2-diols R1CHOHCHOHR2 [R1 = n-hexyl, Ph, Bn, etc.; R2 = H, Ph] and acetals R3CH2CH(OMe)2 [R3 = Ph, 4-MeOC6H4, (4-acetoxyphenyl), etc.] via catalytic vicinal dioxygenation of olefins with hypervalent iodine reagents using Lewis bases as catalysts was reported. The conditions were mild and compatible with various functional groups.

Organic Letters published new progress about Acetals Role: SPN (Synthetic Preparation), PREP (Preparation). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Formula: C8H9BrO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Blinkovsky, Alexander M. published the artcileEnzymic derivatization of saccharides and their chemical polymerization, Recommanded Product: (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, the main research area is propargyl galactopyranoside preparation polymerization; allyl galactopyranoside preparation polymerization; hydrophilic polymer sugar; oligosaccharide transglycosidation enzymic propargyl allyl alc.

The enzymic synthesis of sugar-based acetylene and ethylene derivatives as precursors to hydrophilic polymers is described. Propargyl and allyl alcs. have been used as glycosyl acceptors in the transglycosylation reactions of glycosidases with various disaccharides including lactose, maltose, and cellobiose. Reaction of propargyl and allyl alcs. with lactose catalyzed by β-galactosidase resulted in the formation of propargyl-β-D-galactopyranoside and allyl-β-D-galactopyranoside in 42 and 13% yields, resp. Polymerization of propargyl-β-D-galactopyranoside with AlBr3 in ethanol resulted in the formation of oligomeric poly(acetylenic) species (MW = 1,300). Free radical polymerization of allyl-β-D-galactopyranoside in DMF or water resulted in poly(ethylenic) species with MW > 30,000. The combined enzymic and chem. reactions inherent in these syntheses provide a unique approach in the preparation of hydrophilic polymers containing sugars and their derivatives

Tetrahedron: Asymmetry published new progress about Disaccharides Role: RCT (Reactant), RACT (Reactant or Reagent). 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Recommanded Product: (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kurakake, Masahiro published the artcileSynthesis of New Glycosides by Transglycosylation of N-Acetylhexosaminidase from Serratia marcescens YS-1, Category: alcohols-buliding-blocks, the main research area is oligosaccharide acetamidodeoxy glycoside synthesis enzymic transglycosylation acetylhexosaminidase Serratia marcescens.

Serratia marcescens YS-1, a chitin-degrading microorganism, produced mainly N-acetylhexosaminidase. The purified enzyme had an optimal pH of ∼8-9 and remained stable at 40 °C for 60 min at pH 6-8. The optimum temperature was around 50 °C, and enzyme activity was relatively stable below 50 °C. YS-1 N-acetylhexosaminidase hydrolyzed p-nitrophenyl β-N-acetylgalactosamide by 28.1% relative to p-nitrophenyl β-N-acetylglucosamide. The N-acetylchito-oligosaccharides were hydrolyzed more rapidly, but the cellobiose and chitobiose of disaccharides that had the same β-1,4 glycosidic bond as di-N-acetylchitobiose were not hydrolyzed. YS-1 N-acetylhexosaminidase efficiently transferred the N-acetylglucosamine residue from di-N-acetylchitobiose (substrate) to alcs. (acceptor). The ratio of transfer to methanol increased to 86% in a reaction with 32% methanol. N-Acetylglucosamine was transferred to the hydroxyl group at C1 of mono-alcs. A di-alc. was used as an acceptor when the carbon number was more than 4 and a hydroxyl group existed on each of the two outside carbons. Sugar alcs. with hydroxyl groups in all carbon positions were not proper acceptors.

Journal of Agricultural and Food Chemistry published new progress about Disaccharides Role: RCT (Reactant), RACT (Reactant or Reagent). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khodadadi, Meysam published the artcileOne-pot synthesis of novel spirocyclic-dihydropyrazine-2-(1H)ones through a Ugi 4-CR/deprotection, Recommanded Product: 2,2-Dimethoxyethanamine, the main research area is cycloalkanone benzoic acid isocyanocyclohexane dimethoxyethanamine tandem Ugi cyclization deprotection; benzoyl cyclohexyl spirodihydropyrazinone preparation.

A one-pot approach for the synthesis of new spirocyclic-dihydropyrazine-2-(1H)ones was described. The Ugi four-component condensation of cycloalkanones, carboxylic acids, cyclohexyl isocyanide and aminoacetaldehyde di-Me acetal followed by acid-catalyzed deprotection-cyclization afforded the desired products in moderate to good yields.

Journal of Heterocyclic Chemistry published new progress about Benzoic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Recommanded Product: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Sangh Priya published the artcileSynthesis of β- and γ-lactam fused dihydropyrazinones from Ugi adducts via a sequential ring construction strategy, Computed Properties of 22483-09-6, the main research area is amino oxophenylethyl dimethoxyethyl phenylpropiolamide regioselective cycloisomerization; diphenyl pyrrolopyrazinedione preparation; benzylidene phenyl diazabicyclooctenedione preparation.

A modular approach for the construction of β- and γ-lactam fused dihydropyrazinones from the readily available Ugi adducts was described. The sequential construction of rings through base-mediated cycloisomerization followed by acid-mediated cyclization yielded β-lactam fused dihydropyrazinones. However, the Ugi-derived dihydropyrazinones afforded γ-lactam fused dihydropyrazinones under base-mediated cycloisomerization. The regioselectivity in the cycloisomerization reactions was explained on the basis of ring-strain. Substrate scope, limitations and mechanistic investigations through DFT-calculations was explored.

Chemical Communications (Cambridge, United Kingdom) published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Computed Properties of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hartman, Coral published the artcileBiodegradable polymer coating for controlled release of hydrophobic functional molecules from cotton fabrics, Application In Synthesis of 7575-23-7, the main research area is biodegradable polymer coating cotton fabrics hydrophobic functional mol.

Abstract: Despite major advances in polymer chem., cotton still remains the principal textile component in the global pharmaceutical industry owing to its intrinsic strength, thermal stability, biocompatibility, and pleasant texture. Nevertheless, the hydrophilic nature of cotton requires the development of strategies for the incorporation of hydrophobic functional mols. into the fabric for controlled-release applications. To address this issue, we designed biodegradable crosslinked poly(β-amino ester) (PBAE) coatings as reservoirs for the incorporation of small hydrophobic mols. and studied their release profiles under physiol. conditions. Two PBAEs with different hydrophobic and degradation properties were prepared and crosslinked to cotton fabrics in the presence of azulene, which served as a model hydrophobic, active material. Optimization of the crosslinking process in terms of UV curing time and the amount of solvent revealed that curing time of 15 min using 0.5 mL of chloroform was the optimal crosslinking condition. The coatings were characterized by FTIR, XPS, and SEM as well as TGA and DSC analyses. Sustained release of azulene was observed, and there was a correlation between azulene delivery rates and the hydrophobicity of the coating. These results provide a potentially useful platform for the rational design of cotton-based controlled-release systems for bioactive mol. delivery applications.

Journal of Coatings Technology and Research published new progress about Azulenes Role: SPN (Synthetic Preparation), PREP (Preparation). 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts