Month: December 2022

Kirton, L. G. published the artcileLaboratory and field tests of the effectiveness of the lemon-eucalyptus extract, citriodiol, as a repellent against land leeches of the genus Haemadipsa (Haemadipsidae), Application of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is citriodiol Corymbia citriodora extract land leech repellent.

Citridiol is an extract of the leaves of Corymbia citriodora (Myrtaceae), the lemon eucalyptus, and mostly consists of p-menthane-3,8-diol isomers. The effectiveness of this extract as a repellent against land leeches of the genus Haemadipsa (Haemadipsidae), primarily H. sylvestris, was tested in the laboratory and field, in Peninsular Malaysia. The formulation tested, Mosi-guard Natural spray, contained 40% (weight/weight) citriodiol in a base of EtOH, water, and isopropanol. In the laboratory test, specimens of H. sylvestris that were placed within moist, untreated arenas enclosed by treated paper rings made numerous attempts to cross the rings but were prevented or delayed from crossing over, in a dose-dependent manner. Mortality was high among the leeches that attempted to cross over the paper rings that had been sprayed to saturation point but low among the leeches that attempted to cross over paper rings that had only been partially treated, with a droplet-spray. The field study was carried out using indexes that were formulated to reflect the severity of leech attack and the degree of repellency. Heavy or moderate spraying of footwear and trouser legs (tucked into socks) not only gave complete protection against bites by H. sylvestris and H. picta but also provided high enough repellency to keep the treated footwear virtually free of leeches. Even a light spray greatly reduced the numbers of leeches on footwear and delayed their progression toward biting the test subjects, although it failed to prevent bites completely. There was no decline in the repellency of the citriodiol when hourly assessments were made over a 6-h test period in the field. The results of the study show that citriodiol is highly repellent as well as toxic to leeches, and can be effectively used to prevent leech bites in the field.

Annals of Tropical Medicine & Parasitology published new progress about Corymbia citriodora. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Application of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhattacharjee, Apurba K. published the artcileIn Silico Stereo-Electronic Analysis of PMD (p-Menthane-3-8-Diol) and its Derivatives for Pharmacophore Development May Aid Discovery of Novel Insect Repellents, Formula: C10H20O2, the main research area is menthanediol derivative electrostatic potential model insect repellent.

PMD (p-menthane-3-8-diol) is an insect repellent that can be synthesized chem. or derived from a steam distillate residue of the leaves of lemon eucalyptus, Corymbia citriodora. It is one of the few natural product endorsed by the Center for Disease Control (USA) for topical application to protect against mosquitoes though it is not as effective as the common repellent DEET (N,N-diethyl-1,3-toluamide). However, DEET has several undesirable side effects and toxicity too. Thus, although PMDs are comparatively safer than DEET, no quant. structure activity relationship (QSAR) and pharmacophore modeling studies have been reported in literature to improve efficacy and aid further development of more effective PMD analogs. In this study, we report results of quantum chem. anal. of stereoelectronic properties and pharmacophore modeling of PMD and eight of its synthetic derivatives to aid discovery and design of more effective PMD analogs. Stereo-electronic anal. indicates that lower aqueous stabilization (favorable lipophilicity) and larger separation of electrostatic potential energy together with a large localized neg. electrostatic potential region by the oxygen atom play important roles for repellent activity. Consistent to these properties, the generated pharmacophore model of the PMDs showed two aliphatic hydrophobic and a hydrogen-bond donor features for potent activity. These results aided us to design more effective PMD repellents which are currently under further investigations.

Current Computer-Aided Drug Design published new progress about Corymbia citriodora. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Formula: C10H20O2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Taktak, Nehad E. M. published the artcileNanoemulsions containing some plant essential oils as promising formulations against Culex pipiens (L.) larvae and their biochemical studies, Computed Properties of 124-76-5, the main research area is Culex larva essential oils nanoemulsions formulations larvicidal; Biochemical studies; Culex pipiens; Essential oils; GC/MS; Larvicidal activity; Nanoemulsions.

The chem. composition of cypress, lavender, lemon eucalyptus, and tea tree oils has been investigated using gas chromatog./mass spectrometry (GC/MS). These oils were tested for larvicidal activity against Culex pipiens alongside their nanoemulsions (NEs) and conventional emulsifiable concentrates (ECs). Oil-in-water (O/W) NEs preparation was based on a high-energy ultra-sonication technique. The effect of independent variables of preparation on the different outputs was studied using the response surface method to obtain the optimum preparation technique. The droplet sizes of prepared NEs were significantly different (71.67, 104.55, 211.07, and 70.67 for cypress, lavender, lemon eucalyptus, and Tea tree NEs, resp.). The zeta potentials of NEs were recorded to have a high neg. charge (-28.4, -22.2, -23.6, and – 22.3 mV for cypress, lavender, lemon eucalyptus, and tea tree NEs, resp.). The results showed that the tea tree oil has the most significant effect with LC50 = 60.02 and 57.10 mg/L after 24 and 48 h of exposure, resp. In comparison, cypress oil proved the lowest toxicity with LC50 values of 202.24 and 180.70 mg/L after 24 and 48 h, resp. However, lavender oil does not show any effect against larvae at tested concentrations In addition, pure oil exhibited the lowest larvicidal activity. However, the EC of all tested insecticides slightly improved the toxic action against the larvae. While the NEs showed significantly high toxicity compared to the EO and EC. An in vivo assessment of acetylcholine esterase (AChE), ATPase (ATPase), and gamma-aminobutyric acid transaminase (GABA-T) revealed that the NEs exhibited higher activity than the pure oils and ECs. This work describes these oils with potential use against C. pipiens larvae as eco-friendly products.

Pesticide Biochemistry and Physiology published new progress about Corymbia citriodora. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Putra, T. W. published the artcileIntensification of biolubricant synthesis from waste cooking oil using tetrahydrofuran as co-solvent, Quality Control of 111-87-5, the main research area is intensification biolubricant synthesis waste cooking oil THF cosolvent.

In this study, biolubricant was synthesized through two stages of transesterification. The first transesterification was the reaction between waste cooking oil and ethanol using sodium hydroxide as catalyst to produce fatty acid Et esters (FAEE). The second transesterification was the reaction between FAEE and 1-octanol using potassium hydroxide as catalyst with THF as co-solvent to produce fatty acid octyl esters (biolubricant). This study was focused on the effect of THF as co-solvent in the second transesterification. Biolubricant yield of 94.42% was obtained at reaction conditions (temperature of 125°C, time of 180 min, reactant molar ratio of 1:4, catalyst amount of 1%-weight/weight, vacum pressure of 100 mmHg and co-solvent amount of 25%-weight/weight). The physicochem. properties of biolubricant were kinematic viscosities of 10.47 mm2/s and 2.75 mm2/s at 40°C and 100°C, viscosity index of 103 and acid number of 0.62 mg KOH/g.

IOP Conference Series: Materials Science and Engineering published new progress about Edible oils Role: RCT (Reactant), RACT (Reactant or Reagent). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Quality Control of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gong, Lingzhen published the artcileSelective construction of fused heterocycles by an iridium-catalyzed reductive three-component annulation reaction, Product Details of C10H18O, the main research area is chromenoquinolinone preparation diastereoselective; cyclohexanedione quinolinium bromide selective reductive annulation iridium catalyzed; chromenopyranoquinolinone preparation diastereoselective; hydroxycoumarin quinolinium bromide selective reductive annulation iridium catalyzed.

Here, through an initial pretreatment of N-heteroarenes with alkyl bromide, a syn-selective construction of functional fused heterocycles, chromenoquinolinones I [R1 = H, 7-Br, 10-NO2, etc.; R2 = CH2CH=CH2, Ph, 4-MeC6H4, etc.; R3 = H, Me; R4 = Me, Ph, 2-furyl] and chromenopyranoquinolinones II [R5 = H, 10-Me, 7-Br, etc.; R6 = H, 3-MeO, 2-Br, etc.] via iridium catalyzed reductive annulation of N-heteroarenium salts with formaldehyde and cyclic 1,3-diketones or 4-hydroxycoumarins, proceeding with broad substrate scope, good functional group compatibility, readily available feedstocks, and high step and atom efficiency was described.

Chemical Communications (Cambridge, United Kingdom) published new progress about Benzopyrans Role: RCT (Reactant), RACT (Reactant or Reagent). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yan, Linjie published the artcileDesign, synthesis and evaluation of 2′-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents, Recommanded Product: 3-Pentanol, the main research area is alkylaminopyrrolopyrimidinylethynyl tetrahydrofuranylmethoxyphenoxyphosphorylaminopropanoate preparation diastereoselective antiviral SAR pharmacokinetic; Antiviral; Enterovirus; NITD008; Nucleoside/nucleotide inhibitor.

A series of phosphoamidate derivatives I [R1 = Me, iso-Bu, cyclohexyl etc.; R2 = H, Me, benzyl etc.] (NITD008) were synthesized and evaluated for their in-vitro antiviral activities against the enteroviruses EV71 and EV-D68. The phosphoamidate containing I [R1 = n-hexyl; R2 = Me] a hexyl ester of L-alanine exhibited the most promising activity against EV71 (IC50 = 0.13 ± 0.08 μM) and were 4-times more potent than NITD008. Meanwhile, the derivative containing a cyclohexyl ester of L-alanine I [R1 = cyclohexyl; R2 = Me] exhibited the most potent activity with high selectivity index against both EV71 (IC50 = 0.19 ± 0.27 μM, SI = 117.00) and EV-D68 (IC50 = 0.17 ± 0.16 μM, SI = 130.76), which were both higher than that of NITD008. The results indicated that the phosphoamidate I [R1 = cyclohexyl; R2 = Me] were the most promising candidate for further development as antiviral agents for the treatment of both EV71 and EV-D68 infection.

European Journal of Medicinal Chemistry published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Derasp, Joshua S. published the artcileRhodium-Catalyzed Synthesis of Amides from Functionalized Blocked Isocyanates, Quality Control of 22483-09-6, the main research area is rhodium catalyst coupling boroxine blocked masked isocyanate; synthesis amide.

Isocyanates are useful building blocks for the synthesis of amides, although their widespread use has been limited by their high reactivity, which often results in poor functional group tolerance and a propensity to oligomerize. Herein, a rhodium-catalyzed synthesis of amides is described coupling boroxines with blocked (masked) isocyanates. The success of the reaction hinges on the ability to form both the isocyanate and the organorhodium intermediates in situ. Relying on masked isocyanate precursors and on the high reactivity of the organorhodium intermediate results in broad functional group tolerance, including protic nucleophilic groups such as amines, anilines, and alcs.

ACS Catalysis published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Quality Control of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moradi, Sasan published the artcileAchieving high thermal conductivity in epoxy composites: effect of boron nitride particle size and matrix-filler interface, Quality Control of 7575-23-7, the main research area is boron nitride epoxy composite thermal conductivity particle size interface; boron nitride; differential scanning calorimetry (DSC); epoxy; thermal conductivity; thiol.

For the thermal management of high watt d. circuit layers, it is common to use a filled epoxy system to provide an elec. insulating but thermally conducting bond to a metal substrate. An epoxy-thiol system filled with boron nitride (BN), in the form of 2, 30 and 180μm platelets, has been investigated with a view to achieving enhanced thermal conductivity The effect of BN content on the cure reaction kinetics has been studied by differential scanning calorimetry and the thermal conductivity of the cured samples has been measured by the transient hot bridge method. The heat of reaction and the glass transition temperature of the fully cured samples are both independent of the BN content, but the cure reaction kinetics is systematically affected by both BN content and particle size. These results can be correlated with the thermal conductivity of the cured systems, which is found to increase with both BN content and particle size. For a given BN content, the thermal conductivity found here is significantly higher than most others reported in the literature; this effect is attributed to a Lewis acid-base interaction between filler and matrix.

Polymers (Basel, Switzerland) published new progress about Epoxy resins Role: RCT (Reactant), RACT (Reactant or Reagent). 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Quality Control of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Karakas, Duygu Elma published the artcileKetone transfer hydrogenation reactions catalyzed by catalysts based on a phosphinite ligand, COA of Formula: C5H12O, the main research area is furanylethyldiphenylphosphinite preparation ruthenium iridium complexation; ketone transfer hydrogenation catalyzed furanylethyldiphenylphosphinite ruthenium iridium complex.

Reaction of (±)-1-(2-furyl)ethanol with an equivalent Ph2PCl in the presence of Et3N proceeds in dry toluene under an argon atm. to give 1-(furan-2-yl)ethyldiphenylphosphinite (1) in good yield. Mononuclear complexes [dichloro(η6-p-cymene)(1-furan-2-ylethyldiphenylphosphinite)ruthenium(II)] (2), [dichloro(η6-benzene)(1-furan-2-ylethyldiphenylphosphinite)ruthenium(II)] (3), [chloro(η4-1,5-cyclooctadiene)(1-furan-2-ylethyldiphenylphosphinite)rhodium(I)] (4) and [dichloro(η5-pentamethylcyclopentadienyl)(1-furan-2-ylethyldiphenylphosphinite)iridium(III)] (5) were synthesized and characterized by microanal., IR, MS, and NMR spectroscopies. The complexes are employed as catalysts in transfer hydrogenation of aromatic ketones. The complexes catalyzed reduction of a variety of aromatic ketone substrates bearing electron-withdrawing or donating substituents with very high conversion rates (up to 99%); 5 was the most efficient catalyst for the transfer hydrogenation of ketones.

Journal of Coordination Chemistry published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, COA of Formula: C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Giboulot, Steven published the artcileFlat and Efficient HCNN and CNN Pincer Ruthenium Catalysts for Carbonyl Compound Reduction, Quality Control of 124-76-5, the main research area is arylpyridinylmethanamine benzoquinoline aminomethylpyridine HCNN CNN pincer ruthenium catalyst preparation; carbonyl compound reduction HCNN CNN pincer ruthenium catalyzed; aminomethylbenzoquinoline ruthenium phosphine carbonyl preparation crystal mol structure catalyst; aryl methyl ketone transfer hydrogenation catalyst preparation.

The bidentate HCNN dicarbonyl ruthenium complexes trans,cis-[RuCl2(HCNN)(CO)2] (1-3) and trans,cis-[RuCl2(ampy)(CO)2] (1a) were prepared by reaction of [RuCl2(CO)2]n with 1-[6-(4′-methylphenyl)pyridin-2-yl]methanamine, benzo[h]quinoline (HCNN), and 2-(aminomethyl)pyridine (ampy) ligands. Alternatively, the derivatives 1-3 were obtained from the reaction of RuCl3 hydrate with HCO2H and HCNN. The pincer CNN cis-[RuCl(CNN)(CO)2] (4) was isolated from 1 by reaction with NEt3. The monocarbonyl complexes trans-[RuCl2(HCNN)(PPh3)(CO)] (5-7) were synthesized from [RuCl2(dmf)(PPh3)2(CO)] and HCNN ligands, while the diacetate trans-[Ru(OAc)2(HCNN)(PPh3)(CO)] (8) was obtained from [Ru(OAc)2(PPh3)2(CO)]. Carbonylation of cis-[RuCl(CNN)(PPh3)2] with CO afforded the pincer derivatives [RuCl(CNN)(PPh3)(CO)] (9-11). Treatment of 9 with Na[BArf]4 and PPh3 gave the cationic complex trans-[Ru(CNN)(PPh3)2(CO)][BArf4] (12). The dicarbonyl derivatives 1-4, in the presence of PPh3 or PCy3, and the monocarbonyl complexes 5-12 catalyzed the transfer hydrogenation (TH) of acetophenone (a) in 2-propanol at reflux (S/C = 1000-100000 and TOF up to 100000 h-1). Compounds 1-3, with PCy3, and 6 and 8-10 were proven to catalyze the TH of carbonyl compounds, including α,β-unsaturated aldehydes and bulky ketones (S/C and TOF up to 10000 and 100000 h-1, resp.). The derivatives 1-3 with PCy3 and 5 and 6 catalyzed the hydrogenation (HY) of a (H2, 30 bar) at 70° (S/C = 2000-10000). Complex 5 was active in the HY of diaryl ketones and aryl Me ketones, leading to complete conversion at S/C = 10000.

Organometallics published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Quality Control of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts