Month: December 2022

Dai, Jianxun published the artcileUltrafast Response Polyelectrolyte Humidity Sensor for Respiration Monitoring, Category: alcohols-buliding-blocks, the main research area is polyelectrolyte humidity sensor respiration monitoring; breath monitoring; click reaction; in situ preparation; polyelectrolyte humidity sensors; ultrafast response.

Respiration monitoring is important for evaluating human health. Humidity sensing is a promising way to establish a relationship between human respiration and elec. signal. This work describes polymer humidity sensors with ultrafast response for respiration monitoring. The humidity-sensitive polyelectrolyte is in situ cross-linked on the substrate printed with interdigitated electrodes by a thiol-ene click reaction. The polyelectrolyte humidity sensor shows rapid water adsorption/desorption ability, excellent stability, and repeatability. The sensor with ultrafast response and recovery (0.29/0.47 s) when changing humidity between 33 and 95% shows good application prospects in breath monitoring and touchless sensing. Different respiration patterns can be distinguished, and the breath rate/depth of detection subjects can also be determined by the sensor. In addition, the obtained sensor can sense the skin evaporation in a noncontact way.

ACS Applied Materials & Interfaces published new progress about Breathing (animal). 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

AL-Hashimi, Nabil N. published the artcileCetyl-alcohol-reinforced hollow fiber solid/liquid-phase microextraction and HPLC-DAD analysis of ezetimibe and simvastatin in human plasma and urine, Synthetic Route of 111-87-5, the main research area is ezetimibe simvastatin cetyl alc hollow fiber SLPME HPLC DAD; HPLC-DAD; cetyl alcohol; ezetimibe and simvastatin; plasma; reinforced solid/liquid microextraction; urine.

A new cetyl-alc.-reinforced hollow fiber solid/liquid-phase microextraction (CA-HF-SLPME) followed by high-performance liquid chromatog.-diode array detection (HPLC-DAD) method was developed for simultaneous determination of ezetimibe and simvastatin in human plasma and urine samples. To prepare the CA-HF-SLPME device, the cetyl-alc. was immobilized into the pores of a 2.5 cm hollow fiber micro-tube and the lumen of the micro-tube was filled with 1-octanol with the two ends sealed. Afterwards, the prepared device was introduced into 10 mL of the sample solution containing the analytes with agitation. Under optimized conditions, calibration curves plotted in spiked plasma and urine samples were linear in the ranges of 0.363-25/0.49-25 μg L-1 for ezetimibe/simvastatin and 0.193-25/0.312-25 μg L-1 for ezetimibe/simvastatin in plasma and urine samples, resp. The limit of detection was 0.109/0.174 μg L-1 for ezetimibe/simvastatin in plasma and 0.058/0.093 μg L-1 for ezetimibe/simvastatin in urine. As a potential application, the proposed method was applied to determine the concentration of selected analytes in patient plasma and urine samples after medication and satisfactory results were achieved. In comparison with reference methods, the CA-HF-SLPME-HPLC-DAD method demonstrates considerable potential in the biopharmaceutical anal. of selected drugs.

Biomedical Chromatography published new progress about Biopharmaceuticals. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maghsoudi, Majid published the artcileDevelopment of electrically assisted solvent bar microextraction followed by high performance liquid chromatography for the extraction and quantification of basic drugs in biological samples, SDS of cas: 111-87-5, the main research area is solvent bar microextraction high performance liquid chromatog extraction; Basic drugs; Biological sample; Electrically assisted solvent bar microextraction; Plasma; Urine.

In this study, a new extraction procedure is introduced based on elec. assisted solvent bar microextraction In the first step, the analytes are transferred from sample solution to the hollow fiber supported organic solvent. After that, with the aid of an elec. field, the analytes migrated into the aqueous extractant. The proposed approach was used to extract the three basic drugs (including lidocaine, diltiazem, and propranolol) from the plasma and urine samples. Under the optimized condition, (the supported organic solvent: 1-octanol, stirring rate: 300 rpm, pH of sample solution: 12.0, salt concentration: 2.0% (w/v), extraction time: 15 min, aqueous extractant: (30μL, 100 mM HCl), back-extraction time: 2 min, back-extraction voltage: 100 V), the proposed procedure presented wide linearities with coefficients of determination more than 0.992 over a concentration range of 5.0-1000 ng mL-1. The limit of detection was also determined in the range of 0.5 to 5.0 ng mL-1, repeatability (intra-day) was between 3.3 and 11.1% (n = 4), and reproducibility (inter-day) was between 4.3 and 14.6% (n = 4 days). It was indicated that the proposed approach could effectively extract the analytes from the plasma and urine samples, and the relative recoveries were between 90.2 and 105.6%, indicating the validity of this method.

Journal of Chromatography A published new progress about Biological samples. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Becerra, Jaime-Andres published the artcileTechno-Economic Evaluation of d-Limonene and α-Pinene Separation from Citrus and Turpentine Oils, Quality Control of 124-76-5, the main research area is techno economic limonene alpha pinene Citrus turpentine oil.

The evaluation of the tech. and economic separation of the monoterpenes α-pinene and d-limonene from essential oils, carried out by computational simulation of the vacuum fractional distillation in continuous and batch mode from samples of turpentine and citrus oils, was developed using Aspen Plus software combined with estimations of operational expenses (OPEX) and capital expenses (CAPEX) based on the Guthrie method. The production of d-limonene and α-pinene with high purity from the essential oils is a tech. feasible process. From the economic point of view and based on the average annual import costs of turpentine and orange oils in Colombia, it was found that the selling prices of α-pinene and d-limonene obtained from the distillation module cost anal. depend on the daily production and can be minimized if essential oils are preliminary extracted from local industrial wastes.

Chemical Engineering & Technology published new progress about Batch distillation. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Quality Control of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Farkas, Erzsebet published the artcileRegioselective synthesis of galactosylated tri- and tetrasaccharides by use of β-galactosidase from Bacillus circulans, Product Details of C12H24O11, the main research area is oligosaccharide preparation regioselective transglycosylation catalyst galactosidase Bacillus circulans.

β-Galactosidase from Bacillus circulans (EC 3.2.1.23) catalyzes the transfer of galactose units to various glucose and galactose derivatives, forming β1→4 linkages. The synthesis of several biol. relevant tri- and tetrasaccharides {β-D-Galp-(1→4)-β-D-Galp-(1→4)-α,β-D-Glcp, β-D-Galp-(1→4)-α-D-Glcp-(1→4)-D-Glcp-ol/Manp-ol, β-D-Galp-(1→4)-α-D-Glcp-(1→6)-β-D-Fruf, β-D-Galp-(1→4)-α-D-Glcp-(1→2)-β-D-Fruf, β-D-Galp-(1→4)-α-D-Glcp-(1→2)-β-D-Fruf-(1→2)-β-D-Fruf, β-D-Galp-(1→4)-α-D-Glcp-(1→6)-[α-D-Glcp-(1→2)]-β-D-Fruf, β-D-Galp-(1→4)-α-D-Glcp-(1→2)-[α-D-Glcp-(1→6)]-β-D-Fruf, α-D-Galp-(1→6)-[β-D-Galp-(1→4)]-α-D-Glcp-(1→2)-β-D-Fruf, β-D-Galp-(1→4)-α-D-Galp-(1→6)-α-D-Glcp-(1→2)-β-D-Fruf} has been achieved in 11-59% yields by application of this enzyme.

Synthesis published new progress about Bacillus circulans. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Product Details of C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Di Carluccio, Cristina published the artcileCharacterisation of the Dynamic Interactions between Complex N-Glycans and Human CD22, Related Products of alcohols-buliding-blocks, the main research area is autoimmune disease B cell malignancy CD22 N glycan; N-glycans; NMR spectroscopy; Siglecs; molecular recognition; sialic acids.

CD22 (Siglec-2) is a B-cell surface inhibitory protein capable of selectively recognising sialylated glycans, thus dampening autoimmune responses against self-antigens. Here we have characterised the dynamic recognition of complex-type N-glycans by human CD22 by means of orthogonal approaches including NMR spectroscopy, computational methods and biophys. assays. We provide new mol. insights into the binding mode of sialoglycans in complex with h-CD22, highlighting the role of the sialic acid galactose moieties in the recognition process, elucidating the conformational behavior of complex-type N-glycans bound to Siglec-2 and dissecting the formation of CD22 homo-oligomers on the B-cell surface. Our results could enable the development of addnl. therapeutics capable of modulating the activity of h-CD22 in autoimmune diseases and malignancies derived from B-cells.

ChemBioChem published new progress about Autoimmune disease. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kubisch, Christin published the artcileValorization of a Pyrolytic Aqueous Condensate and Its Main Components for L-Malic Acid Production with Aspergillus oryzae DSM 1863, Product Details of C4H6O5, the main research area is Aspergillus malic acid valorization pyrolytic aqueous condensate.

Pyrolytic aqueous condensate (PAC) might serve as a cost-effective substrate for microbial malic acid production, as it is an unused side stream of the fast pyrolysis of lignocellulosic biomass that contains acetol and acetate as potential carbon sources. In the present study, shake flask cultures were performed to evaluate the suitability of acetol and its combination with acetate as substrates for growth and L-malate production with the filamentous fungus Aspergillus oryzae. Acetol concentrations of up to 40 g/L were shown to be utilized for fungal growth. In combination with acetate, co-metabolization of both substrates for biomass and malate formation was observed, although the maximum tolerated acetol concentration decreased to 20 g/L. Furthermore, malate production on PAC detoxified by a combination of rotary evaporation, overliming and activated carbon treatment was studied. In shake flasks, cultivation using 100% PAC resulted in the production of 3.37 ± 0.61 g/L malate, which was considerably improved by pH adjustment up to 9.77 ± 0.55 g/L. A successful scale-up to 0.5-L bioreactors was conducted, achieving comparable yields and productivities to the shake flask cultures. Accordingly, fungal malate production using PAC was successfully demonstrated, paving the way for a bio-based production of the acid.

Fermentation published new progress about Aspergillus oryzae. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Product Details of C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yeo, Hyunki published the artcilePhotoinduced proton-transfer polymerization: a practical synthetic tool for soft lithography applications, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is photopolymerization proton transfer nanoimprint lithog base catalysis.

Proton-transfer photopolymerization through the thiol-epoxy “”click”” reaction is shown to be a versatile new method for the fabrication of micro- and nanosized polymeric patterns. In this approach, complexation of a guanidine base, diazabicycloundecene (DBU), with benzoylphenylpropionic acid (ketoprofen) generates a photolabile salt. Under illumination at a wavelength of 365 nm, the salt undergoes a photodecarboxylation reaction to release DBU as a base. The base-catalyzed ring opening reaction then creates cross-linked poly(β-hydroxyl thio-ether) patterns. The surface chem. of these patterns can be altered through alkylation of the thio-ether linkages. For example, a reaction with bromoacetic acid produces a hitherto unknown sulfonium/carboxylate-based zwitterionic motif that endows antibiofouling capacity to the micropatterns.

Journal of the American Chemical Society published new progress about Antifouling agents. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gargouri, Wafa published the artcileCoupling xylitol with remineralizing agents improves tooth protection against demineralization but reduces antibiofilm effect, Computed Properties of 64519-82-0, the main research area is antibiofilm xylitol tooth demineralization; CPP-ACP; Chewing gum; Dental plaque; Streptococcus mutans; Tooth demineralization; Xylitol.

To explore the efficiency of xylitol chewing gum enriched or not with remineralizing agents to protect tooth against cariogenic biofilm formation and demineralization. Six groups of chewing gums were prepared; Group 1: isomalt (1.8%), Group 2: casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) (3%) + isomalt (1.8%), Group 3: hydroxyapatite (HAP) (2.5%) + isomalt (1.8%), Group 4: xylitol (1.8%), Group 5: CPP-ACP (3%) + xylitol (1.8%) and Group 6: HAP (2.5%) + xylitol (1.8%). The antibiofilm properties of different chewing gum extracts using seven oral bacterial species including Streptococcus mutans, Streptococcus constellatus, Streptococcus Salivarius and Streptococcus oralis were explored via the crystal violet staining assay. The remineralizing effects of those products were assessed on thirty human permanent teeth, half-protected with varnish before chem. erosion and thermocycling process with chewing gum. Remineralization was evaluated using SEM and microscopic measurements on polarized light microscopy. The ratio R comparing the thickness between unvarnished and varnished sides was evaluated. While the min. biofilm inhibitory concentration (MBIC50) was low for xylitol alone compared to isomalt, it was inconsistent when enriched with remineralizing agents. The min. biofilm eradication concentration (MBEC50) was low for xylitol groups compared to isomalt, for all the studied strains. R was significantly lower in Group 1 and Group 2, while Group 6 showed the highest ratio. Xylitol chewing gums confirmed good antibiofilm properties and showed remineralized potential on eroded teeth. When xylitol is associated to CPP-ACP or HAP, antibiofilm activity decreased while remineralization of eroded teeth increased.

Microbial Pathogenesis published new progress about Antibiofilm agents. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Computed Properties of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Woolard, Katherine J. published the artcileDevelopment of small molecules that work cooperatively with ciprofloxacin to clear salmonella biofilms in a chronic gallbladder carriage model, Application of 2-(3,5-Dichlorophenyl)ethanol, the main research area is piperidine alkylation alc mesylation preparation antibiofilm salmonella gallbladder.

Salmonella enterica serovars cause millions of infections each year that result either in typhoid fever or salmonellosis. Among those serovars that cause typhoid fever, Salmonella enterica subspecies Typhi can form biofilms on gallstones in the gallbladders of acutely-infected patients, leading to chronic carriage of the bacterium. These biofilms are recalcitrant to antibiotic-mediated eradication, leading to chronic fecal shedding of the bacteria, which results in further disease transmission. Herein, we report the synthesis and anti-biofilm activity of a 55-member library of small mols. based upon a previously identified hit that both inhibits and disrupts S.Typhi and S. Typhimurium (a nontyphoidal model serovar for S. Typhi) biofilms. Lead compounds inhibit S. Typhimurium biofilm formation in vitro at sub-micromolar concentrations, and disperse biofilms with five-fold greater potentency than the parent compound Three of the most promising compounds demonstrated synergy with ciprofloxacin in a murine model of chronic Salmonella carriage. This work furthers the development of effective anti-biofilm agents as a promising therapeutic avenue for the eradication of typhoidal Salmonella.

European Journal of Medicinal Chemistry published new progress about Antibiofilm agents. 93427-13-5 belongs to class alcohols-buliding-blocks, name is 2-(3,5-Dichlorophenyl)ethanol, and the molecular formula is C8H8Cl2O, Application of 2-(3,5-Dichlorophenyl)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts