Month: December 2022

Frymark, Justyna published the artcileExcess of polyamine as a factor influencing the mode of coordination in the Eu(III)/α-hydroxy acid/spermine system, Computed Properties of 97-67-6, the main research area is europium complexation hydroxy acid spermine excess polyamine spectroscopy.

The complexes of europium(III) ions in binary and ternary systems with α-hydroxy acids and biogenic amine – spermine were investigated. Studies have been performed in aqueous solution using the potentiometric method with computer anal. of the data. Anal. of the equilibrium constants of the reactions and spectroscopic data have allowed us to determine the type of coordination and effectiveness of the carboxyl groups in the process of complex formation in the systems studied. Furthermore, the results confirmed the occurrence of non-covalent interactions of protonated spermine with coordinated α-hydroxy acid. The effect of biogenic polyamine concentration was clearly confirmed, and their influence on the stability and coordination mode of ternary complexes was found.

Polyhedron published new progress about Circular dichroism. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Computed Properties of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saidi, Chourouk Nait published the artcilePredictions of solvation Gibbs free energies with COSMO-SAC approaches, Safety of 3-Pentanol, the main research area is liquid phase solvation Gibbs free energy activity coefficient simulation.

The modeling of a detailed kinetics mechanism in the liquid phase is still not well understood, and the description of solvent effect on reaction rates remains a challenge. Green and co-workers proposed an approach to predict the kinetic constants in liquid phases, which is based on a correction of the kinetic constants in the gas phase. The correction term in Green′s approach involves the solvation Gibbs free energies of the chem. species involved in the reactions. Examples of applications of the method are the kinetic modeling of the oxidation of liquid fuels or the catalytic pyrolysis of biomass. However, an accurate thermodn. model is required to predict the solvation energies. In this work, several predictive models of solvation energies are compared to the large set of exptl. data reported recently by Moine et al. [J. Phys. Chem. Reference Data, 46, 2017] in the CompSol database. Activity coefficients and solvation Gibbs free energies were calculated with different versions of the COSMO-SAC thermodn. model. We propose a re-optimization of the universal parameters of these COSMO-SAC models, and extend them to CPCM cavities. It is found that these approaches are in general much more accurate than the Abraham solvation model that is usually employed in Green′s approach.

Fluid Phase Equilibria published new progress about Chemical potential. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Safety of 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Xin published the artcileStructural characterization and immunomodulating activities of polysaccharides from a newly collected wild Morchella sextelata, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is polysaccharide Morchella sextelata immunomodulator macrophage; Immunomodulatory; Morchella sextelata; Polysaccharides; Purification.

A purified polysaccharide was acquired from a newly collected wild Morchella. The strain identification initially showed that the strain was Morchella sextelata. This study aimed to investigate the structural features and immunomodulating activities of the polysaccharide. Polysaccharide extracted from mycelia was purified by DEAE-cellulose chromatog. and Sephadex G-25 size-exclusion chromatog. in sequence. The main fraction of polysaccharide (MSP-II) was obtained during purification process. High Performance Liquid Chromatog. (HPLC) anal. revealed that MSP-II was composed of Glc, Ara, Gal, Man, Rha, Fuc, GalUA and GluUA in ratio of 34.95:8.7:9.55:4.55:5.0:1.45:12.7:7.65. The structure of MSP-II was furtherly analyzed by FT-IR spectrum and 1 H and 13 C NMR spectroscopy, the results showed that MSP contained β glycosidic bonds as well as Α glycosidic linkages. In vitro tests proved that MSP-II could not only promote the proliferation and phagocytosis of RAW264.7 cells, but also induce the section of nitric oxide (NO) of macrophages. Consequently, the polysaccharide has a potent immunomodulatory activity by stimulating macrophages and can be considered as a novel potential immunopotentiator in medical and food industries.

International Journal of Biological Macromolecules published new progress about Cell proliferation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zheng, Tingting published the artcilePurification, characterization and immunomodulatory activity of polysaccharides from Leccinum crocipodium (Letellier.) Watliag, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Leccinum macrophage polysaccharide immunomodulatory effect; Characterization; Immunomodulatory activity; Leccinum crocipodium (Letellier.) Watliag; Polysaccharide; Purification.

The polysaccharide obtained from edible fungi has been regarded as the major bioactive component related to the nutritional and human’s health. In the present study, three purified polysaccharides (LCP-1, LCP-2, and LCP-3) were obtained from Leccinum crocipodium (Letellier.) Watliag. The characterizations of LCP-1, LCP-2, and LCP-3 were determined by high-performance liquid chromatog. (HPLC), UV, FT-IR spectrometrys and 1H NMR spectrum. LCP-1 had a mol. weight of 2.303 × 105 Da and 7.519 × 103 Da, and was composed of mannose (Man), ribose (Rib), rhamnose (Rha), glucuronic acid (GluA), galacturonic acid (GalA), glucose (Glu), galactose (Gal), xylose (Xyl), arabinose (Ara) and fucuronic (Fuc). The mol. weight of LCP-2 was 2.655 × 105 Da, and its monosaccharide constituents were Man, Rib, Rha, GluA, Glu, Gal, Xyl, Ara and Fuc. The mol. weight of LCP-3 was 3.783 × 105 Da, and its monosaccharide constituents were Man, Rib, Rha, GluA, GalA, Glu, Gal, Xyl, Ara and Fuc. For the in vitro immunomodulatory experiments demonstrated that three purified polysaccharides could enhance immunomodulatory activities on macrophage RAW 264.7 cells, moreover, LCP-2 and LCP-3 showed stronger immunomodulatory activity than LCP-1. The results indicated that the LCP-1, LCP-2, and LCP-3 could be further developed as functional food or medicine.

International Journal of Biological Macromolecules published new progress about Cell proliferation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yelithao, Khamphone published the artcileStudies on structural properties and immune-enhancing activities of glycomannans from Schizophyllum commune, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Schizophyllum polysaccharide glycomannan immunomodulatory RAW264; Immunomodulatory; Polysaccharides; RAW264.7 cell; Schizophyllum commune.

Polysaccharides were extracted from Schizophyllum commune (a common mushroom) and their structural and immune-enhancing properties were investigated. Crude and fractions (F1 and F2) were composed of sugars (50.3-82.8%), proteins (1.46-20.1%), and sulfates (1.33-7.01%). Monosaccharide compositions of Cr and F1 were mainly composed of glucose (75.5% and 88.2%) with small amounts of mannose, galactose and xylose whereas the F2 was mainly composed of manose (55.2%) with minor amounts of galactose, glucose, and xylose. Their immune-enhancing activities were tested using RAW264.7 cells. Proliferation activity of RAW264.7 cells was over 100% after treatment with these polysaccharides. In addition, RAW264.7 cells produced large amounts of nitric oxide and various cytokines by up-regulating mRNA expression levels and the activation of nuclear factor-kappa (NF-κB) and mitogen-activated protein kinase (MAPK) after treatment with these polysaccharides. In addition, RAW264.7 cells were activated mainly through CR-3 and TLR-4 receptors. The backbone of F2 with excellent immune-enhancing activity was mainly linked by (1→3)-linked-mannopyranosyl and (1→2,3)-linked-mannopyranosyl residues.

Carbohydrate Polymers published new progress about Cell proliferation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, La published the artcileMetformin attenuates hepatoma cell proliferation by decreasing glycolytic flux through the HIF-1α/PFKFB3/PFK1 pathway, Related Products of alcohols-buliding-blocks, the main research area is hepatoma cell metformin glycolytic flux HIF1 alpha PFKFB3 PFK1; Glycolytic flux; Hepatocellular carcinoma; Metformin; PFK1.

Enhanced aerobic glycolysis is an essential hallmark of malignant cancer. Blocking the glycolytic pathway has been suggested as a therapeutic strategy to impair the proliferation of tumor cells. Metformin, a widely used anti-diabetes drug, exhibits anti-tumor properties. Stable isotope tracing technol. and gas chromatog.-mass spectrometry method were utilized to analyze the effect of metformin on glycolytic flux in HCC cells. Western blot and immunohistochem. were utilized to analyze the expression of phosphofructokinase-1 and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 in HCC cells or xenograft tumor tissues. Lactate measurement and glucose uptake assay were used to analyze the level of lactate and glucose in the presence of frucose-2,6-diphosphate in HCC cells treated with metformin. We found that metformin significantly impaired hepatoma cell proliferation by inhibiting the glycolytic flux via PFK1 blockade. Interestingly, activation of PFK1 by F2,6BP reverses the inhibitory effect of metformin on hepatoma cell proliferation and glycolysis. Mechanistically, PFKFB3,a potent allosteric activator of PFK1, was markedly suppressed through inhibiting hypoxia-induced factor 1 accumulation mediated by metformin. Taken together these data indicate that HIF-1α/PFKFB3/PFK1 regulatory axis is a vital determinant of glucose metabolic reprogramming in hepatocellular carcinoma, which gives new insights into the action of metformin in combating liver cancer.

Life Sciences published new progress about Cell proliferation. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vitvitsky, Victor published the artcileThe mitochondrial NADH pool is involved in hydrogen sulfide signaling and stimulation of aerobic glycolysis, Computed Properties of 97-67-6, the main research area is mitochondrial NADH hydrogen sulfide signaling aerobic glycolysis; aerobic glycolysis; electron transport chain; hydrogen sulfide; sulfide quinone oxidoreductase.

Hydrogen sulfide is synthesized by enzymes involved in sulfur metabolism and oxidized via a dedicated mitochondrial pathway that intersects with the electron transport chain at the level of complex III. Studies with H2S are challenging since it is volatile and also reacts with oxidized thiols in the culture medium, forming sulfane sulfur species. The half-life of exogenously added H2S to cultured cells is unknown. In this study, we first examined the half-life of exogenously added H2S to human colonic epithelial cells. In plate cultures, H2S disappeared with a t1/2 of 3 to 4 min at 37 °C with a small fraction being trapped as sulfane sulfur species. In suspension cultures, the rate of abiotic loss of H2S was slower, and we demonstrated that sulfide stimulated aerobic glycolysis, which was sensitive to the mitochondrial but not the cytoplasmic NADH pool. Oxidation of mitochondrial NADH using the genetically encoded mito-LbNOX tool blunted the cellular sensitivity to sulfide-stimulated aerobic glycolysis and enhanced its oxidation to thiosulfate. In contrast, sulfide did not affect flux through the oxidative pentose phosphate pathway or the TCA cycle. Knockdown of sulfide quinone oxidoreductase, which commits H2S to oxidation, sensitized cells to sulfide-stimulated aerobic glycolysis. Finally, we observed that sulfide decreased ATP levels in cells. The dual potential of H2S to activate oxidative phosphorylation at low concentrations, but inhibit it at high concentrations, suggests that it might play a role in tuning electron flux and, therefore, cellular energy metabolism, particularly during cell proliferation.

Journal of Biological Chemistry published new progress about Cell proliferation. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Computed Properties of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Xiaolong published the artcileA neutral polysaccharide with a triple helix structure from ginger: Characterization and immunomodulatory activity, COA of Formula: C6H12O6, the main research area is polysaccharide ginger immunomodulator triple helix structure; Ginger polysaccharide; Immunomodulatory activity; Structure characterization; Triple helix structure; α-(1→4)-glucan.

A neutral ginger polysaccharide fraction (NGP) was isolated from ginger, and its primary structures and immunomodulatory activity were investigated. The results showed that NGP had a low mol. weight of 6305 Da. NGP principally consisted of glucose (93.88%) together with minor levels of galactose (3.27%) and arabinose (1.67%). Besides, results of methylation anal. and 1D/2D NMR spectroscopy demonstrated that NGP was α-glucan which had the main chain of 1,4-linked α-D-Glcp and α-D-Glcp residues branched at C-6 position which was different from the common triple helical β-glucans. NGP also displayed a remarkable immunol. activity on the RAW264.7 cells in vitro. It could significantly enhance the proliferation of macrophages without cytotoxicity and increase the production of immune substances (NO, TNF-α, IL-1β and IL-6). The secretion at the concentration of 200μg/mL was 29.41μM, 1496.71, 44.30 and 1889.83 pg/mL for each substance, resp. The results indicated that NGP could be a potential immune agent and might provide meaningful information for further chain conformation and immune mechanism research.

Food Chemistry published new progress about Cell proliferation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reeves, Benjamin M. published the artcileTransition-Metal-Free Reductive Hydroxymethylation of Isoquinolines, Safety of 2,2-Dimethoxyethanamine, the main research area is isoquinolinium iodide paraformaldehyde reductive hydroxymethylation Cannizzaro Evans Tishchenko; hydroxymethylated tetrahydroisoquinoline preparation; potassium methoxide isoquinolinium iodide paraformaldehyde methylation hydroxymethylation tandem; tetrahydroisoquinoline one pot preparation; formaldehyde; reductive-functionalization; tandem reaction; tetrahydroisoquinoline; transition-metal-free synthesis.

A transition-metal-free reductive hydroxymethylation reaction has been developed, enabling the preparation of tetrahydroisoquinolines, e.g., I, bearing C4-quaternary centers from the corresponding isoquinolines. Deuterium labeling studies and control experiments enable a potential mechanism to be elucidated which features a key Cannizzaro-type reduction followed by an Evans-Tishchenko reaction. When isoquinolines featuring a proton at the 4-position are used, a tandem methylation-hydroxymethylation occurs, leading to the formation of II with 2 new C-C bonds in one pot.

Angewandte Chemie, International Edition published new progress about C-C bond formation. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Safety of 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Lijie published the artcileEffects of Tetragenococcus halophilus and Candida versatilis on the production of aroma-active and umami-taste compounds during soy sauce fermentation, Related Products of alcohols-buliding-blocks, the main research area is Tetragenococcus Candida soy sauce fermentation umami taste; Candida versatilis; Tetragenococcus halophilus; aroma-active; soy sauce; umami-taste compounds.

BACKGROUND : Soy sauce is a well-known condiment worldwide. High salt soy sauce usually has the better quality (aroma and taste) than low salt. Tetragenococcus halophilus and Candida versatilis are important starters for soy sauce fermentation It is of urgent need to explore what the effect of these two strains on the aroma- and taste-attributes of soy sauce to achieve high quality fermentation with low salt. RESULTS : In this study, aroma-active and taste compounds in soy sauce were reviewed and listed. Then, soy sauce fermentation inoculated with different combinations of T. halophilus (at different inoculated time) and C. versatilis were completed. Aroma-active and taste compounds in different samples were quantified. Multivariate anal. was used to analyze these data. The aroma-active compounds which were highly related to the inoculation of T. halophilus and C. versatilis were found. Meanwhile, the addition time of T. halophilus could also be highly related to the production of aroma-active compounds More importantly, T. halophilus was highly correlated with the production of umami-taste compounds in soy sauce, including aspartic acid, glutamic acid, alanine and N-succinyl-glutamic acid. CONCLUSION : These results will provide a better understanding of the effects of T. halophilus and C. versatilis on the formation of significant aroma-active and umami-taste constituents in soy sauce. Furthermore, it will be helpful to realize fermentative control of soy sauce with high quality at low salt.

Journal of the Science of Food and Agriculture published new progress about Candida versatilis. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts