Month: December 2022

Zhu, Rugang published the artcileCharacterization of polysaccharide fractions from fruit of Actinidia arguta and assessment of their antioxidant and antiglycated activities, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is polysaccharide Actinidia antioxidant AGE; Actinidia argute; Antiglycation; Antioxidation; Characterization; Polysaccharide.

A novel cell-wall polysaccharides (AAPs) were extracted from the fruits of Actinidia arguta and separated into four parts which were named water-eluted polysaccharide (WPS), salt-eluted polysaccharide (SPS)-1, SPS-2 and SPS-3. The monosaccharide composition and structural anal. showed that SPS-3 and SPS-2 were homogalacturonan (HG)-rich pectin, SPS-1 was rhamnogalacturonan (RG)-rich pectin and WPS was starch-like polysaccharides. All four kinds of polysaccharides displayed the ability to scavenge free radicals, chelate iron ion, inhibit lipid peroxidation and inhibit protein glycation, but SPS was obviously stronger than WPS. Especially SPS-3 displayed the strongest antioxidant and anti-glycated activities. In addition, the inhibitory effect of AAPs on AGEs formation is attributed to the inhibitory activity on the production of protein carbonyl group and the protective effects on the protein thiol group but not the scavenging capacity of dicarbonyl compounds, suggesting that its mechanisms of antiglycated effects may be of concern to their antioxidant activities.

Carbohydrate Polymers published new progress about Actinidia arguta. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Warnau, Judith published the artcileCOSMO-RS predictions of logP in the SAMPL7 blind challenge, Safety of n-Octanol, the main research area is small drug mol logP COSMO RS simulation; 1-Octanol–water partition coefficient; COSMO-RS; COSMOtherm; logP prediction.

Abstract: We applied the COSMO-RS method to predict the partition coeffecient logP between water and 1-octanol for 22 small drug like mols. within the framework of the SAMPL7 blind challenge. We carefully collected a set of thermodynamically meaningful microstates, including tautomeric forms of the neutral species, and calculated the logP using the current COSMOtherm implementation on the most accurate level. With this approach, COSMO-RS was ranked as the 6st most accurate method (Measured by the mean absolute error (MAE) of 0.57) over all 17 ranked submissions. We achieved a root mean square deviation (RMSD) of 0.78. The largest deviations from exptl. values are exhibited by five SAMPL mols. (SM), which seem to be shifted in most SAMPL7 contributions. In context with previous SAMPL challenges, COSMO-RS demonstrates a wide range of applicability and one of the best in class reliability and accuracy among the phys. methods.

Journal of Computer-Aided Molecular Design published new progress about Molecules (small). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Hang published the artcilePotential of resveratrol in mitigating advanced glycation end-products formed in baked milk and baked yogurt, Name: 3-Pentanol, the main research area is baked milk yogurt resveratrol mitigating glycation end product; Advanced glycation end-products; Baked milk; Baked yogurt; Maillard reaction; Resveratrol.

Throughout the processing, a long-time-high-temperature baking procedure was involved to enhance the formation of a brownish color and desirable flavors; meanwhile, advanced glycation end-products (AGEs) were extensively produced through Maillard reaction (MR). The resveratrol at 1μmol/L was achieved the highest inhibitory rate against the formation of dicarbonyl compounds in the baked milk (3-deoxyglucosone (3-DG): 68.77%, methylglyoxal (MG): 50.46%) and baked yogurt (3-DG: 35.50%, MG: 37.11%). The content of N-(carboxymethyl)lysine (CML) and N-(hydroxyethyl) lysine (CEL) as the two commonly detected AGEs were decreased by higher than 30% and 27% in the baked milk and baked yogurt, resp., when the concentration of resveratrol was 0.1μmol/L. Moreover, the generation of furosine was significantly inhibited by 1μmol/L resveratrol, which was decreased to less than 40% and 60% in the baked milk and baked yogurt, resp. Furthermore, the addnl. level of 0.1μmol/L resveratrol achieved a high inhibitory effect of AGEs, and such an addnl. level would not alter the color and flavor profile of the baked milk and baked yogurt. Considering the high solubility of resveratrol in milk fat, it is speculated that resveratrol mainly acted at an early stage of the degradation, i.e., through the inhibition of the autocatalytic lipid oxidation that generates dicarbonyl compounds but played less as a dicarbonyl compounds scavenger.

Food Research International published new progress about Maillard reaction. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Name: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kong, Jiahui published the artcilePreparation of the key dolutegravir intermediate via MgBr2-promoted cyclization, Synthetic Route of 22483-09-6, the main research area is dolutegravir intermediate preparation; MgBr2-promoted cyclization; chemoselectivity; dolutegravir.

A novel approach for synthesizing the key dolutegravir intermediate is described via MgBr2-promoted intramol. cyclization. Condensation of com. available Me oxalyl chloride and Et 3-(N,N-dimethylamino)acrylate afforded the vinylogous amide in an excellent yield. Subsequent substitution by aminoacetaldehyde di-Me acetal and Me bromoacetate gave rise to the expected precursor for cyclization, which was promoted by MgBr2 to highly selectively convert into pyridinone diester. The key dolutegravir intermediate was finally prepared by the selective hydrolysis of the corresponding diester via LiOH.

Molecules published new progress about Heterocyclization. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Synthetic Route of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ge, Xinyan published the artcileProduction, structure, and bioactivity of polysaccharide isolated from Tremella fuciformis XY, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is polysaccharide Tremella fuciformis; Antioxidant activity; Fermentation optimization; Structure characterization; Tremella fuciformis polysaccharide.

Tremella fuciformis polysaccharide (TFP) is an important bioactive substance in Tremella, that contributes to its use as medicine and food. In this study, a novel fungus Tremella fuciformis XY was isolated and introduced to produce macromol. polysaccharides (TFPB). The fermentation conditions were optimized and results demonstrates that the initial pH, optimal temperature and liquid volume were 6.0, 26°C and 80 mL in a 500 mL flask, resp. The maximum yield of TFPB was 9.05 ± 0.05 g/L, which is 59.05% higher than the basic yield (5.69 ± 0.02 g/L). The TFPB, purified by DEAE column, had a mol. weight (Mw) of 1.14 × 103 kDa and consisted mainly of mannose, glucuronic acid, glucose, galactose, xylose, and rhamnose at a molar ratio of 3.5:1.2:2:1.6:1.4:3. The structure of TFPB was preliminarily investigated by methylation anal., IR spectroscopy, and NMR anal. The main linkage types were identified as 1,4-xylp, 1,4-manp, 1-xylp, 1-manp, 1,4-glcp, and 1,3,4-galp. Moreover, the antioxidant assays showed that TFPB could scavenge reactive oxygen species and hydroxyl radicals.

International Journal of Biological Macromolecules published new progress about Growth, microbial. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bober, Josef R. published the artcileGalactose to tagatose isomerization at moderate temperatures with high conversion and productivity, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Lactobacillus sakei arabinose isomerase galactose tagatose.

There are many industrially-relevant enzymes that while active, are severely limited by thermodn., kinetic, or stability issues (isomerases, lyases, transglycosidases). In this work, we study Lactobacillus sakei L-arabinose isomerase (LsLAI) for D-galactose to D-tagatose isomerization-that is limited by all three reaction parameters. The enzyme demonstrates low catalytic efficiency, low thermostability at temperatures > 40°C, and equilibrium conversion < 50%. After exploring several strategies to overcome these limitations, we show that encapsulating LsLAI in gram-pos. Lactobacillus plantarum that is chem. permeabilized enables reactions at high rates, high conversions, and elevated temperatures In a batch process, this system enables ∼ 50% conversion in 4 h starting with 300 mM galactose (an average productivity of 37 mM h-1), and 85% conversion in 48 h. We suggest that such an approach may be invaluable for other enzymic processes that are similarly kinetically-, thermodynamically-, and/or stability-limited. Nature Communications published new progress about Growth, microbial. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Di Martino, Catello published the artcileEffect of exogenous proline on the ethanolic tolerance and malolactic performance of Oenococcus oeni, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is Oenococcus proline ethanolic tolerance malolactic performance; Ethanol tolerance; Lactic acid bacteria; Malolactic fermentation; l-proline.

Abstract: The use of malolactic starter cultures, often offer no guarantee of microbiol. success due to the chem. and phys. factors (pH, ethanol, SO2, nutrient availability) that occur during the winemaking process. This study was born with the aim of improving the performance of the lactic acid bacteria used as a starter culture in the de-acidification of wines. Two com. strains of Oenococcus oeni, were used. Was evaluated the effect of exogenous L-proline added during the bacterial growth, on the improvement of their survival in the presence of different ethanol concentrations and their ability to degrade L-malic acid in synthetic wine with the presence of 12% (volume/volume) and 13% (volume/volume) of ethanol. The results showed that L-proline improve ethanol tolerance and so the malolactic performances of O. oeni. This work represents an important strategy to ensure good vitality and improve the performance of the malolactic starter.

Journal of Food Science and Technology (New Delhi, India) published new progress about Growth, microbial. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Seong, Yeong-Je published the artcilePhysiological and Metabolomic Analysis of Issatchenkia orientalis MTY1 With Multiple Tolerance for Cellulosic Bioethanol Production, Related Products of alcohols-buliding-blocks, the main research area is Issatchenkia orientalis Cellulosic Bioethanol fermentation; Issatchenkia orientalis; bioethanol; fermentation; metabolomics; multiple tolerance.

Yeast with multiple tolerance onto harsh conditions has a number of advantages for bioethanol production In this study, an alc. yeast of Issatchenkia orientalis MTY1 is isolated in a Korean winery and its multiple tolerance against high temperature and acidic conditions is characterized in microaerobic batch cultures and by metabolomic anal. In a series of batch cultures using 100 g L-1 glucose, I. orientalis MTY1 possesses wider growth ranges at pH 2-8 and 30-45°C than a conventional yeast of Saccharomyces cerevisiae D452-2. Moreover, I. orientalis MTY1 showes higher cell growth and ethanol productivity in the presence of acetic acid or furfural than S. cerevisiae D452-2. I. orientalis MTY1 produces 41.4 g L-1 ethanol with 1.5 g L-1 h-1 productivity at 42°C and pH 4.2 in the presence of 4 g L-1 acetic acid, whereas a thermo-tolerant yeast of Kluyvermyces marxianus ATCC36907 does not grow. By metabolomics by GC-TOF MS and statistical anal. of 125 metabolite peaks, it is revealed that the thermo-tolerance of I. orientalis MTY1 might be ascribed to higher contents of unsaturated fatty acids, purines and pyrimidines than S. cerevisiae D452-2. Conclusively, I. orientalis MTY1 could be a potent workhorse with multiple tolerance against harsh conditions considered in cellulosic bioethanol production

Biotechnology Journal published new progress about Growth, microbial. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Scettri, Anna published the artcileQuantification of polyols in sugar-free foodstuffs by qNMR, Computed Properties of 64519-82-0, the main research area is polyol quantification sugar free foodstuff NMR; Polyols; Sugar alcohols; Sugar-free foodstuff; qNMR.

We present a qNMR method for the determination of low calories sweeteners (erythritol, mannitol, maltitol, sorbitol, isomalt and xylitol) in sugar-free foodstuff. The structural similarities of these compounds determine often a severe spectral overlap that hampers their quantification via conventional 1D and 2D NMR spectra. This problem is here overcome by exploiting the resolving capabilities of the CSSF-TOCSY experiment, allowing the quantification of all six polyols, with satisfactory results in terms of LoQ (2.8-7.4 mg/L for xylitol, mannitol, sorbitol, 15 mg/L for erythritol, 38 mg/L for maltitol and 91 mg/L for isomalt), precision (RSD% 0.40-4.03), trueness (bias% 0.15-4.81), and recovery (98-104%). Polyols quantification in different sugar-free confectionary products was performed after a simple water extraction without any addnl. sample treatment. While these results demonstrate the robustness of the proposed method for polyols quantification in low calories foods, its applicability can be further extended to other food matrixes or biofluids.

Food Chemistry published new progress about Food (sugar free). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Computed Properties of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Yajuan published the artcileNorm index for predicting the rate constants of organic contaminants oxygenated with sulfate radical, Name: 3-Pentanol, the main research area is surface water sulfate radical organic contaminant oxygenation rate modeling; Norm index; Organic contaminants; QSPR; Second-order rate constants; Sulfate radical.

The degradation of organic contaminants in aquatic systems has raised immense attention worldwide, and the second-order rate constant (kSO.-4) of water pollutants oxidized by sulfate radical anion is an important index for assessing the degradation efficiency of organics Herein, a new norm math. formula is defined. Based on this, four new descriptors are proposed and a QSPR model is developed for predicting kSO.-4 using 30 families of emerging organic pollutants in water. The statistical results fully prove that this model has good fitting effect and stability with R2 of 0.8862, Q2LOO of 0.8466, and Q25-fold of 0.8329, resp. The validation results including cross validation, applicability domain anal., and model comparison show that this model has good robustness, predictive performance, and reliability. These decent results indicate that the new norm math. formula is effective in calculating descriptors and the norm indexes have a great application for evaluating the transformation fate of organic pollutants by sulfate radical in aquatic systems.

Environmental Science and Pollution Research published new progress about Electronegativity. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Name: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts