Month: December 2022

Ponce, Nora M. A. published the artcileFucoidans from the phaeophyta Scytosiphon lomentaria: Chemical analysis and antiviral activity of the galactofucan component, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Scytosiphon fucoidan galactofucan antiviral; Antiviral; Brown seaweeds; Fucoidans; Galactofucans; Scytosiphon lomentaria.

The brown seaweed Scytosiphon lomentaria produces moderate amounts of fucoidans. By cetrimide fractionation, typical heavily sulfated galactofucans are obtained, with no major signs of chem. heterogeneity, together with fractions with higher proportions of xylose, mannose and uronic acids. Anyway, fucose is the most important monosaccharide in most of the subfractions of the subsequent extracts The fucan moieties appear to be mostly as 3-linked α-L-fucopyranosyl units, with several patterns of sulfate and branching. Galactose is mostly 6-linked, whereas mannose appears to be 2-linked, and xylose appears mostly as terminal stubs. Small amounts of 2-O-acetylated fucose units appear. A high and selective antiviral activity against HSV-1 and HSV-2 was determined for the galactofucan fractions whereas the uronofucoidans were inactive.

Carbohydrate Research published new progress about Antiviral agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sokolova, Anastasiya S. published the artcileMonoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process, Computed Properties of 124-76-5, the main research area is preparation monoterpenoid filovirus entry inhibitor glycoprotein structure; Borneol; Camphor; Ebola virus; Glycoprotein; Marburg virus; Mutagenesis study.

In this study, we screened a large library of (+)-camphor and (-)-borneol derivatives to assess their filovirus entry inhibition activities using pseudotype systems. Structure-activity relationship studies revealed several compounds exhibiting submicromolar IC50 values. These compounds were evaluated for their effect against natural Ebola virus (EBOV) and Marburg virus. Compound 3b (As-358) exhibited the good antiviral potency (IC50 = 3.7 μM, SI = 118) against Marburg virus, while the hydrochloride salt of this compound 3b·HCl had a strong inhibitory effect against Ebola virus (IC50 = 9.1 μM, SI = 31) and good in vivo safety (LD50 > 1000 mg/kg). The results of mol. docking and in vitro mutagenesis analyses suggest that the synthesized compounds bind to the active binding site of EBOV glycoprotein similar to the known inhibitor toremifene.

European Journal of Medicinal Chemistry published new progress about Antiviral agents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Yuqing published the artcileAntioxidant and immunomodulatory activities of polysaccharides from the rhizome of Dryopteris crassirhizoma Nakai, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Dryopteris rhizome polysaccharide antioxidant immunomodulation antiviral; Antioxidant activity; Dryopteris crassirhizoma Nakai polysaccharides; Immunomodulatory activity.

Rhizome of the fern Dryopteris crassirhizoma Nakai is used as an antiviral drug in China. The objective was to characterize physicochem. properties, structural features and antioxidant and immunol. activities of D. crassirhizoma polysaccharides. An acidic polysaccharide fraction (DCP-3) was obtained from Dryopteris crassirhizoma Nakai by purification with DEAE-52 and Sephadex G-100. DCP-3 was a novel triple-helical polysaccharide with an average MW of 273.2 kDa. This fraction was mainly composed of galactose (36.65%), xylose (34.75%), arabinose (17.07%) and mannose (9.22%). DCP-3 had strong activity for scavenging DPPH radical (IC50: 2.04 mg/mL), hydroxyl radical (IC50: 1.70 mg/mL), and superoxide anions (IC50: 4.20 mg/mL) and also was capable of reducing ferric ions. In addition, nitric oxide production was enhanced in RAW264.7 macrophages stimulated by DCP-3. Based on these bioactivities, we inferred that DCP-3 was a functional component of D. crassirhizoma and may confer antivirus activity, with potential applications in functional food and drug industries.

International Journal of Biological Macromolecules published new progress about Antiviral agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Smither, Sophie J. published the artcileInvestigative study into whether an insect repellent has virucidal activity against SARS-CoV-2, SDS of cas: 42822-86-6, the main research area is COVID SARSCoV Mosi guard natural insect repellent virucidal activity; Citriodiol; SARS-CoV-2; anti-viral activity; insect repellent; skin.

A small-scale study with Mosi-guard Natural spray, an insect repellent containing Citriodiol, was performed to determine if it has virucidal activity against SARS-CoV-2. A liquid test examined the activity of the insect repellent and the individual components for virucidal activity. A surface contact test looked at the activity of the insect repellent when impregnated on a latex surface as a synthetic skin for potential topical prophylactic application. Both Mosi-guard Natural spray and Citriodiol, as well as other components of the repellent, had virucidal activity in the liquid contact test. On a latex surface used to simulate treated skin, the titer of SARS-CoV-2 was less over time on the Mosi-guard Natural-treated surface but virus was still recovered.

Journal of General Virology published new progress about Antiviral agents. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, SDS of cas: 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Jinhe published the artcileMolecular design, synthesis, and biological evaluation of bisamide derivatives as cyclophilin A inhibitors for HCV treatment, Recommanded Product: 2,2-Dimethoxyethanamine, the main research area is bisamide preparation mol design docking SAR antiviral human; Bisamide; Cyclophilin A inhibitor; Hepatitis C virus; Molecular modeling; Ugi reaction.

Hepatitis C virus (HCV) is a major cause of end-stage liver diseases. Direct-acting antivirals including inhibitors of nonstructural proteins (NS3/4A protease, NS5A, and NS5B polymerase), represent key components of anti-HCV treatment. Previous reports have shown that bisamides could be a novel class of cyclophilin A (CypA) inhibitors for treating HCV as a member of combinational therapies. To fully elucidate SARs of bisamide derivatives and find a better hit compound with diverse binding modes, sixteen bisamides I (R1 = Cy, t-Bu; R2 = C6H5, 3,4-MeO2C6H3, 3,4,5-MeO3C6H2, 2,3,4-MeO3C6H2; R3 = C6H5, 4-MeOC6H4, 4-BrC6H4, etc.; R4 = indol-2-yl, 1-(4-methoxybenzyl)-1H-indol-3-ylmethyl, 1H-indol-3-ylmethyl) were designed with the help of docking program. They were then synthesized using one-pot four-component Ugi reaction. Compound I (R1 = Cy; R2 = 3,4,5-MeO3C6H2; R3 = (3,4-dimethoxyphenyl)ethyl; R4 = 1H-indol-3-ylmethyl) with selectivity index of more than 18.9 (50% effective concentration of 5.3μM, but no cytotoxicity at 100μM) and unique binding mode that could be dived into gatekeeper pocket was selected as a new hit compound Surface plasmon resonance experiments revealed that the above compound is able to bind to CypA with a KD of 3.66μM. Taken together, these results suggest that the above compound as a CypA inhibitor could be used as an alternative anti-HCV agent in combinational therapy in the future.

European Journal of Medicinal Chemistry published new progress about Antiviral agents. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Recommanded Product: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kiiski, Iiro published the artcileThe material-enabled oxygen control in thiol-ene microfluidic channels and its feasibility for subcellular drug metabolism assays under hypoxia in vitro, Formula: C17H28O8S4, the main research area is thiolene microfluidic channel subcellular drug metabolism hypoxia oxygen control.

Tissue oxygen levels are known to be critical to regulation of many cellular processes, including the hepatic metabolism of therapeutic drugs, but its impact is often ignored in in vitro assays. In this study, the material-induced oxygen scavenging property of off-stoichiometric thiol-enes (OSTE) was exploited to create physiol. relevant oxygen concentrations in microfluidic immobilized enzyme reactors (IMERs) incorporating human liver microsomes. This could facilitate rapid screening of, for instance, toxic drug metabolites possibly produced in hypoxic conditions typical for many liver injuries. The mechanism of OSTE-induced oxygen scavenging was examined in depth to enable precise adjustment of the on-chip oxygen concentration with the help of microfluidic flow. The oxygen scavenging rate of OSTE was shown to depend on the type and the amount of the thiol monomer used in the bulk composition, and the surface-to-volume ratio of the chip design, but not on the phys. or mech. properties of the bulk. Our data suggest that oxygen scavenging takes place at the polymer-liquid interface, likely via oxidative reactions of the excess thiol monomers released from the bulk with mol. oxygen. Based on the kinetic constants governing the oxygen scavenging rate in OSTE microchannels, a microfluidic device comprising monolithically integrated oxygen depletion and IMER units was designed and its performance validated with the help of oxygen-dependent metabolism of an antiretroviral drug, zidovudine, which yields a cytotoxic metabolite under hypoxic conditions.

Lab on a Chip published new progress about Antiviral agents. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Formula: C17H28O8S4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhimaneni, SaiPriyanka published the artcileAbscisic acid and aloe-emodin against NS2B-NS3A protease of Japanese encephalitis virus, Recommanded Product: n-Octanol, the main research area is Japanese encephalitis virus protease abscisic acid aloe emodin; Molecular docking studies; Molecular dynamics simulations; NS2B-NS3A protease; Pharmacokinetics prediction; Target specific assay.

There are no specific drugs for the treatment of Japanese Encephalitis. Thus, new chem. entities or exploration of existing mols. is required. We have tested the antiviral potential of abscisic acid and aloe-emodin against protease of the Japanese encephalitis virus (JEV) using the computational and target-based assay. Maestro Schrodinger glide suite 2019 was used for mol. docking and dynamic studies, and NS2B-NS3A JEV protease kit was used to confirm protease inhibitory activity of abscisic acid and aloe-emodin. The abscisic acid and aloe-emodin have shown optimum binding affinity towards NS2B-NS3A protease of JEV. Furthermore, mol. dynamic simulation results have also shown the stability of abscisic acid and aloe-emodin within the binding pocket of NS2B-NS3A protease. The ADME parameters of both compounds were also found in an acceptable range. The IC50 values were found to be 100μg/mL and 7.3μg/mL for abscisic acid and aloe-emodin resp. which indicate more potency of aloe-emodin over the abscisic acid. However, the toxicity prediction results have shown a good safety profile of abscisic acid as compared to aloe-emodin. Thus, further, more detailed exptl. studies are required to develop abscisic acid and aloe-emodin as a specific protease inhibitor of JEV.

Environmental Science and Pollution Research published new progress about Antiviral agents. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hamdi, Assia published the artcileCytotoxicity and Antiviral Activities of Haplophyllum tuberculatum Essential Oils, Pure Compounds, and Their Combinations against Coxsackievirus B3 and B4 #, SDS of cas: 111-87-5, the main research area is Haplophyllum tuberculatum essential oil cytotoxicity antiviral coxsackievirus.

Haplophyllum tuberculatumis a plant commonly used in folk medicine to treat several diseases including vomiting, nausea, infections, rheumatism, and gastric pains. In the current study, H. tuberculatumessential oils, hydrosols, the pure compounds R-(+)-limonene, S-(-)-limonene, and 1-octanol, as well as their combinations R-(+)-limonene/1-octanol and S-(-)-limonene/1-octanol, were screened for their cytotoxicity on HEp-2 cells after 24, 48, and 72 h, and then tested for their activity against Coxsackievirus B3 and B4 (CV-B3 and CV-B4) at 3 different moments: addition of the plant compounds before, after, or together with virus inoculation. Results showed that the samples were more cytotoxic after 72 h than after 24 h or 48 h cell contact. However, the combinations R-(+)-limonene/1-octanol and S-(-)-limonene/1-octanol showed less effect on HEp-2 cells than pure R-(+)-limonene and S-(-)-limonene after 24 h, 48 h, and 72 h. 1-octanol exhibited the highest concentration causing 50% cytotoxicity (CC50) on HEp-2 cells after 24 h (CC50 = 93 μg/mL) and 48 h (CC50 = 83 μg/mL). The antiviral assays showed that the tested samples exhibited potent inhibition of CV-B. IC 50values ranged from 0.66 μg/mL to 28.4 μg/mL. In addition, CV-B3 was more sensitive than CV-B4. Both CV-B strains are more inhibited when cells were pretreated with the plant compounds The hydrosols have no effect, neither on HEp-2 cells nor on the virus. 1-octanol, S-(-), and R-(+)-limonene/1-octanol had important selectivity indexes over time. Although essential oils had potent antiviral activity, they can be considered for application in the pretreatment of cells. However, 1-octanol and the combinations are within the safety limits, and thus, they can be used as an active natural antiviral agent for CV-B3 and CV-B4 inhibition.

Planta Medica published new progress about Antiviral agents. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Yi-yong published the artcileOptimization of microwave assisted extraction, chemical characterization and antitumor activities of polysaccharides from porphyra haitanensis, SDS of cas: 59-23-4, the main research area is microwave extraction antitumor polysaccharide porphyra; Antitumor; Chemical characterization; Microwave assisted extraction; Polysaccharides; Porphyra haitanensis.

Microwave assisted extraction (MAE) technol. was used to extract polysaccharides from Porphyra Haitanensis (PHP) with water. Polysaccharide yield was used as index to evaluate the extraction process. Effects of ratio of water to raw material (X1), microwave power (X2) and extraction time (X3) on polysaccharide yield were investigated. Based on single factor experiment, MAE process of PHP was optimized using response surface methodol. Chem. characterization of PHP was investigated based on anal. of chem. compositions, monosaccharide and thermal gravimetric. The antitumor activities of PHP in vivo and in vitro were evaluated. The results indicated that the optimal conditions for MAE of PHP were ratio of water to raw material 28.98(mL/g), microwave power 77.84 W and extraction time 14.14 min. MAE was a suitable and efficient technique for PHP extraction compared with traditional hot water extraction Anal. of chem. characterization showed that PHP contained 75.36 ± 1.48% of total carbohydrates, 24.63 ± 1.69% of uronic acid residue and no proteins with monosaccharides such as rhamnose, arabinose, xylose, mannose, glucose, and galactose in a molar ratio of 10.25:9.38:1:12.45:9.9:11.55. Thermal gravimetric anal. suggested that PHP was relatively stable below 170°C. PHP had obvious effect on inhibiting proliferation, inducing apoptosis of SGC-7901 tumor cells in vitro and antitumor effect on SGC-7901 tumor-bearing mice in vivo. The results suggested that PHP had the potential for clin. use in cancer prevention and treatment.

Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oliveira, Ruberney S. published the artcileStructure elucidation of a bioactive fucomannogalactan from the edible mushroom Hypsizygus marmoreus, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is fucomannogalactan mushroom Hypsizygus structure antitumor; Antimelanoma; B16-F10 cell; Chemical structure; Fucomannogalactan; Hypsizygus marmoreus; Mushroom.

A fucomannogalactan (FMG-Hm), with a mol. weight of 17.1 kDa, obtained from fruiting bodies of Hypsizygus marmoreus exhibited promising in vitro antimelanoma effects. FMG-Hm was not cytotoxic, nor did it alter the cell morphol. and proliferation, but was able to inhibit colony-forming ability and cell migration in B16-F10 murine melanoma cells. An anal. of the monosaccharide composition indicated that FMG-Hm was composed of fucose, mannose, and galactose in a ratio of 1.00:1.08:3.17. The FMG-Hm was structurally characterized based on methylation anal., partial acid hydrolysis, and NMR experiments The results indicated that FMG-Hm contained a α-(1→6)-linked galactopyranosyl main chain, partially substituted at O-2 by non-reducing ends of α-L-fucopyranose and β-D-mannopyranose. The predicted structure of the heteropolysaccharide was established.

Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts