Month: December 2022

Pan, Kai published the artcilePhoto-Cross-Linked Polycarbonate Coating with Surface-Erosion Behavior for Corrosion Resistance and Cytocompatibility Enhancement of Magnesium Alloy, Synthetic Route of 7575-23-7, the main research area is magnesium alloy photocrosslinking polycarbonate coating corrosion resistance; corrosion resistance; cytocompatibility; magnesium alloy; surface-eroding coating; thiol−ene photo-cross-linking.

Absorbable magnesium (Mg) materials are promising for medical implant applications. However, their corrosion rate and potential toxicity remain a challenge. Herein, a photo-cross-linked coating with suitable durability and unique surface-eroding behavior for enhancement of anticorrosion property and cytocompatibility of AZ31 Mg alloy was developed. The biodegradable allyl-functional polycarbonate, poly[(5-methyl-5-allyloxycarbonyl-1,3-propanediol carbonate)-co-(trimethylene carbonate)] [P(MAC-co-TMC), PMT], was first synthesized by ring-opening copolymerization The PMT copolymer, pentaerythritol tetrakis(3-mercaptopropionate), and a photoinitiator were then applied on AZ31 Mg alloy by dip coating, and these films were cross-linked via the subsequent photoinitiated thiol-ene click reaction. The poly(L-lactide) (PLLA) and poly(1,3-trimethylene carbonate) (PTMC) coatings without crosslinking were prepared and used as control. Our results show that the cross-linked PMT coatings exhibited superior mech. properties compared with PLLA and PTMC coatings. Meanwhile, the surface-erosion behavior of the cross-linked PMT coatings remained, as confirmed by SEM anal. As a result, the cross-linked PMT-coated Mg alloy showed lower corrosion rates, better in vitro corrosion resistance, and much lower cytotoxicity, compared with bare Mg and ones coated with PLLA and PTMC coatings. Results indicate that the cross-linked PMT coatings with unique surface-erosion behavior and good cytocompatibility might be promising to improve the safety and success rate of Mg-based devices and implants.

ACS Applied Bio Materials published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Synthetic Route of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tao, Yangchun published the artcilePseudo target release behavior of simvastatin through pH-responsive polymer based on dynamic imine bonds: Promotes rapid proliferation of osteoblasts, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is simvastatin release polymer pH osteoblast cell proliferation; Controlled release; Simvastatin; Stimuli-responsive polymer; pH-responsive polymer.

In this article, a simvastatin loaded pentaerythritol tetra(3-mercaptopropionate)-allylurea-poly(ethylene glycol) (SIM-loaded PETMP-AU-PEG) polymer with excellent biocompatibility by means of in-situ loading method was synthesized. The presence of the imine bonds has given the polymer system an excellent response performance to weak acidic environment. Specifically, for the SIM-loaded polymer, the simvastatin cumulative release dose is only 2.2% in the first 2 h, and the first 32 h of the cumulative release dose is less than 10% in pH 7.4; However, in pH 6.0, the first 2 h of the cumulative release dose is 65.2%, and the first 32 h of the cumulative release dose is almost 100%. MC3T3-E1 osteoblast cell culture experiments show that the SIM-loaded polymer at pH 6.0 can accelerate the proliferation of osteoblasts significantly, which is expected to promote the rapid proliferation of bone cells in clin. applications and accelerate the healing of the lesion region.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dehghan, Mohamed Hassan G. published the artcileAssessment of Isomalt for Colon-Specific Delivery and Its Comparison with Lactulose, Related Products of alcohols-buliding-blocks, the main research area is isomalt colon drug delivery system amino salicylic acid bioavailability.

Lactulose is used as a triggering substance in a unique colon-specific delivery technol. called CODESTM. Colonic microflora degrades lactulose and forms short-chain fatty acids to activate the CODESTM system. However, lactulose has been reported to cause a Maillard-type reaction with substances containing primary or secondary amino groups that may produce carcinogenic compounds Thus, the aim of this study was to look into the possibility to substitute lactulose with isomalt for fabrication of CODESTM. The in vitro degradation of both sugars before incorporating them into the CODESTM system was evaluated with the help of rat caecal microflora. The results showed that isomalt was less efficient with regard to its rate and extent of degradation into short-chain fatty acids by the microflora compared to lactulose. However, the in vitro dissolution study did not show a significant difference in the performance between lactulose and isomalt when they were incorporated sep. in CODESTM. A similar result was also obtained in the in vivo study. Based on the above results, isomalt could be used as an alternative to lactulose for colonic delivery system utilizing the principles of CODESTM.

AAPS PharmSciTech published new progress about Biocompatibility. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Chang published the artcileGlucose and H2O2 dual-sensitive nanogels for enhanced glucose-responsive insulin delivery, Application In Synthesis of 7575-23-7, the main research area is diabetes glucose hydrogen peroxide nanogel insulin delivery polyethylene glycol.

Diabetes is a chronic metabolic disorder disease characterized by high blood glucose levels and has become one of the most serious threats to human health. In recent decades, a number of insulin delivery systems, including bulk gels, nanogels, and polymeric micelles, have been developed for the treatment of diabetes. Herein, a kind of glucose and H2O2 dual-responsive polymeric nanogel was designed for enhanced glucose-responsive insulin delivery. The polymeric nanogels composed of poly(ethylene glycol) and poly(cyclic phenylboronic ester) (glucose and H2O2 dual-sensitive groups) were synthesized by a one-pot thiol-ene click chem. approach. The nanogels displayed glucose-responsive release of insulin and the release rate could be promoted by the incorporation of glucose oxidase (GOx), which generated H2O2 at high glucose levels and H2O2 further oxidizes and hydrolyzes the phenylboronic ester group. The nanogels have characteristics of long blood circulation time, a fast response to glucose, and excellent biocompatibility. Moreover, s.c. delivery of insulin to diabetic mice with the insulin/GOx-loaded nanogels presented an effective hypoglycemic effect compared to that of injection of insulin or insulin-loaded nanogels. This kind of nanogel would be a promising candidate for the delivery of insulin in the future.

Nanoscale published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qiu, Yaxin published the artcileSelectively Sensing Capacities of Biocompatible Shape Memory Materials Based on Cross-Linked Poly(L-malic acid): Visual Discrimination of the Solvents with Similar Structures, HPLC of Formula: 97-67-6, the main research area is sensor biocompatibility shape memory crosslinking polymalic acid solvent discrimination.

A biomass-derived and biocompatible poly(L-malic acid) (PMA) based material with shape memory effect (SME) was developed in this work. 1,8-Octanediol was used as the crosslinker to construct crosslinking networks with hydrophilic backbone chain of PMA, tuning the d. of networks and their swelling capacities by controlling -COOH/-OH ratios. The solvent-induced SME of as-obtained crosslinked PMAs was activated under mild conditions in this way. Using the shape recovery levels of U-shaped samples as the probes, the mixed methanol/ethanol/water systems with various ratios could be easily discriminated because the crosslinked PMAs show different sensing capacities to different components. The mechanisms were then studied in terms of the solvent mol.-polymer interactions. This work provides an interesting approach of visible discrimination of the solvents with similar structures, or their mixtures with various ratios, and also opens applications of biocompatible shape memory polymers in biomedical and chem. industries.

ACS Applied Polymer Materials published new progress about Biocompatibility. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, HPLC of Formula: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gray, Geoffrey M. published the artcileSecondary structure of peptides mimicking the Gly-rich regions of major ampullate spidroin protein 1 and 2, Synthetic Route of 111-87-5, the main research area is spider silk dope secondary structure helix simulation; 3(1)-helices; Dope; Secondary structure; Simulation; Spider silk.

Spider dragline silk has highly desirable material properties, possessing high extensibility, strength, and biocompatibility. Before it is spun, the constituent proteins are stored in a concentrated dope that is void of fibrils. To investigate the structural properties of the amorphous fiber regions in the dope, computer simulations were performed on model peptides representing the N. clavipes Gly-rich regions. Anal. of the secondary structure found predominantly turns, bends and coils; a small 31-helical population decreased with increasing concentration Interestingly, the population of 31-helixes saw a large increase in octanol. These results indicate that the unusual 31-helical secondary structure of the Gly-rich region of the fiber is a consequence of the spinning process, and that the low dielec. environment of the fiber may assist in favoring this structure.

Biophysical Chemistry published new progress about Biocompatibility. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Elkassih, Sussana A. published the artcileDegradable redox-responsive disulfide-based nanogel drug carriers via dithiol oxidation polymerization, SDS of cas: 7575-23-7, the main research area is drug carrier nanogel oxidative radical polymerization.

Stimuli-responsive nanogels are important drug and gene carriers that mediate the controlled release of therapeutic mols. Herein, we report the synthesis of fully degradable disulfide cross-linked nanogel drug carriers formed by oxidative radical polymerization of 2,2′-(ethylenedioxy)diethanethiol (EDDET) as a monomer with different cross-linkers, including pentaerythritol tetramercaptoacetate (PETMA). Because the poly(EDDET) backbone repeat structure and crosslinking junctions are composed entirely of disulfide bonds, these nanogels specifically degrade to small mol. dithiols intracellularly in response to the reducing agent glutathione present inside of cells. Cross-linked nanogels were synthesized using controlled microfluidic mixing in the presence of a nonionic Pluronic surfactant PLU-127 to increase the nanogel stability. Adjusting the monomer to cross-linker ratio from 5 : 1 to 100 : 1 (mol/mol) tuned the crosslinking d., resulting in swelling ratios from 1.65 to >3. Increasing the amount of stabilizing Pluronic surfactant resulted in a decrease of nanogel diameter, as expected due to increased surface area of the resulting nanogels. The monomer to cross-linker ratio in the feed had no effect on the formed nanogel diameter, providing a way to control crosslinking d. with constant nanogel size but tunable drug release kinetics. Nanogels exhibited an entrapment efficiency of up to 75% for loading of Rhodamine B dye. In vitro studies showed low cytotoxicity, quick uptake, and fast degradation kinetics. Due to the ease of synthesis, rapid gelation times, and tunable functionality, these non-toxic and fully degradable nanogels offer potential for use in a variety of drug delivery applications.

Biomaterials Science published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, SDS of cas: 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Xiaorong published the artcileThiol-branched graphene oxide and polydopamine-induced nanofibrillated cellulose to strengthen protein-based nanocomposite films, Application In Synthesis of 7575-23-7, the main research area is thiol graphene oxide polydopamine nanofibrillated cellulose strengthen protein.

Soy protein isolate (SPI)-based composite materials possess a variety of excellent properties including biodegradability, biocompatibility, low cost, and easy availability, which have great potential for replacing petroleum-based materials. However, the inferior mech. properties and high moisture sensitivity severely restrict their practical applications. In this study, novel integrated ternary hybrid nanocomposite films with multiple network structures were fabricated through introducing functionalized building blocks [graphene oxide (GO) sheets and nanofibrillated cellulose (NFC)] in a SPI matrix, in which, the interface interactions and building blocks worked synergistically to result in excellent integrated mech. properties. First, the functionalized GO (SGO) sheets were successfully prepared via the thiol-ene click reaction with four-armed HS-terminated compound pentaerythritol tetra (3-mercaptopropionate) (PETMP) and were thus covalently cross-linked with catechol moieties of polydopamine layers on NFC (PNFC) by the Michael addition reaction. Then, the catechol moieties of PNFC covalently cross-linked to form the other crosslinked network with amino-containing SPI chains through Michael addition and/or Schiff base reactions. Moreover, H-bonding and π-π interactions also formed in such cross-linked networks. The resultant ternary SPI/SGO/PNFC films exhibited an optimal tensile strength of 11.10 MPa, which was nearly 2.81-fold higher than that of the neat SPI film. These films had the lowest water vapor permeability value of 3.91, which was 64.70% less than that of the neat SPI film. This work provides an effective and scalable design strategy for combining the synergistic effects of multiple building blocks and interfacial interactions and may show promise for various biomass applications.

Cellulose (Dordrecht, Netherlands) published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Feng published the artcileA comparison study of hyaluronic acid hydrogel exquisite micropatterns with photolithography and light-cured inkjet printing methods, SDS of cas: 7575-23-7, the main research area is hyaluronic acid hydrogel photolithog inkjet printing.

The microstructure design of hydrogel materials offers a broad range of practical applications and is extensively used in flexible sensors, polymer microneedles, microfluidic chips, and other biomedical engineering fields. Among the bio-sourced hydrogels, oligomeric hyaluronic acid (HA) possesses wound healing, anti-tumor, and angiogenesis properties. However, micropatterning soft hydrogels, such as HA-relative hydrogels containing 90% water by weight, continue to pose difficulties for both high precision and micro-scale lithog. The purpose of this study was to compare the photolithog. and light-cured inkjet printing methods of methacryloyl HA hydrogel (HAMA-gel) to those for synthetic light-curable polymer resins. Photolithog. and light-cured inkjet printing methods with designed scale, high resolution, and little processing times were used to effectively prepare micropatterns of HAMA-gel. The well-shaped micropatterns consisted of parallel channels in tens of micrometers and strip/grid lines in the hundreds of micrometers. Human vein endothelial cells cultured on the material′s surface demonstrated that HAMA-gel had good biocompatibility. The width of the flow channel (10 and 20 μm) was regulated on the surface of the microstructure to allow for simultaneous control of cell growth along the flow channel and groove directions.

e-Polymers published new progress about Biocompatibility. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, SDS of cas: 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dessy, V. J. published the artcileGC-MS analysis of bioactive compounds present in different extracts of rhizome of Curcuma aeruginosa Roxb., Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Curcuma rhizome bioactive compound GCMS.

To analyze and characterize the chem. composition of the different crude extracts from the rhizome of Curcuma aeruginosa Roxb a medicinal plant. The air-dried rhizomes were powd. and subjected to Soxhlet extraction using solvent n-hexane and Supercritical fluid extraction Then, each of the extracts was further subjected to gas chromatog.-mass spectrometry. Qual. determination of the different biol. active compounds from crude extracts of C aeruginosa Roxb using gas chromatog.-mass spectrometry revealed different types of high and low mol. weight chem. entities with varying quantities present in each of the extracts These chem. compounds are considered biol. and pharmacol. important. Furthermore, the two different extracts SCF and n-hexane possess unique physicochem. characteristics. The two extracts possess major bioactive compounds that were identified and characterized spectroscopically. Thus, identification of different biol. active compounds in the extracts of C aeruginosa Roxb warrants further biol. and pharmacol. studies.

Journal of Drug Delivery and Therapeutics published new progress about Bioactive agents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts