Month: December 2022

Xia, Yong-Gang published the artcileA high methyl ester pectin polysaccharide from the root bark of Aralia elata: Structural identification and biological activity, Synthetic Route of 59-23-4, the main research area is Aralia hepatocellular lung cancer root methyl ester pectin polysaccharide; Anti-tumor activity; Antioxidant activity; Aralia elata; Polysaccharides; Structural characteristics.

In this study, a high Me ester pectin polysaccharide, AER-A3 (Mw, 1.12 x 105 g/mol; O-Me ester groups (wt%), 3.81%), was isolated and purified from the root bark of Aralia elata by ion exchange and gel-filtration chromatog. Its planar structure was investigated in combination with UPLC-ESI+-MS, FT-IR, HILIC-UPLC-ESI–HCD-MS/MS, GC-MS and NMR techniques. The main chain of AER-A3 was unambiguously determined to be smooth region and hairy region with a chain length ratio of 1:1, characterized by occurrence of (1 → 2)-α-Rhap, (1 → 2,3)-α-Rhap, (1 → 2,4)-α-Rhap, (1 → 2,3,4)-α-Rhap, and (1 → 4)-α-GalpA, whereas the branched chain included T-α-Rhap, T-α-Araf, (1 → 5)-α-Araf, (1 → 3,5)-α-Araf, T-β-Galp, (1 → 3)-β-Galp, (1 → 3,4,6)-β-Galp, (1 → 4)-Glcp, (1 → 3)-Glcp, and (1 → 3)-Manp. Meanwhile, SEC-MALLS-RID, CD and Congo red assays showed that AER-A3 had no helical conformations but existed as a globular shape with branching. In addition, AER-A3 had good scavenging activities against DPPH, hydroxyl, and superoxide radicals. Anti-tumor assay investigated the effects of AER-A3 on human A549 and HepG2 cancer cell lines in vitro. These results provided a scientific basis for the use of the polysaccharides in A. elata root barks in pharmaceuticals.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hassine, Dorsaf Ben published the artcileEucalyptus brevifolia F. Muell and Eucalyptus stricklandii Maiden leaves extracts: HPLC-DAD, GC-MS analysis and in vitro biological activities, combined with the principal component analysis, Application In Synthesis of 124-76-5, the main research area is Eucalyptus brevifolia stricklandii leaf extract HPLC MS biol activitiy.

Natural products always have been relevant for the advancement of new pharmacol. products intended to prevent oxidative stress and many diseases since ancient times. Herein, the chem. composition was investigated via chromatog. anal. of varying polarity solvents (petroleum ether, Et acetate, methanol and distilled water) from Tunisian Eucalyptus brevifolia F.M and Eucalyptus stricklandii M. leaves. In vitro provision of biol. activities through their antioxidant power (ABTS.+), ability to inhibit 15-lipoxygenase (15-LOX), acetylcholinesterase (AChE), xanthine oxidase (XOD), as well as, cytotoxic potency were undertaken. Chem. profiling showed that the methanolic extracts of both species were the richest in total phenolic compounds GC-MS anal. of the two Eucalyptus species revealed that spathulenol, globulol, epiglobulol, and trans-Z-alpha-bisabolene-epoxide were the main volatile compounds detected in the different extracts In addition, the derivatization procedure allowed the identification of ethylene glycol, and D-fructofuranose as very abundant mols. The HPLC-DAD has enabled the identification of eight new mols. among them icariin (1.1 mg/g dr), and 5-hydroxy-3prime-methoxyflavone (7.5 mg/g dr) in the E. stricklandii MeOH and EtOAc extracts Aqueous E. brevifolia extract possessed the highest anti-AChE with an IC50 (10 mug/mL). Whereas, the MeOH E. stricklandii extract possessed the highest anti 15-LOX with an IC50 (9.7 mug/mL), as well as, the most important percentage of XOD inhibition 51.1%. All extracts revealed an antiproliferative potency against human cancer cell lines HCT-116, MCF-7 and OVCAR, with an inhibition percentage up to 96%. Taken together, both Eucalyptus species have a broad range of potential applications in several fields, such pharmaceutical, medical and food industries as nutraceutical supplements.

South African Journal of Botany published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application In Synthesis of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sahin Yaglioglu, Ayse published the artcileThe antiproliferative and antioxidant activities of the essential oils ofJuniperus species from Turkey, Product Details of C10H18O, the main research area is Juniperus antiproliferative antioxidant essential oil carcinoma population.

The present study aimed to determine the essential oil compositions of four different types of Juniperus species including Juniperus oxycedrus ssp oxycedrus L., Juniperus foetidissima Willd., Juniperus excelsa M. Bieb, and Juniperus communis L. with their antioxidant and antiproliferative activities. The antiproliferative activity of the essential oils was determined against HeLa (human cervix carcinoma) and C6 (rat brain tumor cell) cell lines by BrdU cell proliferation assay. The essential oils were tested for their total reducing power activity, DPPH (2,2′-diphenyl-1-picrylhydrazyl) free radical scavenging activities, and hydrogen peroxide scavenging activities. The overall results of the study showed that the needles of Juniperus species have strong antiproliferative activities as cell selective against C6 cells.

Flavour and Fragrance Journal published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Chen published the artcileOptimation for preparation of oligosaccharides from flaxseed gum and evaluation of antioxidant and antitumor activities in vitro, Application In Synthesis of 59-23-4, the main research area is flaxseed gum oligosaccharide antioxidant antitumor activity; Antioxidant activity; Antitumor activity; Flaxseed polysaccharides; Oligosaccharides preparation.

Flaxseed oligosaccharides (FGOS) were prepared by degradation of flaxseed gum (FG) using enzymic method. Factors affecting the enzymic hydrolysis of FG were investigated by single factor and orthogonal tests. In the optimum hydrolysis conditions (reaction time 12 h, temperature 50°C, pH 4.5, cellulase concentration 100 U/mL), the reducing sugar ratio and extraction yield of FGOS were 33.6 ± 0.35% and 56.8 ± 0.41%, resp. The average mol. weight of FGOS was about 1.6 kDa, which consists of mannose, galactose, glucose, arabinose, glucuronic acid, xylose, rhamnose, ribose, galacturonic acid. Fourier-transform IR spectra and NMR indicated that FG was successfully degraded to FGOS. FGOS exhibited better antioxidant activities than FG on scavenging hydroxyl, ABTS and DPPH radicals. In vitro cytotoxicities experiments reveal FGOS acquire the ability of antiproliferation against HepG2 and Hela cells in a dose-dependent manner.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Yaping published the artcileCharacterization of a polysaccharide with antioxidant and anti-cervical cancer potentials from the corn silk cultivated in Jilin province, Quality Control of 59-23-4, the main research area is corn silk polysaccharide anticervical cancer antioxidant activity; Anti-cervical cancer; Antioxidant; Characterization; Corn silk; Polysaccharides.

Corn silk polysaccharides (CSPs) were extracted from the corn silk cultivated in Jilin province, China, where is one of the golden corn belts worldwide. Three fractions (CSP-1, CSP-2 and CSP-3) were obtained by DEAE-52 cellulose and the former two fractions were further purified by Sephadex G-150 column chromatog. to obtain CSP-S-1 and CSP-S-2. The mol. weights of CSP-S-1 and CSP-S-2 were calculated to be 586 kDa and 813 kDa, resp. CSP-S-1 was composed of galactose, arabinose, xylose and rhamnose at a molar ratio of 4.16:1.00:1.01:6.32 and CSP-S-2 was composed of galactose, arabinose, glucose and rhamnose at a molar ratio of 8.71:3.58:0.169:1.00. CSP-S-2 outperformed CSP-S-1 in scavenging DPPH, ABTS and hydroxyl radicals, and significantly inhibited the proliferation of HeLa cells. IR and NMR anal. indicated that CSP-S-2 was pyranose. CSP-S-2 consisted of 1 → 4 and 1 → 6 linkages and exhibited a triple helix configuration. In summary, CSP-S-2 possesses high potential to be developed as a novel antioxidant and anti-cervical cancer agent.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Quality Control of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schiffmann, L. M. published the artcileMitochondrial respiration controls neoangiogenesis during wound healing and tumour growth, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is mitochondrial respiration neoangiogenesis wound healing lung carcinoma melanoma.

Abstract: The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here we assess the impact of mitochondrial bioenergetics on neovascularisation, by deleting cox10 gene encoding an assembly factor of cytochrome c oxidase (COX) specifically in mouse ECs, providing a model for vasculature-restricted respiratory deficiency. We show that EC-specific cox10 ablation results in deficient vascular development causing embryonic lethality. In adult mice induction of EC-specific cox10 gene deletion produces no overt phenotype. However, the angiogenic capacity of COX-deficient ECs is severely compromised under energetically demanding conditions, as revealed by significantly delayed wound-healing and impaired tumor growth. We provide genetic evidence for a requirement of mitochondrial respiration in vascular endothelial cells for neoangiogenesis during development, tissue repair and cancer.

Nature Communications published new progress about Angiogenesis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Ning published the artcileDesign and semisynthesis of oleanolic acid derivatives as VEGF inhibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs, Product Details of C4H11NO2, the main research area is semisynthesis oleanolic acid derivative VEGF inhibitor VEGFR2 angiogenesis; Angiogenesis; Oleanolic acid; Structural modification; VEGF inhibitor; VEGFR2.

Angiogenesis inhibitors targeting the VEGF signaling pathway are developed into drugs for the treatment of vaious diseases, such as cancer, rheumatoid arthritis, and age-related macular degeneration. Recent studies have revealed that oleanolic acid (OA), a natural pentacyclic triterpenoid, inhibited the VEGF/VEGFR2 signaling pathway and angiogenesis in HUVECs, which may represent an attractive VEGF inhibitor. In this paper, rational structural modification towards OA was performed in order to improve its inhibitory effects aganist VEGF and anti-angiogenesis potential. As a result, a series of novel OA derivatives, possessing α,β-unsaturated ketone system in ring A and amide functional group at C-28, were prepared and evaluated for cytotoxicity and their ability to inhibit VEGF-induced abnormal proliferation of HUVECs. The results showed that two promising derivatives, OA-1 and OA-16, exhibited no in vitro cytotoxicity against HUVECs but showed more potent inhibitory activity against VEGF-induced proliferation and angiogenesis in HUVECs, compared with OA. The results of Western blot indicated that OA-1 and OA-16 inhibited VEGF-induced VEGFR2 activation. Furthermore, small interfering RNA experiments were performed to confirm that both compounds inhibited VEGF-induced angiogenesis via VEGFR2. Thus, the present study resulted in the discovery of new promising OA-inspired VEGF inhibitors, which can serve as potential lead compounds for the treatment of angiogenesis-related diseases.

Chinese Journal of Natural Medicines (Amsterdam, Netherlands) published new progress about Angiogenesis. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Product Details of C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Davidov, Tzila published the artcilePorcine arterial ECM hydrogel: Designing an in vitro angiogenesis model for long-term high-throughput research, Synthetic Route of 97-67-6, the main research area is angiogenesis porcine arterial ECM hydrogel; ECM hydrogel; angiogenesis; arterial ECM; in vitro model.

The field of angiogenesis research provides deep understanding regarding this important process, which plays fundamental roles in tissue development and different abnormalities. In vitro models offer the advantages of low-cost high-throughput research of angiogenesis while sparing animal lives, and enabling the use of human cells. Nevertheless, prevailing in vitro models lack stability and are limited to a few days’ assays. This study, therefore, examines the hypothesis that closely mimicking the vascular microenvironment can more reliably support longer angiogenesis processes in vitro. To this end, porcine arterial extracellular matrix (paECM)- a key component of blood vessels-was isolated and processed into a thermally induced hydrogel and characterized in terms of composition, structure, and mech. properties, thus confirming the preservation of important characteristics of arterial extracellular matrix. This unique hydrogel was further tailored into a three-dimensional model of angiogenesis using endothelial cells and supporting cells, in a configuration that allows high-throughput quant. anal. of cell viability and proliferation, cell migration, and apoptosis, thus revealing the advantages of paECM over frequently used biomaterials. Markedly, when applied with well-known effectors of angiogenesis, the model measures reflected the expected response, hence validating its efficacy and establishing its potential as a promising tool for the research of angiogenesis.

FASEB Journal published new progress about Angiogenesis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Synthetic Route of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ranarivelo, Lalasoa R. published the artcileChemical Composition and Antimicrobial Activity of Leaf Essential Oil of Tetradenia nervosa Codd from Madagascar, Collected at Different Stages of Vegetative Growth and Age, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Tetradenia nervosa leaf essential oil chem composition antimicrobial activity.

The chem. composition and antimicrobial activities of the essential oil isolated from the leaves of Tetradenia nervosa, a medicinal shrub from Madagascar have been investigated. The essential oil from the fresh leaves was obtained using hydrodistillation in a Clevenger-type apparatus, and characterized by gas chromatog./mass spectrometry (GC/MS) and gas chromatog./flame ionization detection (GC/FID). Eighty-one components that are 93.68-98.61% of the total composition were quantified and identified. The essential oil composition was dominated by sesquiterpenes (68.69-79.87%) represented by β-Caryophyllene, Bicycloelemene, Bicyclogermacrene, (-)-Spathulenol, and Caryophyllene oxide. Monoterpenes (15.51-24.99%) were characterized by α-Pinene, β-Pinene, 1,8-Cineole, and (+)-Fenchone. β-Caryophyllene remains the major component according to vegetative growth and plant age. The essential oils of T. nervosa tested were active against 16 Gram-pos. and 2 Gram-neg. bacteria strains. The vegetative growth and the plant age did not have any influence on the antimicrobial activity.

ACS Symposium Series published new progress about Aging, plant. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kong, Qiuhong published the artcileIn vitro fermentation characteristics of polysaccharide from Sargassum fusiforme and its modulation effects on gut microbiota, Synthetic Route of 59-23-4, the main research area is polysaccharide Sargassum fusiforme fermentation gut microbiota; Fermentation; Gut microbiota; Sargassum fusiforme polysaccharide (SFP); Short chain fatty acids (SCFAs); Structural characteristics.

In this study, polysaccharides from Sargassum fusiforme (SFP) were obtained by cellulase assisted hot water extraction The chem. composition, structural characteristics, and in vitro fermentation properties of SFP were investigated. Results showed that the contents of total carbohydrate, protein, uronic acid and sulfate in SFP were 83.25%, 1.42%, 12.80% and 7.81%, resp. It mainly consisted of fucose glucose and galactose, with mol. weight of 255.83 kDa. UV spectrum, FTIR, SEM and AFM results showed that SFP was a typical sulfate polysaccharide with relative smooth surface and regular shape. After in vitro fermentation for 24 h, the pH value of fermentation medium declined significantly (p < 0.05), utilization of carbohydrate was 53.17%. The contents of total SCFAs increased by 10.77 times. Moreover, SFP fermentation could change obviously the microbiota composition It significantly increased the abundance of Faecalibacterium (increased by 49.07% compared with the Blank24 group), Phascolarctobacterium (increased by 88.06%), Bifidobacterium (increased by 139.13%), Ruminococcaceae_UCG-014 (increased by 177.78%), and Lactobacillus (increased by 400.00%), decreased the abundance of Prevotella_9 (decreased by 34.54%) and Blautia (decreased by 40.79%) at genus level. These results showed that SFP could be utilized by microbiota in human feces, and may have the potential to improve intestinal health. Food and Chemical Toxicology published new progress about Agathobacter. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts