Month: December 2022

Kiferle, Claudia published the artcileEffect of Iodine treatments on Ocimum basilicum L.: Biofortification, phenolics production and essential oil composition, Formula: C10H18O, the main research area is Ocimum iodine essential oil biofortification phenolics.

Iodine biofortification has been gaining interest in recent years as a sustainable and innovative approach to eradicate iodine deficiency disorders. Studying the impact of iodine biofortification on plant phenotype, biochem. and physiol. parameters is crucial to leverage the expertise and best practices for the agro-food industry and human health. The aim of this study was to evaluate iodine biofortification on the main quant. and qual. traits of basil (Ocimum basilicum L.) plants cultivated both in open field and in growth chamber. The impact of KI and KIO3 treatments was evaluated on biomass production, as well as on the synthesis of phenolic compounds, especially rosmarinic acid and other caffeic acid derivatives, and on the essential oil (EO) composition These compounds are typically accumulated in basil leaves and strongly contribute to the plant nutraceutical value and aroma. In open field, the use of increasing concentrations of both iodine salts gradually enhanced iodine accumulation in leaves, also determining an increase of the antioxidant power, total phenolics, rosmarinic acid and cinnamic acid accumulation. The composition of EO was only slightly affected by the treatments, as all the samples were characterized by a linalool chemotype and a minor alteration in their relative content was observed A growth chamber experiment was performed to test EO variation in controlled conditions, broadening the range of iodine concentrations In this case, plant chemotype was significantly affected by the treatments and large EO variability was observed, suggesting that iodine form and concentration can potentially influence the EO composition but that in open field this effect is overcome by environmental factors.

PLoS One published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cautela, Domenico published the artcileCharacterization of essential oil recovered from fennel horticultural wastes, Application In Synthesis of 124-76-5, the main research area is fennel horticultural waste essential oil; antioxidant activity; essential oil; fennel wastes; phytochemical recovery.

Fennel crop has been traditionally used as spice in cooking and fragrances, and in folk medicine for its spectrum of useful properties. Mediterranean is the elective natural cultivation area for this plant with Italy being a leader producer. A limit of this production is due to the high amount of wastes derived still rich of phytochems., which are usually underused. Hence, the extraction and characterization of essential oil from residues of fennel horticultural market was investigated to understand the potential profit of their recycling. Forty-eight compounds resulted for fennel oil waste, analyzed by GC-FID-MS, with the most abundant among components was anethole. Other constituents contributing to fennel flavor were the monoterpenes limonene and nerol. The exploitation of this oil as a good source of bioactive compounds was assessed by means of its antioxidant power measured with DPPH test.

Natural Product Research published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application In Synthesis of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Fan published the artcileCombined toxic effects of dioxin-like PCB77 with Fe-based nanoparticles in earthworm Eisenia fetida, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is Eisenia iron PCB77 dioxin nanoparticle toxicity; PCBs; Physiological and morphological change; Synergistic effect; Vermiremediation; nZVI.

Iron-based nanomaterials hold promise for in situ remediation of persistent halogenated contaminants such as dioxin-like polychlorinated biphenyls, however, their complex interactions and joint toxicity toward beneficial soil biol. functions remain unknown. This study examined the effects of nano-zero valent iron (nZVI) on the physiol. and morphol. changes, on the bioaccumulation of co-existed dioxin-like 3,3,4,4-tetrachloro-biphenyls (PCB77), and the joint toxicity of nZVI and PCB77 in earthworms Eisenia fetida. An orthogonally designed experiment was conducted through the exposure of E. fetida to the combined and sep. nZVI and PCB77 at various concentrations in soil for 28 days (nZVI at the levels of g-Fe/kg-soil and PCB77 at the levels of mg-PCB/kg-soil). Indicated that both nZVI and PCB77 inhibited the growth and reproduction of earthworms, and the combined exposure resulted in a synergistic effect. The addition of 10 g/kg nZVI decreased the contents of PCB77 and significantly increased the accumulation of PCB77 to a level ranging 14-97 mg/kg in earthworms in a nZVI dose dependent manner. The observed synergism might relate to the aggravated damage of earthworm epidermis in the presence of nZVI. PCB77 and nZVI at their corresponding high levels (10 mg/kg and 10 g/kg) induced oxidative stress and lipid peroxidation in the earthworms through the increased levels of reactive oxygen species and the subsequent inhibition of antioxidant enzymes including superoxide dismutase and catalase. Further metabolomics analyses revealed that the normal glutamic acid metabolism and tricarboxylic acid cycle were disturbed in earthworms exposed to the combined treatment of 10 mg/kg PCB77 and 10 g/kg nZVI. Our findings suggested that earthworms as a sentinel species could be readily employed in toxicity and tolerance studies to succeed the safe applications of nZVI and interestingly earthworms themselves also hold promise for vermiremediation owing to the high bioaccumulation potential of PCBs from contaminated soils.

Science of the Total Environment published new progress about Antioxidants. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fu, Yuan published the artcilePolysaccharides from loquat (Eriobotrya japonica) leaves: Impacts of extraction methods on their physicochemical characteristics and biological activities, Application In Synthesis of 59-23-4, the main research area is Eriobotrya polysaccharide extraction method physicochem characteristics biol activity; Bioactivity; Chemical structure; Extraction method; Loquat; Polysaccharide.

Impacts of hot water extraction (HWE), pressurized water extraction (PWE), high-speed shearing homogenization extraction, microwave assisted extraction (MAE), ultrasound assisted extraction (UAE), ultrasound assisted enzymic extraction, and ultrasound-microwave assisted extraction (UMAE) on physicochem. characteristics and bioactivities of polysaccharides from loquat (Eriobotrya japonica) leaves (LLPs) were investigated. Results showed that the degrees of esterification, contents of phenolics and uronic acids, constituent monosaccharides, apparent viscosities, and mol. weights of LLPs varied by different extraction methods. Bioactivities of LLPs were also significantly affected by different extraction methods. The high mol. weight and high degree of esterification of LLP-W and LLP-P extracted by HWE and PWE, resp., might contribute to their strong binding capacities. The strong antioxidant activities and inhibitory effects on α-amylase and α-glucosidase were found in LLP-M and LLP-U extracted by MAE and UAE, resp., which might be attributed to their contents of uronic acids, contents of total phenolics, and mol. weights The low mol. weights and viscosities of LLP-U and LLP-UM extracted by UMAE might contribute to their strong prebiotic effects. These findings could provide scientific foundations for selecting appropriate extraction methods to obtain LLPs with desired bioactivities for applications in the pharmaceutical and functional food industries.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Jian published the artcileObservation and Mitigation of Leachables from Non-Product Contact Materials in Electromechanical Delivery Devices for Biotechnology Products, SDS of cas: 124-76-5, the main research area is triethylene glycol electromech delivery device biotechnol; 2‑hydroxy‑2-methylpropiophenone; Device batteries; Electromechanical devices; Extractables; Holistic approach; Leachables.

Battery-powered drug delivery devices are widely used as primary containers for storing and delivering therapeutic protein products to improve patient compliance and quality of life. Compared to conventional delivery approaches such as pre-filled syringes, battery-powered devices are more complex in design requiring new materials/components for proper functionality, which could cause potential product safety and quality concerns from the extractable and leachables (E&L) of the new materials/components. In this study, E&L assessments were performed on a battery-powered delivery device during the development and qualification of the device, where novel compound 2-hydroxy-2-methylpropiophenone (HMPP) and related compounds were observed in both E&L. The source of the HMPP and related compounds was identified to be the nonproduct contact device batteries, in which HMPP photo-initiator was used as a curing agent in the battery sealant to prevent leakage of the battery electrolytes. Toxicol. assessment was performed, which showed the levels of HMPP observed in the device lots were acceptable relative to the permitted daily exposure. A drug product HMPP spike study was also performed, where no product impact was observed Based on these assessments, an action threshold and specification limits could be established as a control strategy, if needed, to mitigate the potential risks associate with the observed leachables. As a full resolution, seven battery candidates from different suppliers were screened and one new battery was successfully qualified for the delivery devices. Overall, the holistic E&L approach was fully successful in the development and qualification of the battery-powered devices for biotherapeutic products delivery ensuring product quality and patient safety. Non-product contact materials are commonly rated as low or no risk and typically considered as out of scope of E&L activities for delivery systems following industry benchmark and regulatory agency guidance. This case study is novel as it brings into attention the materials that might not normally be in consideration during the development process. It is highly recommended to understand materials in the context of intended use on a case-by-case basis and not to generalize to ensure successful development and qualification.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, SDS of cas: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Florez-Fernandez, Noelia published the artcileRecovery of bioactive and gelling extracts from edible brown seaweed Laminaria ochroleuca by non-isothermal autohydrolysis, Related Products of alcohols-buliding-blocks, the main research area is bioactive gelling extract Laminaria seaweed isothermal autohydrolysis; Alginate; Antioxidant; Autohydrolysis; Cytotoxicity; Fucoidan; Laminaria ochroleuca.

The non-isothermal autohydrolysis temperature impact of edible brown seaweed Laminaria ochroleuca was studied to recover high valuable compounds Extraction yield was determined, above 80% was obtained at 220 °C. The maximal fucose content (17% d.b.) was attained at 180 °C, whereas the maximal sulfate was achieved at 160 °C, and phenolic and protein content at 220 °C. The maximum sulfated fucoidan content (41.38 g fucoidan/100 g extract) was obtained at 160 °C, whereas the maximum fucose oligosaccharides was obtained at 180 °C. The antioxidant capacity was equivalent to 32 mg Trolox/g dry extract produced at 220 °C. The milder processing condition was selected to study the potentiality of the precipitated alginate in terms of viscoelastic properties determined by rheol. Alginate extraction (14.94 g/100 g extract) was determined at 160 °C. The crude fucoidan fractions were tested at 25-500 μg/mL, showed up to 50% cell growth inhibition in four selected tumoral cell lines.

Food Chemistry published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gu, Jie published the artcileProcuring biologically active galactomannans from spent coffee ground (SCG) by autohydrolysis and enzymatic hydrolysis, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is galactomannan spent coffee ground autohydrolysis enzymic hydrolysis; Autohydrolysis; Biologically active; Enzymatic hydrolysis; Galactomannan; Spent coffee grounds.

Spent coffee grounds (SCG) are a promising raw material for galactomannan (GalM) production based upon its enrichment in galactomannan polysaccharides. In this work, SCG was pretreated by autohydrolysis for maximumly improving GalM extractability by endo-mannanase. The GalM in the prehydolyzate (GalM-PH) and enzymic hydrolyzate (GalM-EH) were obtained by ethanol precipitation and characterized. Under the optimized autohydrolysis conditions, 50.1% of GalM in pretreated SCG was converted into free GalM in enzymic hydrolyzate. Compositional anal. results revealed that GalM-PH was comprised of 81.7% galactomannan, higher than that of GalM-EH (76.4%). The mol. weight of GalM-PH and GalM-EH were 44.5 kDa and 28.0 kDa, resp. Antioxidant assays indicated that both GalM-EH and GalM-PH could scavenge 2,2-diphenyl-1-picryl-hydrazyl radicals and hydroxyl radicals. Immunol. and prebiotics anal. showed all GalM preparations exhibited pronounced activities for proliferating the probiotics and proliferating the Macrophages cell for NO production, in which the GalM-EH outperformed the GalM-PH. These results imply that the GalM extracted from SCG are the bioactive substances that can be used as antioxidant, prebiotics, and immunostimulants.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Yu published the artcileCharacterization, hypolipidemic and antioxidant activities of degraded polysaccharides from Ganoderma lucidum, Computed Properties of 59-23-4, the main research area is polysaccharide ganoderma lucidum hypolipidemic antioxidant activity; Antioxidant; Degradation; Ganoderma lucidum polysaccharides; Hypolipidemic.

The aim of this work is to characterize the primary structure and physicochem. properties of natural polysaccharides (GLP) and degraded polysaccharides (GLPUD) from Ganoderma lucidum, and evaluate their hypolipidemic and antioxidant activities. The results of particle size distribution and SEM (SEM) showed that Ganoderma lucidum polysaccharides were effectively degraded by ultrasonic method. GLPUD was composed of the same monosaccharide units as GLP but with different molar ratios. IR spectra and NMR showed that the primary structure of polysaccharides had not been changed by ultrasonic degradation Meanwhile, the thermal stability of polysaccharides increased after ultrasonic treatment. After administration by GLP and GLPUD four weeks, body weight, visceral index, atherosclerosis index (AI) and biochem. indicators in serum and in liver were determined The results showed that GLPUD had stronger hypolipidemic and antioxidant activities than GLP. GLPUD was more effective than the GLP for reducing AI, total cholesterol (TC), triglycerides (TG) and low-d. lipoprotein cholesterol (LDL-C), raising high d. lipoprotein (HDL-C) (p < 0.01), reducing malondialdehyde (MDA) content, as well as increasing the glutathione peroxidase (GSH-Px) in mice serum, increasing superoxide dismutase (SOD) activity and reducing MDA content in liver (p < 0.05 or p < 0.01). In addition, the histopathol. observations of mice livers showed that GLPUD could significantly improve lipid metabolism disorder in hepatocytes. Thus, GLPUD might be tested as a more effective hypolipidemic drug. International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aldogman, Bashayr published the artcileInvestigation of Chemical Compositions and Biological Activities of Mentha suaveolens L. from Saudi Arabia, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Mentha gas chromatog mass spectrometry flame ionization detector; Mentha suaveolens L.; antifungal activity; antioxidant; carvone; rosmarinic acid.

Mentha is an aromatic plant used since antiquity for its pharmaceutical virtues. The climate of Saudi Arabia favors the growth of aromatic plants including Mentha suaveolens L. The aim of this study is to analyze the volatile oils of different parts of fresh and dried Mentha suaveolens L. grown in Saudi Arabia (Aljouf area) using Gas Chromatog./Mass Spectrometry (GC/MS) and Gas Chromatog. Flame Ionization Detector (GC/FID) techniques, to recognize the effect of drying on chem. composition, then to evaluate the antioxidant and antifungal activities of different extracts In total, 118 compounds were identified via GC/MS and GC/FID, in which carvone is the main volatile constituent (stems, leaves, whole plant 45-64%). This investigation deduces that Mentha belonged to the carvone chemotype. Then, the anal. of non-volatile constituents of fresh and dried Mentha was performed by HPLC. The main phenolic compound of fresh and dried Mentha for different parts was rosmarinic acid (ranging from 28,002.5 to 6558 μg/g). The ethanolic extract of fresh stem showed the highest antifungal activity (53% inhibition) compared with miconazole (60% inhibition) but the ethanoic extract of dry stem showed no activity. Addnl., all ethanolic extracts, whether for fresh or dry Mentha, have antioxidant activity more than 90% while the antioxidant activity of whole plant volatile oil is equal to 53.33%. This research shows that M. suaveolens L. could be applied to manufacture natural antioxidants, antifungal, and flavoring agents.

Molecules published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Qiang published the artcileAqueous enzyme-ultrasonic pretreatment for efficient isolation of essential oil from Artemisia argyi and investigation on its chemical composition and biological activity, SDS of cas: 124-76-5, the main research area is Artemisia argyi plant essential oil enzyme ultrasonic biol activity.

The in-depth study of plant essential oil (EO) to provide valuable resources for the development of natural medicinal products is one of the current research hotspots. The present work realized the efficient isolation of EO from Artemisia argyi leaves using aqueous enzyme-ultrasonic pretreatment followed by microwave-assisted hydrodistillation (EUP-MHD). Because of the synergistic reaction mechanism, the combination of enzyme and ultrasound doubly improved the separation of EO. After the optimization process (single factor experiments, Plackett-Burman design, and Box-Behnken design), mixed enzyme (cellulose + pectinase + papain), concentration of 10 U/mg, ultrasonic frequency of 45 kHz, ultrasonic power of 200 W, ultrasonic time of 20 min, reaction temperature of 50°C, pH of 5, microwave power of 650 W, microwave time of 10 min, and liquid-solid ratio of 10 mL/g performed best, with the yield of EO of 5.32 ± 0.20 mg/g. A distinct advantage of this technique was found as compared with other techniques, which highlighted the pos. influence of the pretreatment process. Addnl., the oxygenated components of EO from EUP-MHD accounted for a higher proportion than other methods, including eucalyptol, borneol, camphor, neointermedeol, and terpinen-4-ol. Finally, the evaluation of the biol. activity of A. argyi EO pointed out that the EO had excellent antioxidant activity and higher inhibitory activity against Phytophthora capsica but presented weaker cytotoxic activity. In general, the technique used in this study is promising in the field of separating EO from crop materials.

Industrial Crops and Products published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, SDS of cas: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts