Month: December 2022

Jarmuszkiewicz, Wieslawa published the artcileLung mitochondria adaptation to endurance training in rats, Name: (S)-2-hydroxysuccinic acid, the main research area is lung mitochondria endurance training oxidative metabolism hypoxia; Endurance training and mitochondrial biogenesis; Hypoxia; Lung mitochondria function; Oxidative metabolism; Oxidative stress.

We elucidated the impact of eight weeks of endurance training on the oxidative metabolism of rat lungs. Adult 3.5-mo-old male rats were randomly allocated to a treadmill training group or a sedentary group as control. In the lungs, endurance training raised the expression level of the oxygen sensors hypoxia inducible factor 1α (HIF1α) and lysine-specific demethylase 6A (KDM6A) as well as stimulated mitochondrial oxidative capacity and mitochondrial biogenesis, while lactate dehydrogenase activity was reduced. Endurance training enhanced antioxidant systems (the coenzyme Q content and superoxide dismutase) in lung tissue but decreased them (and uncoupling protein 2) in lung mitochondria. In the lung mitochondria of trained rats, the decreased Q content and Complex I (CI) activity and the enhanced cytochrome pathway activity (CIII + CIV) may account for the diminished Q reduction level, resulting in a general decrease in H2O2 formation by mitochondria. Endurance training enhanced oxidation of glutamate and fatty acids and caused opposite effects in functional mitochondrial properties during malate and succinate oxidation, which were related to reduced activity of CI and increased activity of CII, resp. In addition, endurance training downregulated CI in supercomplexes and upregulated CIII in the CIII2+CIV supercomplex in the oxidative phosphorylation system. We concluded that the adaptive lung responses observed could be due to hypoxia and oxidative stress induced by strenuous endurance training.

Free Radical Biology & Medicine published new progress about Antioxidants. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Name: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Yang published the artcileExtraction and biological activity of exopolysaccharide produced by Leuconostoc mesenteroides SN-8, COA of Formula: C6H12O6, the main research area is exopolysaccharide Leuconostoc antioxidant activity; Bioactivity; Extracellular polysaccharide; Leuconostoc mesenteroides; Structure.

An exopolysaccharide (EPS)-producing strain SN-8 isolated from Dajiang was identified as Leuconostoc mesenteroides. When sucrose was used as the carbon source for fermentation, the output of EPS was 2.42 g/L. High performance liquid chromatog. anal. confirmed the presence of monomers such as glucan and mannose. The mol. weight detection value is 2.0 x 105 Da. Fourier transform IR spectroscopy displayed the EPS had the basic skeleton and functional groups of a typical polysaccharide structure. SEM showed smooth surfaces and compact structure. Thermal performance anal. showed that the highest heat resistance temperature of the EPS was 80°C. Compared with vitamin C, its hydroxyl radical scavenging rate was as high as 32% and 1,1-diphenyl-2-picrylhydrazyl scavenging rate was as high as 40% under the same concentration The peanut oil was the most emulsifiable at a concentration of 1.5 mg/mL, and the emulsification index was 0.55. These results might show that the EPS had high application value.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tandee, Kanokwan published the artcileAntioxidant activities and volatile compounds in longan (Dimocarpus longan Lour.) wine produced by incorporating longan seeds, Synthetic Route of 505-10-2, the main research area is Dimocarpus Saccharomyces antioxidant volatile compound wine seed fermentation temperature; 2,3-Butylene glycol (PubChem CID: 262); 4-Hydroxyphenethyl alcohol (PubChem CID: 10393); 5-Hydroxymethyl-2-furaldehyde (PubChem CID: 237332); Antioxidant; Ethyl hydrogen succinate (PubChem CID: 70610); Longan wine; Phenethyl alcohol (PubChem CID: 6054); Seed; Volatile compound.

The seeds of dried longan, one of the major processed fruits in Thailand, contain several bioactive compounds In this study, we developed longan wine by incorporating its seeds during juice preparation and evaluated the antioxidant activities and volatile compounds in different conditions. The results suggested that Saccharomyces cerevisiae EC-1118 was suitable for fermentation of longan juice supplemented with 50% seed and 20% initial soluble solids at an optimal temperature of 30°C. Different yeast strains showed various extents of antioxidant activities; however, the fermentation temperature and initial soluble solids of longan juice had little effect on the inhibition of reactive species. Antioxidant activities were significantly increased with increasing seed content. Dominant volatile compounds, which were independent of the winemaking conditions, were found to be phenethyl alc., 2,3-butylene glycol, 5-hydroxymethyl-2-furaldehyde, Et hydrogen succinate, and 4-hydroxyphenethyl alc. These compounds highly influenced the antioxidant activities of longan wine produced by incorporating the seeds.

Food Chemistry published new progress about Antioxidants. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Synthetic Route of 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mohammed, Jalaleldeen Khaleel published the artcilePreparation, deproteinization, characterization, and antioxidant activity of polysaccharide from Medemia argun fruit, Application In Synthesis of 59-23-4, the main research area is Medemia fruit polysaccharide deproteinization antioxidant; Antioxidant activity; Deproteinization; Structural characterization.

In this study, the crude polysaccharide from argun palm (Medemia argun) fruit was extracted with hot water and deproteinized by four different methods. Its structure characterization, thermal property and antioxidant activity were investigated by FT-IR spectroscopy, Scanning electron microscope, Congo-red, I2-KI, DPPHâ€?assay, ABTSâ€? assay, TGA and DSC anal. It indicated that the NaCl method was the best method in deproteinization. The argun fruit polysaccharide linked by the β-glycosidic bonds. The mol. weight of polysaccharide deproteinized with NaCl was 4.46 × 105 Da. It showed that the polysaccharide from argun palm fruit consisted of fructose, arabinose, rhamnose, galactose, glucose, xylose, and galacturonic acid. The result of TGA and DSC assay indicated that argun fruit polysaccharide has a favorable thermal stability. It was proved that, the argun fruit polysaccharide possessed high antioxidant activity and would be a new natural antioxidant.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Duan, Guo-Liang published the artcileIsolation, purification, characterization, and antioxidant activity of low-molecular-weight polysaccharides from Sparassis latifolia, Computed Properties of 59-23-4, the main research area is Sparassis low mol weight polysaccharide antioxidant; Antioxidant activity; Isolation; Polysaccharide; Sparassis latifolia; Structure-function relationship.

Six polysaccharides (SF-FB11, SF-HW21, SF-CA31, SF-HA41, SF-FF51, and SF-FR61) of similar mol. weights (MW) (30-50 kDa) were extracted from the fermentation liquor, mycelia, and basidiomata of Sparassis latifolia by different methods. Structural analyses of these purified polysaccharides indicated that they were all branched, with a degree of branching (DB) ranging from 0.2 to 0.4. The polysaccharides exhibited strong scavenging activities for 2,2-diphenyl-1-picrylhydrazyl and hydroxyl radicals. Their antioxidant activities were correlated to some extent with their composition but significantly with the DB. The polysaccharides with a low 1,3-D-glucose content and glucose: galactose ratio, or a low DB (0.2-0.3) had higher antioxidant activities. Addnl., the correlation between the extraction yield and antioxidant activities of the polysaccharides was assessed. The low-MW polysaccharides extracted by alkali treatments had both high yield and antioxidant activities. Addnl., both the yield and antioxidant activities were found to be influenced by the size, extraction method, and source (fermentation liquor, mycelia, or basidiomata) of the polysaccharides. These results indicate that polysaccharides isolated from S. latifolia have strong antioxidant activities closely associated with the polysaccharide structure and extraction method, thus providing a scientific basis for further use of these polysaccharides.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Yue published the artcileUltrasound-assisted modified pectin from unripe fruit pomace of raspberry (Rubus chingii Hu): Structural characterization and antioxidant activities, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Rubus antioxidant pectin fruit pomace.

With the aim of making full use of the resource of Rubus Chingii Hu, this work comparatively investigated the structural characterization and antioxidant activities of pectin (RP) from unripe fruit pomaces of Rubus chingii Hu and ultrasonic-modified pectin (URP) from unripe fruit pomaces of Rubus Chingii Hu. Compared with the original RP, ultrasound treated RP (URP) significantly changed the chem. composition The SEM (SEM) results suggested that the conformation of RP was filiform, smooth and slim and a large number of spherical pectins were produced by ultrasonic modification. Both RP and URP exhibited the potential antioxidant activity and α-glucosidase inhibitory activity. Moreover, RP and URP effectively attenuated the oxidative damage induced by H2O2 and reduced intracellular reactive oxygen species (ROS) levels in human hepatic L02 cells and URP showed higher activity than RP. These results suggested that the unripe fruit pomace of Rubus chingii Hu could be used as a potential resource to obtain the antioxidant pectin and the ultrasound-assisted modification could significantly change the phys. structure of pectin and effectively improve its antioxidant activities.

LWT–Food Science and Technology published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An, Qi published the artcileStructure analysis of polysaccharides purified from Cyclocarya paliurus with DEAE-Cellulose and its antioxidant activity in RAW264.7 cells, Application In Synthesis of 59-23-4, the main research area is Cyclocarya polysaccharide CPPD macrophage cell viability antioxidant; Antioxidant; Cyclocarya paliurus; Polysaccharide; Structural analysis.

CPP was isolated from Cyclocarya paliurus (C. paliurus) and CPP-D was purified from CPP with a further step by DEAE-Cellulose. In this study, the structure and antioxidant activities of these two polysaccharides were investigated. The mol. weight of CPP was determined as 1.15 × 105 Da and the monosaccharides of it were Rha, Ara, Xyl, Man, Glc, Gal in a molar ratio of 0.021:0.237:0.020:0.036:0.454:0.231, while the mol. weight of CPP-D was 9.1 × 103 Da and the monosaccharides of it were Man, Glc, Gal in a molar ratio of 0.235:0.677:0.088. CPP-D consisted of three structural residues â†?- β-D-Glc-(1â†? â†?,6)- β-D-Man-(1â†?and â†?)- β-D-Gal. These structures were characterized by SEM, FT-IR, GC-MS, HPGPC, and NMR. The antioxidant assay in RAW264.7 cell showed that both CPP and CPP-D promoted cell viability and antioxidant activity, which decreased the content of MDA and increased the activity of SOD, T-AOC, CAT (P < .05). As a result, CPP-D isolated by DEAE-Cellulose didn't reduce the antioxidant activity of C. paliurus polysaccharide and could enhance the cell viability. International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qiang, Yueyue published the artcileSpatial variation of volatile organic compounds and antioxidant activity of turmeric (Curcuma longa L.) essential oils harvested from four provinces of China, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is volatile organic compound antioxidant Curcuma longa essential oil; Antioxidant activity; Curcuma longa L; DPPH; HS-SPME-GC-MS; Turmeric essential oils (TEOs).

The objective of this study was to investigate the spatial variation of volatile organic compounds and antioxidant activity of turmeric essential oils (TEOs) harvested from four provinces of China. The major chem. components of these TEOs were analyzed using headspace solid-phase micro-extraction gas chromatog.-mass spectrometry. More than forty volatile organic compounds in TEOs were identified, which accounted for 82.09-93.64% of the oil components. The relative abundances of the main volatile organic compounds in TEOs at the genus level were visualized by a heat map. The antioxidant activity of the TEOs of five different origins was characterized by the DPPH free radical scavenging activity, in which the antioxidant activity of the TEOs from Guangxi was superior to those of other sources. Furthermore, the IC50 values of the antioxidants TEOs collected from Guangxi, Sichuan, Yunnan, Changting, and Liancheng were 33.30, 42.5, 35.22, 63.27, and 39.96 mg/mL, resp., which indicated the excellent free radical scavenging activity of those TEOs. Therefore, the TEOs might be considered as a natural antioxidant with potential applications in food and pharmaceutical industries.

Current Research in Food Science published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Jingqin published the artcileGreen synthesis, characterization, cytotoxicity, antioxidant, and anti-human ovarian cancer activities of Curcumae kwangsiensis leaf aqueous extract green-synthesized gold nanoparticles, COA of Formula: C10H18O, the main research area is Curcuma leaf gold nanoparticle antioxidant cytotoxicity green chem.

The present work indicated the green synthesis, characterization, cytotoxicity, antioxidant, and anti-human ovarian cancer activities of gold nanoparticles containing Curcumae Kwangsiensis Folium (Leaf) aqueous extract Characterization of gold nanoparticles was done by Field Emission SEM (FE-SEM), Transmission Electron Microscopy (TEM), Fourier Transformed IR Spectroscopy (FT-IR), and UV-Visible Spectroscopy (UV-Vis). MTT assay was used on common ovarian cancer cell lines i.e., SW-626, PA-1, and SK-OV-3 to survey the cytotoxicity and anti-ovarian cancer effects of gold chloride, Curcumae Kwangsiensis Folium leaf aqueous extract, and gold nanoparticles. The best results of cytotoxicity and anti-ovarian cancer properties were seen in the case of gold nanoparticles. They had very low cell viability and high anti-ovarian cancer activities dose-dependently against PA-1, SW-626, and SK-OV-3 cell lines without any cytotoxicity on the normal cell line (HUVEC). For investigating the antioxidant properties of gold chloride, Curcumae Kwangsiensis Folium leaf aqueous extract, and gold nanoparticles, the DPPH test was used in the presence of butylated hydroxytoluene as the pos. control. The best results of antioxidant properties were seen in the case of gold nanoparticles. They inhibited half of the DPPH mols. in the concentration of 153μg/mL. Maybe significant anti-human ovarian cancer potentials of gold nanoparticles synthesized by Curcumae Kwangsiensis Folium leaf aqueous extract against common human ovarian cancer cell lines are linked to their antioxidant activities.

Arabian Journal of Chemistry published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, COA of Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Yancong published the artcileZinc(II) and manganese(II) complexes with 1,3-bis(1-allylbenzimidazol-2-yl)-2-oxapropane: synthesis, crystal structures, antioxidant activities and DNA-binding properties, Computed Properties of 110-99-6, the main research area is zinc manganese allylbenzimidazolyloxapropane complex preparation crystal structure antioxidant; DNA interaction zinc manganese allylbenzimidazolyloxapropane complex.

Two new zinc(II) and manganese(II) complexes with the ligand 1,3-bis(1-allylbenzimidazol-2-yl)-2-oxopropane (aobb), with composition [Zn(aobb)2](pic)2·DMF·CH3OH and [Mn(aobb)(DMF)2(H2O)](pic)2 (pic = picrate; DMF = N,N-dimethylformamide), were synthesized and characterized by elemental anal., elec. conductivities, x-ray single-crystal diffraction, IR, and UV-visible spectra. Single-crystal x-ray revealed that Zn(II) and Mn(II) centers are both located in the six-coordinate distorted octahedral geometry. The DNA-binding modes of the ligand and the complexes were studied by electronic absorption titration, competitive binding with ethidium bromide and viscosity measurements. The exptl. evidence indicated the ligand and complexes interact with calf thymus DNA through intercalation. The binding strength follows the order >>aobb. Addnl., displays potential superoxide dismutase activity in vitro studies.

Journal of Coordination Chemistry published new progress about Antioxidants. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Computed Properties of 110-99-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts