Month: December 2022

Cheng, Haiyang published the artcileCyclization of citronellal to p-menthane-3,8-diols in water and carbon dioxide, Category: alcohols-buliding-blocks, the main research area is citronellal cyclization menthanediol green chem.

A clean process has been developed for the synthesis of p-menthane-3,8-diols from cyclization of citronellal in CO2-H2O medium without any additives. With the addition of CO2, the reaction rate could be enhanced about 6 times for the cyclization of citronellal in H2O, because CO2 dissolved into water and formed carbonic acid inducing an increase of the acidity. Although, the reaction conversion in CO2-H2O is slightly lower compared to that obtained with sulfuric acid as catalyst, CO2-H2O could replace the sulfuric acid at a relative higher reaction temperature The reaction kinetics studies showed that the hydration of isopulegol to p-menthane-3,8-diols is a reversible reaction. The equilibrium constant and the maximum equilibrium yield obtained in CO2-H2O at a range of CO2 pressures are similar to that with sulfuric acid catalyst.

Green Chemistry published new progress about Cyclization. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Xianheng published the artcilePreparation of Dolutegravir Intermediate Diastereomer, Safety of 2,2-Dimethoxyethanamine, the main research area is dolutegravir tricyclic intermediate diastereoselective preparation.

A convenient method was developed to prepare the diastereomer of dolutegravir tricyclic intermediate in the catalysis of EDCI/DMAP in up to 87% yield. Different solvents, temperature, and times were optimized. The synthesized diastereomer 6′ could be used as a standard for the industrial manufacture requirement of dolutegravir active pharmaceutical ingredient.

Journal of Heterocyclic Chemistry published new progress about Cyclization. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Safety of 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hussain, Mulla Althafh published the artcileTotal synthesis of (±)-aspidostomide B, C, regioisomeric N-methyl aspidostomide D and their derivatives, HPLC of Formula: 22483-09-6, the main research area is aspidostomide B C D analog regioselective synthesis; cyclization total synthesis aspidostomide B C D; dehydration total synthesis aspidostomide B C D; regioselective ring opening total synthesis aspidostomide B C D.

A full account of the total synthesis of aspidostomide B, C, their analogs and our synthetic efforts towards the synthesis of aspidostomide D, which led to the synthesis of regioisomeric N-Me aspidostomide D, its analogs via epoxide opening strategy is presented. The synthesis of regioisomeric N-Me aspidostomide D involves an efficient, five-step sequence, with 36.3% overall yield, starting from 3,4,5-tribromo-1H-pyrrole-2-carboxylic acid. The key features of this protocol are intramol. cyclization, dehydration, oxidation, and a Lewis acid-mediated regioselective epoxide ring opening by C-3 position of 2,5-dibromo-1H-indole to furnish the title compounds

Tetrahedron Letters published new progress about Cyclization. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, HPLC of Formula: 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wong, Shaio Wen published the artcileCatalysis in competing isocyanate reactions, COA of Formula: C7H18N2O, the main research area is phenyl isocyanate butanol esterification kinetics; dipropylenetriamine catalyst isocyanate butanol esterification; organotin catalyst isocyanate butanol esterification; amine catalyst isocyanate butanol esterification.

The effects of various organotin and tertiary amine catalysts on the product distributions in the esterification of Ph isocyanate (I) [103-71-9] with n-BuOH (II) [71-36-3] as model reaction for the preparation of polyurethanes were determined The esterification in the presence of N,N,N’,N’,N”-pentamethyldipropylenetriamine (III) [66537-05-1] catalyst in MeCN at 50° was first order with respect to I and III concentrations and half order with respect to II concentration with an apparent activation energy of 22.9 kcal/mol. Tri-Ph isocyanurate (IV) [1785-02-0], Bu phenylcarbamate  [1538-74-5], and Bu α,γ-diphenylallophanate  [21367-12-4] were formed by the reaction with IV being the major reaction product. The presence of H2O delayed the reaction rate and inhibited the formation of IV.

Polimeri (Zagreb, Croatia) published new progress about Cyclization. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, COA of Formula: C7H18N2O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jia, Yanan published the artcileChemical structure and inhibition on α-glucosidase of polysaccharides from corn silk by fractional precipitation, Product Details of C6H12O6, the main research area is corn silk polysaccharide alpha glucosidase; Antioxidant; Corn silk; Polysaccharide fraction; Structure; α-Glucosidase.

Aimed to explore different corn silk polysaccharide (CSP) fractions derived by ethanol precipitation on the physicochem. properties and biol. activities, four fractions (CSP20, CSP40, CSP60, and CSP80) were obtained. CSPs consisted of mannose, galactose, arabinose, rhamnose, xylose, and glucose with different ratios, and exhibited different total sugar content, uronic acid content, protein content, and total phenols content. All fractions also showed different phys. properties, such as mol. weight, intrinsic viscosity, particle size, and microstructure. Besides, CSP80 exhibited stronger antioxidant activity and α-glucosidase inhibitory activity than the other three fractions. Enzyme kinetic anal. suggested that CSP80 inhibited α-glucosidase by mixed type and reversible mechanisms, resp. Fluorescence intensity measurements confirmed that the secondary structure of α-glucosidase was changed by the binding of CSP80. Isothermal titration calorimetry (ITC) results illustrated that the binding of CSP80 to α-glucosidase complex was spontaneous driven by enthalpy and hydrogen bonds played a major role in the binding.

Carbohydrate Polymers published new progress about Corn (silk). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ndindayino, F. published the artcileDirect compression and molding properties of co-extruded isomalt/drug mixtures, Related Products of alcohols-buliding-blocks, the main research area is direct compression property isomalt drug mixture extrusion.

Isomalt, a disaccharide alc. was co-extruded with paracetamol or hydrochlorothiazide (HCT) in order to improve its tabletting properties. After extrusion, isomalt was transformed into an amorphous form, while paracetamol remained crystalline Hot stage microscopy showed that HCT was amorphous in the isomalt carrier up to a concentration of 1%. Direct compression of mixtures formulated with co-extruded isomalt/paracetamol powders yielded harder tablets compared with phys. mixtures and no powder agglomeration was observed Direct molding of isomalt co-extruded with either paracetamol or HCT was feasible, yielding hard tablets. A fast dissolution rate was seen for both the compressed and the molded tablets (>80% paracetamol and 60% HCT released within 20 min). The compressed tablets showed a dramatic decrease in tensile strength during storage at 85% RH, while the tensile strength of the molded tablets remained above 0.80 MPa after a 6-mo storage at the same conditions. Co-extrusion of isomalt with paracetamol and HCT dramatically improved the tabletting properties of the mixtures (compared with phys. mixtures of drug and isomalt). Direct molding proved to be a suitable technique to produce isomalt-based tablets.

International Journal of Pharmaceutics published new progress about Compression. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gabrielsson, Jon published the artcileMultivariate Methods in the Development of a New Tablet Formulation, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is excipient tablet disintegration.

The overall objective of this article is to use an efficient approach to find a suitable tablet formulation for direct compression. By using traditional approaches to statistical exptl. design in tablet formulation, the number of experiments quickly grows when many descriptive variables or many excipients are included. To facilitate the screening process, a multivariate design, which allows a systematical evaluation of a large number of excipients with a limited number of experiments, was implemented. Formulations with acceptable values for disintegration time and crushing strength were obtained with some of the formulations in the present study. The multivariate exptl. design strategy yielded PLS models that will be used to identify a region of interest for the optimization. The strategy is general and can be applied in many different areas of pharmaceutical research and development.

Drug Development and Industrial Pharmacy published new progress about Compression. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Belhachemi, Asma published the artcileGC-MS and GC-FID analyses of the essential oil of Eucalyptus camaldulensis grown under greenhouses differentiated by the LDPE cover-films, SDS of cas: 124-76-5, the main research area is volatile compound terpene identification quantification climate; greenhouse condition.

The chem. composition of essential oils (EOs) can vary from one plant to another of the same species and can be affected by several factors including the environment of growth. The research was carried out on the EOs of Eucalyptus camaldulensis leaves grown in three sep. greenhouses differentiated by their low-d. polyethylene (LDPE) covering material. This study aimed to compare the impact of the type of the greenhouse cover film on the internal microclimate, light intensity, and chem. composition of E. camaldulensis EOs. Eucalyptus species was initially cultivated from the seeds and the EOs were extracted from the leaves of 14 wk aged trees. The extraction was performed by hydrodistillation using a Clevenger-type apparatus Qual. and quant. analyses of the extracted EOs were performed using gas chromatog. coupled with mass spectrometry (GC-MS) and gas chromatog. coupled with a flame ionization detector (GC-FID). The analyzed samples were rich in terpenes with a total of 66 identified compounds The oxygenated monoterpenes pinocarvone and -carvone were only identified in the essential oils from multilayered greenhouses. cis-1-Methyl-4-(1-methylethyl-)-2-cyclohexen-1-ol was absent in eucalyptus EOs from the three-layer greenhouse, unlike the others that had it. Different compound contents were detected in the extracted essential oils, according to their greenhouse cover conditions. 1,8-Cineol was the compound present in a higher amount as expected, with the highest value of c.a 164.78 mg/gdw from the leaves of E. camaldulensis cultivated in the ordinary greenhouse. Contents of 51.55 mg/gdw and 42.11 mg/gdw were obtained from E. camaldulensis cultivated in the three-layers and monolayer greenhouses, resp. In contrast, the EOs of E. camaldulensis grown under the monolayer greenhouse presented the highest content of some aromadendranes family compounds This study shows that the greenhouse cover-film should be chosen thoughtfully because it plays a major function regarding its effect on the chem. composition of the EOs of E. camaldulensis cultivated in greenhouse environments.

Industrial Crops and Products published new progress about Composition. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, SDS of cas: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sibirtsev, Stephan published the artcileAutomation of a Procedure for the Experimental Investigation of Liquid-Liquid Phase Separation, Formula: C8H18O, the main research area is octanol water liquid phase separation automation process.

Optimal design of a liquid-liquid settler requires exptl. investigation on phase separation behavior of the used material system under the same operating conditions as in the tech. application. Performing these experiments and evaluating the obtained data is highly time-consuming. To reduce manual effort, the procedure was largely automated. In this work, the exptl. setup, the automated procedure, and its validation results at various operating temperatures are presented. The results show the suitability of the automated procedure and the influence of temperature on phase separation behavior of the liquid-liquid system 1-octanol/water.

Chemie Ingenieur Technik published new progress about Coalescence. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Andrade, Brenda published the artcileNonionic Surfactant Properties of Amphiphilic Hyperbranched Polyglycerols, Category: alcohols-buliding-blocks, the main research area is nonionic surfactant amphiphilic hyperbranched polyglycerol.

The surfactant properties of amphiphilic hyperbranched polyglycerols (HPGs) were investigated. The HPGs were prepared by ring-opening multibranching polymerization of glycidol using hydrophobic initiators of varying size and structure. The cloud points for all HPG surfactants were found to be >80 °C in deionized water with >1 wt % NaCl. The HPG surfactants with hydrophilic-lipophilic balance values between 16 and 18 were found to form stable octanol/water (o/w) emulsions within a 24 h period. Several surface properties, including critical micelle concentration (CMC), efficiency of surface tension reduction (pC20), effectiveness of surface tension reduction (γCMC), surface excess concentration at the CMC (Γmax), min. area/mol. at the interface (Amin), and the CMC/C20 ratio of the HPG surfactants were measured in deionized water at 22.6 °C. In general, increasing HPG size was marked by an increase in min. surface area per mol. (Amin) at the aqueous liquid/air interface. This increase in size also led to lower CMC and greater pC20 values of HPG surfactants prepared with Tergitol 15-S-7 initiator (HPG 5a-5d), a com. available ethylene glycol oligomer with a branched hydrophobic tail.

Langmuir published new progress about Cloud point. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts