Month: December 2022

Lazar, Roxana Georgiana published the artcileMechanism, influencing factors exploration and modeling on the reactive extraction of 2-ketogluconic acid in presence of a phase modifier, Recommanded Product: n-Octanol, the main research area is modeling reactive extraction ketogluconate phase modifier.

Taking into account that limited research was carried out on the reactive extraction of 2-ketogluconic acid, this study was focused on analyzing the pH dependent extraction performance and the molar ratios of acid and extractant (Amberlite LA-2) dissolved in three solvents with 1-octanol as phase modifier. Back extraction was successfully performed using NaOH solutions The mechanism of the interfacial reaction in the presence of 1-octanol, pointed out that, indifferent of the pH value and solvent polarity, only one mol. of 2-ketogluconic acid and one of extractant react at the interface. The pos. effect of 1-octanol on extraction efficiency was quantified by the amplification factor, its maximum values being 2.43 for dichloromethane, 3.67 for Bu acetate and 3.64 for n-heptane. In addition, the process was modeled using statistical regression and Artificial Neural Networks (ANNs) determined with chaos based Differential Evolution algorithm. The best ANN model had a mean squared error for the testing phase of 0.19 and modeled the process with an acceptable error.

Separation and Purification Technology published new progress about Extractants. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Tingting published the artcilePhysicochemical properties and immunological activities of polysaccharides from both crude and wine-processed Polygonatum sibiricum, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Polygonatum polysaccharide wine processing immunol activity physicochem property; Immunological activity; Polygonatum sibiricum; Polysaccharide; Spleen deficiency; Wine-processing.

Polygonatum sibiricum (PS) is a traditional Chinese herb used in both food and medicine with great bioactivity. The wine-processed pieces of PS are the main form for clin. application, while research has focused on the polysaccharides of their crude form. This study evaluated the physicochem. properties and immunol. activities of water-soluble polysaccharides from both crude (PSPC) and wine-processed PS (PSPW). PSPC and PSPW had significant differences in their physicochem. properties. PSPC was mainly composed of galactose, mannose, glucose, and galacturonic acid, in molar ratios of 29.63:36.10:15.09:10.20, while PSPW was mainly composed of galactose, mannose, and galacturonic acid, in molar ratios of 78.77:5.50:13.84. Both kinds of polysaccharides can enhance the cells viability, phagocytic capacity, acid phosphatase activity, and NO production of RAW264.7 cells. We found that PSPC and PSPW enhanced the immune functions of the immunosuppressive model for spleen deficient mice and reversed the decline of the secretions of IL-2, IL-6, TNF-α, and IFN-γ to a normal range. The PSPW showed more potent immunol. activities than PSPC. The results of the study identify the importance of wine-processing for PS and provide application foundations for the further development of PSPW as a functional food.

International Journal of Biological Macromolecules published new progress about Erythrocyte. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Balakrishnan, Bijina published the artcileNovel mRNA-Based Therapy Reduces Toxic Galactose Metabolites and Overcomes Galactose Sensitivity in a Mouse Model of Classic Galactosemia, Product Details of C6H12O6, the main research area is galactose GALT mutation fibroblast galactosemia; GALT; IEM; POI; ataxia; classic galactosemia; galactose toxicity; galactose-1 phosphate; galactose-1 phosphate uridylyltransferase; inborn errors of metabolism; mRNA therapy; primary ovarian insufficiency; speech dyspraxia.

Classic galactosemia (CG) is a potentially lethal inborn error of galactose metabolism that results from deleterious mutations in the human galactose-1 phosphate uridylyltransferase (GALT) gene. Previously, we constructed a GalT-/- (GalT-deficient) mouse model that exhibits galactose sensitivity in the newborn mutant pups, reduced fertility in adult females, impaired motor functions, and growth restriction in both sexes. In this study, we tested whether restoration of hepatic GALT activity alone could decrease galactose-1 phosphate (gal-1P) and plasma galactose in the mouse model. The administration of different doses of mouse GalT (mGalT) mRNA resulted in a dose-dependent increase in mGalT protein expression and enzyme activity in the liver of GalT-deficient mice. Single i.v. (i.v.) dose of human GALT (hGALT) mRNA decreased gal-1P in mutant mouse liver and red blood cells (RBCs) within 24 h with low levels maintained for over a week. Repeated i.v. injections increased hepatic GalT expression, nearly normalized gal-1P levels in liver, and decreased gal-1P levels in RBCs and peripheral tissues throughout all doses. Moreover, repeated dosing reduced plasma galactose by 60% or more throughout all four doses. Addnl., a single i.p. dose of hGALT mRNA overcame the galactose sensitivity and promoted the growth in a GalT-/- newborn pup.

Molecular Therapy published new progress about Erythrocyte. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Deliang published the artcileEffects of intramolecular hydrogen bonds on lipophilicity, Related Products of alcohols-buliding-blocks, the main research area is methoxyaniline bromophenol hydrogen bond lipophilicity drug design; Computational chemistry; Drug design; Hydrogen bonding capability; Intramolecular hydrogen bond; Lipophilicity; Partition coefficient; Physicochemical property.

Intramol. hydrogen bonds (IMHBs) affect the lipophilicity and physicochem. properties of small organic mols. and drug candidates. Considering IMHBs in drug design is an important strategy for improving the lipophilicity and physicochem. properties of drug candidates. However, how IMHBs affect the lipophilicity and partition coefficients are not well understood. Based on the relationship between the effect of IMHBs on the exptl. partition coefficients and the H-bonding capabilities of H-bond forming atoms, we explore how IMHBs affect water/n-octanol partition coefficients, water/chloroform partition coefficients, water/hexadecane partition coefficients and lipophilicity. We found that IMHBs may increase or decrease or have no effect on water/n-octanol partition coefficients, but always increase water/chloroform partition coefficients, water/hexadecane partition coefficients and lipophilicity. We introduced ΔHBC, which is the difference between the calculated and actual H-bonding capabilities of mols., for assessing the propensity of mols. to form IMHBs and the relative strengths of IMHBs. This study may help to improve the physicochem. properties of drug candidates and increase the success of drug design.

European Journal of Pharmaceutical Sciences published new progress about Drug design. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Hao published the artcileCharacterization of the Partition Rate of Ibuprofen Across the Water-Octanol Interface and the Influence of Common Pharmaceutical Excipients, Product Details of C8H18O, the main research area is ibuprofen bolus injection interfacial partition excipient dissolution; 2-phase dissolution; biomimetic; biorelevant; diffusion; dissolution test; interface; in vitro; partition; polymer; surfactant.

This work reports the measurement of the partition rate of a model drug, ibuprofen (IBU), from aqueous solutions into octanol in the absence and presence of common pharmaceutical excipients including glucose, lactose, maltoheptaose, hydroxypropyl methylcellulose, polyvinylpyrrolidone, polyvinylpyrrolidone-vinyl acetate, hydroxypropyl methylcellulose AS, sodium dodecyl sulfate, Tween 80, and sodium taurocholate at varying concentrations This attempts to assess the kinetic aspect of IBU partitioning across the water-octanol interface by applying a mechanistic model and to characterize the interfacial resistance. A significant reduction in Pi across the water-octanol interface was observed with extremely low concentration of the selected excipients in the aqueous media. These results reveal the presence of a surface excess of adsorbed excipients at the water-octanol interface. The retardation of the Pi of IBU was found to be sensitive to (1) the mol. weight or the d.p. of these excipients, (2) the hydrodynamic condition of the exptl. method, and (3) the pH of the aqueous media. Retardation of the Pi of IBU in the presence of excipients observed in this study is proposed by a steric obstruction mechanism through the adsorbed surface excess layer of excipients located at the water-octanol interface.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Dissolution. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lenz, Elisabeth published the artcileImpact of fillers on dissolution kinetic of fenofibrate dry foams, Safety of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is fenofibrate tablet fast release drug delivery Maltrin Soluthin dissolution; Dissolution rate; dry foam granulation; eroding tablets; fast dissolving; starch derivatives; sugar alcohols.

Dry foam technol. reveals the opportunity to improve the dissolution behavior of poorly soluble drugs tending to agglomeration due to micronization. In this study, the impact of fillers on the manufacturability, the properties of dry foams and granules as well as the dissolution kinetics of dry foam tablets was investigated using fenofibrate as a model compound Different maltodextrins and dried glucose syrups, a maltodextrin-phosphatidylcholine complex, isomalt and a 1:1 mixture of mannitol/glucose syrup were used as filler. Within the group of maltodextrins and glucose syrups, the influences of dextrose equivalent (DE), particle morphol. and botanical source of starch were investigated. Comparable macroscopic foam structures were obtained with maltodextrins and glucose syrups whereas different foam morphologies were obtained for the other fillers tested. Regarding the maltodextrins and glucose syrups, different physicochem. and particle properties had a minor impact on granule characteristics and tablet dissolution Using the maltodextrin-phosphatidylcholine complex resulted in a low sp. surface area of the granules and a slow tablet dissolution caused by a slow disintegration. In contrast, a high sp. surface area and a fast release were obtained with isomalt and glucose syrup/mannitol mixture indicating that high soluble low mol. weight fillers enable the development of fast dissolving dry foam tablets.

Pharmaceutical Development and Technology published new progress about Dissolution. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Safety of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Casian, Tibor published the artcileQbD for pediatric oral lyophilisates development: risk assessment followed by screening and optimization, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is oral lyophilisate tablet drug release delivery system; D-optimal design; Orodispersible tablets; failure mode effect analysis; freeze drying; pediatric formulation.

This study proposed the development of oral lyophilisates with respect to pediatric medicine development guidelines, by applying risk management strategies and DoE as an integrated QbD approach. Product critical quality attributes were overviewed by generating Ishikawa diagrams for risk assessment purposes, considering process, formulation and methodol. related parameters. Failure Mode Effect Anal. was applied to highlight critical formulation and process parameters with an increased probability of occurrence and with a high impact on the product performance. To investigate the effect of qual. and quant. formulation variables D-optimal designs were used for screening and optimization purposes. Process parameters related to suspension preparation and lyophilization were classified as significant factors, and were controlled by implementing risk mitigation strategies. Both quant. and qual. formulation variables introduced in the exptl. design influenced the product’s disintegration time, mech. resistance and dissolution properties selected as CQAs. The optimum formulation selected through Design Space presented ultra-fast disintegration time (5 s), a good dissolution rate (above 90%) combined with a high mech. resistance (above 600 g load). Combining FMEA and DoE allowed the science based development of a product with respect to the defined quality target profile by providing better insights on the relevant parameters throughout development process. The utility of risk management tools in pharmaceutical development was demonstrated.

Drug Development and Industrial Pharmacy published new progress about Dissolution. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nadernezhad, Ali published the artcileMelt Electrowriting of Isomalt for High-Resolution Templating of Embedded Microchannels, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is isomalt melt electrowriting high resolution templating microchannel.

Fabrication of microchannels using 3D printing of sugars as fugitive material is explored in different fields, including microfluidics. However, establishing reproducible methods for the controlled production of sugar structures with sub-100μm dimensions remains a challenge. This study pioneers the processing of sugars by melt electrowriting (MEW) enabling the fabrication of structures with so far unprecedented resolution from Isomalt. Based on a systematic variation of process parameters, fibers with diameters down to 20μm can be fabricated. The flexibility in the adjustment of fiber diameter by on-demand alteration of MEW parameters enables generating constructs with perfusable channels within polydimethylsiloxane molds. These channels have a diameter that can be adjusted from 30 to 200μm in a single design. Taken together, the experiments show that MEW strongly benefits from the thermal and phys. stability of Isomalt, providing a robust platform for the fabrication of small-diameter embedded microchannel systems.

Advanced Materials Technologies (Weinheim, Germany) published new progress about Dissolution. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anuja, Katariya-Jain published the artcileAn overview of HPDLC films and their applications, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is polymer dispersed liquid crystal film application.

The fusion of holog. to the LC-polymer composites give rise to holog. polymer dispersed liquid crystal (HPDLC) technol. The concentration of monomer unit in HPDLC films is quite high as compared to the other polymer-LC composite films. Difference in the rate of polymerization in different regions of composite film gives rise to alternate bright and dark fringes. In this review article along with the underlying principle of HPDLC films, we have discussed some electro-optical (EO) parameters like response time, diffraction efficiency (DE) and driving voltages necessary for the evaluation of a film. The classification and types of HPDLC gratings, which actually depend upon writing set up, grating period and thickness, has also found good space in this article. Recent advances to improve the efficiency of HPDLC films by varying material mixture and fabrication techniques is also discussed. Different types of evolved morphologies typically, LC droplet, Policryps and Polymer Scaffolding is described. Some trending applications of HPDLC films such as sensor, photonic crystals, mirrorless lasing etc are also highlighted.

Liquid Crystals published new progress about Diffraction. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

MacQueen, Blake published the artcileOptimum Reaction Conditions for 1,4-Anhydroerythritol and Xylitol Hydrodeoxygenation over a ReOx-Pd/CeO2 Catalyst via Design of Experiments, Related Products of alcohols-buliding-blocks, the main research area is anhydroerythritol xylitol hydrodeoxygenation ReO palladium Ceria catalyst.

In this study, we demonstrate that for the simultaneous hydrodeoxygenation (HDO) of 1,4-anhydroerythritol a comparable yield of THF is obtained at half the previously reported H2 pressure. The simultaneous hydrodeoxygenation was conducted using a heterogeneous ReOx-Pd/CeO2 catalyst. An L9 Taguchi design of experiment was enacted to elucidate the temperature, pressure, and catalyst loading effects on the yield of the HDO reaction by testing pressures ranging from 40 to 80 bar H2, temperatures of 100-180 °C, and Re loadings of 2-4 weight %. Our design showed that the yield of this reaction is significantly affected by the reaction temperature only. An L9 Taguchi design was conducted for xylitol simultaneous hydrodeoxygenation with pressures ranging from 5 to 10 bar H2, temperatures of 140-180 °C, and Re loadings of 2-4 weight %. The xylitol design elucidated the direct relation of pressure, and the inverse relation of temperature and catalyst loading, to yield with the optimal reaction condition being 140 °C and 10 bar H2.

Industrial & Engineering Chemistry Research published new progress about Deoxidation. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts