Month: December 2022

Pourmohammadi, Kiana published the artcileEffects of sucrose, isomalt and maltodextrin on microstructural, thermal, pasting and textural properties of wheat and cassava starch gel, Quality Control of 64519-82-0, the main research area is wheat cassava starch gel sucrose isomalt maltodextrin microstructure; PCA; Polyol sugar; Starch; Thermal properties.

This study investigated the effect of different levels (4, 8 and 12%) of sucrose, isomalt and maltodextrin on the microstructural, water absorption, physico-chem., thermal and textural characteristics of wheat and cassava starch gels, by SEM (SEM), rapid visco anal. (RVA), differential scanning calorimetry (DSC) and texture profile anal. According to SEM anal., cassava granules were more impressed than wheat starch in the presence of isomalt > sucrose > maltodextrin. Results showed that water absorption decreased when the amount of sucrose, isomalt and maltodextrin increased. In contrast, onset (To), peak (Tp) and conclusion (Tc) temperature, and enthalpy (ΔH) of wheat and cassava starch gels, increased as the level of addition increased. With increasing the sugar concentration, To, Tp, Tc and ΔH gel enhanced significantly relative to the native starch. The polyols had more remarkable effects on the thermal properties of cassava starch than wheat starch. The texture of wheat and cassava starch gels incorporated with polyol sugars had solid-like properties. The gelatinization of starch was delayed more by isomalt than sucrose and maltodextrin. Moreover, the combination of principal component anal. and cluster anal. proved to be a suitable statistical approach to highlight the effect of adding varying levels of polyols to starch.

International Journal of Biological Macromolecules published new progress about Absorption. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Quality Control of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Xinyuan published the artcilePreparation of a nanoscale dihydromyricetin-phospholipid complex to improve the bioavailability: in vitro and in vivo evaluations, Quality Control of 111-87-5, the main research area is diabetes mellitus dihydromyricetin phospholipid complex bioavailability pharmacokinetic; Bioavailability; Dihydromyricetin; Phospholipid complex; Type 2 diabetes mellitus.

Dihydromyricetin (DMY), a flavanonol compound found as the most abundant and bioactive constituent in Ampelopsis grossedentata (Hand-Mazz) W.T. Wang, possesses numerous pharmacol. activities, such as antioxidant, anti-inflammation, anticancer, anti-microbial, hypoglycemic and hypolipidemic effects, and so on. Recently, DMY shows a promising potential to develop as an agent for the prevention and treatment of Type 2 diabetes mellitus (T2DM). However, the low oral bioavailability of DMY was one of the special concerns to be resolved for its clin. applications. In this study, DMY phospholipid complex (DMY-HSPC COM) was prepared by the solvent evaporation technique and optimized with DMY combination ratio. SEM (SEM), X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and Fourier transform IR spectrophotometry (FT-IR) were carried to characterize the formation of DMY-HSPC COM. The particle size, zeta potential, drug loading and solubility of DMY-HSPC COM were further investigated. The phospholipid complex technol. could significantly improve the solubility of DMY. Pharmacokinetic study results of DMY-HSPC COM in healthy SD rats and T2DM rats demonstrated that the oral bioavailability was significantly increased when compared with pure DMY as well, which could be attributed to the improvement of the aqueous solubility of the complex, absorption promotion and a probable decrease in intestinal and hepatic metabolism In addition, when compared with healthy SD rats, pharmacokinetic parameters of pure DMY and DMY-HSPC COM showed significant difference in T2DM rats. Thus, phospholipid complex technol. holds a promising potential for increasing the oral bioavailability of DMY.

European Journal of Pharmaceutical Sciences published new progress about Absorption. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Quality Control of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Galli, Paola published the artcileCyclic allylic sulfide based photopolymer for holographic recording showing high refractive index modulation, Application In Synthesis of 7575-23-7, the main research area is cyclic allylic sulfide photopolymer holog recording refractive index modulation.

The development and characterization of a new holog. photopolymer system showing high refractive index modulation (Δn) is presented. It exploits the ring-opening polymerization reaction of a cyclic allylic sulfide (CAS) monomer, which is dispersed in a cellulose acetate butyrate (CAB) polymer matrix together with a blue sensitive radical photoinitiator. Volume Phase Holog. Gratings (VPHGs) obtained using these films show a very good fidelity of the transferred pattern, without deviations from the theor. curves. A high Δn is obtained due to the addition to this system of a tetrafunctional thiol crosslinker, which maximizes the material potential (formula limit) of the formulation. It also allows for a thermal post process of the gratings, further enhancing the Δn. The photopolymer properties are evaluated as function of the monomer and thiol concentration to determine the optimal composition, at which a Δn greater than 0.03 is obtained. This is a considerably high value in the field of photopolymers for holog. and it enables the manufacturing of efficient holograms.

Journal of Polymer Science (Hoboken, NJ, United States) published new progress about Absorption. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Yazhi published the artcileDirectly photopatterning of polycaprolactone-derived photocured resin by UV-initiated thiol-ene “”click”” reaction: Enhanced mechanical property and excellent biocompatibility, Synthetic Route of 7575-23-7, the main research area is biomedical polycaprolactone photocured resin UV photopatterning property biocompatibility.

This paper reports a novel routine for the fabrication of a polycaprolactone-derived (PCL-derived) photocured material crosslinked by pentaerythritol tetra (PETMP) with enhanced mech. property and excellent biocompatibility. The photocured material is crosslinked via UV irradiation through thiol-ene “”click”” chem. The main novelty of this technique is the facile fabrication of high-resolution patterns (∼5μm) using photolithog., and without adding photo-initiators. The photocured material is studied regarding to its thermal property, mech. property and cytocompatibility. DSC and DMA suggest that the flexibility and toughness of PCL-derived photocured material have improved. Accordingly, the PCL-derived photocured material achieves enhanced mech. property (with the increase of PCL segment content from 0 to 38.0%, the photocured samples monotonically increased their breaking strength from 0.62 to 3.10 MPa and Young’s modulus from 1.39 to 9.22 MPa). Due to the incorporation of the PCL-derived copolymer, the material shows excellent affinity to cells, which is demonstrated by the cell proliferation and release of LDH. The hemolysis ratio of PCL-derived photocured materials is all <5%, while the PEGDA photocured material is ∼17%. It can also be observed that PCL-derived photocured material will improve the biocompatibility and reduce biotoxicity compared with PEGDA. This facile route for synthesis of biocompatible photocured resin with micrometer-resolute patterns has a good impact in bioengineering and biomedical fields. Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Absorption. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Synthetic Route of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zolek, Teresa published the artcileDeposition of pentamidine analogues in the human body – spectroscopic and computational approaches, Application In Synthesis of 111-87-5, the main research area is pentamidine analog Pneumocystis jiroveci pneumonia prophylaxis therapy pharmacotherapy; Computational modelling; Drug-likeness; HSA and DNA interaction; Pentamidine analogues; Proton dissociation constants; Spectrofluorometry.

Bis-benzamidines are a diverse group of compounds with high potential in pharmacotherapy, and among them, pentamidine is a drug of great therapeutic significance in Pneumocystis jiroveci pneumonia (PJP) prophylaxis and therapy. Pharmacokinetic properties of these cationic species such as transport, acid/base equilibrium, and interactions with potential target mols. are still of interest, especially for recently designed compounds To broaden our knowledge drug-likeness, human serum albumin binding, and acidity constants (Ka) were exptl. and theor. examined for five pentamidine analogs 1 – 5 with -NH-CO-chain-CO-NH-bridges of increasing length and O, N, and S atoms in the chain. The studied analogs display very marked activity against Pneumocystis carinii without cytotoxicity that inspired us to perform an in silico anal. of their mode of action based on the hypothesis that the small DNA groove of rich in adenine-thymine pairs is their mol. target. These studies allowed us to classify them as very promising lead mols.

European Journal of Pharmaceutical Sciences published new progress about Absorption. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application In Synthesis of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Suciu, Stefana published the artcileQbD approach in the development of oral lyophilisates with ibuprofen for paediatric use, SDS of cas: 64519-82-0, the main research area is oral lyophilisates mucosa ibuprofen methylcellulose drug safety xanthan gum.

Quality-by-Design (QbD) concept in drug formulation and development was introduced in order to achieve and ensure an adequate product quality through a good process understanding. By identifying the variability sources that influence the product features, the quality of the product can be built from the development phase. Applying the concept, in the current work it was intended to develop and characterize orodisperable lyophilisates (OLs) for paediatric use. The drug model used was ibuprofen and following risk assessment evaluation, twenty-five exptl. formulations were prepared With a D-optimal exptl. design with six factors and two levels, the influence of the formulation factors on the desired quality target product profile was assessed (QTPP, the quality characteristics of a product that is intended to be achieved considering the aspects related to the safety and efficacy of the product): disintegration time, wetting time, mean dissolution time, texture and bio-adhesive features of the OLs were studied. During this experiment, it was observed that the type of the matrix forming and bio-adhesive agent influenced the disintegration time. All formulation factors influenced the wetting time, while no significant influence was observed for the bio-adhesive properties of the OLs. The hardness and rigidity of the OLs was increased by gelatine, while the methylcellulose and xanthan gum conducted to opposite results. The fracturability of the OLs was influenced only by the quant. factors, resp. the percentage of the matrix forming agent and the bio-adhesive agent. The dissolution profile was slightly influenced by the type of bio-adhesive agent. The design space has been defined based on the obtained results. The QbD approach was successfully applicd within this study and OLs with ibuprofen for paediatric use with desired pharmaceutical characteristics may be successfully obtained by lyophilisation.

Farmacia (Bucharest, Romania) published new progress about Absorption. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, SDS of cas: 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Strubbe-Rivera, Jasiel O. published the artcileThe mitochondrial permeability transition phenomenon elucidated by cryo-EM reveals the genuine impact of calcium overload on mitochondrial structure and function, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is calcium overload mitochondrial permeability transition structure cryogenic electron microscopy.

Mitochondria have a remarkable ability to uptake and store massive amounts of calcium. However, the consequences of massive calcium accumulation remain enigmatic. In the present study, we analyzed a series of time-course experiments to identify the sequence of events that occur in a population of guinea pig cardiac mitochondria exposed to excessive calcium overload that cause mitochondrial permeability transition (MPT). By analyzing coincident structural and functional data, we determined that excessive calcium overload is associated with large calcium phosphate granules and inner membrane fragmentation, which explains the extent of mitochondrial dysfunction. This data also reveals a novel mechanism for cyclosporin A, an inhibitor of MPT, in which it preserves cristae despite the presence of massive calcium phosphate granules in the matrix. Overall, these findings establish a mechanism of calcium-induced mitochondrial dysfunction and the impact of calcium regulation on mitochondrial structure and function.

Scientific Reports published new progress about Absorption. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Craven, John published the artcileRhodopseudomonas palustris-based conversion of organic acids to hydrogen using plasmonic nanoparticles and near-infrared light, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is organic acid hydrogen Rhodopseudomonas palustris conversion plasmonic nanoparticle.

The simultaneous elimination of organic waste and the production of clean fuels will have an immense impact on both the society and the industrial manufacturing sector. The enhanced understanding of the interface between nanoparticles and photo-responsive bacteria will further advance the knowledge of their interactions with biol. systems. Although literature shows the production of gases by photobacteria, herein, we demonstrated the integration of photonics, biol., and nanostructured plasmonic materials for hydrogen production with a lower greenhouse CO2 gas content at quantified light energy intensity and wavelength. Phototrophic purple non-sulfur bacteria were able to generate hydrogen as a byproduct of nitrogen fixation using the energy absorbed from visible and near-IR (NIR) light. This type of biol. hydrogen production has suffered from low efficiency of converting light energy into hydrogen in part due to light sources that do not exploit the organisms’ capacity for NIR absorption. We used NIR light sources and optically resonant gold-silica core-shell nanoparticles to increase the light utilization of the bacteria to convert waste organic acids such as acetic and maleic acids to hydrogen. The batch growth studies for the small cultures (40 mL) of Rhodopseudomonas palustris demonstrated >2.5-fold increase in hydrogen production when grown under an NIR source (167 ± 18μmol H2) compared to that for a broad-band light source (60 ± 6μmol H2) at equal light intensity (130 W m-2). The addition of the mPEG-coated optically resonant gold-silica core-shell nanoparticles in the solution further improved the hydrogen production from 167 ± 18 to 398 ± 108μmol H2 at 130 W m-2. The average hydrogen production rate with the nanoparticles was 127 ± 35μmol L-1 h-1 at 130 W m-2.

RSC Advances published new progress about Absorption. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yun published the artcileGinger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is hepatocellular carcinoma cell cycle arrest apoptosis polysaccharide; Apoptosis; Cell cycle arrest; Ginger polysaccharide.

In this study, ginger polysaccharide (GP) was obtained from ginger by enzymic method, its chem. properties and antitumor activity were investigated. The results indicated that the composition and proportion of GP were L-rhamnose, D-arabinose, D-mannose, D-glucose and D-galactose in a molar ratio of 3.64:5.37:3.04:61.03:26.91, GP had the characteristic absorption peak of polysaccharide. Congo red experiment showed that GP had a triple helix structure, which could have anti-tumor effect. Furthermore, MTT assay, cell morphol. observation, nuclear morphol. observation and reactive oxygen species observation demonstrated that GP had significant antitumor effect. Flow cytometry suggested that GP could promote apoptosis and arrest cells in G0-G1 phase. Real-time fluorescence quantification and Western blot revealed that GP could up-regulate the expression of Bax, Fas, FasL, caspase-3, p21 and p53, and down-regulate the expression of Bcl-2. These studies suggested that GP would be used as an antitumor drug in foods to promote the development of functional foods.

International Journal of Biological Macromolecules published new progress about Absorption. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rozi, Parhat published the artcileIsolationscharacterizations and bioactivities of polysaccharides from the seeds of three species Glycyrrhiza, Product Details of C6H12O6, the main research area is Glycyrrhiza seed polysaccharide bioactivity; Antioxidant activity; Characterization; Glycyrrhiza; Polysaccharide.

In this paper, polysaccharides from the seeds of three species of genus Glycyrrhiza were extracted to investigate the physicochem. properties, structural characteristics and antioxidant activities. The polysaccharides were composed of xylose, mannose, galactose, and glucose with different molar ratio. Fourier transform IR spectroscopy showed the presence of key functional groups of polysaccharides whereas SEM anal. revealed the characteristic morphol. of different polysaccharides, and thermogravimetric anal. exhibited good thermal stability of all samples. The antioxidant activities of polysaccharides were evaluated in vitro. All the three polysaccharides demonstrated strong reducing power, as well as scavenging activity against DPPH, ABTS, and hydroxyl free radicals. Antioxidant assays indicated that all the polysaccharides have obvious antioxidant activities and possess a potential development and application value in food, cosmetics as well as pharmaceutical industries.

International Journal of Biological Macromolecules published new progress about Absorption. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts