Month: December 2022

Yu, Yaling published the artcileAqueous phase hydrogenolysis of sugar alcohol to higher alcohols over Ru-Mo/CMK-3 catalyst, Formula: C5H12O, the main research area is sugar alc ruthenium molybdenum CMK3 hydrogenolysis catalyst.

Recently, great efforts have been devoted to the production of higher alcs. (C2+ alcs.) by chem. synthesis, but it is still quite challenging for the related heterogeneous catalysis. In this work, the hydrogenolysis of sugar alcs. derived from biomass was proposed to efficiently synthesize higher alcs. over the Ru-Mo/CMK-3 catalyst. The C-C and C-O bonds in sorbitol were pos. broken to form C2+ alcs., while the excessive cleavage of C-O bonds to form C1-C6 alkanes was effectively suppressed. The exptl. results indicated that the yield of C2+ alcs. in the products reached 49.0%, and that of C5+ alcs. reached 29.9% in a continuous flow reactor. Preliminary exptl. results and catalyst characterization supported that the synergetic effect of Ru and Mo species, different Ru precursors and the mesoporous channel effect of CMK-3 carrier were the key to such high reactivity.

Fuel Processing Technology published new progress about Biomass. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Formula: C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oliveira de Araujo, Talita published the artcilePaspalum urvillei and Setaria parviflora, two grasses naturally adapted to extreme iron-rich environments, COA of Formula: C4H6O5, the main research area is Paspalum Setaria iron root shoot; Chloroplast; Citrate; Ferritin; Iron plaque; Malate; Oryza sativa; Paspalum urvillei; Perls-DAB method; Setaria parviflora; Setaria viridis; Vacuole; μXANES; μXRF.

Paspalum urvillei and Setaria parviflora are two plant species naturally adapted to iron-rich environments such as around iron mines wastes. The aim of our work was to characterize how these two species cope with these extreme conditions by comparing them with related model species, Oryza sativa and Setaria viridis, that appeared to be much less tolerant to Fe excess. Both Paspalum urvillei and Setaria parviflora were able to limit the amount of Fe accumulated within roots and shoots, compared to the less tolerant species. Perls/DAB staining of Fe in root cross sections indicated that Paspalum urvillei and Setaria parviflora responded through the build-up of the iron plaque (IP), suggesting a role of this structure in the limitation of Fe uptake. Synchrotron μXRF analyses showed the presence of phosphorus, calcium, silicon and sulfur on IP of Paspalum urvillei roots and μXANES analyses identified Fe oxyhydroxide (ferrihydrite) as the main Fe form. Once within roots, high concentrations of Fe were localized in the cell walls and vacuoles of Paspalum urvillei, Setaria parviflora and O. sativa whereas Setaria viridis accumulated Fe in ferritins. The Fe forms translocated to the shoots of Setaria parviflora were identified as tri-iron complexes with citrate and malate. In leaves, all species accumulated Fe in the vacuoles of bundle sheath cells and as ferritin complexes in plastids. Taken together, our results strongly suggest that Paspalum urvillei and Setaria parviflora set up mechanisms of Fe exclusion in roots and shoots to limit the toxicity induced by Fe excess.

Plant Physiology and Biochemistry (Issy-les-Moulineaux, France) published new progress about Biomass. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, COA of Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Brizuela, Natalia Soledad published the artcileWhey permeate as a substrate for the production of freeze-dried Lactiplantibacillus plantarum to be used as a malolactic starter culture, Name: (S)-2-hydroxysuccinic acid, the main research area is wine whey permeate malic acid fermentation Lactiplantibacillus green chem; Freeze-drying; Lactiplantibacillus plantarum; Malolactic fermentation; Whey permeate; Wine.

The aim of this work was to obtain freeze-dried biomass of the native Patagonian Lactiplantibacillus plantarum strain UNQLp 11 from a whey permeate (WP)-based medium and compare it with the growth in com. MRS broth medium. Survival and activity of the freeze-dried Lb. plantarum strain were investigated after inoculation in wine as a starter culture for malolactic fermentation (MLF). The effect of storage and rehydration condition of the dried bacteria and the nutrient supplementation of wine were also studied. The freeze-dried cultures from WP and those grown in MRS showed similar survival results. Rehydration in MRS broth for 24 h and the addition of a rehydration medium to wine as nutrient supplementation improved the survival under wine harsh conditions and guaranteed the success of MLF. Storage at 4°C under vacuum was the best option, maintaining high cell viability for at least 56 days, with malic acid consumption higher than 90% after 7 days of inoculation in a wine-like medium. These results represent a significant advance for sustainable production of dried malolactic starter cultures in an environmentally friendly process, which is low cost and easy to apply in winemaking under harsh physicochem. conditions.

World Journal of Microbiology & Biotechnology published new progress about Biomass. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Name: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Byl, Eline published the artcileElastic recovery of filler-binders to safeguard viability of Lactobacillus rhamnosus GG during direct compression, Product Details of C12H24O11, the main research area is Lactobacillus elastic recovery filler binders direct compression probiotic tablets; Compression; Flow cytometry; Lactobacillus rhamnosus; Probiotic; Respiratory infections; Storage; Tablet; Viability.

Tablets are increasingly explored as dosage form for oral probiotics, especially for applications such as pharyngitis and dental health. In such tablets, the dry form increases the stability and the shelf life of the product. In addition, the probiotic cells are entrapped in the tablet matrix, which protects them against the environmental factors in the human body. However, the development of a probiotic tablet with an adequate number of viable cells remains a challenge due to the stress of the compression process. The adverse conditions during production can damage the cells, which leads to a loss of viability and a failure of the therapy. This study aimed to investigate the effect of the compression behavior of filler-binders on the survival of Lactobacillus rhamnosus GG during tablet production The probiotic tablets were manufactured by direct compression of a freeze-dried mixture of the model L. rhamnosus GG, a filler-binder and a suitable amount of lubricant. The compression behavior was determined by analyzing Heckel and force-displacement plots. The results demonstrated that the elastic recovery of the filler-binder during decompression played a protective role in bacterial survival, reducing the compression stress during manufacturing Consequently, the bacterial cells were less damaged, which resulted in a higher survival rate and a better stability during long-term storage. In conclusion, the elastic recovery of a filler-binder showed to be an important key in safeguarding probiotic cells during direct compression and storage.

European Journal of Pharmaceutics and Biopharmaceutics published new progress about Binders. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Product Details of C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saska, Zs. published the artcileEffect of isomalt as novel binding agent on compressibility of poorly compactable paracetamol evaluated by factorial design, Application In Synthesis of 64519-82-0, the main research area is isomalt compressibility compactability paracetamol tablet.

Tablets containing paracetamol were prepared by wet granulation. The model drug, paracetamol (API) and the diluent, milled isomalt (IM) were applied in different ratios where the granulation liquid was kept constant in each sample. The purpose of the study was to investigate the effect of wet granulation with milled isomalt on the tabletting properties of poorly compressible paracetamol. The results of tabletting process and the tablet characteristics were evaluated with 32 type face-centered full factorial design. The API:IM ratio (X 1) and compression force (X 2) were selected as independent variables. The dependent variables were as follows: the parameters of the tabletting process – lubrication coefficient (R-value), relative elasticity, friction work – and characteristics of the dosage form such as tablet hardness, friability, disintegration time, tensile strength. The results indicated that milled isomalt has an advantageous effect on both the process of compression and the tablet characteristics – due to its binder properties. Furthermore an optimal composition of the API and the diluent is dependent on the compression process and the dosage form.

Powder Technology published new progress about Binders. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application In Synthesis of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kallai, Nikolett published the artcileEvaluation of drug release from coated pellets based on isomalt, sugar, and microcrystalline cellulose inert cores, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, the main research area is diclofenac sodium pellet dissolution isomalt Eudragit microcrystalline cellulose.

The objective of the present study was to investigate the effect of the pellet core materials isomalt, sugar, and microcrystalline cellulose on the in vitro drug release kinetics of coated sustained-release pellets as well as to evaluate the influence of different ratios of polymethacrylate copolymers exhibiting different permeability characteristics on the drug release rate. For characterization of the drug release process of pellets, the effect of osmolality was studied using glucose as an osmotically active agent in the dissolution medium. The pellet cores were layered with diclofenac sodium as model drug and coated with different ratios of Eudragit RS30D and Eudragit RL30D (ERS and ERL; 0:1 and 0.5:0.5 and 1:0 ratio) in a fluid bed apparatus Phys. characteristics such as mech. strength, shape, and size proved that the inert cores were adequate for further processing. The in vitro dissolution tests were performed using a USP Apparatus I (basket method). The results demonstrated that, besides the ratio of the coating polymers (ERS/ERL), the release mechanism was also influenced by the type of starter core used. Sugar- and isomalt-type pellet cores demonstrated similar drug release profiles.

AAPS PharmSciTech published new progress about Binders. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Application of (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mahendran, Thevaki published the artcileAroma volatiles components of ‘Fuerte’ Avocado (Persea americana Mill.) stored under different modified atmospheric conditions, Category: alcohols-buliding-blocks, the main research area is aroma avocado volatile compound ripening.

Modified atm. (MA) storage have direct influence on biogenesis and releasing of aroma volatiles in the ripe fruits. A study was conducted to investigate the influence of MA storage on the volatile constituents of ripe avocados. Mature avocados (cv. Fuerte) were packed in four different packaging materials and the equilibrium gas composition developed within the packs were in perforated polyvinylchloride: SM-60 (Control: 20.8% O2 + 0.03% CO2), Micro-porous polypropylene: MY-15 (4.8% O2 + 8.4% CO2), Low d. polyethylene: LPDE (7.7% O2 + 5.8% CO2) and Micro-porous polypropylene: MD-15 (9% O2 + 5.4% CO2). The MA packs of avocados were stored at 7°C for 4 wk and were ripen at 20°C. The volatile compounds of ripe avocados were investigated by means of gas chromatog. (GC) and GC-mass spectrometry. A total of 68 of components were identified among those Bu acetate, 3-hexenyl acetate, 2-hexenyl acetate and hexyl acetate were only detected from MA stored avocados. Therefore, the MA storage with suitable gas composition could be used as a novel technol. to extend the shelf life without significantly (p > 0.05) affecting the volatile components of the avocados.

Journal of Essential Oil Research published new progress about Avocado. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Akermi, Sarra published the artcileNeuroprotective effect of the essential oil of Lavandula officinalis against hydrogen peroxide-induced toxicity in mice, Product Details of C10H18O, the main research area is essential oil hydrogen peroxide Lavandula officinalis neuroprotective effect toxicity.

Brain is the main organ that manages all other organs and has significant oxygen requirements, which makes it vulnerable to reactive oxygen species, thus causing different neurol. disorders. The aim of this work is the evaluation of Lavandula officinalis essential oil neuroprotective effect against hydrogen peroxide (HP)-induced toxicity in mice. Essential oil was extracted by hydrodistillation using a Clevenger-type apparatus Essential oil anal. is performed using gas chromatog.-mass spectrometry (GC-MS). Biol. activity evaluation carried out the ferric reducing antioxidant power test, DNA (DNA) fragmentation assay, the histopathol. study of the brain, and determination of antioxidant enzyme activities. Chem. characterization of essential oil using GC-MS identified 47 compounds, accounting for almost 80% of the total oil and indicates the occurrence of monoterpenes and sesquiterpenes. The identified major compounds are pentanone (16.55%), propanal (15.89%), Me Et ketone (13.51%), naphthalene (10.81%), terpinen-4-ol (6.55%), cyclopentanecarboxylic acid (4.77%), and isoborneol (2.27%). This study allowed us to investigate the effects of HP on brain function in Mus musculus adult mice by assessing DNA degradation, cell morphol., oxidative balance and brain weight variation. Furthermore, we have highlighted the beneficial effects of L. officinalis essential oil, which could significantly counteract all these alterations by its active compounds, which are endowed with potent biol. activities. We can conclude that HP-induced damage in histomorphol. changes in mice brain, significant atrophy, as well as an important alteration of the genetic expression.

Pharmacognosy Magazine published new progress about Atrophy. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Koendjbiharie, Jeroen G. published the artcileThe PEP-pyruvate-oxaloacetate node: variation at the heart of metabolism, HPLC of Formula: 97-67-6, the main research area is review glycolysis TCA phosphoenolpyruvate pyruvate oxaloacetate; PPO-node; central metabolism; enzyme biochemistry; oxaloacetate; phosphoenolpyruvate; pyruvate.

At the junction between the glycolysis and the tricarboxylic acid cycle-as well as various other metabolic pathways-lies the phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate node (PPO-node). These three metabolites form the core of a network involving at least eleven different types of enzymes, each with numerous subtypes. Obviously, no single organism maintains each of these eleven enzymes; instead, different organisms possess different subsets in their PPO-node, which results in a remarkable degree of variation, despite connecting such deeply conserved metabolic pathways as the glycolysis and the tricarboxylic acid cycle. The PPO-node enzymes play a crucial role in cellular energetics, with most of them involved in (de)phosphorylation of nucleotide phosphates, while those responsible for malate conversion are important redox enzymes. Variations in PPO-node therefore reflect the different energetic niches that organisms can occupy. In this review, we give an overview of the biochem. of these eleven PPO-node enzymes. We attempt to highlight the variation that exists, both in PPO-node compositions, as well as in the roles that the enzymes can have within those different settings, through various recent discoveries in both bacteria and archaea that reveal deviations from canonical functions.

FEMS Microbiology Reviews published new progress about Archaea. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, HPLC of Formula: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vorobyova, Victoria published the artcileSurface modification of the mild steel by multifunctional self-assembling nanolayers from the natural organic compounds of apricot pomace extract, Quality Control of 124-76-5, the main research area is apricot pomace steel nanolayer moisture.

The apricot pomace extract (APE) is tested as corrosion inhibitor of steel in neutral solution and in conditions of periodic condensation of moisture imitating atm. corrosion of metals via weight loss and electrochem. methods. The highest inhibition efficiency of 96.0% was obtained after about 40 h of exposure to inhibitor-containing electrolyte. The composition of the APE was investigated by using both gas and liquid chromatog.-mass spectrometry (GC-MS, LC-MS) anal. The formation of protecting layer on the mild steel surface was proved by scanning electron microscope (SEM) and at. force microscope results (AFM).

Molecular Crystals and Liquid Crystals published new progress about Apricot. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Quality Control of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts