Month: November 2022

Enhanced chemical sensing for Cu²⁺ based on composites of ZIF-8 with small molecules was written by Zhang, Jun;Zhao, Xiuyang;Liu, Xuefeng;Dong, Chuan. And the article was included in RSC Advances in 2020.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

Two organic mols., pyridoxal hydrazide (PAH) and salicylaldehyde based Rhodamine B hydrazone (RBS) were integrated into zeolitic imidazolate framework-8 (ZIF-8) to give composites, namely PAH/ZIF-8 and RBS/ZIF-8. The organic mols. and ZIF-8 are proposed to be assembled via hydrogen bonds and π-π stacking in the composites. The mass fraction of PAH and RBS in the composites was calculated to be 21.86% and 29.3%. The fluorescence of PAH/ZIF-8 is quenched regularly by Cu²⁺. The detection limit for Cu²⁺ was calculated to be 1.42 nM for PAH/ZIF-8, which is one order of magnitude lower than that of PAH. The detection limit for Cu²⁺ was determined to be 0.8 μM for RBS/ZIF-8, which is three times lower than that of RBS. The two composites both display high selectivity to Cu²⁺ over competing metal ions. The PAH/ZIF-8 fluorescent sensor was successfully applied to Cu²⁺ determination in environmental water. PAH/ZIF-8 exhibits excellent cell membrane permeability and low cytotoxicity in cellular imaging. The enhanced chem. sensor was designed by introducing small mols. into ZIF-8 for the specific recognition of Cu²⁺. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Amoeba-inspired magnetic microgel assembly assisted by engineered dextran-binding protein for vaccination against life-threatening systemic infection was written by Liu, Shuo;Zhao, Yan;Guo, Linpei;Yu, Qilin. And the article was included in Nano Research.Product Details of 367-93-1 The following contents are mentioned in the article:

Vaccination is critical for population protection from pathogenic infections. However, its efficiency is frequently compromised by a failure of antigen retention and presentation. Herein, we designed a dextran-binding protein DexBP, which is composed of the carbohydrate-binding domains of Trichoderma reesei cellobiohydrolases Cel6A and Cel7A, together with the sequence of the fluorescent protein mCherry. DexBP was further prepared by engineered Escherichia coli cells and grafted to magnetic nanoparticles. The magnetic nanoparticles were integrated with a dextran/poly(vinyl alc.) framework and a reactive oxygen species-responsive linker, obtaining magnetic polymeric microgels for carrying pathogen antigen. Similar to amoeba aggregation, the microgels self-assembled to form aggregates and further induced dendritic cell aggregation. This step-by-step assembly retained antigens at lymph nodes, promoted antigen presentation, stimulated humoral immunity, and protected the mice from life-threatening systemic infections. This study developed a magnetic microgel-assembling platform for dynamically regulating immune response during protection of the body from dangerous infections. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Product Details of 367-93-1).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Product Details of 367-93-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

De novo biosynthesis and whole-cell catalytic production of 2-acetamidophenol in Escherichia coli was written by Hou, Feifei;Feng, Dexin;Xian, Mo;Huang, Wei. And the article was included in Journal of Agricultural and Food Chemistry in 2022.Name: (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol The following contents are mentioned in the article:

2-Acetamidophenol (AAP) is an aromatic product with promising activities in agricultural applications and medical research. At present, AAP is synthesized by chem. methods from nonrenewable fossil fuel resources, which cause environmental pollution and the reaction conditions are harsh. In this study, we constructed the artificial biosynthetic pathway of AAP with five different expressed proteins in Escherichia coli for the first time. By introducing the hydrogen peroxide degrading enzyme catalase and improving cell tolerance to toxic intermediates or products, the yield of AAP reached 33.54 mg/L using shaking-flask culture. The best-engineered strain could produce 568.57 mg/L AAP by fed-batch fermentation from glucose and precursor (2-aminophenol, 2-AP) addition Furthermore, a one-pot whole-cell cascade biocatalytic pathway to AAP and analogs was developed and optimized. This method can efficiently produce 1.8 g/L AAP using the Me anthranilate hydrolysis product as the substrate. This study provides not only the de novo artificial biosynthetic pathway of AAP in E. coli but also a promising sustainable and efficient strategy to enable the synthesis of AAP on a gram scale. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Name: (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

GC-MS and surface characteristics of polyvinyl siloxane-an in vitro analysis was written by Mohamed, K. Kasim;Banu, R. Fathima;Kumar, V. Anand;Sundaram, Lakshmi;Thyagarajan, S. P.. And the article was included in Journal of Chromatographic Science in 2022.Formula: C10H22O The following contents are mentioned in the article:

To assess the surface characteristics, composition and release of components of Polyvinyl siloxane (PVS) impression material and explore the use of the material other than for impressions. Forty samples of 0.5-mm thickness and 8-mm diameter PVS disks, with ew perforations, were prepared and divided into four groups. Group 1 in methanol was analyzed by GC-MS immediately and on 1st, 7th and 14th day. Group 2 and 3 placed in 10 mL of human saliva and in artificial nasal fluid, resp., were analyzed by GC-MS at 24 h. Group 4 was subjected to surface characteristics anal. by placing five PVS disks each in 1 mL of human saliva and 1 mL of artificial nasal fluid, resp. On Day 1, Dodecanoic acid, Me ester, Cyclononasiloxane, octadecamethyl, Cyclodecasiloxane and eicosamethyl (four peaks) were observed in Group 1. At 24 h, Group 2 had addnl. compounds of 2-Decene,7-methyl-(Z)-, 2-Undecene,8-methyl-(Z)- and Lauryl acetate. Group 3 showed release of 32 compounds, but their retention time was less. Surface characteristics on Day 14 revealed no noticeable changes. The study revealed that there was a lack of any adverse component release from PVS for a period of 2 wk based on GC-MS anal. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Formula: C10H22O).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C10H22O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy was written by Russo, Giacomo;Laneri, Sonia;Di Lorenzo, Ritamaria;Neri, Ilaria;Dini, Irene;Ciampaglia, Roberto;Grumetto, Lucia. And the article was included in Molecules in 2022.Electric Literature of C13H12O2 The following contents are mentioned in the article:

The concentration levels of thirteen organic pollutants and selected heavy metals were investigated in 40 plastics bottled and tap water samples. Some of the selected contaminants have an ascertained or suspected endocrine disrupting activity, such as Bisphenol A (BPA) and its analogs, and Bis 2-ethylhexyl phthalate (DEHP), which are used by industries as plasticizers. The most frequently detected pollutants were Bisphenol AF (BPAF) (detection frequency (DF) = 67.5%, mean 387.21 ng L^-1), DEHP (DF = 62.5%, mean 46.19μg L^-1) and BPA (DF = 60.0%, mean 458.57 ng L^-1), with higher concentration levels found in tap waters. Furthermore, a possible level of exposure to thirteen pollutants via drinking water intake was calculated Our findings show that, even though the occurrence of contaminants and heavy metals in drinking waters does not pose an immediate, acute health risk for the population, their levels should be constantly monitored and ‘hard-wired’ into everyday practice. Indeed, the health impact to the continuous and simultaneous intake of a huge variety of xenobiotics from various sources by humans is complex and still not fully understood. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Electric Literature of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Modeling and optimisation studies on the ultrasound-assisted extraction of phenolic compounds from Azadirachta indica was written by Patil, Sunita S.;Deshannavar, Umesh B.;Ramasamy, M.;Hegde, Prasad G.. And the article was included in Chemical Engineering Communications in 2022.Electric Literature of C20H22O8 The following contents are mentioned in the article:

The need for naturally occurring pharmaceutical compounds has long been a topic of interest. Azadiractin is a naturally occurring biopesticide in margosa species. Green chem. principles are employed to conserve valuable resources and minimize ill effects on the environment. The present study reports the ultrasound-assisted extraction of the total phenolic content from Azadirachta indica leaves. The Taguchi technique was employed to optimize factors affecting the yield of the total phenolic content such as particle size (0.15-0.60 mm), temperature (25-55 °C), the solid to liquid ratio (1:20-1:50 g mL-1), and irradiation time (15-60 min). The statistical anal. revealed that particle size had the most significant effect on the yield, followed by temperature, irradiation time, and the solid to liquid ratio in that order. The optimized conditions resulted in a maximum yield of 30 mg gallic acid equivalent per g plant material of the total phenolic content. The rate constant and effective diffusivity were determined by the first-order kinetic model and Fick′s second law of diffusion, resp. The effective diffusivity evaluated under optimized exptl. conditions was 6.85 x 10-12 m2 s-1. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Electric Literature of C20H22O8).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Electric Literature of C20H22O8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hydrogen production based on the heterologous expression of NAD⁺-reducing [NiFe]-hydrogenase from Cupriavidus necator in different genetic backgrounds of Escherichia coli strains was written by Teramoto, Haruhiko;Shimizu, Tetsu;Suda, Masako;Inui, Masayuki. And the article was included in International Journal of Hydrogen Energy in 2022.Safety of (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol The following contents are mentioned in the article:

This study explored the genetic engineering of Escherichia coli for hydrogen (H₂) production In E. coli W3110, the introduction of NAD⁺-reducing [NiFe]-hydrogenase from Cupriavidus necator, combined with the inactivation of three endogenous [NiFe]-hydrogenases, exhibited not only H₂ production but also H₂ uptake based on exogenous hydrogenase. Although the H₂ production ability was much lower than the H₂ uptake ability, inactivation of the ethanol, lactate, and succinate production pathways resulted in a marked increase in H₂ production, demonstrating the bidirectional hydrogenase function in vivo depending on NADH/NAD⁺. Unexpectedly, H₂ production was completely repressed under conditions for high expression of exogenous hydrogenase. Furthermore, the introduction of the heterologous enzyme markedly repressed the endogenous H₂ production ability of E. coli W3110 but not the HST02. These in vivo behaviors largely correlated with in vitro hydrogenase activity suggested complicated interactions between the native and nonnative functional expression of [NiFe]-hydrogenases. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Safety of (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ultrasensitive molecularly imprinted electrochemiluminescence sensor based on enzyme-encapsulated liposome-linked signal amplification for trace analysis was written by Liu, Guangyan;Ling, Jun;Xie, Hanzhao;Li, Jianping. And the article was included in Sensors and Actuators, B: Chemical in 2022.Application In Synthesis of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate The following contents are mentioned in the article:

A molecularly imprinted polymer (MIP)-electrochemiluminescence (ECL) sensor was prepared and an ultrasensitive strategy was proposed for detecting an ultra-trace amount of ethiprole based on the enzymic signal amplification of glucose oxidase (GOD). The ethiprole mol. on the MIP was marked with GOD-encapsulated liposomes via light-triggered click reaction after elution and readsorption. Many GOD particles were released from the liposomes and catalyzed the reaction to produce a large amount of H2O2 in the presence of glucose, which considerably enhanced the ECL intensity of luminol. Therefore, the sensitivity for ethiprole determination was promoted remarkably. The ECL signal of the sensor was linearly related to the logarithm of ethiprole concentration from 5.00 x 10-16 M to 5.00 x 10-11 M, and the detection limit was 1.00 x 10-16 M, which was the lowest of all the anal. methods used in ethiprole determination Ethiprole in samples was determined directly without the tedious and complicated sample treatment procedures, such as separation and enrichment. The click chem. labeling method using liposomes simplified the operation steps of the MIP-ECL sensor in ethiprole determination This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Application In Synthesis of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Data-driven approach to mitigate quality impact of hygroscopic pharmaceutical raw materials throughout the supply chain was written by Chaves, Mary K.;Kelly, Ron C.;Milne, Jacqueline E.;Burke, Susan E.. And the article was included in Pharmaceutical Development and Technology in 2022.Product Details of 367-93-1 The following contents are mentioned in the article:

The challenges of working with hygroscopic pharmaceutical raw materials can have a significant impact on the industry′s ability to make high-quality medicines. In order to mitigate the impact to the manufacturing process or product quality it is critical to understand the hygroscopicity of the raw materials across the entire supply chain so that the proper management strategies can be implemented, from the raw material manufacturing to the use of the raw material in the drug manufacturing process. Employing suitable controls protects these materials from phys. and chem. changes due to moisture uptake such as caking or hydrolysis. We have developed a fit for purpose and data-driven approach to hygroscopicity classifications of over 200 commonly used chems., excipients, media and resins in drug manufacturing processes. Dynamic vapor sorption data is presented with supporting thermal gravimetric anal. and X-ray powder diffraction data where pertinent. Approx. 60% of all raw materials tested were determined to be hygroscopic. Strategies for applying this data to reduce the potential impact of hygroscopic materials on the manufacturing of pharmaceuticals are discussed with examples. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Product Details of 367-93-1).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Product Details of 367-93-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Light radiation promoted stilbene accumulation in peanut sprouts: a response of the reestablishment of oxidant-antioxidant homeostasis was written by Zhu, Tong;Yang, Jinghui;Zhang, Di;Cai, Qinqin;Shen, Yi;Tu, Siying;Tu, Kang. And the article was included in Acta Physiologiae Plantarum in 2021.Electric Literature of C20H22O8 The following contents are mentioned in the article:

The effect of light radiation on stilbene induction and reactive oxygen species (ROS) metabolism of peanut sprouts were explored in this study. Firstly, different types of light sources with same intensity, including white light-emitting diode (LED), UV-A, UV-B and UV-C, were used to radiate peanuts during germination. Results showed contents of stilbenes and total phenolics were significantly promoted by light radiation and different types of stilbene compound were significantly induced in response to different types of light. Secondly, UV-C radiation was selected to treat peanuts with different intensities during germination. Results showed contents of stilbenes, total phenolics, total flavonoids, activity of antioxidant enzymes and phenylalanine ammonia-lyse (PAL) increased significantly with the increasing UV-C intensity. H2O2 showed a remarkable neg. correlation with stilbenes, antioxidants, PAL, peroxidase and catalase. Contents of stilbenes and antioxidants of peanut sprouts could be increased by light radiation effectively in the germination process and the underlying inducing mechanism by UV-C radiation was involved with the mediation of oxidant-antioxidant homeostasis. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Electric Literature of C20H22O8).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C20H22O8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts