Month: November 2022

Sulfamides direct radical-mediated chlorination of aliphatic C-H bonds was written by Short, Melanie A.;Shehata, Mina F.;Sanders, Matthew A.;Roizen, Jennifer L.. And the article was included in Chemical Science in 2020.HPLC of Formula: 106-21-8 The following contents are mentioned in the article:

Herein, sulfamides served as amine surrogates to guide intermol. chlorine-transfer at γ-C(sp³) centers. This unusual position-selectivity arised because accessed sulfamidyl radical intermediates engaged preferentially in otherwise rare 1,6-hydrogen-atom transfer (HAT) processed through seven-membered transition states. The site-selectivity of C-H abstraction could be modulated by adjusting steric and electronic properties of sulfamide nitrogen substituents, an ability that had not been demonstrated with other substrate classes. The disclosed reaction relied on a light-initiated radical chain-propagation mechanism to oxidize C(sp³)-H bonds efficiently. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8HPLC of Formula: 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.HPLC of Formula: 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Syntheses, crystal structures, spectral studies, and DFT calculations of two new square planar Ni(II) complexes derived from pyridoxal-based Schiff base ligands was written by Mandal, Senjuti;Chatterjee, Sudipta;Modak, Ritwik;Sikdar, Yeasin;Naskar, Barnali;Goswami, Sanchita. And the article was included in Journal of Coordination Chemistry in 2014.Synthetic Route of C8H10ClNO3 The following contents are mentioned in the article:

Two new complexes based on a Schiff base derived from pyridoxal N,N-dimethylethylenediamine (HL¹) and N,N-diethylethylenediamine (HL²), [Ni(L¹)SCN] and [Ni(L²)SCN], were synthesized and structurally characterized by single-crystal x-ray diffraction along with other phys. techniques, including elemental analyses, IR spectra, cyclic voltammetry, UV-visible, and luminescence studies. X-ray studies suggest that in both the complexes Ni lies in a slightly distorted square planar environment occupied by the tridentate ONN ligand and an isothiocyanate moiety. D. functional theory computations were carried out to characterize the complexes. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Synthetic Route of C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anticonvulsant activity of 2,2-disubstituted 1,3-propanediols in electroshock seizures was written by Berger, F. M.. And the article was included in Proceedings of the Society for Experimental Biology and Medicine in 1951.Name: 2-Butyl-2-ethylpropane-1,3-diol The following contents are mentioned in the article:

cf. C.A. 45, 265a. Compounds studied were, 2,2-dimethyl-, 2,2-diethyl-, 2,2-dipropyl-, 2-butyl-, 2,2-dibutyl-, 2-ethyl-2-methyl-, 2-isopropyl-2-methyl-, 2-propyl-2-methyl-, 2-butyl-2-methyl-, 2-butyl-2-ethyl-, 2-ethoxy-2-ethyl-, 2-ethyl-2-phenyl-, 2-phenyl-, 2,2-diphenyl-, 2-phenoxy-2-phenyl-, and 2,2-dibenzyl-1,3-propanediol. All compounds in suitable doses protected mice against electroshock convulsion. The mol. configuration favorable for maximum activity is the presence of a quaternary C atom to which 1 or 2 Ph radicals are attached. Several of the compounds were about as potent as mephenesin. The most potent (the diphenyl derivative) was about 1/6 as potent as Na phenobarbital. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Name: 2-Butyl-2-ethylpropane-1,3-diol).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: 2-Butyl-2-ethylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp³)-H bonds was written by Wu, Xinxin;Zhang, Hong;Tang, Nana;Wu, Zhen;Wang, Dongping;Ji, Meishan;Xu, Yan;Wang, Min;Zhu, Chen. And the article was included in Nature Communications in 2018.Application In Synthesis of 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

A practical and elusive metal-free alc.-directed heteroarylation of remote unactivated C(sp³)-H bonds was disclosed. Phenyliodine bis(trifluoroacetate) (PIFA) was used as the only reagent to enable the coupling of alcs. and heteroaryls. Alkoxy radicals were readily generated from free alcs. under the irradiation of visible light, which trigged the regioselective hydrogen-atom transfer (HAT). A wide range of functional groups were compatible with the mild reaction conditions. Two unactivated C-H bonds were cleaved and one new C-C bond was constructed during the reaction. This protocol provides an efficient strategy for the late-stage functionalization of alcs. and heteroaryls. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Application In Synthesis of 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application In Synthesis of 3,7-Dimethyloctan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chemically modified cellulose strips with pyridoxal conjugated red fluorescent gold nanoclusters for nanomolar detection of mercuric ions was written by Bothra, Shilpa;Upadhyay, Yachana;Kumar, Rajender;Ashok Kumar, S. K.;Sahoo, Suban K.. And the article was included in Biosensors & Bioelectronics in 2017.Application of 65-22-5 The following contents are mentioned in the article:

One-pot approach was adopted for the synthesis of highly luminescent near-IR (NIR)-emitting gold nanoclusters (AuNCs) using bovine serum albumin (BSA) as a protecting agent. The vitamin B₆ cofactor pyridoxal was conjugated with the luminescent BSA-AuNCs through the free amines of BSA and then employed for the nanomolar detection of Hg²⁺ in aqueous medium via selective fluorescence quenching of AuNCs. This nano-assembly was successfully applied for the real sample anal. of Hg²⁺ in fish, tap water and river water. The study also presents chem.-modified cellulosic paper strips with the pyridoxal conjugated BSA-AuNCs for detecting Hg²⁺ ion up to 1 nM. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

N,N’-dipyridoxyl(1,2-diaminocyclohexane) and its Cu(II) complex: Synthesis, experimental and theoretical studies was written by Beyramabadi, S. A.;Morsali, A.;Shams, A.. And the article was included in Journal of Structural Chemistry in 2015.Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

The N,N’-dipyridoxyl(1,2-diaminocyclohexane) [=H₂L] Schiff-base ligand and its square complex [Cu(L)] are newly synthesized and characterized by IR, mass spectroscopy, ¹H NMR, and elemental anal. The full optimization of geometries, the ¹H NMR chem. shifts (for the H₂L) and their vibrational frequencies are calculated using the d. functional theory (DFT) method. The optimized geometry of the ligand is not planar, but each of two pyridine rings and the cyclohexane moiety are in the sep. planes. The tetradentate-dianionic L^2- ligand occupies the four coordination positions of the square complex in the N, N, O^–, O^– manner. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Choline phosphate lipid insertion and rigidification of cell membranes for targeted cancer chemo-immunotherapy was written by Li, Shengran;Mei, Weikang;Wang, Xiaozhen;Jiang, Sangni;Yan, Xinxin;Liu, Sanrong;Yu, Xifei. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Computed Properties of C37H74NO8P The following contents are mentioned in the article:

To prevent tumor reproduction and metastasis, a method to modify the membranes of cancer cells was designed to suppress their vitality. A phosphatidyl choline reversed choline phosphate lipid (CP-Lip) was synthesized and modified with a PD-L1 antibody (CP-αPDL). Drug-loaded nanoparticles of CP-Lip/CP-αPDL (Dox@tCP-Lipos) could be selectively attached to melanoma cells, thus causing CP-Lip to be inserted and to interact strongly with the cell membrane, which largely reduced the fluidity and functionality of the membrane. As a result, the metabolism, reproduction, and migration of melanoma cells were proved to be weakened by CP-Lip and the tumor was 100% suppressed after treatment with Dox@tCP-Lipos. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Computed Properties of C37H74NO8P).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Computed Properties of C37H74NO8P

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Test for the comparison of glass-resin adhesion in laminates, application to glass-polyene ester laminates was written by Zalmanski, Alain. And the article was included in Bulletin de la Societe Chimique de France in 1970.Formula: C9H20O2 The following contents are mentioned in the article:

The adhesion of glass fibers to the polyester matrix in the reinforced laminates was determined by measuring the difference between the bending resistance of the reinforced laminate and the pure resin. The glass fiber content, type of the resin, the modifying diacid, the unsaturation mode of the polyester, and the type of the glycols and monomers used were the main parameters affecting adhesion. An improvement in adhesion was observed when using a polyester containing ∼25% maleic anhydride; modifying with tetrahydro- or hexahydrophthalic anhydride; using neopentyl glycol or 1,3-butylene glycol; and the partial replacing of styrene with Me methacrylate, ethylene glycol dimethacrylate, or chlorostyrene. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Formula: C9H20O2).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C9H20O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Phytochemistry and Antioxidant Activities of Rhus tripartitum (Ucria) Grande Leaf and Fruit Phenolics, Essential Oils, and Fatty Acids was written by Jallali, Ines;Zaouali, Yosr;Mkadmini, Khaoula;Smaoui, Abderrazek;Abdelly, Chedly;Ksouri, Riadh. And the article was included in Natural Product Communications in 2022.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

Rhus tripartitum (Ucria) Grande leaves and fruits were investigated for their contents in phenolic compounds, essential oils, and fatty acids. Chem. composition and antioxidant potential of these secondary metabolites were investigated using chromatog. tools and different antioxidant tests. Results displayed high amounts of phenolic compounds in leaves, concomitant with important antioxidant potentialities, probably due to their richness in phenolic acids and flavonoids as identified by reverse phase high performance liquid chromatog. (RP-HPLC). Amounts of essential oils were higher in leaves. Oxygenated sesquiterpenes are exclusively synthesized by the fruits, expressing better antioxidant activities. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Category: alcohols-buliding-blocks).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Materials for protection against biting insects was written by Travis, B. V.;Smith, Carroll N.. And the article was included in J. Forestry in 1950.Reference of 115-84-4 The following contents are mentioned in the article:

The following compounds were effective against mosquitoes and flies and harmless to the human skin: dimethyl phthalate; di-Me bicyclo[2.2.1]-5-heptene-2,3-dicarboxylate (I); Indalone (n-butyl mesityl oxide oxalate); 6-12 (2-ethyl-1,3-hexane diol); and 2-phenoxyethyl acetate. 2-Butyl-2-ethyl-1,3-propanediol was effective for clothing applications. Against chiggers the above compounds are satisfactory but benzyl or benzyl benzoate are preferable. Most effective against ticks were, in order of preference: N-butylacetanilide, hexyl mandelate, Indalone, I, 2-butyl-2-ethyl-1,3-propanediol, diethyl phthalate, and benzyl benzoate. The 1st compound is too toxic for skin applications. Directions for use are given. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Reference of 115-84-4).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 115-84-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts