Month: November 2022

Naous, M. published the artcileSynergism in mixtures of n-octyl-β-D-thioglucoside and different n-alkyltrimethylammonium bromides: effect of the alkyl chain length, Synthetic Route of 85618-21-9, the publication is Colloid and Polymer Science (2012), 290(11), 1041-1051, database is CAplus.

Mixtures of n-octyl-β-D-thioglucoside with three different n-alkyltrimethylammonium bromides (n = 12 (DTAB), 14 (TTAB), and 16 (CTAB)) have been studied by using fluorescence spectroscopic techniques. The critical micelle concentration values of pure and mixed systems were determined by the pyrene 1:3 ratio method. The exptl. results were treated by using thermodn. mixing approaches based on the pseudo-phase separation model. All the mixed systems show a neg. deviation from ideal behavior, more pronounced with a larger alkyl tail of the co-surfactant. The three mixed systems fulfill the conditions of synergism, this behavior being also dependent on the alkyl chain length. By using the static quenching method, the mean micellar aggregation numbers of mixed micelles were obtained. In all the cases, the aggregation number is initially reduced with the participation of the cationic surfactant, remaining almost constant and close to the aggregation number of the pure cationic micelles. The local viscosity of pure and mixed micelles was examined by the photophys. response of the hydrophobic probe coumarin 6 solubilized in the micellar medium. The participation of the ionic component induces the formation of a less ordered structure than that of pure nonionic micelles. This effect becomes less pronounced as the chain hydrocarbon length of the co-surfactant increases.

Colloid and Polymer Science published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Synthetic Route of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Molina-Bolivar, J. A. published the artcileSurface Activity, Micelle Formation, and Growth of n-Octyl-β-D-Thioglucopyranoside in Aqueous Solutions at Different Temperatures, SDS of cas: 85618-21-9, the publication is Journal of Physical Chemistry B (2004), 108(34), 12813-12820, database is CAplus.

Micellization, surface activity, and structures of the aggregates of the nonionic surfactant n-octyl-β-D-thioglucopyranoside in aqueous solutions through a temperature range have been investigated. By using surface tension measurements, information was obtained on both changes in the critical micelle concentration and adsorption behavior in the air-liquid interface with the temperature These data were used to obtain the thermodn. properties of micellization along with the corresponding adsorption parameters in the air-liquid interface. The results obtained indicated that the surfactant headgroup has a more pronounced hydrophilic character than that of the common polyoxyethylenic nonionic surfactants. Size and structure of the micelles formed at different temperatures were investigated by light scattering measurements. The light scattering data, including static and dynamic experiments, account for micelle growth and hydration. The anal. of the exptl. results was focused on the phase transition from sphere to rodlike structures. To corroborate this point, addnl. measurements of d. and intramol. excimer formation of 1,2-dypyrenylpropane vs. the surfactant concentration were performed. Satisfactory agreement of the results, showing a significant micellar growth starting from a certain surfactant concentration, was observed by means of the different techniques used.

Journal of Physical Chemistry B published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, SDS of cas: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hierrezuelo, J. M. published the artcileMicellar properties of a mixed surfactant system constituted by n-octyl-β-D-thioglucopyranoside and sodium dodecyl sulphate, Related Products of alcohols-buliding-blocks, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2005), 264(1-3), 29-36, database is CAplus.

A fluorescence probe study on micellization of the binary surfactant system formed by n-octyl-β-D-thioglucopyranoside (OTG) and Na dodecyl sulfate (SDS) in 0.1M NaCl aqueous solutions was carried out. The CMC exptl. data, as obtained by the pyrene 1:3 ratio method, were analyzed in the context of the pseudophase separation model. The interaction parameter (β₁₂) determined by using the regular solution theory (RST) is neg. and independent on the solution composition The exptl. data on micellar composition showed a good agreement with those predicted by RST. Data reported by a treatment based on the Gibbs-Duhem equation showed a reasonable agreement with those obtained by RST, suggesting that the mixed system behaves as a regular solution From the mixing thermodn. function values can be inferred that the electrostatic repulsions between the sulfate groups of SDS control the stability of the mixed micelles. Size of micelles was examined through the micellar aggregation number as obtained by the static quenching method. The aggregation number initially increases, giving a maximum value at low content of the ionic component, remaining almost constant at larger content of this one. This behavior was interpreted from the role played by the electrostatic repulsions between the headgroups of SDS in the stabilization of the mixed micelles. Finally, studies based on both pyrene 1:3 ratio index and intramol. excimer forming of 1,3-dipyrenylpropane solubilized in the micellar phase, reported information on the microenvironmental properties of mixed micelles. The results obtained were rationalized from 2 effects: the electrostatic repulsions between the headgroups of the ionic component and the micellar hydration.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pardeshi, Chandrakantsing V. published the artcileMannose-anchored N,N,N-trimethyl chitosan nanoparticles for pulmonary administration of etofylline, Synthetic Route of 96345-79-8, the publication is International Journal of Biological Macromolecules (2020), 165(Part_A), 445-459, database is CAplus and MEDLINE.

Drug delivery to lungs via pulmonary administration offers potential for the development of new drug delivery systems. Here we fabricated the etofylline (ETO) encapsulated mannose-anchored N,N,N-tri-Me chitosan nanoparticles (Mn-TMC NPs). The prominent characteristics like biocompatibility, controlled release, targeted delivery, high penetrability, enhanced phys. stability, and scalability mark Mn-TMC NPs as a viable alternative to various nanoplatform technologies for effective drug delivery. Mannosylation of TMC NPs leads to the evolution of new drug delivery vehicle with gratifying characteristics, and potential benefits in efficient drug therapy. It is widely accepted that following pulmonary administration, the introduction of mannose to the surface of drug nanocarriers provide selective macrophage targeting via receptor-mediated endocytosis. The fabricated Mn-TMC NPs exhibited particle size of 223.3 nm, PDI 0.490, and ζ-potential -19.1 mV, drug-loading capacity 76.26 ± 1.2%, and encapsulation efficiency of 91.75 ± 0.88%. Sustained drug release, biodegradation studies, stability, safety, and aerodynamic behavior revealed the effectiveness of prepared nanoformulation for pulmonary administration. In addition, the in vivo pharmacokinetic studies in Wistar rat model revealed a significant improvement in therapeutic efficacy of ETO, illustrating mannosylation a promising approach for efficient therapy of airway diseases following pulmonary administration.

International Journal of Biological Macromolecules published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Synthetic Route of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Stauber, Gregory B. published the artcileCharacterization and affinity cross-linking of receptors for human recombinant lymphotoxin (tumor necrosis factor-β) on a human histiocytic lymphoma cell line, U-937, COA of Formula: C18H20N2O12, the publication is Journal of Biological Chemistry (1989), 264(6), 3573-6, database is CAplus and MEDLINE.

Recombinant human lymphotoxin (rhLT) was purified and used to examine its receptors on the human histiocytic lymphoma cell line U-937. The rhLT was radioiodinated by the IODO GEN method to a specific activity of 60 μCi/μg. The specific binding reached a plateau within 10, 60, and 180 min at 37, 23, and 4°, resp. Scatchard anal. revealed the presence of a single class of high affinity receptors with an apparent K_d of 0.6 nm and a capacity of 33,000 binding sites/cell. The binding of ¹²⁵I-labeled rhLT to U-937 cells was inhibited by excess unlabeled rhLT or recombinant human tumor necrosis factor-α(rhTNF), suggesting a common receptor for both mols. The crosslinking of the receptor to rhLT revealed 2 distinct bands at approx. mol. masses of 100,000 and 120,000 daltons. Affinity crosslinking of U-937 cells with ¹²⁵I-labeled rhTNF, however, provided only a single band with a mol. mass of about 100,000 daltons. Thus, the manner in which rhLT interacts with its receptor is perhaps somewhat different from that of rhTNF.

Journal of Biological Chemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C16H25BO2, COA of Formula: C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Higuchi, Masahiro published the artcileModulation of two forms of tumor necrosis factor receptors and their cellular response by soluble receptors and their monoclonal antibodies, Formula: C18H20N2O12, the publication is Journal of Biological Chemistry (1992), 267(29), 20892-9, database is CAplus and MEDLINE.

Recently, two different receptors for human tumor necrosis factor (TNF) with mol. masses of 60 kDa (p60) and 80 kDa (p80) have been identified. This report investigated the effect of the soluble forms of these receptors and monoclonal antibodies against them on ligand interaction, receptor down-regulation, and mediation of cellular response in U-937 cells. The results indicate that p60 and p80 constitute 20-30 and 60-80% of the total TNF-binding sites on U-937 cells, resp. However, by crosslinking, only the p80 form of the receptor could be detected. In contrast to unlabeled TNF, the anti-p60 and anti-p80 antibodies together only partially inhibited ligand binding, and this inhibition was not additive. Lack of additive inhibition of binding was not due to stereochem. hindrance. TNF binding to cells can be completely displaced by soluble forms of either the p60 or p80 receptor. However, 100-fold more of the p80 than the p60 form of the soluble receptor is needed for equivalent displacement. Under optimum conditions, TNF and the anti-p80 and anti-p60 antibodies down-regulated 30, 80, and 20% of the TNF receptors, resp. The anti-p60 and anti-p80 antibodies down-regulated not only their own receptors, but also reciprocal receptors, suggesting a cross-communication between the p60 and p80 forms of the TNF receptor. In spite of inhibiting as much as 80% of TNF binding, none of the receptor antibodies significantly inhibited the cytotoxic response to TNF in U-937 cells. Soluble forms of both receptors, however, completely abrogated the cellular response to TNF. Thus, these results indicate that the antibodies against both receptors together inhibit the majority of the receptor-ligand interaction without any significant effect on the biol. response to TNF.

Journal of Biological Chemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Formula: C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pawle, Robert H. published the artcileBandgap Engineering of Conjugated Materials with Nonconjugated Side Chains, Related Products of alcohols-buliding-blocks, the publication is Macromolecules (Washington, DC, United States) (2014), 47(7), 2250-2256, database is CAplus.

Controlling the optical properties of conjugated materials, especially their bandgaps, is critical to nearly all of applications of these materials. The most prevalent strategy involves changes to the structures of conjugated backbones, while side chains are generally reserved for imparting solubility This paper, using a series of donor-acceptor conjugated oligo- and poly(arylene-ethynylene)s that have terephthalate units as the electron-deficient unit, demonstrates examples of how the structures of side chains that are not formally part of the conjugated backbone can have significant effects on bandgaps of these materials. In organic solution, changing alkoxy substituents on the terephthalate unit yields changes in absorbance onsets of, in some cases, greater than 20 nm; the position of absorbance spectra of these materials correlates with the Taft σ* values of the ester alkoxy groups, consistent with the side chains inductively altering the electron-accepting nature of the terephthalate ring. This structure-property relationship persists in the solid state. These results indicate that synthetically simple side-chain substitutions of formally nonconjugated groups may be useful in rational design of the optoelectronic properties of conjugated materials in both solution and the solid state.

Macromolecules (Washington, DC, United States) published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bottari, Giovanni published the artcileSynthesis of Enantioenriched Amines by Iron-Catalysed Amination of Alcohols Employing at Least One Achiral Substrate, Application In Synthesis of 111-29-5, the publication is Advanced Synthesis & Catalysis (2021), 363(24), 5436-5442, database is CAplus.

The synthesis of a broad range of enantioenriched amines by the direct Fe-catalyzed coupling of amines with alcs. through the borrowing hydrogen strategy, while at least one of these substrates was achiral is reported. When starting from α-chiral amines and achiral alcs., a wide range of enantioenriched amine products, including N-heterocyclic moieties was obtained with complete retention of stereochem.. The power of this method was demonstrated in the one-step synthesis of known pharmaceuticals from com. available, simple enantiopure primary amines and achiral alcs. It was also found that the use of β-branched enantioenriched primary alcs. and achiral amines as reaction partners leads to a partial loss of stereochem. integrity in the final product, however, a systematic optimization enabled partial retention of enantiopurity and possible parameters effecting for racemization were identified.

Advanced Synthesis & Catalysis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Application In Synthesis of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Leal, Emilse S. published the artcileDe novo design approaches targeting an envelope protein pocket to identify small molecules against dengue virus, Related Products of alcohols-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2019), 111628, database is CAplus and MEDLINE.

Dengue fever is a mosquito-borne viral disease that has become a major public health concern worldwide. This disease presents with a wide range of clin. manifestations, from a mild cold-like illness to the more serious hemorrhagic dengue fever and dengue shock syndrome. Currently, neither an approved drug nor an effective vaccine for the treatment are available to fight the disease. The envelope protein (E) is a major component of the virion surface. This protein plays a key role during the viral entry process, constituting an attractive target for the development of antiviral drugs. The crystal structure of the E protein reveals the existence of a hydrophobic pocket occupied by the detergent n-octyl-β-d-glucoside (β-OG). This pocket lies at the hinge region between domains I and II and is important for the low pH-triggered conformational rearrangement required for the fusion of the virion with the host’s cell. Aiming at the design of novel mols. which bind to E and act as virus entry inhibitors, we undertook a de novo design approach by “growing” mols. inside the hydrophobic site (β-OG). From more than 240000 small-mols. generated, the 2,4 pyrimidine scaffold was selected as the best candidate, from which one synthesized compound displayed micromolar activity. Mol. dynamics-based optimization was performed on this hit, and thirty derivatives were designed in silico, synthesized and evaluated on their capacity to inhibit dengue virus entry into the host cell. Four compounds were found to be potent antiviral compounds in the low-micromolar range. The assessment of drug-like physicochem. and in vitro pharmacokinetic properties revealed that compounds 3e and 3h presented acceptable solubility values and were stable in mouse plasma, simulated gastric fluid, simulated intestinal fluid, and phosphate buffered saline solution pyrimidine.

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kirkland, Thomas A. published the artcileSynthesis of glutamic acid analogs as potent inhibitors of leukotriene A₄ hydrolase, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Bioorganic & Medicinal Chemistry (2008), 16(9), 4963-4983, database is CAplus and MEDLINE.

Leukotriene B₄ (LTB₄) is a potent pro-inflammatory mediator that has been implicated in the pathogenesis of multiple diseases, including psoriasis, inflammatory bowel disease, multiple sclerosis and asthma. As a method to decrease the level of LTB₄ and possibly identify novel treatments, inhibitors of the LTB₄ biosynthetic enzyme, leukotriene A₄ hydrolase (LTA₄-h), have been explored. Here, the authors describe the discovery of a potent inhibitor of LTA₄-h, arylamide of glutamic acid derivative I, starting from Boc-Glu[NHC₆H₄(OCH₂Ph)-4]-OH. Analogs of I are then described, focusing on compounds that are both active and stable in whole blood. This effort culminated in the identification of amino alc. II and amino ester III which meet these criteria.

Bioorganic & Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts