Month: November 2022

Dharmalingam, K. published the artcileFunctionalization of cellulose-based nanocomposite hydrogel films with zinc oxide complex and grapefruit seed extract for potential applications in treating chronic wounds, Name: 2-(Benzyl(methyl)amino)ethanol, the publication is Polymer (2020), 122620, database is CAplus.

In this study, the influence of grapefruit seed extract (GFSE) was studied on citric acid and zinc oxide incorporated cellulose-based hydrogel films. The effect of GFSE (0.25-1.0%, volume/volume) on hydrogel films was examined for their physico-chem., mech., thermal, antioxidant and antibacterial properties. The swelling ratio, tensile strength and thermal stability of films decreased with increase in GFSE concentrations On the other hand, elongation (%) and antioxidant activity of films were found to be 34-60% and 25-79%, resp. for increasing amounts of GFSE. FESEM and FETEM clearly showed that two different types of nanoparticles (50-90 nm and 5-10 nm) were present in GFSE incorporated films. The release of polyphenolic compounds and zinc from films was in sustained manner. Furthermore, the fabricated hydrogel films exhibited antibacterial activity against both E. coli and S. aureus. All these results indicate that the prepared nanocomposite hydrogel films could find their potential applications in wound healing.

Polymer published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Name: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zou, Zhuanglei published the artcileSurface modification of waste silicone rubber via alcoholysis reaction and its application in polypropylene toughening, Safety of cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Journal of Polymer Research (2022), 29(4), 148, database is CAplus.

With the development of power industry, the recycling of waste insulator silicone rubber (WSR) remains a significant challenge. Herein, an efficient alcoholysis strategy for the surface modification of WSR was explored by using nerol as alcoholysis reagent, and then the nerol modified WSR (Nerol-WSR) was utilized in polypropylene toughening. FTIR spectra indicate that nerol can served as nucleophilic reagent to cleave the Si-O bonds in WSR, resulting in an efficient surface grafting of nerol moieties on WSR. The grafting content of nerol moieties gradually increases with alcoholysis times. Morphol. investigation demonstrates that with the increase of alcoholysis time, the dispersion state of Nerol-WSR particles in PP matrix is significantly improved, along with a much smaller particle size. Accordingly, with the addition of 10 weight% of Nerol-WSR, the resulting PP composites can achieve a remarkable increase of approx. 200% in impact strength. This should be due to the grafted nerol moieties can substantially improve the interfacial adhesion of the composites and hence facilitate the dispersion of WSR particles in PP matrix. Therefore, the stress concentration of PP can also be effectively delivered to the adjacent Nerol-WSR and thus retard the propagation of cracks. In addition, the addition of Nerol-WSR can also increase the loss tangent values of the composites, which indicates its potential application in polymer damping.

Journal of Polymer Research published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C3H8N2S, Safety of cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xie, Zhiyong published the artcileCatalytic activity of nickel and cobalt for amination of ethylene glycol: Which is better?, Synthetic Route of 111-29-5, the publication is Molecular Catalysis (2022), 112243, database is CAplus.

Metal Ni and Co are widely used in the catalytic amination of alcs. and Ni is more favored due to its better catalytic performance. Here we compared their catalytic performance for the amination of ethylene glycol and unexpectedly found that Co is more active than Ni. DFT calculation results showed that the energy barriers for the dissociation of O-H and C-H bond in an ethylene glycol mol. are smaller on Co (0001) plane, accounting for higher ethylene glycol conversion and primary amine yield on metal Co catalyst. The C-C bond dissociation in a glycolaldehyde (dehydrogenation intermediate of ethylene glycol) mol. has significantly lower energy barrier on Ni (111) plane, being consistent with lower selectivity of primary amine on metal Ni catalyst. We also compared their catalytic performance for the amination of other diols and the results showed that Co is more active when short-chain diols are used as the substrate.

Molecular Catalysis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C11H19N, Synthetic Route of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Niu-niu published the artcileSynthesis, evaluation, and mechanism study of new tepotinib derivatives as antiproliferative agents, Recommanded Product: 2-Morpholinoethanol, the publication is Molecules (2019), 24(6), 1173/1-1173/16, database is CAplus and MEDLINE.

Inspired by the potent inhibition activity of the c-Met (mesenchymal-epithelial transition factor) inhibitor Tepotinib, a series of new Tepotinib derivatives were synthesized and evaluated for their ability to act as antiproliferative agents to find the leading compounds with good activity and limited side effects. Among them, compound 31e exhibited potent antiproliferative activity (IC50 (50% inhibitory concentration) = 0.026μM) against hepatic carcinoma 97H (human liver cancer cell) cells and, importantly, had very low inhibitory activity against normal cells. A mechanism study demonstrated that 31e induced G1 phase (First growth phase or G indicating gap) arrest, inhibited the phosphorylation of c-Met and its downstream signaling component, Akt (Protein Kinase B), and also inhibited the migration of hepatic carcinoma 97H cells.

Molecules published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C7H13BrSi, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Henley, Zoe A. published the artcileOptimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target, Name: 2-Morpholinoethanol, the publication is Journal of Medicinal Chemistry (2020), 63(2), 638-655, database is CAplus and MEDLINE.

Optimization of a lead series of PI3Kδ inhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable compound 19. Selectivity profiling of compound 19 showed similar potency for class III PI3K, Vps34, and PI3Kδ, and compound 19 was not well-tolerated in a 7-day rat toxicity study. Structure-based design led to an improvement in selectivity for PI3Kδ over Vps34 and, a focus on oral phramacokinetics properties resulted in the discovery of compound 41, which showed improved toxicol. outcomes at similar exposure levels to compound 19.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Name: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vagapova, L. I. published the artcileSynthesis and structure of new phosphorylated β- and γ-amino acetals containing a sterically hindered phenol group, Category: alcohols-buliding-blocks, the publication is Russian Journal of Organic Chemistry (2015), 51(9), 1268-1271, database is CAplus.

α-Phosphorylated 3,5-di-tert-butyl-4-methylidenecyclohexa-2,5-dien-1-ones reacted with 3,3-diethoxypropan-1-amine and 4,4-diethoxybutan-1-amine to afford new α-amino phosphonates containing sterically hindered phenol and acetal groups.

Russian Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C50H65O4P, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vagapova, L. I. published the artcileβ- and γ-amino acetals containing phosphine oxide groups. Synthesis and reactions with resorcinol derivatives, Safety of 4,4-Diethoxybutan-1-amine, the publication is Russian Journal of Organic Chemistry (2014), 50(6), 778-782, database is CAplus.

New β- and γ-amino acetals containing phosphine oxide groups were synthesized by the Kabachnik-Fields reaction of β- and γ-amino acetals with paraformaldehyde and dialkylphosphine oxides. Heating of the resulting β- and γ-amino acetals with 2-methylresorcinol and pyrogallol in boiling trifluoroacetic acid afforded (dialkylphosphoryl)(ω,ω-diarylalkyl)ammonium trifluoracetates.

Russian Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H6ClN, Safety of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gershonov, Eytan published the artcileRegio- and chemoselectivity in S- and O- difluoromethylation reactions using diethyl (bromodifluoromethyl)phosphonate, Related Products of alcohols-buliding-blocks, the publication is Journal of Fluorine Chemistry (2021), 109867, database is CAplus.

The effective difluoromethylations of various S- and O- based- nucleophiles, presenting a wide range of pKa values, using diethyl(bromodifluoromethyl)phosphonate under basic conditions was described. These reactions, which rely on the quant. generation of difluorocarbene formed through the hydrolysis of phosphonate, were found to be effective only once the starting materials had pKa values of less than ca. 11. Importantly, in cases in which the substrates held two or three nucleophilic centers this feature was successfully implemented to achieve a high chemo- or regioselective difluoromethylation of the center exhibiting the lowest pKa value and the highest polarizability.

Journal of Fluorine Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Alstermark, Christer published the artcileSynthesis and Pharmacological Evaluation of Novel γ-Aminobutyric Acid Type B (GABA_B) Receptor Agonists as Gastroesophageal Reflux Inhibitors, Product Details of C3H8FNO, the publication is Journal of Medicinal Chemistry (2008), 51(14), 4315-4320, database is CAplus and MEDLINE.

We have previously demonstrated that the prototypical GABA_B receptor agonist baclofen inhibits transient lower esophageal sphincter relaxations (TLESRs), the most important mechanism for gastroesophageal reflux. Thus, GABA_B agonists could be exploited for the treatment of gastroesophageal reflux disease. However, baclofen, which is used as an antispastic agent, and other previously known GABA_B agonists can produce CNS side effects such as sedation, dizziness, nausea, and vomiting at higher doses. We now report the discovery of atypical GABA_B agonists devoid of classical GABA_B agonist related CNS side effects at therapeutic doses and the optimization of this type of compound for inhibition of TLESRs, which has resulted in a candidate drug (R)-7 (AZD3355)(I) that is presently being evaluated in man.

Journal of Medicinal Chemistry published new progress about 344413-79-2. 344413-79-2 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Fluorinated Building Blocks, name is (R)-3-Amino-2-fluoropropan-1-ol, and the molecular formula is C3H8FNO, Product Details of C3H8FNO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shubhashish, Shubhashish published the artcileSynthesis of Highly Porous Metal Oxide Nanoparticles for Adsorption Applications, HPLC of Formula: 111-29-5, the publication is ACS Applied Nano Materials (2022), 5(5), 7078-7091, database is CAplus.

Herein, we report a general and straightforward synthesis method for large-pore highly mesoporous metal oxide nanoparticles via a modified inverse micelle formation. The role of diols as solvents has been demonstrated and extended to other metal oxides using ethylene glycol. After scanning most of the metals from the periodic table, magnesium and calcium from the s-block; tin from the p-block; vanadium, nickel, zinc, zirconium, and hafnium from the d-block; and lanthanum and cerium from the f-block elements, all these have been successfully synthesized as large-pore-diameter metal oxides. Because of thermodn. stability of chelate formation, ethylene glycol, 1,3-propanediol, 1,4-butanediol, and 1,5-pentanediol give a higher pore diameter, whereas a further increase in the diol carbon chain (1,6-hexanediol and 1,12-dodecanediol) leads to pore contraction. By varying the synthesis temperature, the effect of viscosity on the pore diameter has also been demonstrated. Potential applications of oxides of magnesium have been tested for carbon dioxide capture and adsorption of macromols. such as proteins and lipids and small mols. such as curcumin, dopamine, and sucrose. As predicted, larger-pore-diameter and higher-pore-volume mesoporous magnesium oxide shows higher carbon dioxide capture and adsorption compared to com. magnesium oxide. A mechanism for the higher pore diameters of mesoporous metal oxide nanomaterials has been proposed based on the results and previous reported literature studies.

ACS Applied Nano Materials published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C10H6F17N, HPLC of Formula: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts