Month: November 2022

Peroxymonosulfate enhanced photocatalytic degradation of serial bisphenols by metal-free covalent organic frameworks under visible light irradiation: mechanisms, degradation pathway and DFT calculation was written by Liu, Fuyang;Dong, Qiqi;Nie, Chenyi;Li, Zhengmao;Zhang, Boaiqi;Han, Peng;Yang, Wulin;Tong, Meiping. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.Product Details of 620-92-8 The following contents are mentioned in the article:

Visible light driven peroxymonosulfate (PMS) activation by metal-free photocatalysts has attracted great attention. In present study, covalent organic frameworks (COF-PRD, PRD refers to pyridine) were synthesized and utilized to activate PMS to degrade bisphenol A (BPA) with visible light (VL) irradiation COF-PRD with PMS improved 3.5 times degradation kinetics for BPA degradation relative to that of COF-PRD without PMS with VL irradiation ·O₂^–, h⁺ and ¹O₂ dominated the BPA degradation in COF-PRD with PMS with VL irradiation Under anaerobic condition, BPA could still be effectively degraded due to the reaction of PMS with e^– to generate ·SO₄^–. In addition to BPA, bisphenol F (BPF), bisphenol B (BPB), bisphenol Z (BPZ) and bisphenol AP (BPAP) could also be effectively degraded by COF-PRD with PMS under VL irradiation conditions. D. functional theory (DFT) calculation together with intermediates determination showed that the main degradation pathway of bisphenols (BPs) included hydroxylation, electrophilic attack and ring-opening reaction. The bioaccumulation effects of BPs were greatly reduced during the degradation process. Moreover, COF-PRD exhibited excellent reusability in ten successive cycles. Clearly, COF-PRD could be employed as photocatalytic PMS activation to degrade bisphenols under both aerobic and anaerobic conditions. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Product Details of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design, synthesis and biological evaluation of novel thiosemicarbazone-indole derivatives targeting prostate cancer cells was written by He, Zhang-Xu;Huo, Jin-Ling;Gong, Yun-Peng;An, Qi;Zhang, Xin;Qiao, Hui;Yang, Fei-Fei;Zhang, Xin-Hui;Jiao, Le-Min;Liu, Hong-Min;Ma, Li-Ying;Zhao, Wen. And the article was included in European Journal of Medicinal Chemistry in 2021.Electric Literature of C8H10ClNO3 The following contents are mentioned in the article:

To discover novel anticancer agents with potent and low toxicity, a range of new thiosemicarbazone-indole analogs I [R = H, Me, Cl, OMe; R¹ = H, Me, R² = H, Me, OH, etc.; R³ = H, Me; X = N, C] based on lead compound II were designed and synthesized previously. Most compounds displayed moderate to high anticancer activities against five tested tumor cells (PC3, EC109, DU-145, MGC803, MCF-7). Specifically, the represented compound I [R = H, R¹ = Me; R² = Me, R³ = H] (III) possessed strong antiproliferative potency and high selectivity toward PC3 cells with the IC₅₀ value of 0.054μM, compared with normal WPMY-1 cells with the IC₅₀ value of 19.470μM. Preliminary mechanism research indicated that compound (III) could significantly suppress prostate cancer cells (PC3, DU-145) growth and colony formation in a dose-dependent manner. Besides, derivative (III) induced G1/S cycle arrest and apoptosis, which may be related to ROS accumulation due to the activation of MAPK signaling pathway. Furthermore, mol. (III) could effectively inhibit tumor growth through a xenograft model bearing PC3 cells and had no evident toxicity in vivo. Overall, based on the biol. activity evaluation, analog (III) can be viewed as a potential lead compound for further development of novel anti-prostate cancer drug. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Electric Literature of C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Interaction of isolinderanolide E obtained from Nectandra oppositifolia with biomembrane models was written by Rosa, Matheus Elias;Alves Conserva, Geanne A.;Lago, Joao Henrique G.;Caseli, Luciano. And the article was included in Biochimica et Biophysica Acta, Biomembranes in 2021.Related Products of 923-61-5 The following contents are mentioned in the article:

A long-tail lactone, named isolinderanolide E, was obtained from Nectandra oppositifolia and incorporated in Langmuir monolayers of dipalmitoyl-phosphoethanolamine (DPPE) as a model of microbial membranes. The compound was dissolved in chloroform and mixed with DPPE to provide mixed solutions spread on the air-water interface. After solvent evaporation, mixed monolayers were formed, and surface pressure-area isotherms, dilatational rheol., Brewster angle microscopy (BAM), and IR spectroscopy were employed to characterize the prodrug-membrane interactions. Isolinderanolide E expanded DPPE monolayers, denoting repulsive interactions. At 30 mN/m, the monolayer presented higher viscoelastic and in-plane elasticity parameters and an increased ratio of all-trans/gauche conformers of the alkyl chains, confirming mol. order. Morphol. of the monolayer was analyzed by BAM, which revealed a more homogeneous distribution of Isolinderanolide E along the DPPE monolayer than the prodrug directly spread at the interface, which tends to aggregate. A mol. model proposing the mol. orientation of the amphiphilic drug is presented and explained by the distortion of the alkyl chains as well as by viscoelastic changes. In conclusion, the prodrug changes the thermodn., rheol., morphol., and structural properties of the DPPE monolayer, which may be essential to understand, at the mol. level, the action of bioactives in selected membrane models. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Related Products of 923-61-5).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 923-61-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hydrogenation of Citral on Pt/SiO₂ Catalysts: Effect of Sn Addition and Type of Solvent was written by Barrales-Cortes, C. A.;Perez-Pastenes, H.;Pina-Victoria, J. C.;Viveros-Garcia, T.. And the article was included in Topics in Catalysis in 2020.Reference of 106-21-8 The following contents are mentioned in the article:

This work deals with the liquid-phase hydrogenation of citral over Pt monometallic and PtSn bimetallic catalysts supported on com. silica. Bimetallic catalysts contain different Sn/Pt molar ratio of 0.5, 1.0 and 1.5. Cyclohexane or 2-propanol were used as solvent. The catalysts were characterized by N₂-physisorption, XRD, NH₃-TPD, H₂-chemisorption, and TPR. Both XRD and TPR results showed the formation of PtSn and Pt₃Sn. The proportion of Pt-Sn alloys was related to the Sn/Pt molar ratio: the greater the Sn/Pt molar ratio, the greater the amount of PtSn alloy species. The amount of these species was related to the catalytic activity and selectivity in the hydrogenation of citral. Pt monometallic catalysts showed a high initial catalytic activity with high selectivity to citronellal. Bimetallic catalysts exhibited high activity and selectivity to unsaturated alcs. as geraniol and nerol. With cyclohexane as solvent, a greater amount of Pt₃Sn species promote consecutive hydrogenations, and with a greater amount of PtSn alloy the formation of compounds related to cyclization of citronellal was observed The results showed that using a balanced amount of species (Pt₃Sn and PtSn) and 2-propanol as solvent, a synergic effect that promotes high activity and selectivity to geraniol and nerol was observed maintaining the same levels of selectivity along reaction time. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Reference of 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Reference of 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Self-Organization and Charge Transport Properties of Selenium and Tellurium Analogues of Polythiophene was written by Ye, Shuyang;Janasz, Lukasz;Zajaczkowski, Wojciech;Manion, Joseph G.;Mondal, Anirban;Marszalek, Tomasz;Andrienko, Denis;Muellen, Klaus;Pisula, Wojciech;Seferos, Dwight S.. And the article was included in Macromolecular Rapid Communications in 2019.Electric Literature of C10H22O The following contents are mentioned in the article:

A series of conjugated polymers comprising polythiophene, polyselenophene, and polytellurophene with branched 3,7-dimethyloctyl side chains, well-matched mol. weight, dispersity, and regioregularity is synthesized. The ionization potential is found to vary from 5.14 to 5.32 eV, with polytellurophene having the lowest potential. Field-effect transistors based on these materials exhibit distinct hole transport mobility that varies by nearly three orders of magnitude, with polytellurophene having the highest mobility (2.5 × 10^-2 cm² V^-1 s^-1). The large difference in mobility demonstrates the significant impact of heteroatom substitution. Although the series of polymers are very similar in structure, their solid-state properties are different. While the thin film microstructure of polythiophene and polyselenophene is identical, polytellurophene reveals globular features in the film topog. Polytellurophenes also appear to be the least crystalline, even though their charge transport properties are superior to other samples. The torsional barrier and degree of planarity between repeat units increase as one moves down group-16 elements. These studies show how a single atom in a polymer chain can have a substantial influence on the bulk properties of a material, and that heavy group-16 atoms have a pos. influence on charge transport properties when all other variables are kept unchanged. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Electric Literature of C10H22O).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Electric Literature of C10H22O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Evaluation of curved root canals filled with a new bioceramic sealer: A microcomputed tomographic study using images with different voxel sizes and segmentation methods was written by Pinto, Jader Camilo;Torres, Fernanda Ferrari Esteves;Lucas-Oliveira, Everton;Bonagamba, Tito Jose;Guerreiro-Tanomaru, Juliane Maria;Tanomaru-Filho, Mario. And the article was included in Microscopy Research and Technique in 2021.Application In Synthesis of 4,4′-Methylenediphenol The following contents are mentioned in the article:

The aim of this study was to investigate the filling ability of a new premixed bioceramic sealer in comparison with an epoxy resin-based sealer in curved root canals using different segmentation methods and voxel sizes in micro-CT images. Twelve curved mesial roots of mandibular molars with two separated canals were selected. All root canals were prepared by using HyFlex EDM files size 25/.08 and filled by the single cone technique and Bio-C Sealer or AH Plus (n = 12). The samples were scanned by micro-CT at 5μm. The images were analyzed at 5, 10, and 20μm for the volumetric anal. of voids in filling. Visual image segmentation was performed by two examiners, and the automatic segmentation was accomplished for comparison. Radiopacity of the sealers was evaluated by radiog. anal. Data were submitted to the two-way ANOVA and non-paired t tests at a significance level of 5%. AH Plus had the highest radiopacity (p < .05). Root canals filled with AH Plus or Bio-C had similar low percentage of voids (p > .05). There was no difference interobserver, which had similar results to those obtained with automatic segmentation for all voxel sizes evaluated (p > .05). Bio-C Sealer had appropriate filling ability. Visual and automatic segmentation can be applied to micro-CT images with voxel sizes from 5 to 20μm to evaluate the filling of sealers with adequate radiopacity. Automatic segmentation should be used as a faster method. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Application In Synthesis of 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of 4,4′-Methylenediphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

lon deletion impairs persister cell resuscitation in Escherichia coli was written by Mohiuddin, Sayed Golam;Massahi, Aslan;Orman, Mehmet A.. And the article was included in mBio in 2022.Recommanded Product: 367-93-1 The following contents are mentioned in the article:

Bacterial persisters are nongrowing cells highly tolerant to bactericidal antibiotics. However, this tolerance is reversible and not mediated by heritable genetic changes. Lon, an ATP-dependent protease, has repeatedly been shown to play a critical role in fluoroquinolone persistence in Escherichia coli. Although lon deletion (Δlon) is thought to eliminate persister cells via accumulation of the cell division inhibitor protein SulA, the exact mechanism underlying this phenomenon is not yet elucidated. Here, we show that Lon is an important regulatory protein for the resuscitation of the fluoroquinolone persisters in E. coli, and lon deletion impairs the ability of persister cells to form colonies during recovery through a sulA- and ftsZ-dependent mechanism. Notably, this observed “viable but nonculturable” state of antibiotic-tolerant Δlon cells is transient, as environmental conditions, such as starvation, can restore their culturability. Our data further indicate that starvation-induced SulA degradation or expression of Lon during recovery facilitates Z-ring formation in Δlon persisters, and Z-ring architecture is important for persister resuscitation in both wild-type and Δlon strains. Our in-depth image anal. clearly shows that the ratio of cell length to number of FtsZ rings for each intact ofloxacin-treated cell predicts the probability of resuscitation and, hence, can be used as a potential biomarker for persisters. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Recommanded Product: 367-93-1).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 367-93-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recruitment of receptors at supported lipid bilayers promoted by the multivalent binding of ligand-modified unilamellar vesicles was written by Di Iorio, Daniele;Lu, Yao;Meulman, Joris;Huskens, Jurriaan. And the article was included in Chemical Science in 2020.Product Details of 923-61-5 The following contents are mentioned in the article:

The development of model systems that mimic biol. interactions and allow the control of both receptor and ligand densities, is essential for a better understanding of biomol. processes, such as the recruitment of receptors at interfaces, at the mol. level. Here we report a model system based on supported lipid bilayers (SLBs) for the investigation of the clustering of receptors at their interface. Subsequently, biotinylated small (SUVs) and giant (GUVs) unilamellar vesicles were bound to the SAv-functionalized SLBs by multivalent interactions and found to induce the recruitment of both SAv on the SLB surface and the biotin moieties in the vesicles. The recruitment of receptors was investigated with quartz crystal microbalance with dissipation monitoring (QCM-D), which allowed the identification of the biotin and SAv densities necessary to obtain receptor recruitment. Different vesicle binding regimes were observed for lower and higher biotin densities in the vesicles and at the SLBs. A more quant. anal. of the mol. parameters implied in the interaction, indicated that approx. 10% of the vesicle area constitutes the contact area. Moreover, the SUV binding and recruitment appeared to be fast on the anal. time scale, whereas the binding of GUVs is slower due to the larger SLB area over which SAv recruitment needs to occur. The mechanisms revealed in this study may provide insight in biol. processes in which recruitment occurs. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Product Details of 923-61-5).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 923-61-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aspartic Acid-Modified Phospholipids Regulate Cell Response and Rescue Memory Deficits in APP/PS1 Transgenic Mice was written by Wang, Xue;Gao, Huiling;Zhang, Xiaoyu;Qian, Shengxu;Wang, Cunli;Deng, Lijing;Zhong, Manli;Qing, Guangyan. And the article was included in ACS Chemical Neuroscience in 2022.Computed Properties of C37H74NO8P The following contents are mentioned in the article:

Misfolding and accumulation of amyloid-β (Aβ) to form senile plaques are the main neuropathol. signatures of Alzheimer’s disease (AD). Decreasing Aβ production, inhibiting Aβ aggregation, and clearing Aβ plaques are thus considered an important strategy for AD treatment. However, numerous drugs cannot enter the AD clin. trials due to unsatisfactory biocompatibility, poor blood-brain barrier penetration, little biomarker impact, and/or low therapeutic indicators. Here, a pair of chiral aspartic acid-modified 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (L– and D-Asp-DPPE) are prepared to build stabilized chiral liposomes. We find that both L– and D-liposomes are able to rescue Aβ aggregation-induced apoptosis, oxidative stress, and calcium homeostasis, in which the effect of D-liposomes is more obvious than that of L-ones. Furthermore, in AD model mice (APPswe/PS1d9 double-transgenic mice), chiral liposomes not only show biosafety but also strongly improve cognitive deficits and reduce Aβ deposition in the brain. Our results suggest that chiral liposomes, particularly, D-liposomes, could be a potential therapeutic approach for AD treatment. This study opens new horizons by showing that liposomes will be used for drug development in addition to delivery and targeting functions. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Computed Properties of C37H74NO8P).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Computed Properties of C37H74NO8P

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Biosynthesis of L-5-methyltetrahydrofolate by genetically engineered Escherichia coli was written by Wang, Yubo;Zhang, Meng;Li, Lexin;Yi, Jihong;Liang, Jiyu;Wang, Shuning;Xu, Ping. And the article was included in Microbial Biotechnology.Application of 367-93-1 The following contents are mentioned in the article:

L-5-Methyltetrahydrofolate (L-5-MTHF) is the only biol. active form of folate in the human body. Production of L-5-MTHF by using microbes is an emerging consideration for green synthesis. However, microbes naturally produce only a small amount of L-5-MTHF. Here, Escherichia coli BL21(DE3) was engineered to increase the production of L-5-MTHF by overexpressing the intrinsic genes of dihydrofolate reductase and methylenetetrahydrofolate (methylene-THF) reductase, introducing the genes encoding formate-THF ligase, formyl-THF cyclohydrolase and methylene-THF dehydrogenase from the one-carbon metabolic pathway of Methylobacterium extorquens or Clostridium autoethanogenum and disrupting the gene of methionine synthase involved in the consumption and synthesis inhibition of the target product. Thus, upon its native pathway, an addnl. pathway for L-5-MTHF synthesis was developed in E. coli, which was further analyzed and confirmed by qRT-PCR, enzyme assays and metabolite determination After optimizing the conditions of induction time, temperature, cell d. and concentration of IPTG and supplementing exogenous substances (folic acid, sodium formate and glucose) to the culture, the highest yield of 527.84 μg g^-1 of dry cell weight for L-5-MTHF was obtained, which was about 11.8 folds of that of the original strain. This study paves the way for further metabolic engineering to improve the biosynthesis of L-5-MTHF in E. coli. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Application of 367-93-1).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 367-93-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts