Month: November 2022

On October 12, 2000, Link, James; Liu, Gang; Pei, Zhonghua; Von Geldern, Thomas W.; Winn, Martin; Xin, Zhili; Wang, Sheldon; Boyd, Steven A.; Zhu, Gui-Dong; Freeman, Jennifer C.; Gunawardana, Indrani W.; Staeger, Michael A.; Jae, Hwan-soo; Lynch, John K. published a patent.Category: alcohols-buliding-blocks The title of the patent was Preparation of 2- or 4-(phenylthio)cinnamides as cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds. And the patent contained the following:

The title compounds (I) [wherein R1-R5 = independently H, halo, (halo)alkyl, alkoxy, cyano, NO2, CHO, and least one of R1 or R3 is an (un)substituted cis- or trans-cinnamide; Ar = (un)substituted (hetero)aryl] were prepared as cell adhesion inhibitors for the treatment of inflammatory and immune diseases. Examples include syntheses for 443 invention compounds and data for 3 bioassays. For instance, a mixture of 2-[(2,4-dichlorophenyl)thio]benzaldehyde (preparation given), malonic acid, piperidine in anhydrous pyridine was heated at 110° for 2 h and then treated with aqueous HCl to give trans-2-[(2,4-dichlorophenyl)thio]cinnamic acid (91%). Conversion to the acid chloride followed by amidation with 6-amino-1-hexanol gave (E)-II (90%). In an integrin LFA-1/ICAM-1 biochem. interaction assay, I demonstrated inhibition at 4 μM. In cell-based adhesion assays which measure the ability of test compounds to block adherence of JY-8 cells (a human EBV-transformed B cell line expressing LFA-1 on its surface) to immobilized ICAM-1 or ICAM-3, I exhibited blocking activity at 4 μM and 0.6 μM, resp. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Category: alcohols-buliding-blocks

The Article related to phenylthio cinnamide preparation cell adhesion inhibitor, aminocarbonylethenylphenyl phenyl sulfide preparation antiinflammatory, sulfide aminocarbonylethenylphenyl phenyl preparation immunosuppressant and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Newcombe, Sonya; Bobin, Mariusz; Shrikhande, Amruta; Gallop, Chris; Pace, Yannick; Yong, Helen; Gates, Rebecca; Chaudhuri, Shuvashri; Roe, Mark; Hoffmann, Eva; Viseux, Eddy M. E. published an article in 2013, the title of the article was Gold amides as anticancer drugs: synthesis and activity studies.HPLC of Formula: 32462-30-9 And the article contains the following content:

Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customization is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).HPLC of Formula: 32462-30-9

The Article related to gold complex triflic amide amino acid derivative preparation, antitumor activity gold complex triflic amide amino acid derivative, thioredoxin reductase inhibition gold complex triflic amide amino acid and other aspects.HPLC of Formula: 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

de Jesus Beleno-Saenz, Kelvin; Caceres-Tarazona, Juan Martin; Nol, Pauline; Jaimes-Mogollon, Aylen Lisset; Gualdron-Guerrero, Oscar Eduardo; Duran-Acevedo, Cristhian Manuel; Barasona, Jose Angel; Vicente, Joaquin; Torres, Maria Jose; Welearegay, Tesfalem Geremariam; Osterlund, Lars; Rhyan, Jack; Ionescu, Radu published an article in 2021, the title of the article was Non-invasive method to detect infection with Mycobacterium tuberculosis complex in wild boar by measurement of volatile organic compounds obtained from feces with an electronic nose system.Formula: C10H22S And the article contains the following content:

More effective methods to detect bovine tuberculosis, caused by Mycobacterium bovis, in wildlife, is of paramount importance for preventing disease spread to other wild animals, livestock, and human beings. In this study, we analyzed the volatile organic compounds emitted by fecal samples collected from free-ranging wild boar captured in Donana National Park, Spain, with an electronic nose system based on organically-functionalized gold nanoparticles. The animals were separated by the age group for performing the anal. Adult (>24 mo) and sub-adult (12-24 mo) animals were anesthetized before sample collection, whereas the juvenile (<12 mo) animals were manually restrained while collecting the sample. Good accuracy was obtained for the adult and sub-adult classification models: 100% during the training phase and 88.9% during the testing phase for the adult animals, and 100% during both the training and testing phase for the sub-adult animals, resp. The results obtained could be important for the further development of a non-invasive and less expensive detection method of bovine tuberculosis in wildlife populations. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Formula: C10H22S

The Article related to mycobacterium feces electronic nose system, mycobacterium bovis, sus scrofa, bovine tuberculosis, chemical gas sensors, diagnosis, feces, gold nanoparticles, organic ligands, volatile organic compounds and other aspects.Formula: C10H22S

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 25, 2020, Zhang, Zhihao; Yang, Ming; Yin, Ailing; Chen, Minmin; Tan, Ninghua; Wang, Majie; Zhang, Yanke; Ye, Hesong; Zhang, Xuefeng; Zhou, Wei published an article.Electric Literature of 621-37-4 The title of the article was Serum metabolomics reveals the effect of electroacupuncture on urinary leakage in women with stress urinary incontinence. And the article contained the following:

Stress urinary incontinence (SUI), which is defined as an involuntary loss of urine upon phys. exertion coughing, sneezing or laughing, has a significant neg. impact on the quality of life of many women. Multi-center, large-scale and randomized clin. trials have illustrated that non-invasive electroacupuncture is an effective treatment for SUI, but its therapeutic mechanism in treating SUI remains unknown. Here, gas chromatog.-mass spectrometry based serum metabolomics was performed to reveal metabolic profiles and diagnostic biomarkers from recruitment of 25 patients and 25 healthy women before and after electroacupuncture. We identified 10 differentially abundant metabolites, including butantriol, 3,4-dihydroxybutanoic acid, succinic acid, 1-deoxypentitol, psicose, citric acid, 3-hydroxybutyric acid, hydracrylic acid, 3-hydroxyphenylacetic acid and D-mannitol, from patients between before and after electroacupuncture. The electroacupuncture therapy altered propanoate metabolism, butanoate metabolism and the tricarboxylic acid cycle. A panel of 8 biomarkers (butantriol, 3,4-dihydroxybutanoic acid, succinic acid, 1-deoxypentitol, psicose, citric acid, 3-hydroxybutyric acid and hydracrylic acid) was evaluated to determine the effect of electroacupuncture on SUI and differentiated well between before and after treatment. The area under the receiver operating characteristic curve was 0.962. The sensitivity, specificity and coincidence rate were 92%, 92% and 96%, resp., at a 95% confidence interval ranging from 0.9053 to 1. Furthermore, the levels of these diagnostic biomarkers were not significantly altered in healthy subjects after sham electroacupuncture. It was indicated that an 8-biomarker panel might be constructed for the therapeutic evaluation of electroacupuncture treatment for SUI. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Electric Literature of 621-37-4

The Article related to metabolomics electroacupuncture urine leakage stress incontinence human woman, electroacupuncture, gas chromatography-mass spectrometry, metabolomics, stress urinary incontinence, therapeutic evaluation and other aspects.Electric Literature of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On February 14, 2018, Peters, David S.; Romesberg, Floyd E.; Baran, Phil S. published an article.Synthetic Route of 32462-30-9 The title of the article was Scalable access to arylomycins via C-H functionalization logic. And the article contained the following:

Arylomycins are a promising class of “latent” antibacterial natural products currently in preclin. development. Access to analogs within this family has previously required a lengthy route involving multiple functional group manipulations that is costly and time-intensive on scale. This study presents a simplified route predicated on simple C-H functionalization logic that is enabled by a Cu-mediated oxidative phenol coupling that mimics the putative biosynthesis. This operationally simple macrocyclization is the largest of its kind and can be easily performed on gram scale. The application of this new route to a formal synthesis of the natural product and a collection of new analogs along with their biol. evaluation is also reported. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Synthetic Route of 32462-30-9

The Article related to natural product arylomycin analog synthesis antibacterial structure activity antibiotic, oxidative phenol coupling copper catalyst macrocyclization solvent effect, mol docking ligand protein interaction and other aspects.Synthetic Route of 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 15, 2010, McConville, Matthew; Blacker, John; Xiao, Jianliang published an article.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol The title of the article was Heck reaction in diols and cascade formation of cyclic ketals. And the article contained the following:

The regioselective Heck arylation of BuOCH:CH2 in alcs. was utilized for the formation of a variety of cyclic ketals. When carried out in ethylene glycol, propane-1,2-diol, or propane-1,3-diol, the Pd-catalyzed arylation afforded dioxolanes or dioxanes directly. With diols such as glycerol, 3-chloropropane-1,2-diol, and 2-methylpropane-1,3-diol, isolation of the Heck adducts and the use of an acid catalyst for the ketalization were necessary; an efficient phosphate was identified. The procedure provides a new pathway for the synthesis of cyclic ketals, particularly those that are functionalized. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

The Article related to bu vinyl ether aryl bromide diol regioselective heck ketalization, enol ether diol ketalization phosphate catalyst, cyclic ketal green preparation, dioxolane green preparation, dioxane green preparation and other aspects.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 3, 2005, Orr, William C. published a patent.Category: alcohols-buliding-blocks The title of the patent was Fuel compositions employing catalyst combustion structure. And the patent contained the following:

Metallic vapor phase fuel compositions relating to a broad spectrum of pollution reducing, improved combustion performance, and enhanced stability fuel compositions for use in jet, aviation, turbine, diesel, gasoline, and other combustion applications include co-combustion agents preferably including trimethoxymethylsilane. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Category: alcohols-buliding-blocks

The Article related to fuel catalyst combustion jet diesel gasoline metal ester silane, oxygenated fuel oil additive combustion catalyst metal salt, gasoline fuel catalyst combustion glycol anhydride phosphite phosphonate ester and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 4, 1996, Lukevics, Edmunds; Belyakov, Sergey; Pudova, Olga published an article.Reference of 2,2′-(tert-Butylazanediyl)diethanol The title of the article was A new pathway for the synthesis of 1,3-dioxa-6-aza-2-germacyclooctanes: molecular structure of 2,2-di(2-thienyl)-6-methyl-1,3-dioxa-6-aza-2-germacyclooctane. And the article contained the following:

A novel reaction pathway has been applied for the synthesis of 1,3-dioxa-6-aza-2-germacyclooctanes I (R = Me, CMe3). Compounds of this type were obtained by the dehydrocondensation of di(2-thienyl)germane and diethanolamines without a catalyst. The mol. structure of 2,2-di(2-thienyl)-6-methyl-1,3-dioxa-5-azacyclooctane I (R = Me) has been determined by x-ray diffraction study. The interat. N → Ge distance of 2.446 Å indicates the presence of a weak transannular bond. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Reference of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to azadioxagermacyclooctane thienyl methyl preparation, crystal mol structure dithienylmethyldioxaazacyclooctane, dehydrocondensation thienylgermane diethanolamine, germocane preparation crystal mol structure and other aspects.Reference of 2,2′-(tert-Butylazanediyl)diethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 16, 2017, Mpampos, Konstantin; Andersson, Thomas published a patent.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Process for the production of a mixture of 2,2-dialkyl-1,3-propanediols by aldol reaction and subsequent crossed Cannizzaro reaction of formaldehyde with 2-methylpropanal and at least one other 2-alkylalkanal. And the patent contained the following:

The invention is related to a process for the production of mixed 2,2-dialkyl-1,3-propanediols by aldol reaction and subsequent crossed Cannizzaro reaction characterized in, that formaldehyde in presence of a strong base is subjected to aldol reaction and subsequent Cannizzaro reaction with 2-methylpropanal and at least one other 2-alkylalkanal at a molar ratio formaldehyde to 2-methylpropanal and the at least one other 2-alkylalkanal of 2-2.2:1, that 2-methylpropanal and the at least one other 2-alkylalkanal are present in a weight ratio of between 1:99 and 99:1, such as between 60:40 and 95:5, and that the process yields a mixture of 2,2-dimethyl-l,3- propanediol and at least one other 2,2-dialkyl-1,3-propanediol. The invention provides the major advantage of obtaining a ready for use diol mixture in high yield in a single reactor/production plan in the absence of any cross-aldol coupling of the substrate aldehydes, allowing the mixture to be supplied as such thus reducing the number of compounds necessary to store and/or ship by the producer and/or end user and reducing the number of and investments in reactors/production plants. For example, a reactor was charged with the specified amount of water, formaldehyde and 2-ethylhexanal and the mixture was under stirring adjusted 20° over a period of 10 min, after the 10 min, charging of sodium hydroxide commenced followed by charging of the 2-methylpropanal with a minute delay, the total charging time was 30 min, the temperature was set to increase from 20° to 30° during the same period, the temperature was after completed charging of reactants increased to 60° over a period of 15 min followed by stirring at the temperature for a further 30 min, the resulting reaction mixture was, after completed reaction, cooled to < 30° and pH was adjusted by addition of formic acid, the reaction mixture was then recovered, purified and analyzed. Following the above procedure a reaction solution containing 11.2 parts by weight of 2-ethylhexanal, 96.2 parts by weight of 2-methylpropanal, 187.6 parts by weight of 48% aqueous formaldehyde, 125.2 parts by weight of 50% aqueous sodium hydroxide and 670.0 parts by weight of water was subjected to aldol reaction and subsequent Cannizzaro reaction. 1084.5 parts by weight of a reaction mixture were, after completed reactions, isolated and the pH was adjusted to 5.5 by addition of 11.2 parts by weight of formic acid, the synthesis resulted, after recovery and purification, in a 2,2-dimethyl-1,3- propanediol yield of 97.2% and a 2-butyl-2-ethyl-1,3-propanediol yield of 96.6%, the amount of unreacted aldehydes was determined to be < 0.1% of 2-methylpropanal, < 0.1% of 2-ethylhexanal and 1.4% of formaldehyde. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

The Article related to dialkylpropanediol production methylpropanal alkylpropanal aldol addition cannizzaro reaction, dimethylpropanediol butylethylpropanediol preparation methylpropanal ethylhexanal formaldehyde sodium hydroxide and other aspects.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 9, 2011, Liu, Jian; Luo, Chuanyun; Smith, Peter A.; Chin, Jodie K.; Page, Malcolm G. P.; Paetzel, Mark; Romesberg, Floyd E. published an article.Name: H-Phg(4-OH)-OH The title of the article was Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase. And the article contained the following:

Glycosylation of natural products, including antibiotics, often plays an important role in determining their phys. properties and their biol. activity, and thus their potential as drug candidates. The arylomycin class of antibiotics inhibits bacterial type I signal peptidase and is comprised of three related series of natural products with a lipopeptide tail attached to a core macrocycle. Previously, we reported the total synthesis of several A series derivatives, which have unmodified core macrocycles, as well as B series derivatives, which have a nitrated macrocycle. We now report the synthesis and biol. evaluation of lipoglycopeptide arylomycin variants whose macrocycles are glycosylated with a deoxy-α-mannose substituent, and also in some cases hydroxylated. The synthesis of the derivatives bearing each possible deoxy-α-mannose enantiomer allowed us to assign the absolute stereochem. of the sugar in the natural product and also to show that while glycosylation does not alter antibacterial activity, it does appear to improve solubility Crystallog. structural studies of a lipoglycopeptide arylomycin bound to its signal peptidase target reveal the mol. interactions that underlie inhibition and also that the mannose is directed away from the binding site into solvent which suggests that other modifications may be made at the same position to further increase solubility and thus reduce protein binding and possibly optimize the pharmacokinetics of the scaffold. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Name: H-Phg(4-OH)-OH

The Article related to arylomycin lipoglycopeptide antibiotic synthesis antibacterial structure activity solubility, crystal structure lipoglycopeptide signal peptidase complex modeling, tyrosine coupling cyclization glycosylation and other aspects.Name: H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts