Month: November 2022

On January 22, 2020, De Francesco, Raffaele; Donnici, Lorena; Guidotti, Luca; Iannacone, Matteo; Di Fabio, Romano; Summa, Vincenzo; Bencheva, Leda Ivanova; De Matteo, Marilenia; Ferrante, Luca; Prandi, Adolfo; Randazzo, Pietro published a patent.Related Products of 62640-03-3 The title of the patent was Preparation of arylaminocarbonyl bicyclic sulfonamides as inhibitors of hepatitis B virus. And the patent contained the following:

The invention relates to preparation of arylaminocarbonyl bicyclic sulfonamides (I) that are inhibitors of hepatitis B virus (HBV). Compounds I wherein B is a 6-membered aryl optionally containing one or more N atoms; X is N (un)substituted with R4, or is O; Y is a single bond, a double bond, C1-4 alkanediyl, etc.; Z is C(O) or CR2R3; R1 is H, OH, etc.; R2 is H, DNH2, etc.; R3 is absent, H, D, etc.; R4 is H, OH, C1-4 alkyl; R5 is C1-3 alkyl (un)substituted with OH; R6 is C1-4 alkyl; etc., are claimed. The example compound II was prepared from an intermediate(also prepared) and formaldehyde (procedure given). The compounds of the invention were evaluated for their biol. activity (data given). Compounds I are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The invention also relates to pharmaceutical compositions containing I. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Related Products of 62640-03-3

The Article related to arylaminocarbonyl bicyclic sulfonamide preparation antiviral hepatitis b combination therapy, hbv infection prophylaxis combination treatment arylaminocarbonyl bicyclic sulfonamide preparation and other aspects.Related Products of 62640-03-3

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Alcohol – Wikipedia,
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On January 23, 2020, De Francesco, Raffaele; Donnici, Lorena; Guidotti, Luca; Iannacone, Matteo; Di Fabio, Romano; Summa, Vincenzo; Bencheva, Leda Ivanova; De Matteo, Marilenia; Ferrante, Luca; Prandi, Adolfo; Randazzo, Pietro published a patent.Electric Literature of 62640-03-3 The title of the patent was Preparation of arylaminocarbonyl bicyclic sulfonamides as inhibitors of hepatitis B virus. And the patent contained the following:

The invention relates to preparation of arylaminocarbonyl bicyclic sulfonamides (I) that are inhibitors of hepatitis B virus (HBV). Compounds I wherein B is a 6-membered aryl optionally containing one or more N atoms; X is N (un)substituted with R4, or is O; Y is a single bond, a double bond, C1-4 alkanediyl, etc.; Z is C(O) or CR2R3; R1 is H, OH, etc.; R2 is H, DNH2, etc.; R3 is absent, H, D, etc.; R4 is H, OH, C1-4 alkyl; R5 is C1-3 alkyl (un)substituted with OH; R6 is C1-4 alkyl; etc., are claimed. The example compound II was prepared from an intermediate (also prepared) and formaldehyde (procedure given). The compounds of the invention were evaluated for their biol. activity (data given). Compounds I are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The invention also relates to pharmaceutical compositions containing I. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Electric Literature of 62640-03-3

The Article related to arylaminocarbonyl bicyclic sulfonamide preparation antiviral hepatitis b combination therapy, hbv infection prophylaxis combination treatment arylaminocarbonyl bicyclic sulfonamide preparation and other aspects.Electric Literature of 62640-03-3

Referemce:
Alcohol – Wikipedia,
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On January 31, 2013, Li, Yalin; Yang, Hai-Jian; Zhou, Tao published an article.Reference of 2-Methyl-2-propylpropane-1,3-diol The title of the article was New CO2-philic propane derivatives: design, synthesis and phase behavior in supercritical carbon dioxide. And the article contained the following:

Three new potent CO2-philic propane derivatives, i.e. 1,3-bis(3-chloropropionyloxy)-2,2-diethylpropane, 1,3-bis(3-chloropropionyloxy)-2-butyl-2-ethylpropane, and 1,3-bis(3-chloropropionyloxy)-2-methyl-2-propylpropane, were designed and synthesized. Their structures were characterized by NMR, FTIR, and elemental anal. Phase behavior of the three compounds was investigated at temperatures ranging from 313 K to 333 K and pressures from 9.1 MPa to 16.1 MPa in supercritical carbon dioxide, the solubility differences were discussed. The exptl. solubility data were calculated and correlated by the two d.-based models: Bartle and Chrastil, and satisfied agreements were obtained. Addnl., the partial molar volumes V2 for each compound were also estimated in the supercritical phase using the theory developed by Kumar and Johnston. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Reference of 2-Methyl-2-propylpropane-1,3-diol

The Article related to propanediol chloropropionic acid diester preparation carbon dioxide philic, solubility supercritical carbon dioxide, kumar johnston theory partial molar volume, bartle chrastil model solubility and other aspects.Reference of 2-Methyl-2-propylpropane-1,3-diol

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Alcohol – Wikipedia,
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On June 15, 2022, Li, Zhiheng; Chen, Jiazheng; Chen, Jie; Jin, Jiaojun; Chen, Hanmei; Liu, Huijun published an article.Product Details of 473-81-4 The title of the article was Metabolomic analysis of Scenedesmus obliquus reveals new insights into the phytotoxicity of imidazolium nitrate ionic liquids. And the article contained the following:

Due to the persistence of ionic liquids (ILs) in aquatic environments, it is necessary to reveal their ecol. risk to aquatic organisms. Herein, the biotoxicity of two alkyl-methylimidazolium nitrate ILs ([C10mim]NO3 and [C12mim]NO3) against Scenedesmus obliquus were studied. The results showed that the growth inhibition of S. obliquus increased with increasing concentrations of ILs, maximum values of 94.61% at 4 mg/L of [C10mim]NO3 and 97.34% at 0.8 mg/L of [C12min]NO3 were observed The fluorescence parameters of photosystem II, such as light quantum yield and electron transfer rate, showed a neg. relationship with the exposure dose. [C12mim]NO3 had a more significant effect than [C10mim]NO3. Moreover, the redox homeostasis of algae was disrupted; the accumulation of reactive oxygen species, leading to obvious inhibition of superoxide dismutase and catalase activities was observed A metabolomic anal. indicated that the contents of most metabolites were reduced significantly, and fructose and galactose decreased significantly by 42.3% and 88.6%, resp., in the [C10mim]NO3 treatment compared to those in the control. The inhibition of amino acid biosynthesis and glyoxylate and dicarboxylate metabolism explained the more serious biotoxicity of [C12mim]NO3 than that of [C10mim]NO3. This study facilitates a better understanding of the environmental safety and ecol. risks of ILs. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Product Details of 473-81-4

The Article related to scenedesmus phytotoxicity imidazolium nitrate ionic liquid, 1-alkyl-3-methylimidazolium nitrate ionic liquid, metabolomic analysis, oxidative stress, photosynthetic system, scenedesmus obliquus and other aspects.Product Details of 473-81-4

Referemce:
Alcohol – Wikipedia,
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On July 31, 2021, Karsai, Syrus; Weiss, Christel; Luetgerath, Constantin; Ott, Isabel; Faulhaber, Jorg published an article.Electric Literature of 111-29-5 The title of the article was Comparison of novel aluminium lactate versus aluminium chloride-based antiperspirant in excessive axillary perspiration: First prospective cohort study. And the article contained the following:

Aluminum chloride-based antiperspirants are an effective topical therapeutic option for mild to moderate states of excessive perspiration. Its use is primarily limited by the occurrence of skin irritation, especially in sensitive skin types. The objective of this study was to compare the antiperspirant efficacy and tolerability of a novel antiperspirant with 12.5% aluminum lactate, and a 12.5% aluminum chloride-based antiperspirant. This cohort study was conducted as a two-sided self-assessment comparison between both preparations in healthy volunteers to generate selfcare-related data. Almost half of the participants stated that aluminum chloride was more efficacious than aluminum lactate; 22% stated aluminum lactate was more efficacious than aluminum chloride; 28% observed no difference in the efficacy of both preparations (p = 0.04). However, 88% described greater tolerability with aluminum lactate (p < 0.0001). In this study, aluminum lactate showed significantly greater tolerability than aluminum chloride, although the latter tended to show slightly greater efficacy. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Electric Literature of 111-29-5

The Article related to aluminum lactate chloride antiperspirant axillary perspiration human, aluminium chloride, aluminium lactate, antiperspirant, clinical efficacy, cohort study, excessive perspiration, tolerability and other aspects.Electric Literature of 111-29-5

Referemce:
Alcohol – Wikipedia,
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On January 31, 2021, Jiang, Qian; Liu, He; Zhang, Yan; Cui, Min-hua; Fu, Bo; Liu, Hong-bo published an article.Name: 2,4-Di-tert-butylphenol The title of the article was Insight into sludge anaerobic digestion with granular activated carbon addition: Methanogenic acceleration and methane reduction relief. And the article contained the following:

In this study, the multiple effects of granular activated carbon (GAC) on sludge anaerobic digestion at ambient (16-24°C), mesophilic (35°C) and thermophilic (55°C) temperature were investigated. After GAC addition, although the methane yields of raw sludge were reduced by 6.5%-36.9%, the lag phases of methanogenesis were shortened by 19.3%-30.6% and the reductions of methane yields were declined to only 5.9%-8.1% simultaneously for pretreated sludge. The inhibitory substances like phenols that generated by thermal pretreatment were reduced after GAC addition, which were demonstrated to be responsible for the methanogenic acceleration. Meanwhile, the methane reduction due to the non-selective adsorption by GAC could be mitigated by pretreatment and elevated temperature Thus, a strategy coupling thermal pretreatment with detoxification by GAC was proposed to improve the methane production rate and avoid the neg. effects during sludge anaerobic digestion with GAC addition The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Name: 2,4-Di-tert-butylphenol

The Article related to methanogenic acceleration methane reduction sludge anaerobic digestion, anaerobic digestion, granular activated carbon, methane reduction relief, methanogenic acceleration, waste activated sludge and other aspects.Name: 2,4-Di-tert-butylphenol

Referemce:
Alcohol – Wikipedia,
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On July 17, 2015, Diez, Veronica; Loznik, Mark; Taylor, Sandra; Winn, Michael; Rattray, Nicholas J. W.; Podmore, Helen; Micklefield, Jason; Goodacre, Royston; Medema, Marnix H.; Mueller, Ulrike; Bovenberg, Roel; Janssen, Dick B.; Takano, Eriko published an article.Application In Synthesis of H-Phg(4-OH)-OH The title of the article was Functional Exchangeability of Oxidase and Dehydrogenase Reactions in the Biosynthesis of Hydroxyphenylglycine, a Nonribosomal Peptide Building Block. And the article contained the following:

A key problem in the engineering of pathways for the production of pharmaceutical compounds is the limited diversity of biosynthetic enzymes, which restricts the attainability of suitable traits such as less harmful byproducts, enhanced expression features, or different cofactor requirements. A promising synthetic biol. approach is to redesign the biosynthetic pathway by replacing the native enzymes by heterologous proteins from unrelated pathways. In this study, we applied this method to effectively re-engineer the biosynthesis of hydroxyphenylglycine (HPG), a building block for the calcium-dependent antibiotic of Streptomyces coelicolor, a nonribosomal peptide. A key step in HPG biosynthesis is the conversion of 4-hydroxymandelate to 4-hydroxyphenylglyoxylate, catalyzed by hydroxymandelate oxidase (HmO), with concomitant generation of H2O2. The same reaction can also be catalyzed by O2-independent mandelate dehydrogenase (MdlB), which is a catabolic enzyme involved in bacterial mandelate utilization. In this work, we engineered alternative HPG biosynthetic pathways by replacing the native HmO in S. coelicolor by both heterologous oxidases and MdlB dehydrogenases from various sources and confirmed the restoration of calcium-dependent antibiotic biosynthesis by biol. and UHPLC-MS anal. The alternative enzymes were isolated and kinetically characterized, confirming their divergent substrate specificities and catalytic mechanisms. These results demonstrate that heterologous enzymes with different physiol. contexts can be used in a Streptomyces host to provide an expanded library of enzymic reactions for a synthetic biol. approach. This study thus broadens the options for the engineering of antibiotic production by using enzymes with different catalytic and structural features. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Application In Synthesis of H-Phg(4-OH)-OH

The Article related to hydroxyphenylglycine biosynthesis oxidase dehydrogenase functional exchangeability, hmo, mdlb, uhplc-ms, calcium-dependent antibiotics, l-hpg biosynthesis, nonribosomal peptide, synthetic biology and other aspects.Application In Synthesis of H-Phg(4-OH)-OH

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Alcohol – Wikipedia,
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On January 1, 2021, Wang, Yuhong; Mi, Tian; Li, Yiming; Kan, Weijuan; Xu, Gaoya; Li, Jingya; Zhou, Yubo; Li, Jia; Jiang, Xuefeng published an article.Name: 1-Decanethiol The title of the article was Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity. And the article contained the following:

In this work, the designed lenalidomides I [R = Et, Ph, 2-naphthyl, etc.; X = S, Se] and pomalidomides II [R1 = Et, pentyl, hexyl, 4-MeC6H4, 6-chloro-2-pyridyl; Y = S, Se] were synthesized and evaluated. The anti-proliferative activity against MM.1S cell line of compound I [R = 4-FC6H4, X = S] (IC50 = 79 nM) was similar to lenalidomide (IC50 = 81 nM). Compared to compound I [R = 4-F3CC6H4CH2], the half-live (T1/2) of compound I [R = 4-FC6H4, X = S] in human liver microsomes was promoted from 3 min to 416.7 min. The corresponding metabolic factor of compound I [R = 4-FC6H4, X = S] was increased from 2.8% to 79.5%, which was slightly lower than lenalidomide (91.5%). Moreover, the IKZF1 degradation of compounds I [R = 2-MeOC6H4, 4-FC6H4, X = S] was well related with corresponding IC50 values, which suggested the IKZF1 degradation efficiency was correlated to the responses of MM1.S cells. Furthermore, the oral administration of compounds I [R = 2-MeOC6H4, 4-FC6H4, X = S] at dosages of 60 mg/kg could delay tumor growth in female CB-17 SCID mice. This research helped to prompt the stability of thioether lenalidomide analogs, which paved the way for developing better mols. for treating multiple myeloma. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Name: 1-Decanethiol

The Article related to thioether containing lenalidomide preparation antitumor human sar, pomalidomide thioether containing preparation antitumor human sar, late-stage sulfuration, lenalidomide, mm.1s, multiple myeloma and other aspects.Name: 1-Decanethiol

Referemce:
Alcohol – Wikipedia,
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On July 31, 2022, Kim, Sooah; Hwang, Jiwon; Kim, Jungyeon; Lee, Sun-Hee; Cheong, Yu Eun; Lee, Seulkee; Kim, Kyoung Heon; Cha, Hoon-Suk published an article.Name: 2,3-Dihydroxypropanoic acid The title of the article was Metabolic discrimination of synovial fluid between rheumatoid arthritis and osteoarthritis using gas chromatography/time-of-flight mass spectrometry. And the article contained the following:

Rheumatoid arthritis (RA) and osteoarthritis (OA) are clinicopathol. different. We aimed to assess the feasibility of metabolomics in differentiating the metabolite profiles of synovial fluid between RA and OA using gas chromatog./time-of-flight mass spectrometry. We first compared the global metabolomic changes in the synovial fluid of 19 patients with RA and OA. Partial least squares-discriminant, hierarchical clustering, and univariate analyses were performed to distinguish metabolites of RA and OA. These findings were then validated using synovial fluid samples from another set of 15 patients with RA and OA. We identified 121 metabolites in the synovial fluid of the first 19 samples. The score plot of PLS-DA showed a clear separation between RA and OA. Twenty-eight crucial metabolites, including hypoxanthine, xanthine, adenosine, citrulline, histidine, and tryptophan, were identified to be capable of distinguishing RA metabolism from that of OA; these were found to be associated with purine and amino acid metabolism Our results demonstrated that metabolite profiling of synovial fluid could clearly discriminate between RA and OA, suggesting that metabolomics may be a feasible tool to assist in the diagnosis and advance the comprehension of pathol. processes for diseases. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Name: 2,3-Dihydroxypropanoic acid

The Article related to metabolome synovial fluid gas chromatog tofms rheumatoid arthritis osteoarthritis, gas chromatography–mass spectrometry, metabolite profiling, osteoarthritis, rheumatoid arthritis, synovial fluid and other aspects.Name: 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 31, 2020, Li, Zhuo; Wang, Bing; Zhang, Bingbing; Cui, Guoyi; Zhang, Fenyan; Xu, Long; Jiao, Linyu; Pang, Lingyan; Ma, Xiaoxun published an article.Computed Properties of 621-37-4 The title of the article was Synthesis, Characterization and Optoelectronic Property of Axial-Substituted Subphthalocyanines. And the article contained the following:

Two novel substituted subphthalocyanines have been prepared introducing m-hydroxybenzoic acid and m-hydroxyphenylacetic acid into the axial position of bromo-subphthalocyanine. The compounds have been characterized by Fourier transform IR (FT-IR), NMR (NMR) and single-crystal X-rays diffraction (XRD) methods. Their photophys. properties show that the axial substitution results into a relatively higher fluorescence quantum efficiency (FF = 5.74 for m-hydroxybenzoic acid and 9.09% for m-hydroxyphenylacetic acid) in comparison with that of the prototype compound, despite the almost negligible influence on the maximum absorption or the emission position. Moreover, the electrochem. behaviors show that the axial-substituted subphthalocyanines also exhibit enhanced specific capacitances of 395 F/g (m-hydroxybenzoic acid) and 362 F/g (m-hydroxyphenylacetic acid) compared with 342 F/g (the prototype) to the largest capacitance at the scan rate of 5 mV/s, and the significantly larger capacitance retentions of 83.6% and 82.1% vs. 37.3% upon d. up to 3 A/g. These results show the potential of these axial-substituted subphthalocyanines in the use as organic photovoltaics and supercapacitors. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Computed Properties of 621-37-4

The Article related to subphthalocyanine organic photovoltaic supercapacitor optoelectronic property, axial-substitution, electrochemical properties, organic optoelectronics, photophysical properties, subphthalocyanines and other aspects.Computed Properties of 621-37-4

Referemce:
Alcohol – Wikipedia,
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