Month: November 2022

On January 19, 2022, Rozsar, Daniel; Formica, Michele; Yamazaki, Ken; Hamlin, Trevor A.; Dixon, Darren J. published an article.Formula: C7H7FS The title of the article was Bifunctional Iminophosphorane Catalyzed Enantioselective Sulfa-Michael Addition to Unactivated α,β-Unsaturated Amides. And the article contained the following:

The first metal-free catalytic intermol. enantioselective Michael addition to unactivated α,β-unsaturated amides was described. Consistently high enantiomeric excesses and yields were obtained over a wide range of alkyl thiol pronucleophiles and electrophiles under mild reaction conditions, enabled by a novel squaramide-based bifunctional iminophosphorane (BIMP) catalyst. Low catalyst loadings (2.0 mol %) were achieved on a decagram scale, demonstrating the scalability of the reaction. Computational anal. revealed the origin of the high enantiofacial selectivity via anal. of relevant transition structures and provided substantial support for specific noncovalent activation of the carbonyl group of the α,β-unsaturated amide by the catalyst. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Formula: C7H7FS

The Article related to bifunctional iminophosphorane catalyst preparation potential energy surface, unsaturated amide thiol iminophosphorane catalyst enantioselective michael addition, thioamide preparation and other aspects.Formula: C7H7FS

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On February 28, 2022, Xu, Kailin; Zhang, Qiuya; Wang, Chuqiao; Xu, Jinmei; Bu, Yiming; Liang, Bin; Liu, Yushuai; Wang, Liping published an article.Application In Synthesis of 2,3-Dihydroxypropanoic acid The title of the article was 0D boron carbon nitride quantum dots decorated 2D Bi4O5I2 as 0D/2D efficient visible-light-driven photocatalysts for tetracyclines photodegradation. And the article contained the following:

A series of 0D boron carbon nitride quantum dots (BCNQDs) modified 2D Bi4O5I2(0D/2D Bi4O5I2/BCNQDs) composites were synthesized and applied to photodegradation of tetracyclines (TCs), including tetracycline (TC) and oxytetracycline (OTC). The Bi4O5I2/BCNQDs (1) (1 mL BCNQDs) composite exhibits the highest photocatalytic performance for TCs degradation The degradation rate constants of TC and OTC by the optimal sample were 4.95 and 2.17 times that of Bi4O5I2, resp. This can be attributed to the fact that the narrow bandgap Bi4O5I2is the electron acceptor, and the oxygen-containing functional group with the neg. charge on BCNQDs can promote the formation of photoexcited holes, which makes the effective separation of photoexcited carriers easier. Furthermore, the active substance (h+ and ·O-2) is the major active substance for TCs photodegradation On this basis, the possible photocatalytic reaction mechanism of Bi4O5I2/BCNQDs (1) composite is proposed. This study provides a new idea for 0D/2D interface engineering of BCNQDs heterojunction. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application In Synthesis of 2,3-Dihydroxypropanoic acid

The Article related to boron carbon nitride quantum dot bismuth oxyiodide photocatalyst photodegradation, 0d/2d heterojunction, bi(4)o(5)i(2), boron carbon nitride quantum dots, photocatalysis, tetracyclines and other aspects.Application In Synthesis of 2,3-Dihydroxypropanoic acid

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On May 1, 2022, Li, Yan; Xin, Jianpan; Tian, Runan published an article.COA of Formula: C8H9NO3 The title of the article was Physiological defense and metabolic strategy of Pistia stratiotes in response to zinc-cadmium co-pollution. And the article contained the following:

Pistia stratiotes is a cadmium (Cd) hyperaccumulating plant with strong bioaccumulation and translocation capacity for Cd. A hydroponic experiment was used to evaluate the combined effect of Zinc (Zn) and Cd at different concentrations on leaf growth and metabolism of P. stratiotes. This study revealed the physiol. defense and metabolic strategy of responses to Zn-Cd co-pollution. With the Zn50Cd1, Zn50Cd10, Zn100Cd1, and Zn100Cd10 treatments for 9 d, the relative crown diameter, relative leave number, and ramet number of the plant had no significant difference with the control. Under the compound treatments containing Zn50Cd50 and Zn100Cd50, the activity of the glyoxalase system and amino acid metabolism in the leaves were inhibited. The leaf photosynthetic apparatus increased heat dissipation to reduce the damage to the photosystem II (PS II) reaction center caused by excess excitation energy under Zn-Cd stress. This safeguarded the balance between the absorption and utilization of light energy. Compared to the control, the Zn and Cd co-pollution for 9 d had no effect on the reduced glutathione (GSH) and oxidized glutathione (GSSG) contents. There was no effect on the dehydroascorbate reductase (DHAR) and glutathione reductase (GR) activities, but there was increased ascorbate peroxidase (APX) activity and oxidized ascorbic acid (DHA) content. These increased the antioxidant capacity of the ascorbate-glutathione (AsA-GSH) cycle. The treated plants also had increased levels of carnosol and substances related to lipid metabolism including 9, 10-Dihydroxystearate, Prostaglandin G2, Sphingosine, and 13-L-Hydroperoxylinoleic acid, maintaining the cell stability and resistance to the Zn-Cd stress. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).COA of Formula: C8H9NO3

The Article related to pistia physiol defense metabolism zinc cadmium pollution, ascorbate-glutathione cycle, glyoxalase system, metabolomics, photosynthesis, pistia stratiotes, zinc-cadmium co-contamination and other aspects.COA of Formula: C8H9NO3

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On July 12, 2019, Wu, Jie; Mu, Ran; Sun, Mingna; Zhao, Nan; Pan, Miaomiao; Li, Hongshuang; Dong, Yi; Sun, Zhaogang; Bai, Jie; Hu, Minwan; Nathan, Carl F.; Javid, Babak; Liu, Gang published an article.Recommanded Product: 2,4,6-Trihydroxy-3-methylbenzaldehyde The title of the article was Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis. And the article contained the following:

This article reports the rational medicinal chem. of a natural product, agrimophol (1), as a new disruptor of intrabacterial pH (pHIB) homeostasis in Mycobacterium tuberculosis (Mtb). Through the systematic investigation of the structure-activity relationship of 1, scaffold-hopping of the diphenylmethane scaffold, pharmacophore displacement strategies, and studies of the structure-metabolism relationship, a new derivative 5a was achieved. Compound 5a showed 100-fold increased potency in the ability to reduce pHIB to pH 6.0 and similarly improved mycobactericidal activity compared with 1 against both Mycobacterium bovis-BCG and Mtb. Compound 5a possessed improved metabolic stability in human liver microsomes and hepatocytes, lower cytotoxicity, higher selectivity index, and similar pKa value to natural 1. This study introduces a novel scaffold to an old drug, resulting in improved mycobactericidal activity through decreasing pHIB, and may contribute to the critical search for new agents to overcome drug resistance and persistence in the treatment of tuberculosis. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).Recommanded Product: 2,4,6-Trihydroxy-3-methylbenzaldehyde

The Article related to agrimophol derivative antitubercular disruption ph homeostasis mycobacterium tuberculosis, agrimophol, coumarin, diphenylmethane scaffold, intrabacterial ph homeostasis, pharmacophores and other aspects.Recommanded Product: 2,4,6-Trihydroxy-3-methylbenzaldehyde

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On May 4, 2020, Zhou, Kejin; Johnson, Lindsay T.; Xiong, Hu; Barrios, Sergio; Minnig, Jonathan T.; Yan, Yunfeng; Abram, Bethanie; Yu, Xueliang; Siegwart, Daniel J. published an article.Related Products of 143-10-2 The title of the article was Hydrophobic Domain Structure of Linear-Dendritic Poly(ethylene glycol) Lipids Affects RNA Delivery of Lipid Nanoparticles. And the article contained the following:

In this work, a series of linear-dendritic poly(ethylene glycol) (PEG) lipids (PEG-GnCm) were synthesized through a strategy using sequential aza- and sulfa-Michael addition reactions. The effect of modulating the hydrophobic domain of linear-dendritic PEG lipids was systematically investigated for in vitro and in vivo small RNA delivery as the surface-stabilizing component of 5A2-SC8 dendrimer lipid-based nanoparticles (DLNPs). The lipid alkyl lengths (C8, C12, and C16) and dendrimer generations (G1, G2, and G3) were altered to create PEG-GnCm with different phys. properties and anchoring potential. The tail chem. structure of PEG-GnCm did not affect the formulation of 5A2-SC8 DLNPs, including the nanoparticle size, RNA encapsulation, and stability. However, the tail chem. structure did dramatically affect the RNA delivery efficacy of the formed 5A2-SC8 DLNPs with different PEG-GnCm. First-generation PEG lipids (PEG-G1C8, PEG-G1C12, and PEG-G1C16) and a second-generation PEG lipid (PEG-G2C8) formed 5A2-SC8 DLNPs that could deliver siRNAs effectively in vitro and in vivo. 5A2-SC8 DLNPs formulated with second-generation PEG lipids (PEG-G2C12 and PEG-G2C16) and all three third-generation PEG lipids (PEG-G3C8, PEG-G3C12, and PEG-G3C16) lost the ability to deliver siRNA effectively in vitro and in vivo. Overall, we determined that the hydrophobic domain chem. structure of linear-dendritic poly(ethylene glycol) lipids affected the RNA delivery of DLNPs by impacting the escape of 5A2-SC8 DLNPs from endosomes at early cell incubation times, thereby indicating how PEG lipid anchoring and chem. structure can modulate in vitro and in vivo siRNA delivery efficacies. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Related Products of 143-10-2

The Article related to hydrophobic linear dendritic polyethylene glycol lipid rna carrier nanoparticle, rna delivery, linear-dendritic pegylated lipids, linear-dendritic block copolymers, lipid nanoparticles and other aspects.Related Products of 143-10-2

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On November 9, 2020, Lee, Yih Hong; Shi, Wenxiong; Yang, Yijie; Kao, Ya-Chuan; Lee, Hiang Kwee; Chu, Rongrong; Pang, Yee Ling; Lay, Chee Leng; Li, Shuzhou; Ling, Xing Yi published an article.Related Products of 111-29-5 The title of the article was Modulating Orientational Order to Organize Polyhedral Nanoparticles into Plastic Crystals and Uniform Metacrystals. And the article contained the following:

In nanoparticle self-assembly, the current lack of strategy to modulate orientational order creates challenges in isolating large-area plastic crystals. Here, we achieve two orientationally distinct supercrystals using one nanoparticle shape, including plastic crystals and uniform metacrystals. Our approach integrates multi-faceted Archimedean polyhedra with mol.-level surface polymeric interactions to tune nanoparticle orientational order during self-assembly. Experiments and simulations show that coiled surface polymer chains limit interparticle interactions, creating various geometrical configurations among Archimedean polyhedra to form plastic crystals. In contrast, brush-like polymer chains enable mol. interdigitation between neighboring particles, favoring consistent particle configurations and result in uniform metacrystals. Our strategy enhances supercrystal diversity for polyhedra comprising multiple nondegenerate facets. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Related Products of 111-29-5

The Article related to silver orientational order polyhedral nanoparticle plastic crystal, nanoparticle self-assembly, nanoscale surface chemistry, orientational order, plastic crystals, uniform metacrystals and other aspects.Related Products of 111-29-5

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Becker, Dominic; Kazmaier, Uli published an article in 2015, the title of the article was Synthesis of simplified halogenated chondramide derivatives with strong cytostatic properties.HPLC of Formula: 32462-30-9 And the article contains the following content:

Removing the Me groups and the stereogenic centers from the ω-hydroxy acid of the chondramides results in a significant drop in the cytotoxicity of these interesting depsipeptides. This effect can be almost compensated for by introduction of a second chlorine atom on the β-tyrosine moiety of the natural products. These simplified chondramides are much easier accessible than natural chondramides. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).HPLC of Formula: 32462-30-9

The Article related to cyclic peptide depsipeptide halogenated chondramide enantioselective synthesis antitumor agent, hydroxy acid esterification tryptophan protection amination peptide coupling cyclization and other aspects.HPLC of Formula: 32462-30-9

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Li, Tianpeng; Fan, Jing; Sun, Tingting published an article in 2021, the title of the article was Effective removal of methylene blue dye from water with nanocomposite ceramsites in a fixed-bed column.Application of 96-76-4 And the article contains the following content:

The study aims to remove methylene blue dye from water with a fixed-bed column packed with Cu2O nanocomposite ceramsites. The column showed the advantages of fixed-bed column adsorption and photocatalytic oxidation The Cu2O nanocomposite ceramsites with strong photocatalytic oxidation activity and well-developed porous structure were successfully prepared with the chem. vapor deposition process, which also met with the China’s industrial standard of CJ/T 299-2008 and China’s national standard of GB 5085.3-2007. The breakthrough time and saturation time under UV radiation were 36.0% and 26.83% longer than those under the conditions without UV radiation, because the micro-pore structure of ceramsite was closely related to optical excitation properties of nano-Cu2O. The Yoon-Nelson and Adams-Bohart models were applied to describe the obtained breakthrough curves using non-linear regression, in which the Yoon-Nelson model gave the better prediction results for breakthrough curves, with R2>0.98. Besides, amines were the dominant intermediates at saturation point and final products were inorganic anions. This study confirmed that the fixed-bed column packed with Cu2O nanocomposite ceramsites could efficiently treat methylene blue dye wastewater, due to the structure-function relationship between ceramsite and nano-Cu2O. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Application of 96-76-4

The Article related to methylene blue adsorption photocatalytic oxidation copper oxide ceramsite nanocomposite, ceramsite, breakthrough curves, kinetic analysis, nanocomposite, structure-function relationship and other aspects.Application of 96-76-4

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On July 19, 2020, Trinklein, Timothy J.; Prebihalo, Sarah E.; Warren, Cable G.; Ochoa, Grant S.; Synovec, Robert E. published an article.Application In Synthesis of 1-Decanethiol The title of the article was Discovery-based analysis and quantification for comprehensive three-dimensional gas chromatography flame ionization detection data. And the article contained the following:

Basic principles are introduced for implementing discovery-based anal. with automated quantification of data obtained using comprehensive three-dimensional gas chromatog. with flame ionization detection (GC3-FID). The GC3-FID instrument employs dynamic pressure gradient modulation, providing full modulation (100% duty cycle) with a fast modulation period (PM) of 100 ms. Specifically, tile-based Fisher-ratio anal., previously developed for comprehensive two-dimensional gas chromatog. with time-of-flight mass spectrometry (GCxGC-TOFMS), is adapted and applied for GC3-FID where the third chromatog. dimension (3D) is treated as the “spectral” dimension. To evaluate the instrumental platform and software implementation, ten “non-native” compounds were spiked into a ninety-component base mixture to create two classes with a concentration ratio of two for the spiked analyte compounds The Fisher ratio software identified 95 locations of potential interest (i.e., hits), with all ten spiked analytes discovered within the top fourteen hits. All 95 hits were quantified by a novel signal ratio (S-ratio) algorithm portion of the F-ratio software, which determines the time-dependent S-ratio of the 3D chromatograms from one class to another, thus providing relative quantification. The average S-ratio for spiked analytes was 1.94 ± 0.14 mean absolute error (close to the nominal concentration ratio of two), and 1.06 ± 0.16 mean absolute error for unspiked (i.e., matrix) components. The appearance of the S-ratio as a function of 3D retention time in the GC3 dataset, referred to as an S-ratiogram, provides indication of peak purity for each hit. The unique shape of the S-ratiogram for hit 1, α-pinene, suggested likely 3D overlap. Parallel factor anal. (PARAFAC) decomposition of the hit location confirmed that overlap was occurring and successfully decomposed α-pinene from a highly overlapped (3Rs = 0.1) matrix interferent. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Application In Synthesis of 1-Decanethiol

The Article related to discovery analysis 3d gas chromatog flame ionization detection data, chemometrics, dynamic pressure gradient modulation, comprehensive three-dimensional gas chromatography, fisher ratio and other aspects.Application In Synthesis of 1-Decanethiol

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Masip, Jenifer; Rallon, Norma; Yeregui, Elena; Olona, Montserrat; Resino, Salvador; Benito, Jose M.; Vilades, Consuelo; Garcia-Pardo, Graciano; Alcami, Jose; Ruiz-Mateos, Ezequiel; Gomez-Bertomeu, Frederic; Vargas, Montserrat; Navarro, Marta; Oteo, Jose A.; Pineda, Juan A.; Marti, Anna; Alba, Veronica; Vidal, Francesc; Peraire, Joaquin; Rull, Anna; ECRIS Integrated In The Spanish AIDS Research Network published an article in 2022, the title of the article was Elevated α-ketoglutaric acid concentrations and a lipid-balanced signature are the key factors in long-term HIV control.Name: 2,3-Dihydroxypropanoic acid And the article contains the following content:

Long-term elite controllers (LTECs) are a fascinating small subset of HIV individuals with viral and immunol. HIV control in the long term that have been designated as models of an HIV functional cure. However, data on the LTEC phenotype are still scarce, and hence, the metabolomics and lipidomics signatures in the LTEC-extreme phenotype, LTECs with more than 10 years of viral and immunol. HIV control, could be pivotal to finding the keys for functional HIV remission. Metabolomics and lipidomics analyses were performed using high-resolution mass spectrometry (ultra-high-performance liquid chromatog.-electrospray ionization-quadrupole time of flight [UHPLC-(ESI) qTOF])in plasma samples of 13 patients defined as LTEC-extreme, a group of 20 LTECs that lost viral and/or immunol. control during the follow-up study (LTEC-losing) and 9 EC patients with short-term viral and immunol. control (less than 5 years; no-LTEC patients). Long-term viral and immunol. HIV-1 control was found to be strongly associated with elevated tricarboxylic acid (TCA) cycle function. Interestingly, of the nine metabolites identified in the TCA cycle, α-ketoglutaric acid (p = 0.004), a metabolite implicated in the activation of the mTOR complex, a modulator of HIV latency and regulator of several biol. processes, was found to be a key metabolite in the persistent control. On the other hand, a lipidomics panel combining 45 lipid species showed an optimal percentage of separation and an ability to differentiate LTEC-extreme from LTEC-losing, revealing that an elevated lipidomics plasma profile could be a predictive factor for the reignition of viral replication in LTEC individuals. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Name: 2,3-Dihydroxypropanoic acid

The Article related to long term hiv control alpha ketoglutaric acid lipidomics metabolomics, hiv infection, kreb’s cycle, elite controllers (ecs), lipidomics, long-term, mass spectrometry, metabolomics, viral and other aspects.Name: 2,3-Dihydroxypropanoic acid

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