Month: November 2022

On May 1, 2020, Behera, Rakesh R.; Ghosh, Rahul; Panda, Surajit; Khamari, Subrat; Bagh, Bidraha published an article.Name: Pentane-1,5-diol The title of the article was Hydrosilylation of Esters Catalyzed by Bisphosphine Manganese(I) Complex: Selective Transformation of Esters to Alcohols. And the article contained the following:

A tricarbonylruthenium Xantphos complex I was prepared and characterized by X-ray crystallog.; in the presence of I, esters underwent chemoselective hydrosilylation with phenylsilane under neat conditions (followed by workup with base) to yield esters. Aryl, alkyl, and alkenyl mono- and dicarboxylates and lactones underwent chemoselective reduction to alcs. and diols; ketoesters underwent reduction to diols. Poly(1,6-hexanediol adipate) underwent hydrosilylation to 1,6-hexanediol. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Name: Pentane-1,5-diol

The Article related to alc diol preparation, xantphos manganese complex preparation chemoselective hydrosilylation catalyst crystal structure, manganese catalyst chemoselective hydrosilylation ester and other aspects.Name: Pentane-1,5-diol

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Yang, Wu; Li, Yingzi; Zhu, Jiefeng; Liu, Wentan; Ke, Jie; He, Chuan published an article in 2020, the title of the article was Lewis acid-assisted Ir(III) reductive elimination enables construction of seven-membered-ring sulfoxides.HPLC of Formula: 72364-46-6 And the article contains the following content:

Iridium has played an important role in the evolution of C-H activation chem. over the last half century owing to its high reactivity towards stoichiometric C-H bond cleavage; however, the use of Ir(III) complexes in catalytic C-H functionalization/C-C bond formation appears to have fallen off significantly. The main problem lies in the reductive elimination step, as iridium has a tendency to form stable and catalytically inactive Ir(III) species. Herein, with a rationally designed Lewis acid assisted oxidatively induced strategy, the sluggish Ir(III) reductive elimination is successfully facilitated, enabling the facile C-C bond formation. The X-ray crystal structure of a silver salt adduct of iridacycle and DFT calculations demonstrate that the sulfoxide group acts as a key bridge connecting the Ir(III) metal center with the silver Lewis acid, which facilitates the reductive elimination of the Ir(III) metallacycle. Further identification of oxidants was carried out by performing stoichiometric reactions, which enables the development of catalytic construction of various highly functionalized seven-membered-ring sulfoxides e.g., 5,7-dihydrodibenzo[c,e]thiepine 6-oxide, that are of great interest in medicinal chem. and materials science. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).HPLC of Formula: 72364-46-6

The Article related to dihydrodibenzothiepine oxide preparation chemoselective regioselective density functional theory, aralkyl sulfoxide oxidative reductive elimination lewis acid iridium catalyst and other aspects.HPLC of Formula: 72364-46-6

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Brandhofer, Tobias; Stinglhamer, Martin; Derdau, Volker; Mendez, Maria; Poverlein, Christoph; Garcia Mancheno, Olga published an article in 2021, the title of the article was Easy access to drug building-blocks through benzylic C-H functionalization of phenolic ethers by photoredox catalysis.Category: alcohols-buliding-blocks And the article contains the following content:

A visible light-mediated photocatalyzed C-C-bond forming method for the benzylic C-H functionalization of phenolether containing synthetic building blocks based on a radical-cation/deprotonation strategy is reported. This method allows the mild, selective generation of benzyl radicals in phenolic complex mols. and drug-like compounds, providing new entries in synthetic and medicinal chem. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Category: alcohols-buliding-blocks

The Article related to tyrosine methyl ester functionalization alkylation methyl acrylate photoredox catalysis, peptide synthesis alkylation photoredox catalysis reaction mechanism cyclic voltammetry and other aspects.Category: alcohols-buliding-blocks

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On December 12, 1996, Hulin, Bernard; Hoover, Dennis J.; Treadway, Judith L.; Martin, William H. published a patent.Recommanded Product: 62640-03-3 The title of the patent was Preparation of substituted indole-2-carboxamides and derivatives as glycogen phosphorylase inhibitors.. And the patent contained the following:

Title compounds [I; dotted line = optional double bond; A = CH, CR20, CH2, CHR21; ; R20 = alkyl, halo; R21 = alkyl; R1, R10, R11 = H, halo, NO2, cyano, alkyl, alkoxy, CH2F, CHF2, CF3; R2 = H, R3 = H, alkyl; R4 = H, Me, Et, Pr, hydroxyalkyl, alkoxyalkyl, (substituted) phenylalkyl, phenylhydroxyalkyl, thienylalkyl, furylalkyl, pyridylalkyl, thiazolylalkyl, triazinylalkyl, etc.; R5 = H, OH, F, alkyl, alkoxy, alkanoyl, amionoalkoxy, carboxyalkoxy, etc.; R6 = CO2H, alkoxycarbonyl, CONR8R9, COR12; R8 = H, alkyl, OH, alkoxy; R9 = H, (substituted) alkyl, OH, alkoxy, methylene-perfluorinated alkyl, Ph, pyridyl, thienyl, furyl pyrrolyl, pyrrolidinyl, oxazolyl, thiazolyl, pyranyl, piperidinyl, morpholinyl, pyridazinyl, pyrimidinyl, pyrazinyl, etc.; R12 = piperazin-1-yl, 4-alkylpiperazin-1-yl, thiomorpholino, substituted oxazetidin-2-yl, etc.], were prepared as glycogen phosphorylase inhibitors (no data). Thus, iso-Pr (3S)-amino-4-phenyl-(2R)-hydroxybutyrate, 5-chloroindole-2-carboxylic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, and 1-hydroxybenzotriazole were stirred 18 h in CH2Cl2 to give 91% iso-Pr (3S)-[(5-chloro-1H-indole-2-carbonyl)amino]-(2R)-hydroxy-4-phenylbutyrate. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Recommanded Product: 62640-03-3

The Article related to indolecarboxamide substituted preparation glycogen phosphorylase inhibitor, cardiovascular agent indolecarboxamide substituted, diabetes treatment indolecarboxamide substituted and other aspects.Recommanded Product: 62640-03-3

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On September 9, 2011, Layton, Mark E.; Kelly, Michael J.; Hartingh, Timothy J. published a patent.Application In Synthesis of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol The title of the patent was Preparation of benzothiadiazole and thiadiazolopyridine dioxides as positive allosteric modulators of mGluR2. And the patent contained the following:

The present invention is directed to 5-substituted 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide and 1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2,-dioxide derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurol. and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The compounds of the invention have general formula I, wherein X is C or N; Y is C1-6 alkyl; R1 is (un)substituted benzyl, (un)substituted C2-8 alkyl, etc.; each R2 is independently halo, OH, C1-4 alkyl, etc.; A is (un)substituted aryl or (un)substituted heteroaryl. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved. Synthetic procedures for preparing I are exemplified. Example compound II, prepared in a 5-step synthesis that culminated in reaction of III with 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile, potentiated mGluR2 activity in a FLIPR assay with an EC50 of 5.0 nM. The experimental process involved the reaction of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol(cas: 1333264-06-4).Application In Synthesis of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol

The Article related to benzothiadiazole thiadiazolopyridine dioxide preparation allosteric mglur2 modulator therapy, neurol psychiatric disorder treatment benzothiadiazole thiadiazolopyridine dioxide and other aspects.Application In Synthesis of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol

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Alcohol – Wikipedia,
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Haewpetch, Patinya; Rudeekulthamrong, Prakarn; Kaulpiboon, Jarunee published an article in 2022, the title of the article was Enzymatic Synthesis of Maltitol and Its Inhibitory Effect on the Growth of Streptococcus mutans DMST 18777.Product Details of 585-88-6 And the article contains the following content:

This study aimed to synthesize maltitol using recombinant CGTase from Bacillus circulans A11 with β-cyclodextrin (β-CD) and sorbitol as a glucosyl donor and acceptor, resp., and assess its antibacterial activity. Optimal conditions for producing the highest yield, 25.0% (weight/weight), were incubation of 1% (w/v) β-CD and sorbitol with 400 U/mL of CGTase in 20 mM phosphate buffer at pH 6.0 and 50°C for 72 h. Subsequently, maltitol underwent large-scale production and was purified by HPLC. By mass spectrometry, the mol. weight of the synthesized maltitol was 379.08 daltons, corresponding exactly to that of standard maltitol. The relative sweetness of synthesized and standard maltitol was ~90% of that of sucrose. Spot assay on the agar plate showed that maltitol inhibited the growth of Streptococcus mutans DMST 18777 cells. In addition, the MIC and MBC values of synthesized and standard maltitol against S. mutans were also determined as 20 and 40 mg/mL, resp. These results show that the synthesized maltitol can be produced at high yields and has the potential to be used as an anticariogenic agent in products such as toothpaste. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Product Details of 585-88-6

The Article related to streptococcus mutan maltitol growth inhibitory effect, streptococcus mutans, antibacterial activity, anticariogenic activity, cyclodextrin glycosyltransferase (cgtase), maltitol and other aspects.Product Details of 585-88-6

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On July 1, 2022, Patel, Monika; Fatnani, Dhara; Parida, Asish Kumar published an article.COA of Formula: C3H6O4 The title of the article was Potassium deficiency stress tolerance in peanut (Arachis hypogaea) through ion homeostasis, activation of antioxidant defense, and metabolic dynamics: Alleviatory role of silicon supplementation. And the article contained the following:

Potassium (K) scarcity of arable land is one of the important factors that hamper the growth of the plants and reduce yield worldwide. In the current study, we examine the physiol., biochem., and metabolome response of Arachis hypogaea (GG7 genotype: fast-growing, tall, early maturing, and high yielding) under low K either solitary or in combination with Si to elucidate the ameliorative role of Si. The reduced fresh and dry biomass of peanut and photosynthetic pigments content was significantly alleviated by Si. Si application did not affect the leaf and stem K+, although it enhanced root K+ in K-limitation, which is probably due to up-regulated expression of genes responsible for K uptake. Si improves the potassium use efficiency in K-limitation as compared to control. K-deficiency increased MDA, O·-2, and H2O2 levels in leaf and root of peanut. Si improved/maintained the activity of antioxidative enzymes, which significantly lowered the ROS accumulation in K-limitation. The AsA/DHA and GSH/GSSG ratio was approx. unaffected in both leaf and root, suggesting the maintained cellular redox potential in K-starved peanut. Si promotes accumulation of sugars and sugar alcs., phytohormones indicating their probable involvement in signal transduction, osmotic regulation, and improvement of stress tolerance. Down-regulation of aspartic acid and glutamic acid while up-regulation of lysine, histidine, and arginine could maintain charge balance in K-deprived peanut. The significant accumulation of polyphenols under K limitation supplemented with Si suggests the role of polyphenols for ROS scavenging. Our results demonstrated that Si as a beneficial element can mitigate K-nutrient toxicity and improve KUE of peanut under K-limitation conditions. Moreover, our results demonstrate that Si application can improve crop yield, quality, and nutrient use efficiency under nutrient limitation conditions. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).COA of Formula: C3H6O4

The Article related to arachis potassium deficiency stress tolerance antioxidant silicon ion homeostasis, arachis hypogaea, aspartic acid, metabolomics, myo-inositol, phytohormones, potassium, silicon and other aspects.COA of Formula: C3H6O4

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On January 31, 2022, Miao, Hua; Wu, Xia-Qing; Wang, Yan-Ni; Chen, Dan-Qian; Chen, Lin; Vaziri, Nosratola D.; Zhuang, Shougang; Guo, Yan; Su, Wei; Ma, Shi-Xing; Zhang, Huan-Qiao; Shang, You-Quan; Yu, Xiao-Yong; Zhao, Yan-Long; Mao, Jia-Rong; Gao, Ming; Zhang, Jin-Hua; Zhao, Jin; Zhang, Yuan; Zhang, Li; Zhao, Ying-Yong; Cao, Gang published an article.Name: 3-Hydroxyphenylacetic acid The title of the article was 1-Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway. And the article contained the following:

In chronic kidney disease (CKD), patients inevitably reach end-stage renal disease and require renal transplant. Evidence suggests that CKD is associated with metabolite disorders. However, the mol. pathways targeted by metabolites remain enigmatic. Here, we describe roles of 1-hydroxypyrene in mediating renal fibrosis. We analyzed 5406 urine and serum samples from patients with Stage 1-5 CKD using metabolomics, and 1-hydroxypyrene was identified and validated using longitudinal and drug intervention cohorts as well as 5/6 nephrectomized and adenine-induced rats. We identified correlations between the urine and serum levels of 1-hydroxypyrene and the estimated GFR in patients with CKD onset and progression. Moreover, increased 1-hydroxypyrene levels in serum and kidney tissues correlated with decreased renal function in two rat models. Up-regulated mRNA expression of aryl hydrocarbon receptor and its target genes, including CYP1A1, CYP1A2 and CYP1B1, were observed in patients and rats with progressive CKD. Further we showed up-regulated mRNA expression of aryl hydrocarbon receptor and its three target genes, plus up-regulated nuclear aryl hydrocarbon receptor protein levels in mice and HK-2 cells treated with 1-hydroxypyrene, which caused accumulation of extracellular matrix components. Treatment with aryl hydrocarbon receptor short hairpin RNA or flavonoids inhibited mRNA expression of aryl hydrocarbon receptor and its target genes in 1-hydroxypyrene-induced HK-2 cells and mice. Metabolite 1-hydroxypyrene was demonstrated to mediate renal fibrosis through activation of the aryl hydrocarbon receptor signalling pathway. Targeting aryl hydrocarbon receptor may be an alternative therapeutic strategy for CKD progression. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Name: 3-Hydroxyphenylacetic acid

The Article related to renal fibrosis 1 hydroxypyrene aryl hydrocarbon receptor, 1-hydroxypyrene, aryl hydrocarbon receptor, chronic kidney disease, flavonoid, glomerular filtration rate, metabolomics and other aspects.Name: 3-Hydroxyphenylacetic acid

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Wang, Linqing; Yang, Dongxu; Li, Dan; Liu, Xihong; Wang, Pengxin; Wang, Kezhou; Zhu, Haiyong; Bai, Lutao; Wang, Rui published an article in 2018, the title of the article was The Important Role of the Byproduct Triphenylphosphine Oxide in the Magnesium(II)-Catalyzed Enantioselective Reaction of Hemiacetals and Phosphorus Ylides.Formula: C9H10O2 And the article contains the following content:

By employing a simple in situ generated magnesium catalyst, a direct asym. reaction between hemiacetals and phosphorus ylides was achieved through a tandem Wittig-oxa-Michael reaction sequence. Enantioenriched chromans, isochromans, and tetrahydropyrans were obtained in good chem. yields, and (-)-erythrococcamide B was synthesized in enantioenriched form. The byproduct triphenylphosphine oxide was identified as a necessary additive for this process. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Formula: C9H10O2

The Article related to triphenylphosphine oxide byproduct magnesium catalyst enantioselective hemiacetal phosphorus ylide, asymmetric synthesis, chiral ethers, hemiacetals, magnesium, phosphorus ylides and other aspects.Formula: C9H10O2

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On February 15, 2021, Yu, Tzu-Yu; Pang, Haobo; Cao, Yilin; Gallou, Fabrice; Lipshutz, Bruce H. published an article.HPLC of Formula: 143-10-2 The title of the article was Safe, Scalable, Inexpensive, and Mild Nickel-Catalyzed Migita-Like C-S Cross-Couplings in Recyclable Water. And the article contained the following:

A new approach to C-S couplings is reported that relies on nickel catalysis under mild conditions, enabled by micellar catalysis in recyclable water as the reaction medium. The protocol tolerates a wide range of heteroaromatic halides and thiols, including alkyl and heteroaryl thiols, leading to a variety of thioethers in good isolated yields. The method is scalable, results in low residual metal in the products, and is applicable to syntheses of targets in the pharmaceutical area. The procedure also features an associated low E Factor, suggesting a far more attractive entry than is otherwise currently available, especially those based on unsustainable loadings of Pd catalysts. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).HPLC of Formula: 143-10-2

The Article related to thiol aryl iodide nickel cross coupling catalyst, thioether aryl preparation, migita cross-couplings, aqueous micellar catalysis, axitinib, designer surfactants, nickel catalysis and other aspects.HPLC of Formula: 143-10-2

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