Month: November 2022

Zarraga O., M.; Darouch, M.; Lisboa, E.; Arroyo P., P.; Miranda M., A. published an article in 2021, the title of the article was Synthesis of 6-tert-octyl and 6,8-ditert-butyl coumarins, two coumarins of biological interest.Product Details of 96-76-4 And the article contains the following content:

In this study, the synthesis of new coumarins with aliphatic chains is discussed. The incorporation of the 6-tert-octyl and 6,8-ditert-Bu chains into a coumarin structure from alkylphenols, allows obtaining hydrophobic coumarins with good yields. These coumarins can be potential modulators of TRPV1 receptors. Synthesis and spectroscopic data of these new coumarins are analyzed. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Product Details of 96-76-4

The Article related to tert octyl ditert butyl coumarin preparation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Product Details of 96-76-4

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On May 31, 1987, Cottet, F.; Cottier, L.; Descotes, G. published an article.Computed Properties of 42900-89-0 The title of the article was New syntheses of isochromene. And the article contained the following:

Isochromene (I) was synthesized in 3 steps from homophthalic acid (II) as well as from 2-indanone (III). Esterification of II, followed by selective reduction with diisobutylaluminum hydride gave 52% 3-hydroxyisochroman (IV). IV was also obtained by Baeyer-Villiger oxidation of III with m-chloroperbenzoic acid to 3-isochromanone and subsequent reduction with diisobutylaluminum hydride. IV was dehydrated to I by distillation in the presence of KHSO4 in a total yield of 48% from II and 69% from III. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Computed Properties of 42900-89-0

The Article related to isochromene preparation, homophthalate reduction, dehydration isochromanol, isochromanone hydrogenation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Computed Properties of 42900-89-0

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On April 17, 2015, Liu, Yan-Kai; Li, Zhi-Long; Li, Ji-Yao; Feng, Huan-Xi; Tong, Zhi-Ping published an article.Quality Control of Isochroman-3-ol The title of the article was Open-Close: An Alternative Strategy to α-Functionalization of Lactone via Enamine Catalysis in One Pot under Mild Conditions. And the article contained the following:

An open-close strategy in asym. catalysis is newly developed. With this powerful strategy, lactols are directly applied as potential precursors of lactones in enamine-based asym. Michael reactions providing a facile access to α-functionalized lactones containing two adjacent stereogenic centers as a single diastereomer, e.g. I, in good to excellent yields (up to 99%) and with excellent enantioselectivities (most cases >99%). Moreover, the reaction products are shown to give highly functionalized derivatives by stepwise systematic transformations. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Quality Control of Isochroman-3-ol

The Article related to lactol nitroalkene stereoselective michael reaction enamine catalysis, functionalized lactone stereoselective preparation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Quality Control of Isochroman-3-ol

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On August 12, 2022, Liu, Bowen; Wang, Lei; Qin, Yunfei; Xu, Xianxiu; Zhao, Jinbo published an article.Recommanded Product: 2,4-Di-tert-butylphenol The title of the article was Synthesis of Trisubstituted Chromanes by Lewis-Base-Catalyzed Three-Component Electrophilic Thiofunctionalization of Cyclopropene with Phenols via a Formal [3 + 3] Annulation. And the article contained the following:

A Lewis-base-catalyzed three-component electrophilic thiofunctionalization of cyclopropene with phenol is developed to furnish various trisubstituted chromanes in high trans-diastereoselectivity. This metal-free protocol is easy to scale-up, offers a unique 2,2,3-substitution pattern, and delivers chromanes with diversified core substitution patterns. The unprecedented tolerance of strong electron-withdrawing substituents at the phenol renders the protocol indispensable to access the otherwise inaccessible chromane chem. space that is important for medicinal chem. campaigns. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Recommanded Product: 2,4-Di-tert-butylphenol

The Article related to alkyl aryl arylthio chromane preparation diastereoselective triphenylphosphine sulfide antitumor, phenol cyclopropene phenylsulfenyl phthalimide annulation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Recommanded Product: 2,4-Di-tert-butylphenol

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On February 7, 2018, Perinu, Cristina; Bernhardsen, Ida M.; Pinto, Diego D. D.; Knuutila, Hanna K.; Jens, Klaus-J. published an article.COA of Formula: C8H19NO2 The title of the article was NMR Speciation of Aqueous MAPA, Tertiary Amines, and Their Blends in the Presence of CO2: Influence of pKa and Reaction Mechanisms. And the article contained the following:

The diamine 3-(methylamino)propylamine (MAPA) and eight tertiary amines were studied as single and blended aqueous CO2 absorbents at different concentrations and ratios to investigate their reaction mechanisms. After absorption (40 °C) and desorption (80 °C) experiments, quant. 13C NMR experiments were performed on each liquid sample. After absorption, the following CO2-derived species were identified and quantified: (bi)carbonate in each amine system, primary and secondary MAPA carbamate and MAPA dicarbamate in MAPA systems, and tertiary amine carbonate in tertiary amine systems. Concerning desorption, the main CO2 species removed was (bi)carbonate, followed in the blends by MAPA dicarbamate. Since, after CO2 absorption, the concentration of MAPA dicarbamate was negligible in single MAPA and, in the blends, mainly increased at increasing pKa of the tertiary amines, it is concluded that the tertiary amines increase the availability of MAPA species to react further with CO2. MAPA and tertiary amines appear to influence each other also for the CO2 release. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).COA of Formula: C8H19NO2

The Article related to methylaminopropylamine tertiary amine carbon dioxide carbamate carbonate, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.COA of Formula: C8H19NO2

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On October 31, 2021, Van de Voorde, Babs; Benmeridja, Lara; Giol, Elena Diana; Van der Meeren, Louis; Van Damme, Lana; Liu, Zhen; Toncheva, Antoniya; Raquez, Jean-Marie; Van den Brande, Niko; Skirtach, Andre; Declercq, Heidi; Dubruel, Peter; Van Vlierberghe, Sandra published an article.Recommanded Product: Pentane-1,5-diol The title of the article was Potential of poly(alkylene terephthalate)s to control endothelial cell adhesion and viability. And the article contained the following:

Poly(ethylene terephthalate) (PET) is known for its various useful characteristics, including its applicability in cardiovascular applications, more precisely as synthetic bypass grafts for large diameter (≥ 6 mm) blood vessels. Although it is widely used, PET is not an optimal material as it is not interactive with endothelial cells, which is required for bypasses to form a complete endothelium. Therefore, in this study, poly(alkylene terephthalate)s (PATs) have been studied. They were synthesized via a single-step solution polycondensation reaction, which requires mild reaction conditions and avoids the use of a catalyst or additives like heat stabilizers. A homologous series was realized in which the alkyl chain length varied from 5 to 12 methylene groups (n = 5-12). Molar masses up to 28,000 g/mol were obtained, while various odd-even trends were observed with modulated differential scanning calorimetry (mDSC) and rapid heat-cool calorimetry (RHC) to access the thermal properties within the homologous series. The synthesized PATs have been subjected to in vitro cell viability assays using Human Umbilical Vein Endothelial Cells (HUVECs) and Human Dermal Microvascular Endothelial Cells (HDMECs). The results showed that HUVECs adhere and proliferate most pronounced onto PAT(n = 9) surfaces, which could be attributed to the surface roughness and morphol. as determined by at. force microscopy (AFM) (i.e. Rq = 204.7 nm). HDMECs were investigated in the context of small diameter vessels and showed superior adhesion and proliferation after seeding onto PAT(n = 6) substrates. These preliminary results already pave the way towards the use of PAT materials as substrates to support endothelial cell adhesion and growth. Indeed, as superior endothelial cell interactivity compared to PET was observed, time-consuming and costly surface modifications of PET grafts could be avoided by exploiting this novel material class. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: Pentane-1,5-diol

The Article related to polyalkylene terephthalate endothelial cell adhesion viability, endothelial cell adhesion, poly(alkylene terephthalate), solution polycondensation, synthetic bypass graft and other aspects.Recommanded Product: Pentane-1,5-diol

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Alcohol – Wikipedia,
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On March 22, 2022, Elimelech, Orian; Aviv, Omer; Oded, Meirav; Peng, Xiaogang; Harries, Daniel; Banin, Uri published an article.Name: 1-Decanethiol The title of the article was Entropy of Branching Out: Linear versus Branched Alkylthiols Ligands on CdSe Nanocrystals. And the article contained the following:

Surface ligands of semiconductor nanocrystals (NCs) play key roles in determining their colloidal stability and physicochem. properties and are thus enablers also for the NCs flexible manipulation toward numerous applications. Attention is usually paid to the ligand binding group, while the impact of the ligand chain backbone structure is less discussed. Using isothermal titration calorimetry (ITC), we studied the effect of structural changes in the ligand chain on the thermodn. of the exchange reaction for oleate coated CdSe NCs, comparing linear and branched alkylthiols. The investigated alkylthiol ligands differed in their backbone length, branching position, and branching group length. Compared to linear ligands, lower exothermicity and entropy loss were observed for an exchange with branched ligands, due to steric hindrance in ligand packing, thereby justifying their previous classification as “entropic ligands”. Mean-field calculations for ligand binding demonstrate the contribution to the overall entropy originating from ligand conformational entropy, which is diminished upon binding mainly by packing of NC-bound ligands. Model calculations and the exptl. ITC data both point to an interplay between the branching position and the backbone length in determining the entropic nature of the branched ligand. Our findings suggest that the most entropic ligand should be a short, branched ligand with short branching group located toward the middle of the ligand chain. The insights provided by this work also contribute to a future smarter NC surface design, which is an essential tool for their implementation in diverse applications. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Name: 1-Decanethiol

The Article related to entropy linear branched alkylthiol ligand cdse nanocrystal, cdse nanocrystals, branched ligands, conformational entropy, isothermal titration calorimetry, ligand exchange and other aspects.Name: 1-Decanethiol

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Nannini, Giulia; Meoni, Gaia; Tenori, Leonardo; Ringressi, Maria Novella; Taddei, Antonio; Niccolai, Elena; Baldi, Simone; Russo, Edda; Luchinat, Claudio; Amedei, Amedeo published an article in 2021, the title of the article was Fecal metabolomic profiles: a comparative study of patients with colorectal cancer vs adenomatous polyps.Application In Synthesis of 3-Hydroxyphenylacetic acid And the article contains the following content:

BACKGROUND Colorectal cancer (CRC), the third most common cause of death in both males and females worldwide, shows a pos. response to therapy and usually a better prognosis when detected at an early stage. However, the survival rate declines when the diagnosis is late and the tumor spreads to other organs. Currently, the measures widely used in the clinic are fecal occult blood test and evaluation of serum tumor markers, but the lack of sensitivity and specificity of these markers restricts their use for CRC diagnosis. Due to its high sensitivity and precision, colonoscopy is currently the gold-standard screening technique for CRC, but it is a costly and invasive procedure. Therefore, the implementation of custom-made methodologies including those with minimal invasiveness, protection, and reproducibility is highly desirable. With regard to other screening methods, the screening of fecal samples has several benefits, and metabolomics is a successful method to classify the metabolite shift in living systems as a reaction to pathophysiol. influences, genetic modifications, and environmental factors. AIM To characterize the variation groups and potentially recognize some diagnostic markers, we compared with healthy controls (HCs) the fecal NMR (NMR) metabolomic profiles of patients with CRC or adenomatous polyposis (AP). METHODS Proton NMR spectroscopy was used in combination with multivariate and univariate statistical approaches, to define the fecal metabolic profiles of 32 CRC patients, 16 AP patients, and 38 HCs well matched in age, sex, and body mass index. RESULTS NMR metabolomic analyses revealed that fecal sample profiles differed among CRC patients, AP patients, and HCs, and some discriminatory metabolites including acetate, butyrate, propionate, 3-hydroxyphenylacetic acid, valine, tyrosine and leucine were identified. CONCLUSION In conclusion, we are confident that our data can be a forerunner for future studies on CRC management, especially the diagnosis and evaluation of the effectiveness of treatments. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application In Synthesis of 3-Hydroxyphenylacetic acid

The Article related to metabolomics feces adenomatous polyps colorectal cancer, adenomatous polyps, colorectal cancer, fecal metabolomics, fecal samples, nuclear magnetic resonance metabolomics and other aspects.Application In Synthesis of 3-Hydroxyphenylacetic acid

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On March 31, 2021, Bresciani, Letizia; Di Pede, Giuseppe; Favari, Claudia; Calani, Luca; Francinelli, Veronica; Riva, Antonella; Petrangolini, Giovanna; Allegrini, Pietro; Mena, Pedro; Del Rio, Daniele published an article.SDS of cas: 621-37-4 The title of the article was In vitro (poly)phenol catabolism of unformulated- and phytosome-formulated cranberry (Vaccinium macrocarpon) extracts. And the article contained the following:

Cranberries (Vaccinium macrocarpon) represent an important source of anthocyanins, flavan-3-ols and flavonols. This study aimed at investigating in vitro the human microbial metabolism of (poly)phenols, principally flavan-3-ols, of unformulated- and phytosome-formulated cranberry extracts After powder characterization, a 24-h fermentation with human faecal slurries was performed, standardizing the concentration of incubated proanthocyanidins. Cranberry (poly)phenol metabolites were quantified by uHPLC-MS2 analyses. The native compounds of both unformulated- and phytosome-formulated cranberry extracts were metabolized under faecal microbiota activity, resulting in twenty-four microbial metabolites. Although some differences appeared when considering different classes of colonic metabolites, no significant differences in the total amount of metabolites were established after 24 h of incubation period. These results suggested that a different formulation had no effect on flavan-3-ol colonic metabolism of cranberry and both unformulated- and phytosome-formulated extract Both formulations displayed the capability to be a potential source of compounds which could lead to a wide array of gut microbiota metabolites in vitro. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

The Article related to vaccinium extract microbial polyphenol metabolism phytosome, cranberry, flavan-3-ols, in vitro fermentation, microbial metabolism, phytosome formulation, proanthocyanidins and other aspects.SDS of cas: 621-37-4

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Alcohol – Wikipedia,
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Zhang, Ziyan; Wu, Xiaojin; Zhou, Meng; Qi, Jiaqian; Zhang, Rui; Li, Xueqian; Wang, Chang; Ruan, Changgeng; Han, Yue published an article in 2022, the title of the article was Plasma metabolomics identifies the dysregulated metabolic profile of primary immune thrombocytopenia (ITP) based on GC-MS.Computed Properties of 473-81-4 And the article contains the following content:

ITP is a common autoimmune bleeding disorder with elusive pathogenesis. Author study was implemented to profile the plasma metabolic alterations of patients diagnosed with ITP, aiming at exploring the potential novel biomarkers and partial mechanism of ITP. The metabolomic anal. of plasma samples was conducted using GC-MS on 98 ITP patients and 30 healthy controls (HCs). Age and gender matched samples were selected to enter the training set or test set resp. OPLS-DA, t-test with FDR correction and ROC analyses were employed to screen out and evaluate the differential metabolites. Possible pathways were enriched based on metabolomics pathway anal. (MetPA). A total of 85 metabolites were investigated in author’s study and 17 differential metabolites with diagnostic potential were identified between ITP patients and HCs. MetPA showed that the metabolic disorders of ITP patients were mainly related to phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine metabolism and glyoxylate and dicarboxylate metabolism Addnl., author discriminated 6 differential metabolites and 5 enriched pathways in predicting the resistance to glucocorticoids in chronic ITP patients. The distinct metabolites discovered in author’s study could become novel biomarkers for the auxiliary diagnosis and prognosis prediction of ITP. Besides, the dysregulated pathways might contribute to the development of ITP. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4

The Article related to metabolome immune thrombocytopenia gcms, opls -da, gas chromatography tandem mass spectrometry, metabolomics, metabolomics pathway analysis, primary immune thrombocytopenia and other aspects.Computed Properties of 473-81-4

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Alcohol – Wikipedia,
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