Month: November 2022

On May 16, 2022, Yan, Hao; Zhao, Mingyue; Feng, Xiang; Zhao, Siming; Zhou, Xin; Li, Shangfeng; Zha, Minghao; Meng, Fanyu; Chen, Xiaobo; Liu, Yibin; Chen, De; Yan, Ning; Yang, Chaohe published an article.Computed Properties of 473-81-4 The title of the article was PO43- Coordinated Robust Single-Atom Platinum Catalyst for Selective Polyol Oxidation. And the article contained the following:

Achieving efficient catalytic conversion over a heterogeneous catalyst with excellent resistance against leaching is still a grand challenge for sustainable chem. synthesis in aqueous solution Herein, we devised a single-atom Pt1/hydroxyapatite (HAP) catalyst via a simple hydrothermal strategy. Gratifyingly, this robust Pt1/HAP catalyst exhibits remarkable catalytic selectivity and catalyst stability for the selective oxidation of C2-C4 polyols to corresponding primary hydroxy acids. It is found that the Pt-(O-P) linkages with strong electron-withdrawing function of PO43- (Pt1-OPO43- pair active site) not only realize the activation of the C-H bond, but also destabilize the transition state from adsorbed hydroxy acids toward the C-C cleavage, resulting in the sharply increased selectivity of hydroxy acids. Moreover, the strong PO43–coordination effect provides electrostatic stabilization for single-atom Pt, ensuring the highly efficient catalysis of Pt1/HAP for over 160 h with superior leaching resistance. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4

The Article related to polyol platinum oxidation mechanism kinetics free energy, coordination effects, hydroxyl acid, polyols, selective oxidation, single-atom catalysts, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Computed Properties of 473-81-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 17, 2020, Hiscox, Afton; Stenne, Brice; Chrovian, Christa; Gelin, Christine; Samant, Andrew; Letavic, Michael A.; Dvorak, Curt published a patent.Related Products of 386704-04-7 The title of the patent was Substituted heteroaromatic pyrazolo-pyridines and their use as glun2b receptor modulators. And the patent contained the following:

Substituted Pyrazolo-pyridines as GluN2B receptor ligands. Such compounds may be used in GluN2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by GluN2B receptor activity. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Related Products of 386704-04-7

The Article related to pyrazolopyridine glun2b receptor therapy, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Related Products of 386704-04-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 30, 2021, Smith, Chad; Trageser, Kyle J.; Wu, Henry; Herman, Francis J.; Iqbal, Umar Haris; Sebastian-Valverde, Maria; Frolinger, Tal; Zeng, Emma; Pasinetti, Giulio Maria published an article.Recommanded Product: 621-37-4 The title of the article was Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation. And the article contained the following:

Sleep deprivation is a form of stress that provokes both inflammatory responses and neuropsychiatric disorders. Because persistent inflammation is implicated as a physiol. process in anxiety disorders, we investigated the contributions of NLRP3 inflammasome signaling to anxiety and anxiolytic properties of flavanol diets in a model of chronic sleep deprivation. The results show a flavanol-rich dietary preparation (FDP) exhibits anxiolytic properties by attenuating markers of neuroimmune activation, which included IL-1β upregulation, NLRP3 signaling, and microglia activation in the cortex and hippocampus of sleep-deprived mice. Production of IL-1β and NLRP3 were critical for both anxiety phenotypes and microglia activation. Individual FDP metabolites potently inhibited IL-1β production from microglia following stimulation with NLRP3-specific agonists, supporting anxiolytic properties of FDP observed in models of sleep deprivation involve inhibition of the NLRP3 inflammasome. The study further showed sleep deprivation alters the expression of the circadian gene Bmal1, which critically regulated NLRP3 expression and IL-1β production The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Recommanded Product: 621-37-4

The Article related to sleep deprivation nlrp3 inflammasome anxiolytic, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Recommanded Product: 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 7, 2013, Wang, Guqi; Lu, Qilong published an article.Name: 2-Methyl-2-propylpropane-1,3-diol The title of the article was A Nitrate Ester of Sedative Alkyl Alcohol Improves Muscle Function and Structure in a Murine Model of Duchenne Muscular Dystrophy. And the article contained the following:

Nitric oxide (NO) has major physiol. and cellular effects on muscle growth, repair, and function. In most muscle biopsies from humans with myopathies, sarcolemma-localized neuronal nitric oxide synthase (nNOS) is either reduced or not detected, particularly in dystrophin-deficient Duchenne muscular dystrophy (DMD). Abnormal NO signaling at the sarcolemmal level is integrally involved in the pathogenesis and accounts, at least in part, for the muscle weakness of DMD. Dystrophic muscle fibers exhibit an increased susceptibility to contraction-induced membrane damage. Muscle relaxants function to prevent muscle wasting by decreasing nerve impulses and reducing calcium influx that regulates tensing or tightening of muscle fibers. We have recently developed a new class of nitric esters that combines the pharmacol. functions of NO and muscle relaxation. Here, we report the synthesis and properties of the nitric ester (MMPN) of 2-methyl-2-n-propyl-1,3-propanediol (MPP) and its effect in mdx dystrophic mice, a murine model of DMD. MMPN produced significant improvements in biochem., pathol., and functional phenotypes in the mouse model. The endurance of exercise was extended by 47% in time to exhaustion and 84% in running distance. Serum CK level was decreased by 30%. Addnl., MMPN decreased intracellular free calcium concentration without causing skeletal muscle weakness. No hepatic or renal toxicities were observed during the study. Our investigations unveil a potential new treatment for muscular diseases. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Name: 2-Methyl-2-propylpropane-1,3-diol

The Article related to nitrate ester sedative muscle duchenne dystrophy, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Name: 2-Methyl-2-propylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2020, Wang, Jun; Zhao, Danyue; Tiano, Simoni; Esteban-Fernandez, Adelaida; Yuan, Bo; Smith, Chad; Brathwaite, Justin; Jlayer, Zahra; Wu, Qingli; Simon, James E.; Trageser, Kyle J.; Pasinetti, Giulio M. published an article.Category: alcohols-buliding-blocks The title of the article was Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress. And the article contained the following:

Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in exptl. models. Inflammatory cytokine interleukin-6 (IL-6) has emerged as a potential therapeutic target. Our studies demonstrated that metabolism of flavanol rich cocoa preparation (FRP) led to the accumulation of select phenolic acids that may contribute to its anti-inflammatory activity. Using a repeated social defeat stress (RSDS) model of depression, we showed that oral administration of FRP attenuates susceptibility to RSDS-mediated depression, supporting the further development of FRP as a novel therapeutic for the treatment of stress disorders and anxiety in humans. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks

The Article related to social stress flavanol metabolite resilience prophylaxis, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 2, 2011, Wang, Guqi; Lu, Qi Long published a patent.Computed Properties of 78-26-2 The title of the patent was Nitrate esters and their use for the treatment of muscle and muscle related diseases. And the patent contained the following:

Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula: Et-C(R1)(R2)(R3), wherein,R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, or CH2CH2CH3, or H;R2 is ONO2, CH2ONO2, Cn””H2n””+1OH, Cn””H2n””+1OH, CH2CH2CH3 or H; andR3 is ONO2, CH2ONO2, Cn'””H2n””+1OH, Cn””H2n””+1OH, CH2CH2CH3 or H; wherein n is an integer from 0 to 9, n’ is an integer from 0 to 9, and n”” is an integer from 0 to 9, and n+n’+n””≤9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ONO2, CH2ONO2, and combinations thereof. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Computed Properties of 78-26-2

The Article related to muscular dystrophy alkyl nitrate ester nitric oxide prodrug, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Computed Properties of 78-26-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 22, 2021, Wallace, Jason U.; Marshall, Kenneth L.; Batesky, Donald J.; Kosc, Tanya Z.; Hoffman, Brittany N.; Papernov, Semyon; Garrett, Londrea; Shojaie, Jalil; Demos, Stavros G. published an article.Computed Properties of 111-29-5 The title of the article was Highly Saturated Glassy Liquid Crystal Films Having Nano- and Microscale Thicknesses for High-Power Laser Applications. And the article contained the following:

The optical properties of glassy liquid crystals (GLC’s) designed to provide high resistance to laser-induced damage are explored. GLC’s readily enable freezing of the anisotropic ordering of liquid crystals into the glassy state. This solidity avoids issues of fluid leakage while providing mech. robustness and the promise of single-substrate coatings or stand-alone films of nanometer to micrometer thicknesses. A series of three increasingly saturated GLC’s were synthesized and tested for their thin-film (hundreds of nanometers to tens of micrometers) high-peak-power laser-damage resistance with nanosecond pulses at 1053, 532, and 351 nm, as well as their durability under continuous-wave, broadband UV illumination. The GLC’s with higher degrees of saturation demonstrated high resistance to laser-induced damage, extending from the near-IR to the UV spectral region. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Computed Properties of 111-29-5

The Article related to saturated glassy liquid crystal film nano microscale thickness laser, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Electronic Spectroscopy and other aspects.Computed Properties of 111-29-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 5, 2012, Wang, Guqi; Lu, Qi Long published a patent.Quality Control of 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Nitrate esters and their use for the treatment of muscle and muscle related diseases. And the patent contained the following:

Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula I wherein, R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, CH3, CH2CH3, CH2CH2CH3, or H; R2 is ON02, CH2ONO2, Cn H2n +1OH, Cn H2n +1OH, CH3, CH2CH3, CH2CH2CH3, or H; R3 is ON02, CH2ONO2, Cn””H2n””+1OH, Cn””H2n””+1OH, CH3, CH2CH3, CH2CH2CH3, or H; and R4 is ON02, CH2ONO2, Cn””H2n””+1OH, Cn””H2n””+1OH, CH3, CH2CH3, CH2CH2CH3, or H; wherein n is an integer from 0 to 9, n’ is an integer from 0 to 9, and n”” is an integer from 0 to 9, and n+n’+n”” ≤ 9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ON02, CH2ONO2, and combinations thereof. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Quality Control of 2-Methyl-2-propylpropane-1,3-diol

The Article related to alkyl nitrate ester nitric oxide prodrug muscular dystrophy treatment, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Quality Control of 2-Methyl-2-propylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 25, 2009, Raynolds, Peter Webb; Stykes, James A. published a patent.Recommanded Product: 78-26-2 The title of the patent was Aqueous dispersions of adhesion promoters for coating applications. And the patent contained the following:

An aqueous dispersion of a water-insoluble polyolefin-based adhesion promoter is produced by dissolving the adhesion promoter in at least one olefinically unsaturated monomer, forming a miniemulsion with high shear in the presence of water, a surfactant, and other additives, and polymerizing the monomer with a monomer-soluble, substantially water-insoluble radical initiator. The polymerized product, a stable dispersion (latex) of polyolefin adhesion promoter and the polymerized monomer in water, is useful as a primer or as an additive for improving the adhesion of coatings to polyolefin substrates. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Recommanded Product: 78-26-2

The Article related to maleated polyolefin adhesion promoter aqueous dispersion coating ink adhesive, Coatings, Inks, and Related Products: Drying Oils, Solvents, Plasticizers, and Other Additives and other aspects.Recommanded Product: 78-26-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 25, 2009, Raynolds, Peter Webb; Stykes, James A. published a patent.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Aqueous dispersions of adhesion promoters for coating applications. And the patent contained the following:

An aqueous dispersion of a water-insoluble polyolefin-based adhesion promoter is produced by dissolving the adhesion promoter in at least one olefinically unsaturated monomer, forming a miniemulsion with high shear in the presence of water, a surfactant, and other additives, and polymerizing the monomer with a monomer-soluble, substantially water-insoluble radical initiator. The polymerized product, a stable dispersion (latex) of polyolefin adhesion promoter and the polymerized monomer in water, is useful as a primer or as an additive for improving the adhesion of coatings to polyolefin substrates. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

The Article related to maleated polyolefin adhesion promoter aqueous dispersion coating ink adhesive, Coatings, Inks, and Related Products: Drying Oils, Solvents, Plasticizers, and Other Additives and other aspects.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts