Month: November 2022

Rima, Maya; Trognon, Jeanne; Latapie, Laure; Chbani, Asma; Roques, Christine; El Garah, Fatima published an article in 2022, the title of the article was Seaweed Extracts: A Promising Source of Antibiofilm Agents with Distinct Mechanisms of Action against Pseudomonas aeruginosa.Application In Synthesis of 2,4-Di-tert-butylphenol And the article contains the following content:

The organization of bacteria in biofilms is one of the adaptive resistance mechanisms providing increased protection against conventional treatments. Thus, the search for new antibiofilm agents for medical purposes, especially of natural origin, is currently the object of much attention. The objective of the study presented here was to explore the potential of extracts derived from three seaweeds: the green Ulva lactuca, the brown Stypocaulon scoparium, and the red Pterocladiella capillacea, in terms of their antibiofilm activity against P. aeruginosa. After preparation of extracts by successive maceration in various solvents, their antibiofilm activity was evaluated on biofilm formation and on mature biofilms. Their inhibition and eradication abilities were determined using two complementary methods: crystal violet staining and quantification of adherent bacteria. The effect of active extracts on biofilm morphol. was also investigated by epifluorescence microscopy. Results revealed a promising antibiofilm activity of two extracts (cyclohexane and Et acetate) derived from the green alga by exhibiting a distinct mechanism of action, which was supported by microscopic analyses. The Et acetate extract was further explored for its interaction with tobramycin and colistin. Interestingly, this extract showed a promising synergistic effect with tobramycin. First analyses of the chem. composition of extracts by GC-MS allowed for the identification of several mols. Their implication in the interesting antibiofilm activity is discussed. These findings suggest the ability of the green alga U. lactuca to offer a promising source of bioactive candidates that could have both a preventive and a curative effect in the treatment of biofilms. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Application In Synthesis of 2,4-Di-tert-butylphenol

The Article related to seaweed extract antibiofilm agent pseudomonas, pseudomonas aeruginosa, ulva lactuca, anti-biofilm, biofilm-matrix, seaweed extracts, synergistic activity, Microbial, Algal, and Fungal Biochemistry: Antimicrobial Sensitivity and other aspects.Application In Synthesis of 2,4-Di-tert-butylphenol

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Alcohol – Wikipedia,
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Salerno, Anna; Fragasso, Gabriele; Montanaro, Claudia; Cera, Michela; Torlasco, Camilla; Maranta, Francesco; Margonato, Alberto published an article in 2010, the title of the article was Role of metabolic modulation in the management of chronic ischemic heart disease.SDS of cas: 32462-30-9 And the article contains the following content:

Abstract: Coronary artery disease (CAD) is a major cause of morbidity and mortality in the world. Therapy for stable CAD is currently based on conventional medical therapy, including nitrates, β-blockers and calcium-channels antagonists and, more recently, metabolic therapy, of which a pivotal therapeutic role is increasingly recognized. Under normoxic condition, the healthy heart derives 2/3 of its energy from the free fatty acid (FFA) pathway, the other source of energy being derived from glucose oxidation However, glycolysis requires less O2 per mol of ATP generated compared with FFA oxidation On this basis, shifting energy substrate utilization from fatty acid metabolism to glucose metabolism can be more efficient in terms of ATP production per mol of oxygen utilized. A number of different approaches have been used to manipulate energy metabolism in the heart. These approaches include direct agents, such as dichloroacetate, -carnitine, ribose or lipoic acid which directly increase glucose oxidation, or indirect methods, through the inhibition of free fatty acids oxidation Among these, the most important are carnitil-palmitoyl-transpherase I (CPT-I) inhibitors, which inhibit FFA mitochondrial uptake (e.g. etomoxir, perhexiline, oxphenicine), or 3-ketoacyl-coenzyme-A thiolase (3-KAT) inhibitors, such as trimetazidine, which inhibits the last enzyme involved in β-oxidation In most patients with ischemic heart disease metabolic abnormalities, if not adequately treated, will heavily contribute to the occurrence of complications, of whom severe left ventricular dysfunction is at present one of the most frequent and insidious. In this paper, all possible metabolic approaches to ischemic heart disease are reviewed and discussed. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).SDS of cas: 32462-30-9

The Article related to metabolic therapy ischemic heart disease cardioprotectant, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.SDS of cas: 32462-30-9

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Alcohol – Wikipedia,
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On April 30, 1978, Perchonock, Carl D.; Loev, Bernard published an article.Synthetic Route of 42900-89-0 The title of the article was Synthesis of some aromatic prostaglandin analogs. And the article contained the following:

Some aromatic prostaglandin analogs, with a benzene (I) (R = H, Me) or a dimethoxybenzene ring (II) in place of the cyclopentane moiety, were synthesized. The key intermediates in the syntheses were lactols III and IV, which were elaborated to the final products via two olefination reactions. I (R = H) was twice as potent as phenylbutazone and nine times as potent as aspirin in inhibiting prostaglandin synthetase activity. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Synthetic Route of 42900-89-0

The Article related to aromatic prostaglandin analog, benzene prostaglandin analog, Alicyclic Compounds: Cyclopentanes, Including Fulvenes and Fulvalenes and other aspects.Synthetic Route of 42900-89-0

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Alcohol – Wikipedia,
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On May 1, 2013, Greco, M. N.; Connelly, M. A.; Leo, G. C.; Olson, M. W.; Powell, E.; Huang, Z.; Hawkins, M.; Smith, C.; Schalk-Hihi, C.; Darrow, A. L.; Xin, H.; Lang, W.; Damiano, B. P.; Hlasta, D. J. published an article.Name: (2-Fluorophenyl)methanethiol The title of the article was A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice. And the article contained the following:

By screening directed libraries of serine hydrolase inhibitors using the cell surface form of endothelial lipase (EL), the authors identified a series of carbamate-derived (EL) inhibitors. Compound (I) raised plasma HDL-C levels in the mouse, and a correlation was found between HDL-C and plasma compound levels. Spectroscopic and kinetic studies support a covalent mechanism of inhibition. The authors’ findings represent the first report of EL inhibition as an effective means for increasing HDL-C in an in vivo model. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Name: (2-Fluorophenyl)methanethiol

The Article related to thiocarbamate endothelial lipase hdl cholesterol preparation, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.Name: (2-Fluorophenyl)methanethiol

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Hayashi, Mikihiro; Obara, Haruna; Miwa, Yohei published an article in 2021, the title of the article was Design and basic properties of polyester vitrimers combined with an ionomer concept.Reference of Pentane-1,5-diol And the article contains the following content:

Vitrimers are a novel class of crosslinked materials containing associative bond exchange properties. Here we demonstrate the preparation of vitrimers with ionic components to investigate the effects of ion-rich domain formation on vitrimer properties. An amorphous polyester that bears COOH side groups was synthesized, and some fraction of COOH was neutralized with Zn2+. The residual non-neutralized COOH was reacted with diepoxy crosslinkers, resulting in a network with ester bonds, OH groups, and COOH groups neutralized with Zn2+. The sample was further thermally annealed to induce aggregation of Zn2+ ionic groups. The aggregated Zn2+ groups in the network remained active for trans-esterification-based bond exchange, wherein the degree of ion aggregation can be a factor in tuning the bond-exchange properties. The present study provides some important knowledge on the design of new mol. systems of vitrimers with tunable bond exchange properties. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Reference of Pentane-1,5-diol

The Article related to polyester vitrimer polycondensation michael addition reaction, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Reference of Pentane-1,5-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jablonsky, Michal; Majova, Veronika; Strizincova, Petra; Sima, Jozef; Jablonsky, Jozef published an article in 2020, the title of the article was Investigation of total phenolic content and antioxidant activities of spruce bark extracts isolated by deep eutectic solvents.Recommanded Product: 111-29-5 And the article contains the following content:

Extracts from spruce bark obtained using different deep eutectic solvents were screened for their total phenolic content (TPC) and antioxidant activities. Water containing choline chloride-based deep eutectic solvents (DESs) with lactic acid and 1,3-propanediol, 1,3-butanediol, 1,4-butanediol, and 1,5-pentanediol, with different molar ratios, were used as extractants. Basic characteristics of the DESs (d., viscosity, conductivity, and refractive index) were determined All the DESs used behave as Newtonian liquids The extractions were performed for 2 h at 60°C under continuous stirring. TPC was determined spectrophotometrically, using the Folin-Ciocalteu reagent, and expressed as gallic acid equivalent (GAE). The antioxidant activity was determined spectrophotometrically by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The TPC varied from 233.6 to 596.2 mg GAE/100 g dry bark; radical scavenging activity (RSA) ranged between 81.4% and 95%. This study demonstrated that deep eutectic solvents are suitable solvents for extracting phenolic compounds from spruce bark. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: 111-29-5

The Article related to phenolic content antioxidant activity spruce bark deep eutectic solvent, Cellulose, Lignin, Paper, and Other Wood Products: Wood and Other Cellulosic Materials and other aspects.Recommanded Product: 111-29-5

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Alcohol – Wikipedia,
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Campbell, Stewart John; Darwish, David published an article in 1976, the title of the article was Asymmetric induction in the Sommelet rearrangement of chiral benzylsulfonium salts.Synthetic Route of 58966-31-7 And the article contains the following content:

The Sommelet rearrangement of (+)-ethylmethyl-p-nitrobenzylsulfonium perchlorate (I) and (+)-ethylmethyl-p-chlorobenzylsulfonium perchlorate (II) are described. Elution of I through a hydroxide exchange resin generated ethylmethylsulfonium p-nitrobenzylide [(+)-III] which decomposed in methanol at room temperature to Et 2-methyl-5-nitrobenzyl sulfide and (+)-Me α-(2-methyl-5-nitrophenyl)ethyl sulfide with 18 to 20.3% asymmetric induction. Decomposition of II in NaOMe solution at 70° produced Et 2-methyl-5-chlorobenzyl sulfide and (+)-Me α-(2-methyl-5-chlorophenyl)ethyl sulfide with 21 to 25.5% asymmetric induction. The lower estimates of asymmetric induction for each sulfide were made by comparison with sp. rotations of authentic samples obtained by synthesis and resolution The higher estimates were obtained by the use of a chiral lanthanide shift reagent Eu(hfbc)3 with the sulfone derivatives of these chiral sulfides. The ylide (+)-III reacted with aldehydes to produce oxiranes with no induction of asymmetry. The experimental process involved the reaction of 1-(5-Chloro-2-methylphenyl)ethanol(cas: 58966-31-7).Synthetic Route of 58966-31-7

The Article related to asym sommelet rearrangement benzylsulfonium, sulfonium asym sommelet rearrangement, Physical Organic Chemistry: Rearrangements, Including Isomerization and Tautomerization and other aspects.Synthetic Route of 58966-31-7

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On October 31, 2020, He, Liao; Sang, Yimin; Yu, Wang; Li, Wanxin; Jiao, Yuhai; Ma, Fujun; Li, FasHeng; Liu, Yuqin; Gu, Qingbao published an article.HPLC of Formula: 96-76-4 The title of the article was Polymerization and Carbonization Behaviors of 2-Methylnaphthalene in Contaminated Soil During Thermal Desorption. And the article contained the following:

Despite the important niche and broad applicability of thermal remediation (TD), little work has been done to discuss chem. reactions of methylnaphthalene contaminated soil. The 2-methylnaphthalene desorption amount (MDA) of TD is studied here under different conditions, and the carbonation (chem. polymerized or condensed) behavior of 2-methylnaphthalene is explained by analyzing the changes of soil organic carbons (SOCs), off-gas products, and surface chem. properties. It indicates that the influence sequence of MDA from high to low is heating time, heating temperatures, and flow rates of carrier gas. MDA increases steadily with the increase of temperatures (200-300°C) but decreases slightly after 300°C; the reason may be the chem. conversion of 2-methylnaphthalene. GC-MS anal. of off-gas confirms that partial 2-methylnaphthalene is polymerized to form 2-methylbenzo[b]thiophene and 2,4-di-tert-butylpheno at 400°C, which is the first step of carbonization process. The XPS results of soil indicate that the C content decreases, but C-(C, H) chem. structure increases, indicating that new carbonaceous substances are generated. A layer of “char” is seen by scanning electron microscope to be left on the surface of the soil particles. As the temperature increases (200-400°C), the SOCs generally decreases from 1.14 to 0.82%, which is the result of the equilibrium between SOCs pyrolysis and 2-methylnaphthalene carbonization. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).HPLC of Formula: 96-76-4

The Article related to methylnaphthalene contaminated soil thermal desorption polymerization carbonization, Fossil Fuels, Derivatives, and Related Products: Petroleum Geochemistry and Prospecting and other aspects.HPLC of Formula: 96-76-4

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Rozsar, Daniel; Formica, Michele; Yamazaki, Ken; Hamlin, Trevor A.; Dixon, Darren J. published an article in 2021, the title of the article was Bifunctional iminophosphorane catalyzed enantioselective sulfa-Michael addition to unactivated α,β-unsaturated amides.SDS of cas: 72364-46-6 And the article contains the following content:

The first metal-free catalytic intermol. enantioselective sulfa-Michael addition to unactivated α,β-unsaturated amides is described. Consistently high enantiomeric excesses, and yields were obtained over a wide range of alkyl thiol pronucleophiles and electrophiles under mild reaction conditions, enabled by a novel squaramide-based bifunctional iminophosphorane (BIMP) catalyst. Low catalyst loadings (2 mol%) were achieved on a decagram scale, demonstrating the scalability of the reaction. Computational anal. revealed the origin of the high enantiofacial selectivity, corresponding transition states, and provided substantial evidence for specific non-covalent activation of the carbonyl group of the α,β-unsaturated amide by the catalyst. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).SDS of cas: 72364-46-6

The Article related to bifunctional iminophosphorane catalyst enantioselective sulfa michael addition, sulfa michael addition unsaturated amide mol modeling, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.SDS of cas: 72364-46-6

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 24, 2004, Corbett, Jeffrey Wayne; Groppi, Vincent Edward, Jr. published a patent.Name: (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol The title of the patent was A preparation of azabicycloalkane derivatives, useful as α7 nicotinic acetylcholine receptor (α7 nAChR) agonists. And the patent contained the following:

The invention relates to azabicycloalkane derivatives of formula azabicyclo-N(R1)-C(:X)-W [wherein: R1 is H, (cyclo)alkyl, or haloalkyl, etc.; X is O or S; W is a substituted benzene], useful as α7 nAChR agonists. Pharmacokinetics of the prepared compounds were evaluated (no biol. data). Blood-brain barrier penetration was investigated (no biol. data). For instance, chiral azabicycloheptane derivative I was prepared via addition of Me 3-bromopropargylate to N-Boc-pyrrole, reduction of the obtained azabicyclo[2.2.1]heptadiene II, hydrolysis of the obtained azabicycloheptane derivative III (R2 = OMe), reaction of the carboxylic acid III (R2 = OH) with diphenylphosphoryl azide and benzyl alc., resolution of the obtained exo-derivative IV, and hydrogenation. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Name: (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol

The Article related to azabicycloalkane preparation alpha7 nachr agonist nicotinic acetylcholine receptor antialzheimer, pyrrole bromo propargylate addition reduction resolution, Alicyclic Compounds: Bicyclic Compounds, Including Azulenes, Heptalenes, and Pentalenes and other aspects.Name: (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol

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Alcohol – Wikipedia,
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