Month: November 2022

On December 31, 2020, Ma, Yibao; Wang, Wei; Devarakonda, Teja; Zhou, Huiping; Wang, Xiang-Yang; Salloum, Fadi N.; Spiegel, Sarah; Fang, Xianjun published an article.SDS of cas: 32462-30-9 The title of the article was Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation. And the article contained the following:

Abstract: Fatty acid oxidation (FAO) is a key bioenergetic pathway often dysregulated in diseases. The current knowledge on FAO regulators in mammalian cells is limited and sometimes controversial. Previous FAO analyses involve nonphysiol. culture conditions or lack adequate quantification. We herein described a convenient and quant. assay to monitor dynamic FAO activities of mammalian cells in physiol. relevant settings. The method enabled us to assess various mol. and pharmacol. modulators of the FAO pathway in established cell lines, primary cells and mice. Surprisingly, many previously proposed FAO inhibitors such as ranolazine and trimetazidine lacked FAO-interfering activity. In comparison, etomoxir at low micromolar concentrations was sufficient to saturate its target proteins and to block cellular FAO function. Oxfenicine, on the other hand, acted as a partial inhibitor of FAO. As another class of FAO inhibitors that transcriptionally repress FAO genes, antagonists of peroxisome proliferator-activated receptors (PPARs), particularly that of PPARa, significantly decreased cellular FAO activity. Our assay also had sufficient sensitivity to monitor upregulation of FAO in response to environmental glucose depletion and other energy-demanding cues. Altogether this study provided a reliable FAO assay and a clear picture of biol. properties of potential FAO modulators in the mammalian system. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).SDS of cas: 32462-30-9

The Article related to monocytic lymphoma breast carcinoma fatty acid oxidation mitochondria, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.SDS of cas: 32462-30-9

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On May 13, 2022, Shang, Rui; Liu, Can published a patent.Related Products of 386704-04-7 The title of the patent was Application method of thiophenol photocatalyst in defluorination alkylation or defluorination protonation reaction. And the patent contained the following:

The title method includes (1) mixing a trifluoromethyl compound (with a formula I as shown in Claim 2, such as trifluoromethyl (hetero)alkyl compounds, trifluoroacetamide compounds, etc.) and/or polyfluoroalkyl compound (with a formula II, such as pentafluoroacetamide compounds, etc.), thiophenol photocatalyst (4-methoxythiophenol, 4-methylthiophenol, etc.), formate salt (sodium formate, calcium formate, etc.) and organic solvent (DMF, THF, etc.) to form a reaction mixture. (2) Irradiating under the protection of inert gas for a defluorination reaction to obtain a difluoromethyl free radical and/or polyfluoroalkyl free radical intermediate product. (3) Reacting with unsaturated olefin (with formula III as shown in Claim 5, such as dimethyl(phenyl)(vinyl)silane, but-3-en-1-ol, etc.) to obtain a defluorination alkylation product (6-(3-(dimethyl(phenyl)silyl)-1,1-difluoropropyl)pyridin-2-amine, 5-(6-aminopyridin-2-yl)-5,5-difluoropentan-1-ol, etc.). (4) Or reacting the intermediate product as hydrogen donor with formate salt to obtain a defluorination protonation product. In formulas I-III, R is amido, ester group, aryl or heteroaryl; and R’ is or cycloalkyl. The thiophenol photocatalyst has the advantages of low cost and environment friendliness. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Related Products of 386704-04-7

The Article related to thiophenol photocatalyst alkylsilane preparation defluorination alkylation, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.Related Products of 386704-04-7

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On May 22, 2003, Walker, Daniel P.; Jacobsen, Jon E.; Acker, Brad A.; Groppi, Vincent E.; Piotrowski, David W. published a patent.Application of 280752-78-5 The title of the patent was Preparation of N-(azabicyclyl)arylamides for therapeutic use as nicotinic acetylcholine receptor agonists. And the patent contained the following:

N-(azabicyclyl)arylamides, such as RNR1C(:X)W [R = azabicyclyl; R1 = H, alkyl, cycloalkyl, haloalkyl, aryl; W = heteroaryl; X = O, S], were prepared for therapeutic use as nicotinic acetylcholine receptor agonists. These amides are useful for the treatment of central nervous system disorders, such as cognitive and attention deficit symptoms of Alzheimer’s, neurodegeneration associated with diseases such as Alzheimer’s disease, pre-senile dementia (mild cognitive impairment), senile dementia, schizophrenia, psychosis, attention deficit disorder, attention deficit hyperactivity disorder, mood and affective disorders, amyotrophic lateral sclerosis, borderline personality disorder, traumatic brain injury, behavioral and cognitive problems associated with brain tumors, AIDS dementia complex, dementia associated with Down’s syndrome, dementia associated with Lewy Bodies, Huntington’s disease, depression, general anxiety disorder, age-related macular degeneration, Parkinson’s disease, tardive dyskinesia, Pick’s disease, post traumatic stress disorder, dysregulation of food intake including bulimia and anorexia nervosa, withdrawal symptoms associated with smoking cessation and dependent drug cessation, Gilles de la Tourette’s Syndrome, glaucoma, neurodegeneration associated with glaucoma, or symptoms associated with pain. Thus, amide I was prepared in 71% yield by an amidation reaction of 1,4-benzodioxane-6-carboxylic acid with 3-(R)-aminoquinuclidine dihydrochloride using DIEA and HATU in MeCN at -10°. The prepared amides were assayed for human α7-5HT3 receptor binding activity. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Application of 280752-78-5

The Article related to azabicyclic heteroaryl amide preparation nicotinic acetylcholine receptor agonist, Alkaloids: Alkaloids Containing One Nitrogen Atom At A Bridgehead and other aspects.Application of 280752-78-5

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On May 31, 1983, Liepins, E.; Birgele, I.; Zelcans, G.; Urtane, I.; Lukevics, E. published an article.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol The title of the article was Nitrogen-containing organosilicon compounds. CXII. Carbon-13, silicon-29, and nitrogen-15 NMR spectra of a series of cyclic organosilicon esters of N-substituted diethanolamines and their methiodides. And the article contained the following:

The title NMR of 28 (I, R = Me, Ph, p-MeC6H4, 2-thienyl; R1 = Me, Ph, Pr, MeO, Cl, H, CH:CH2; RR1 = OCMe2CMe2O; X = NMe, NH, NCMe3, N+Me2 I-) were studied. The influence of N-substitution on N→Si interaction was also discussed. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to nmr dioxaazasilacyclooctane, azadioxasilacyclooctane nmr, siladioxaazacyclooctene nmr, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

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On March 31, 1979, Bennett, E. O. published an article.COA of Formula: C8H19NO2 The title of the article was Corrosion inhibitors as preservatives for metalworking fluids – ethanolamines. And the article contained the following:

Fifty-nine monoethanolamines, diethanolamines, and triethanolamines were studied for their antimicrobial properties in 13 cutting fluid products. 2-(N-Amyl) ethanolamine [35161-67-2] exhibited outstanding activity in all of the products. Other compounds producing significant inhibition of microbial growth included N-Me ethanolamine [109-83-1], N-Et ethanolamine [110-73-6], N-Bu ethanolamine [111-75-1], 2-N-methyl-N-heptyl) ethanolamine [71247-70-6], 2-cyclohexyl ethanolamine [2842-38-8], and N-benzyl ethanolamine [104-63-2]. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).COA of Formula: C8H19NO2

The Article related to ethanolamine derivative corrosion inhibitor bactericide, cutting fluid anticorrosion antimicrobial agent, Fossil Fuels, Derivatives, and Related Products: Lubricating Oils and other aspects.COA of Formula: C8H19NO2

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Anisimov, Anton A.; Temnikov, Maxim N.; Krizhanovskiy, Ilya; Timoshina, Ekaterina I.; Milenin, Sergey A.; Peregudov, Alexander S.; Dolgushin, Fedor M.; Muzafarov, Aziz M. published an article in 2021, the title of the article was A thiol-ene click reaction with preservation of the Si-H bond: a new approach for the synthesis of functional organosilicon compounds.COA of Formula: C10H22S And the article contains the following content:

This work presents an approach for the preparation of functional hydrosilanes. The essence of the method is a thiol-ene click reaction on vinyl or allylsilanes. In this case, the Si-H bond in the substrate mol. is not affected. The reaction proceeds with radical (AIBN) or UV initiation with yields close to quant. This makes it possible to obtain aliphatic, aromatic, carboxyl and alkoxysilyl derivatives of the corresponding silanes. Crystalline tris(3-(phenylthio)propyl) silane was obtained and characterized for the first time. In the case when the thiol-ene reaction leads to the formation of a three-dimensional network, it was possible to obtain Si-H-containing materials – a transparent monolith and an aerogel with a d. of 0.26 g ml-1. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).COA of Formula: C10H22S

The Article related to crystal structure mol hydrosilane preparation, thiolene click reaction vinyl allyl silane silicon hydrogen bond, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.COA of Formula: C10H22S

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On September 30, 1988, Urtane, I.; Zelcans, G.; Lukevics, E.; Mazeika, I.; Gaukhman, A. P. published an article.Electric Literature of 2160-93-2 The title of the article was Synthesis and mass spectra of spirocyclic silicon ethers of diethanolamines. And the article contained the following:

Heating Si(OMe)4 or Si(OEt)4 with glycols Z(OH)2 [Z = CH2CH2, (CH2)3, CMe2CMe2, C(CF3)2C(CF3)2, CMe2CH2CMe2; CMe2CH2CMeR, R = nonyl] and diethanolamines (HOCHR1CH2)2NR2 (R1 = H, Me; R2 = H, Me, CMe3) gave 29-100% of 13 asym. spirocyclic ethers I (same Z, R1, R2). Heating Si(OMe)4 with (HOCHMeCH2)2NMe or with (Me3SiOCH2CH2)2NPh gave 33-36% sym. spirocyclic ethers I [Z = R2N(CH2CHR1O)2; R1 = R2 = Me; R1 = H, R2 = Ph], resp. Mass spectral fragmentation patterns for I indicate a pronounced transannular N→Si bond in the mixed spirocycles and a much weaker one in the sym. spirocycles. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Electric Literature of 2160-93-2

The Article related to spirocyclic silicon ether preparation mass spectrum, diethanolamine cyclocondensation alkoxysilane glycol, transannular nitrogen silicon bond spirocycle, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.Electric Literature of 2160-93-2

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Sikorska, Wioleta; Wasyleczko, Monika; Przytulska, Malgorzata; Wojciechowski, Cezary; Rokicki, Gabriel; Chwojnowski, Andrzej published an article in 2021, the title of the article was Chemical degradation of PSF-PUR blend hollow fiber membranes-assessment of changes in properties and morphology after hydrolysis.Safety of Pentane-1,5-diol And the article contains the following content:

In this study, the authors focused on obtaining polysulfone-polyurethane (PSF-PUR) blend partly degradable hollow fiber membranes (HFMs) with different compositions while maintaining a constant PSF:PUR = 8:2 weight ratio. It was carried out through hydrolysis, and evaluation of the properties and morphol. before and after the hydrolysis process while maintaining a constant cut-off. The obtained membranes were examined for changes in ultrafiltration coefficient (UFC), retention, weight loss, morphol. assessment using SEM and MeMoExplorer Software, as well as using the Fourier-transform IR spectroscopy (FT-IR) method. The results of the study showed an increase in the UFC value after the hydrolysis process, changes in retention, mass loss, and FT-IR spectra. The evaluation in MeMoExplorer Software showed the changes in membranes’ morphol. It was confirmed that polyurethane (PUR) was partially degraded, the percentage of ester bonds has an influence on the degradation process, and PUR can be used as a pore precursor instead of superbly known polymers. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Safety of Pentane-1,5-diol

The Article related to polysulfone polyurethane blend hollow fiber membrane morphol hydrolysis, psf-pur membranes, pur degradation, hydrolysis process, partly degradable hollow fiber membranes, Physical Properties of Synthetic High Polymers: Polymer Structure and other aspects.Safety of Pentane-1,5-diol

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On October 31, 1979, Ferrari, G.; Casagrande, C. published an article.Category: alcohols-buliding-blocks The title of the article was Synthesis and chemical properties of N- and O-phosphorylated derivatives of creatinol. And the article contained the following:

Treatment of HOCH2CH2NMeC(:NH)NH2.HBr (I.HBr) with POCl3 gave, after hydrolysis, HOCH2CH2NMeC(:NH)NHP(O)(OH)2 (II), from which the di-Na, Ca and Ba salts were prepared II was also prepared by treating I.HBr with H3PO4 and heating the resultant I.H3PO4 to 165° under 5 min pressure. Treatment of Na+ [(4-O2NC6H4CH2O)2P(O)NCN]- with MeNHCH2CH2OH.HCl followed by hydrogenolysis gave HOCH2CH2NMeC(:NH)NHP(O)(OH)2, which rearranged to II upon heating at 155° for 1 h. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Category: alcohols-buliding-blocks

The Article related to phosphorylated creatinol, Aliphatic Compounds: Alcohol and Thiol Esters With Inorganic Acids and other aspects.Category: alcohols-buliding-blocks

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On December 31, 2021, Cagetti, Maria Grazia; Cocco, Fabio; Calzavara, Ezio; Augello, Davide; Zangpoo, Phunchok; Campus, Guglielmo published an article.Recommanded Product: 585-88-6 The title of the article was Study protocol for a randomized clinical trial to evaluate the effect of the use of Xylitol gum in the prevention of caries lesions in children living in Ladakh-the Caries Prevention Xylitol in Children (CaPreXCh) trial. And the article contained the following:

Xylitol use is reported to be able to reduce dental plaque amount and cariogenic bacteria and, as a consequence, the caries increment. Only few data on the oral health of Ladakh’s population are available. The aim of the present protocol will be to record the caries prevalence of primary and permanent molars of school children living in Ladakh and to implement a school-based Xylitol program, named the Caries Prevention Xylitol in Children (CaPreXCh) trial, using chewing gums. The protocol is designed as a triple-blind randomized, controlled, parallel-group clin. trial in children aged 5-14 years. The study should have been carried out from August 2021 to August 2024 in Zanskar Valley (Ladakh), but the COVID-19 pandemic does not allow today to make predictions on the exact start. Participants will be randomly allocated into two groups: subjects who will receive a chewing gum with Xylitol (70% w/v) as only sweetener, and those who will receive a sugared chewing gum containing Maltitol (23% w/v). The subjects will be instructed to chew a total of 6 pellets for 5 min divided into 3 intakes a day (2 in the morning, 2 after the midday meal and 2 in the afternoon) for one school year. Clin. examination will comprise an oral examination in which caries index (ICDAS scores), bleeding on probing and plaque pH evaluation after sucrose challenge will be recorded at baseline (t0); the clin. examination will be repeated after 12 mo since the beginning of the chewing gum administration period (t1), after another 12-mo period (t2) and finally after further 12 mo (t3) (24 mo from the end of the chewing gum use). The primary outcome will be the caries increment measured both at enamel and dentinal levels on primary and permanent molars. Data anal. will be conducted through Kaplan-Meyer graphs to evaluate caries increment. A comparison of the methods will be carried out with Cox regression with shared frailty. The net caries increment for initial, moderate and severe caries levels, using ICDAS (Δ-initial, Δ-moderate and Δ-severe), will be calculated This trial will be the first trial conducted in India assessing the efficacy of a school-based caries preventive program through the use of chewing gum containing only Xylitol as a sweetener. The findings could help strengthen the evidence for the efficacy of Xylitol use in community-based caries prevention programs in children. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Recommanded Product: 585-88-6

The Article related to xylitol chewing gum dental caries india, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Recommanded Product: 585-88-6

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