Month: November 2022

On March 23, 2017, Axten, Jeffrey Michael; Faucher, Nicolas Eric; Daugan, Alain Claude-Marie published a patent.Product Details of 386704-04-7 The title of the patent was Preparation of imidazolidinone derivatives as inhibitors of PERK. And the patent contained the following:

The title imidazolidinones I [R1 = (un)substituted bicycloheteroaryl, heteroaryl; R2 = alkyl, (un)substituted aryl, heteroaryl, etc.; R3 = H, NH2, NH(alkyl), etc.; R4 and R5 = (independently) H and alkyl; R4 and R5 taken together with the carbon atoms to which they are attached form 3-4 membered cycloalkyl, optionally substituted with 1-3 alkyl; R6 = H, alkyl, CF3, etc.; R7 = H, alkyl, CF3, etc.; X = N or (un)substituted CH; Y1 and Y2 = (independently) H, CF3, alkyl; or Y1 and Y2 are taken together with the carbon to which they are attached to form C3-6 cycloalkyl; z = 0-1] or salts thereof including a pharmaceutically acceptable salts thereof, which are inhibitors of PERK and can be useful in the treatment of cancer, pre-cancerous syndromes, Alzheimer’s disease, neuropathic pain, etc., were prepared and formulated. E.g., a multi-step synthesis of II, starting from 4-bromo-3-fluoroaniline and 1-chloro-2-isocyanatoethane, was described. Exemplified compounds I were tested for activity against PERK (data given). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound I. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound I or a pharmaceutical composition comprising I. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Product Details of 386704-04-7

The Article related to imidazolidinone preparation perk inhibitor antitumor analgesic alzheimer’s disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Product Details of 386704-04-7

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On March 23, 2020, Martin, Caterina; Trajkovic, Milos; Fraaije, Marco W. published an article.Safety of Pentane-1,5-diol The title of the article was Production of Hydroxy Acids: Selective Double Oxidation of Diols by Flavoprotein Alcohol Oxidase. And the article contained the following:

Flavoprotein oxidases can catalyze oxidations of alcs. and amines by merely using mol. oxygen as the oxidant, making this class of enzymes appealing for biocatalysis. The FAD-containing (FAD=FAD) alc. oxidase from P. chrysosporium facilitated double and triple oxidations for a range of aliphatic diols. Interestingly, depending on the diol substrate, these reactions result in formation of either lactones or hydroxy acids. For example, diethylene glycol could be selectively and fully converted into 2-(2-hydroxyethoxy)acetic acid. Such a facile cofactor-independent biocatalytic route towards hydroxy acids opens up new avenues for the preparation of polyester building blocks. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Safety of Pentane-1,5-diol

The Article related to alc oxidase diol double oxidation, biocatalysis, diols, enzymes, lactones, oxidation, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.Safety of Pentane-1,5-diol

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Alcohol – Wikipedia,
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On July 5, 2007, Buettelmann, Bernd; Han, Bo; Knust, Henner; Thomas, Andrew published a patent.SDS of cas: 386704-04-7 The title of the patent was Preparation of arylisoxazolyl imidazoles as GABAA α5 receptor ligands for the treatment of cognitive disorder and Alzheimer’s disease. And the patent contained the following:

Title compounds I [wherein R1, R2, R3 = H or halo; R4 = H, alkyl, cycloalkyl, etc.; R5 = (un)substituted (CH2)m-(hetero)aryl; m = 0-1; R6 = H, CHO, cycloalkyl, etc.] and pharmaceutically acceptable acid addition salts thereof were prepared as GABAA α5 receptor ligands. For instance, II was synthesized in 43% yield by N-alkylation of the corresponding imidazole with 4-fluoroacetophenone. This compound has a Ki value of 4.7 nM for displacement of [3H]flumazenil from GABAA α5 subunits. I and their pharmaceutical compositions are useful for the treatment of diseases related to the GABAA a5 subunits, such as cognitive disorder and Alzheimer’s disease. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).SDS of cas: 386704-04-7

The Article related to arylisoxazolyl imidazole preparation gabaa receptor ligand cognitive enhancer antialzheimer, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.SDS of cas: 386704-04-7

Referemce:
Alcohol – Wikipedia,
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On February 28, 2021, Fan, Xiaojing; Jiao, Xin; Liu, Jinguang; Jia, Meng; Blanchard, Chris; Zhou, Zhongkai published an article.Category: alcohols-buliding-blocks The title of the article was Characterizing the volatile compounds of different sorghum cultivars by both GC-MS and HS-GC-IMS. And the article contained the following:

The current study applied both GC-MS and GC-IMS for characterizing volatile compounds of six Australian sorghum cultivars. For raw sorghum, the result of GC-MS showed that ester compounds were abundant in six raw samples. Among these esters, the content of hexadecanoic acid Et ester was highest in all of the raw samples. Compound 3-octanone only existed in Apollo, Bazley and Liberty, and 2-undecanone was found to be in MR43. Result of GC-IMS showed that signals of benzaldehyde, 2,3-butanedione were generally noted in six raw samples. In general, The Apollo and Buster had more volatile compounds, followed by Bazley and Liberty. In contrast, MR43 and G44 had least volatile compounds For cooked sorghums, more fatty aldehydes are formed compared to its corresponding raw sample, in which current data indicated that 40 volatile compounds were identified by GC-MS, and 11 of them were identified as the key aroma compounds More important, variation in the compounds of hexanal, heptanal, octanal, 2-heptenal, nonanal, trans- 2-octenal, benzeneaceldehyde, (E)-2-nonenal, 1-octen-3-ol, 1-pentanol, 2-methoxy-4-vinylphenol and 2-pentylfuran might be applied for explaining the aroma characteristics among six sorghum cultivars. Result of GC-IMS showed that 26 volatile compounds but not in results from GC-MS detection, indicating advantage of methodol. combination for a better understanding impact of cultivars and cooking on volatile characteristics of sorghums. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Category: alcohols-buliding-blocks

The Article related to sorghum volatile compound gc ms ims, gc-ims, gc-ms, odor-active value, sorghum, volatile compound, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
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On June 11, 2015, Kane, John L., Jr.; Matthews, Gloria; Metz, Markus; Kothe, Michael; Liu, Jinyu; Scholte, Andrew published a patent.Category: alcohols-buliding-blocks The title of the patent was Benzimidazole and imidazopyridine derivatives as tropomyosin-related kinase (Trk) inhibitors and their preparation and use for the treatment of diseases. And the patent contained the following:

The invention relates to benzimidazole and imidazopyridine derivatives of formula I, which are tropomyosin-related kinase (Trk) inhibitors and which are useful in the treatment of diseases. Compounds of formula I wherein Q1 is H, halo, (un)substituted C6-14 aryl, etc.; Q2 is (un)substituted C6-14 aryl, (un)substituted C2-9 heteroaryl, etc.; R1 is H, halo, C1-10 alkyl, etc.; R2 is H, halo, C1-10 alkyl, C1-10 alkoxy, etc.; L is (CR3R4)1-5; R3 and R4 are independently H, NH2, C1-10 alkyl, etc.; Z is (CR5R6)0-4; R5 and R6 are independently H, NH2, C1-10 alkyl, etc.; X is CH, halo, NH, etc.; and pharmaceutically acceptable salts thereof, are disclosed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their Trk inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values of 0.001 μM and 0.0005 μM towards TrkA and TrkB, resp. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Category: alcohols-buliding-blocks

The Article related to imidazopyridine preparation trk inhibitor treatment disease, benzimidazole preparation trk inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 1, 2020, Wang, Yanling; Berhow, Mark A.; Black, Molly; Jeffery, Elizabeth H. published an article.Application of 621-37-4 The title of the article was A comparison of the absorption and metabolism of the major quercetin in brassica, quercetin-3-O-sophoroside, to that of quercetin aglycone, in rats. And the article contained the following:

Although flavonoid sophorosides are common glycosides in brassica vegetables, red raspberries and other food plants, there is a lack of studies of absorption and metabolism of any sophoroside. The aim of this study was to characterize the absorption, phase II metabolism and microbial catabolism of quercetin-3-O-sophoroside, compared to that of quercetin aglycon. Quercetin-3-O-sophoroside was purified from Apocynum venetum and characterized by MS2, 1H and 13C NMR. Using an in situ rat gut model, we found intact, methylated, sulfated and both methylated and sulfated quercetin sophoroside in the plasma following jejunal introduction of the sophoroside; we found derivatives of benzoic acid, phenylacetic acid, and Ph propionic acid in the cecal contents following cecal introduction. This novel finding, that quercetin sophoroside was absorbed intact, without deglycosylation, points to a possible role for the terminal sugar and/or the type of linkage among glycosidic moieties in the mechanism of absorption of flavonoid glycosides. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application of 621-37-4

The Article related to quercetin sophoroside aglycon absorption metabolism intestine, flavonol absorption, metabolism, microbial catabolism, quercetin sophoroside, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Application of 621-37-4

Referemce:
Alcohol – Wikipedia,
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On May 31, 2020, Sezgin, Sema; Dalar, Abdullah; Uzun, Yusuf published an article.Product Details of 96-76-4 The title of the article was Determination of antioxidant activities and chemical composition of sequential fractions of five edible mushrooms from Turkey. And the article contained the following:

Tricholoma scalpturatum, Tricholoma populinum, Neolentinus cyathiformis, Chlorophyllum agaricoides, and Lycoperdon utriforme have been traditionally utilized as food in Turkey for a long time. The present study focused on determining antioxidant activities, total phenolic groups contents (flavonols, hydroxycinnamic acids, proanthocyanidins, and anthocyanins), phenolic compounds and fatty acids of sequential extracts (n-hexane, Et acetate, chloroform, acetone, ethanol, and pure water) obtained from five wild edible macrofungi species. Ethanol and acetone (or Et acetate) were found as the most efficient solvents in terms of antioxidant activities and extraction efficiency. Antioxidant studies showed that L. utriforme, C. agaricoides, and T. populinum exhibited the highest radical scavenging and reducing activities and contained the highest phenolic contents. Chromatog. studies revealed that phenolic acids (protocatechuic, gallic, and chlorogenic acids) and fatty acids (oleic, linoleic, and palmitic acids) were the major contributors of the antioxidant activities of the extracts The results obtained suggest the utilization of these macrofungi species as significant sources of natural antioxidants. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Product Details of 96-76-4

The Article related to antioxidant activity chem composition sequential fraction edible mushroom, antioxidant, extraction, fatty acid, mushroom, phenolic compound, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Product Details of 96-76-4

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 18, 2014, Ikegami, Satoru; Watanabe, Atsushi; Hirano, Kimio; Ohyama, Tadashi published a patent.Application of 386704-04-7 The title of the patent was Preparation of 4-alkynyl imidazole derivatives for the treatment of EP4 receptor-related diseases. And the patent contained the following:

The present invention provides 4-alkynyl imidazole derivatives I [ring A = (un)substituted cycloalkyl, aryl or heteroaryl; ring B = cycloalkyl, aryl or heteroaryl; m = 0-2; n = 1-3; R1 = H, alkyl, alkoxy, etc.; R2 and R3 = independently H, halogen, alkyl or carbocyclic ring when taken together; R4 and R5 = independently H, alkyl or carbocyclic ring when taken together; R6 and R7 = independently H, alkyl, alkoxy, etc.; X = OR8, NR9R10 or halogen; R8 = H, alkyl or haloalkyl; R9 and R10 = independently H, alkyl or heterocycle when taken together; Y = single bond, O or S; E = CO2H, CO2P or biol. equivalent of carboxyl group; CO2P = pharmacol. acceptable ester prodrug] and their pharmaceutically acceptable salts. Thus, compound II (preparation given) was subjected to a coupling reaction with 4-(1-aminocyclopropyl)benzoic acid Me ester followed by O-methylation and hydrolysis to provide compound III. Compound III exhibited antagonistic activity against rat EP4 receptor with an IC50 value of 1.7 nmol/L. The invention compounds have excellent EP4 receptor antagonist effects and are useful as medicines for treating diseases associated with EP4 receptors, for example, anti-inflammatory agents and/or analgesics for inflammatory diseases and diseases associated with various kinds of pain, and also as medicines for treating immune diseases that occur as a result of Th1 cell and/or Th17 cell activation, which causes tissue destruction and gives rise to inflammation. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7

The Article related to alkynyl imidazole derivative preparation ep4 receptor antagonist, inflammatory disease pain immune disease treatment antiinflammatory agent, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application of 386704-04-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 30, 2022, Sapara, Komal K.; Agarwal, Parinita; Gupta, Kapil; Agarwal, Pradeep K. published an article.Recommanded Product: 473-81-4 The title of the article was Expression of B. subtilis Phytase gene driven by fruit specific E8 promoter for enhanced minerals, metabolites and phytonutrient in cucumber fruit. And the article contained the following:

The fruit nutrigenomics is an interesting and important research area towards nutrition enhancement. The phytic acid is one of the major antinutrient compound, present in seeded fruits and crops. It hinders the absorption of iron (Fe), zinc (Zn), magnesium (Mg), potassium (K) and calcium (Ca), causing mineral deficiencies. In the present study, the BsPhy gene was overexpressed in the cucumber fruits using the tomato fruit specific E8 and constitutive CaMV 35S promoter. The E8 promoter imparted heterologous expression of GUS gene in cucumber fruits, furthermore, the fruit specific expression of E8 promoter with BsPhy gene was confirmed in transgenics (E8: BsPhy) using anti rabbit-phytase antibody. The physio-biochem. anal. of transgenics revealed, maximum phytase activity in E8: BsPhy cucumber fruits at 10 days after anthesis (DAA) compared to 35S: BsPhy and wild-type (WT) fruits. Consequently, E8: BsPhy fruits also showed increased amount of inorganic phosphorus (Pi), total phosphorus (P), minerals (Zn, Fe, Mg, K, Ca), total carotenoid and other macronutrients at 10 DAA compared to 35S: BsPhy fruits. The metabolite profiling of fruits (10 DAA) showed increased sugars, amino acids, sugar acids and polyols, in both E8: BsPhy and 35S: BsPhy transgenics suggesting higher phytate metabolism, compared to WT fruits. Interestingly, both the transgenic fruits showed higher fruit biomass and yield along with improved nutritional quality, which can be attributed to increased P and Zn contents in transgenic fruits, compared to WT fruits. Our findings reveal that the BsPhy gene enhances minerals and macronutrients in transgenic cucumber fruits making it nutritious and healthy. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 473-81-4

The Article related to bacillus subtilis mineral cucumber fruit metabolite phytonutrient, antinutrient, heterologous, metabolites, minerals, nutrigenomics, transgenic, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Recommanded Product: 473-81-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ni, Hui; Jiang, Qing-Xiang; Zhang, Ting; Huang, Gao-Ling; Li, Li-Jun; Chen, Feng published an article in 2020, the title of the article was Characterization of the aroma of an instant white tea dried by freeze drying.Recommanded Product: 96-76-4 And the article contains the following content:

The aroma of an instant white tea (IWT) was extracted through simultaneous distillation-extraction (SDE) and analyzed by sensory evaluation, gas chromatog.-mass spectrometry-olfactometry (GC-MS-O), aroma reconstruction, omission test and synergistic interaction anal. Sensory evaluation showed the IWT was dominated with floral and sweet notes. The SDE extract had the aroma similar to the IWT. The main volatile components in the SDE extract were benzyl alc., linalool, hotrienol, geraniol, α-terpineol, coumarin, camphene, benzeneacetaldehyde, 2-hexanone, cis-jasmin lactone and phenylethyl alc. GC-MS-O and aroma reconstruction experiments showed 16 aroma-active compounds Linalool, trans-β-damascenone and camphene were the major contributors to floral, sweet and green notes based on flavor dilution anal. and omission test. Linalool and trans-β-damascenone had synergistic effect to promote floral and sweet notes. Camphene and trans-β-damascenone had synergistic effect to reduce green and sweet notes. The study helps to understand the aroma of IWT and antagonism interactions among aroma-active volatiles. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Recommanded Product: 96-76-4

The Article related to aroma instant white tea dried freeze drying, gc-ms, gc-ms-o, aroma reconstruction and omission test, instant white tea, synergistic interactions, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Recommanded Product: 96-76-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts