Month: November 2022

Chen, Jiying; Zhou, Qinger; Zhang, Yonggang; Tan, Wenqing; Gao, Hanchao; Zhou, Liying; Xiao, Shuixiu; Gao, Jinhua; Li, Jing; Zhu, Zhiying published an article in 2021, the title of the article was Discovery of novel serum metabolic biomarkers in patients with polycystic ovarian syndrome and premature ovarian failure.Recommanded Product: H-Phg(4-OH)-OH And the article contains the following content:

Several widely recognized metabolites play a role in regulating the pathophysiol. processes of various disorders. Nonetheless, the lack of effective biomarkers for the early diagnosis of polycystic ovarian syndrome (PCOS) and premature ovarian failure (POF) has led to the discovery of serum-based metabolic biomarkers for these disorders. We aimed to identify various differentially expressed metabolites (DEMs) through serum-based metabolic profiling in patients with PCOS and POF and in healthy individuals by using liquid chromatog.-mass spectrometry anal. Furthermore, heatmap clustering, correlation, and Z-score analyses were performed to identify the top DEMs. Kyoto Encyclopedia of Genes and Genomes enriched pathways of DEMs were determined using metabolite-based databases. Moreover, the clin. significance of these DEMs was evaluated on the basis of area under the receiver operating characteristic curve. Significantly dysregulated expressions of several metabolites were observed in the intergroup comparisons of the PCOS, POF, and healthy control groups. Furthermore, 6 DEMs were most frequently observed among the three groups. The expressions of these DEMs were not only directly correlated but also exhibited potential significance in patients with PCOS and POF. Novel metabolites with up/downregulated expressions can be discovered in patients with PCOS and POF using serum-based metabolomics; these metabolites show good diagnostic performance and can act as effective biomarkers for the early detection of PCOS and POF. Furthermore, these metabolites might be involved in the pathophysiol. mechanisms of PCOS and POF via interplay with corresponding genes. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: H-Phg(4-OH)-OH

The Article related to polycystic ovarian syndrome premature failure metabolic biomarkers human, metabolic biomarkers, polycystic ovarian syndrome, premature ovarian failure, Mammalian Pathological Biochemistry: Obstetrics – Gynecology and other aspects.Recommanded Product: H-Phg(4-OH)-OH

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Alcohol – Wikipedia,
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Deidda, Martino; Noto, Antonio; Cadeddu Dessalvi, Christian; Andreini, Daniele; Andreotti, Felicita; Ferrannini, Eleuterio; Latini, Roberto; Maggioni, Aldo P.; Magnoni, Marco; Mercuro, Giuseppe; on behalf of the CAPIRE Investigators published an article in 2022, the title of the article was Why Do High-Risk Patients Develop or Not Develop Coronary Artery Disease? Metabolic Insights from the CAPIRE Study.Computed Properties of 473-81-4 And the article contains the following content:

Traditional cardiovascular (CV) risk factors (RFs) and coronary artery disease (CAD) do not always show a direct correlation. We investigated the metabolic differences in a cohort of patients with a high CV risk profile who developed, or did not develop, among those enrolled in the Coronary Atherosclerosis in Outlier Subjects: Protective and Novel Individual Risk Factors Evaluation (CAPIRE) study. We studied 112 subjects with a high CV risk profile, subdividing them according to the presence (CAD/High-RFs) or absence of CAD (No-CAD/High-RFs), assessed by computed tomog. angiog. The metabolic differences between the two groups were identified by gas chromatog.-mass spectrometry. Characteristic patterns and specific metabolites emerged for each of the two phenotypic groups: high concentrations of pyruvic acid, pipecolic acid, p-cresol, 3-aminoisobutyric acid, isoleucine, glyceric acid, lactic acid, sucrose, phosphoric acid, trimethylamine-N-oxide, 3-hydroxy-3-methylglutaric acid, erythritol, 3-hydroxybutyric acid, glucose, leucine, and glutamic acid; and low concentrations of cholesterol, hypoxanthine, glycerol-3-P, and cysteine in the CAD/High-RFs group vs the No-CAD/High-RFs group. Our results show the existence of different metabolic profiles between patients who develop CAD and those who do not, despite comparable high CV risk profiles. A specific cluster of metabolites, rather than a single marker, appears to be able to identify novel predisposing or protective mechanisms towards CAD beyond classic CVRFs. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4

The Article related to pyruvic pipecolic acid isoleucine p cresol coronary artery disease, atherosclerosis, cardiovascular risk factors, coronary artery diseases, metabolomics, Mammalian Pathological Biochemistry: Cardiovascular Diseases and other aspects.Computed Properties of 473-81-4

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On August 4, 2022, Bacani, Genesis M.; Chai, Wenying; Chung, De Michael; Goldberg, Steven D.; Hirst, Gavin; Kaushik, Virendar; Mercado-Marin, Eduardo V.; Raymond, Donald; Seierstad, Mark; Smith, Russel C.; Sundberg, Thomas; Tichenor, Mark S.; Venable, Jennifer D.; Wei, Jianmei; Xavier, Ramnik published a patent.Electric Literature of 386704-04-7 The title of the patent was Heteroaromatics as small molecule inhibitors of salt inducible kinases and their preparation. And the patent contained the following:

Small mol. inhibitors of salt inducible kinases (SIKs) are provided. In particular, compounds of formula I, and tautomers, stereoisomers, pharmaceutically acceptable salts and solvates thereof are provided. Also provided are pharmaceutical compositions containing the compounds, methods of preparing the compounds, and methods of using the compounds for inhibiting SIKs, such as SIK1 and SIK2, and methods of treating diseases mediated by SIKs. Compounds of formula I wherein X1, X2 and X3 are independently N and CH; Q1 and Q2 are independently N and CH; Z is O, OCH2, OCH2CH2 and NH and derivatives, and NHCH2 and derivatives; R1 is COR5, Ph, 5- to 6-membered heteroaryl, etc.; R2 is (un)substituted 4- to 7-membered monocyclic heterocyclyl, (un)substituted 6- to 9-membered bicyclic heterocyclyl, (un)substituted C3-6 cycloalkyl, etc.; R3 is H, Me, Et, propynyl, CN, etc.; R5 is (un)substituted cyclopropyl; and stereoisomers, tautomers, pharmaceutically acceptable salts and solvates thereof, are claimed. Example compound II was prepared by O-arylation of (R)-(1-methylpyrrolidin-3-yl)methanol with N-(5-(5-chloro-2-cyanopyridin-4-yl)pyrazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide. The invention compounds were evaluated for their SIK inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values in the range of 0.00226088μM to 0.0591017μM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Electric Literature of 386704-04-7

The Article related to heteroaromatic preparation sik inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Electric Literature of 386704-04-7

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Alcohol – Wikipedia,
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On February 20, 2014, Barr, Kenneth Jay; MacLean, John; Zhang, Hongjun; Beresis, Richard Thomas; Zhang, Dongshan published a patent.Product Details of 62640-03-3 The title of the patent was 3-Cyclohexenyl and cyclohexyl-substituted indole and indazole compounds as ROR-gamma-T inhibitors and their preparation. And the patent contained the following:

The invention relates to compounds of formula I, and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of ROR-gamma-T-mediated diseases or conditions. Compounds of formula I wherein dashed bond is single and double bond; X is CH2, CO and CRb; Y is CH, CRa and N; n is 0, 1, 2, 3, and 4; A4 is CR5 and N; A5 is CR5 and N; A6 is CR6 and N; A7 is CR7 and N; with the proviso that no more than two of A4 – A7 are N; Ra and Rb are independently C1-4 alkyl; R1 is (un)substituted C3-12 carbocyclyl and (un)substituted 4- to 12-membered heterocyclyl; R2 is hydroxycarbonyl, hydroxycarbonyl-C1-10 alkyl, and carbamoyl; R3 is H, halo, CN, NO2, etc.; R4 – R7 are independently H, halo, amino, CN, OH, etc.; and pharmaceutically acceptable salts and solvates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their RORγ-T inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of 18 nM. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Product Details of 62640-03-3

The Article related to indole indazole preparation rorgammat inhibitors, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Product Details of 62640-03-3

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Alcohol – Wikipedia,
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On April 12, 2018, Chrovian, Christa C.; Letavic, Michael A.; Rech, Jason C.; Rudolph, Dale A.; Johnson, Akinola Soyode; Stenne, Brice M.; Wall, Jessica L. published a patent.Application of 386704-04-7 The title of the patent was Preparation of substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones and their use as GluN2B receptor modulators. And the patent contained the following:

Provided are substituted 1H-imidazo[4,5-b]pyridin-2(3H)-ones of formula I as NR2B receptor modulators useful for the treatment of diseases, disorders, and conditions mediated by NR2B receptor activity. Compounds of formula I [wherein R1 = H, CH2F, or CH3; R2 = (un)substituted Ph, (un)substituted pyridinyl,(un)substituted thienyl, etc.; R3 = H; R4 = for example, pyrazin-2-ylmethyl, oxetan-2-ylmethyl, pyridazin-3-ylmethyl, etc.] or pharmaceutically acceptable salts, solvates, stereoisomers, isotopic variants, or N-oxides or pharmaceutical compositions thereof, are claimed and exemplified. Example compound II was prepared from a multistep procedure (preparation given). Exemplified I were evaluated for NMDA receptor antagonistic activity using human NR1/NR2B ion channel expressing mammalian cells from which II demonstrated an IC50 value of 2.740 μM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7

The Article related to imidazopyridinone preparation glun2b receptor modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application of 386704-04-7

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Alcohol – Wikipedia,
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Hu, Ping; Zhao, Fangzhou; Wang, Jing; Zhu, Weiyun published an article in 2021, the title of the article was Metabolomic profiling reveals the effects of early-life lactoferrin intervention on protein synthesis, energy production and antioxidative capacity in the liver of suckling piglets.Synthetic Route of 32462-30-9 And the article contains the following content:

This study aimed to determine the effects of an early-life lactoferrin (LF) intervention on liver metabolism in suckling piglets. Sixty newborn piglets with an average initial body weight (BW) of 1.51 ± 0.05 kg were assigned to a control (CON) group and an LF group. At age 1 to 7 days, the piglets in the LF group were orally administered LF solution (0.5 g per kg BW daily), whereas the piglets in the CON group were orally administered the same dose of physiol. saline. Plasma, jejunum and liver samples were collected on days 8 and 21. The LF piglets showed a decreased plasma urea nitrogen level on day 8 and an increased plasma albumin level on day 21. Pathway anal. of the metabolomic profiles showed that the LF treatment affected amino acid metabolism in the liver. In addition, the LF treatment upregulated the gene expression levels of proteolytic enzymes and amino acid transporters (APA, APN, EAAC1, Pept1, CAT1, B0AT1 and ASCT2) in the jejunum, and it enhanced the phosphorylation levels of mTOR and p70S6K in the liver. The LF treatment also upregulated the expression of a β-oxidation-related gene (CPT1) and affected the tricarboxylic acid cycle in the liver on day 21. Furthermore, the LF piglets showed a decreased level of malondialdehyde and increased levels of GSH, GSH-Px and GCLC in the liver mitochondria. Overall, the early-life LF intervention affected the protein synthesis, energy production and antioxidative capacity in the liver of the neonatal piglets. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Synthetic Route of 32462-30-9

The Article related to liver lactoferrin protein energy antioxidative metabolomics, Animal Nutrition: Proteins and Nonprotein-Nitrogen Substances and other aspects.Synthetic Route of 32462-30-9

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Alcohol – Wikipedia,
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On August 1, 2021, Hauk, Armin; Pahl, Ina; Dorey, Samuel; Menzel, Roberto published an article.Computed Properties of 96-76-4 The title of the article was Using extractables data from single-use components for extrapolation to process equipment-related leachables: The toolbox and justifications. And the article contained the following:

Quant. information on process equipment-related leachables (PERLs) is required for process qualification and within a safety assessment. Extractables data for single-use equipment are suitable and applicable if the extractables study conditions fit or are bracketing the expected conditions of use. It is necessary to extrapolate extractables data when the expected in-use conditions are not covered by the test conditions. Methods for such quant. extrapolation of extractables data toward potential PERLs are therefore needed. They are comprehensively described in this publication and include: scaling of extractables data for devices of different sizes adjusted to process-volumes, extrapolation to temperatures different from the extraction temperature, extrapolations to different solvent compositions, extrapolation to various contact times, and the combination of extractables data from individual components to assess assemblies. These extrapolation methods yield extractables data as if an extractables study had been performed. The methods presented are consistently derived from basic physicochem. principles. The relevant, underlying phys. parameters are obtained from extractables experiments and are compared with published data. The applicability and justification of the proposed calculation methods are discussed and benchmarked against exptl. findings. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Computed Properties of 96-76-4

The Article related to hexadecane dodecane film temperature phase equilibrium algorithm, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Computed Properties of 96-76-4

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On January 15, 2021, Duran-Acevedo, Cristhian Manuel; Caceres-Tarazona, Juan Martin published an article.Quality Control of 1-Decanethiol The title of the article was Low-cost desorption unit coupled with a gold nanoparticles gas sensors array for the analysis of volatile organic compounds emitted from the exhaled breath (gastric cancer and control samples). And the article contained the following:

This paper describes the development and validation of a low-cost desorption unit (DU) equipment for the desorption of pre-concentrated volatile compounds in adsorption tubes ORBO-420 Tenax. The system initially heats the tubes to a temperature of 250C degrees, releasing the trapped VOCs and then drags them by compressed nitrogen flow to a gold nanoparticles gas sensor array. In each of the exptl. tests, the equipment was able to ensure the same desorption conditions in the set of measurements carried out, preventing the sample from being contaminated by external agents or from being diluted during extraction On the other hand, good repetitiveness and selectivity were observed in the sensors responses. To validate the functioning of the equipment, a set of previously acquired samples of exhaled breath from patients confirmed with gastric cancer and control patients (i.e, with gastritis and ulcer) were analyzed. The results were compared with a previous study and it was shown that the desorption unit was able to extract the volatile compounds emitted from exhaled breath and improving the classification. The samples were analyzed through data processing techniques such as: Principal Component Anal. (PCA), Discriminant Function Anal. (DFA), Probabilistic Neural Network (PNN) and Supporting Vector Machines (SVM), for the anal. and the classification of the data obtained, where 98.31% of the total variance was reached through the PCA anal. and 100% success rate was obtained in the classification by using SVM. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Quality Control of 1-Decanethiol

The Article related to gold nanoparticle gas sensor du volatile organic compound breath, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Quality Control of 1-Decanethiol

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Gfeller, David; Michielin, Olivier; Zoete, Vincent published an article in 2012, the title of the article was Expanding molecular modeling and design tools to non-natural sidechains.Safety of H-Phg(4-OH)-OH And the article contains the following content:

Protein-protein interactions encode the wiring diagram of cellular signaling pathways and their deregulations underlie a variety of diseases, such as cancer. Inhibiting protein-protein interactions with peptide derivatives is a promising way to develop new biol. and therapeutic tools. Here, the authors develop a general framework to computationally handle hundreds of non-natural amino acid sidechains and predict the effect of inserting them into peptides or proteins. The authors first generate all structural files (pdb and mol2), as well as parameters and topologies for standard mol. mechanics software (CHARMM and Gromacs). Accurate predictions of rotamer probabilities are provided using a novel combined knowledge and physics based strategy. Non-natural sidechains are useful to increase peptide ligand binding affinity. The authors’ results obtained on non-natural mutants of a BCL9 peptide targeting beta-catenin show very good correlation between predicted and exptl. binding free-energies, indicating that such predictions can be used to design new inhibitors. Data generated as well as PyMOL and UCSF Chimera plug-ins for user-friendly visualization of non-natural sidechains, are all available at http://www.swisssidechain.ch. The authors’ results enable researchers to rapidly and efficiently work with hundreds of non-natural sidechains. © 2012 Wiley Periodicals, Inc. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to mol model design nonnatural side chain protein peptide interaction, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Safety of H-Phg(4-OH)-OH

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On April 6, 2006, Eagan, Robert Lee; Williams, Kevin Alan; Cheek, Allen Morgan published a patent.Related Products of 78-26-2 The title of the patent was Modified chlorinated carboxylated polyolefins and their use as adhesion promoters. And the patent contained the following:

Solvent- and water-based primer compositions include at least one chlorinated carboxylated polyolefin that has been modified with one or more polyfunctional alcs. The chlorinated carboxylated polyolefins are obtained by the reaction of polyolefins with at least one of unsaturated carboxylic esters, unsaturated carboxylic acids, unsaturated carboxylic anhydrides, acrylic monomers, and mixtures thereof then chlorinated. The chlorinated carboxylated polyolefins are then further modified by reaction with one or more polyfunctional alcs. These polyfunctional alc.-modified chlorinated carboxylated polyolefins may also contain pendant carboxyl groups, which have the propensity to form hydrophilic salts with amines or inorganic bases, thereby rendering the polyfunctional alc.-modified chlorinated carboxylated polyolefins water-dispersible. These primer compositions are useful for significantly improving the adhesion of paints, adhesives, and inks to various plastic and metal substrates. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Related Products of 78-26-2

The Article related to polyfunctional alc modified chlorinated carboxylated polyolefin primer, Coatings, Inks, and Related Products: Other Coating Materials and other aspects.Related Products of 78-26-2

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