Month: November 2022

On March 31, 2020, Ahmad, Khuram Shahzad published an article.Recommanded Product: 96-76-4 The title of the article was Environmental contaminant 2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide remediation via Xanthomonas axonopodis and Aspergillus niger. And the article contained the following:

Alachlor, a chloroacetanilide endocrine disruptor herbicide is precarious for humans as well as the environment. Though banned by the European Union and classified as moderately hazardous by WHO, yet it is nevertheless used in several countries posing austere human and environmental health issues. Alachlor attenuation was scrutinized through simulated biodegradation experiments using soil-isolated microbes. Bio-disintegrative assays of pure three fungal and one bacterial strain; Aspergillus flavus (AF), Penicillium chrysogenum (PC), Aspergillus niger (AN) and Xanthomonas axonopodis (XA), resp. were utilized. Initial Alachlor concentration (10 mg/L) was prepared with individual microbial suspension and monitored for 35 d. Alachlor bio-transformation was analyzed quant. and qual. by gas chromatog. mass spectroscopy. XA and AN displayed maximal potential to metabolise the herbicide while forming residues; 1-chloroacetyl, 2,3- dihydro-7 ethylindole, 7 ethylindole, 7-ethyl-3-methyl-2-methoxy-2,3-dihydroindole, N- (2,6-diethylphenyl)-methyleneamine and 7-Ethyl-N-methylindole. Alachlor degradation by AF, PC, AN and XA was found to be 17.1%, 5.5%, 72.6% and 82.1%, resp., after 35 d. Microbes have displayed cometabolism as the main mechanism for Alachlor degradation This research can influence imperative and significant environmental friendly bio-remedial strategies for xenobiotic eradication. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Recommanded Product: 96-76-4

The Article related to xanthomonas alachlor biodegradation wastewater treatment, bacteria, biodegradation, chloroacetanilide, cometabolism, fungi, Waste Treatment and Disposal: Biological Treatment Of Aqueous Wastes and other aspects.Recommanded Product: 96-76-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 30, 1984, Osman, Fayez H.; Gawad, Mahfouz M. Abdel; Abbasi, Mohamed M. published an article.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol The title of the article was The behavior of N-tert-butyl-2,2′-iminodiethanol towards some trivalent phosphorus compounds. And the article contained the following:

Treating (HOCH2CH2)2NCMe3 (I) with PCl3 or HMPT in C6H6 gave the 2:3 adduct II, which was hydrolyzed by H2O to give the dioxazaphosphocane oxide III (R = H) (IV) and I. Treating IV with o-chloranil gave a crystalline product which in solution gave an equilibrium mixture of V (R = OH) and III (R = OC6Cl4OH-2). PhPCl2 or (Me2N)2PPh reacted with I to give dioxazaphosphocane VI, which added o-chloranil to give an equilibrium mixture of VII and V (R = Ph). Treating VI with PhN3 gave the imine VIII. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to dioxazaphosphocane derivative, iminodiethanol cyclization phosphorus compound, butyliminodiethanol cyclization phosphorus compound, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 30, 2020, Ahmad, Khuram Shahzad; Gul, Palwasha; Gul, Mahwash Mahar published an article.Quality Control of 2,4-Di-tert-butylphenol The title of the article was Efficient fungal and bacterial facilitated remediation of thiencarbazone methyl in the environment. And the article contained the following:

Triazole herbicide, Thiencarbazone-Me (TCM) applied on different crops for weedicidal activity is associated with an inherent toxicity towards bladder and urinary functionality. TCM has been first time explored for its biodegradative behavior utilizing microbes, previously isolated from soils. Simulated bio-transformation assemblies of five fungal strains; Aspergillus flavus (AF), Penicillium chrysogenum (PC), Aspergillus niger (AN), Aspergillus terrus (AT), Aspergillus fumigatus (AFu) and two bacterial strains: Xanthomonas citri (XC), Pseudomonassyringae (PS), were utilized. 10 mg/L TCM concentration was set up utilizing each microbe and analyzed for 42 days. TCM bio-degradation was evaluated by UV-Visible spectrophotometery and gas chromatog. mass spectroscopy. Aspergillus terrus (R2 = 0.86) and Penicillium chrysogenum (R2 = 0.88) exhibited highest capability to metabolize TCM while forming intermediate metabolites including; 2,4-dihydro-[1,2,4] triazol-3-one, semicarbazide and urea, Me 4-isocyanatosulfonyl-5-methylthiophene-3-carboxylate. TCM degradation by all strains AF, AFu, AN, PC, AT, PS and XC was found to be 74, 74, 81, 95, 98, 90 and 95%, resp. after 42 days elucidating the effectiveness of all the utilized strains in degrading TCM. Furthermore, present research can be extended to the optimization of the bio-deteriorative assays to be employed on the practical scale for the successful management of environment through sustainable and cost effective ways. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Quality Control of 2,4-Di-tert-butylphenol

The Article related to thiencarbazone methyl fungal bacterial facilitated remediation biodegradation, bacteria, biodegradation, fungi, thiencarbazone-methyl, triazine, Waste Treatment and Disposal: Biological Treatment Of Aqueous Wastes and other aspects.Quality Control of 2,4-Di-tert-butylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huangfu, Xinlei; Wang, Yueqiao; Lu, Guozhang; Cao, Yinwei; Tang, Guo; Zhao, Yufen published an article in 2020, the title of the article was Direct synthesis of phosphorotrithioites and phosphorotrithioates from white phosphorus and thiols.Synthetic Route of 143-10-2 And the article contains the following content:

White phosphorus (P4) is still the major com. P-atom source for the production of organophosphorus compounds Conventionally, C-S-P bonds were constructed from environmentally questionable P(O)X directly or indirectly. From the green chem. point of view, formation of C-S-P bonds from inorganic mol. P4 in an easy-to-operate and atom-economical way is essential because it will avoid the hazardous chlorination process. Only five methods for the formation of C-S-P bonds from P4 have been developed over the past 70 years. Here, the first general and high-yielding synthesis of P(SR)3 and P(O)(SR)3 involving P4 and thiols is presented. With the use of KOH or K2CO3 as a base and DMSO-toluene as a solvent, both arythiols and alkylthiols are tolerant in this transformation. The reaction is characterized by a complete conversion of white phosphorus. This operationally simple and environmentally sound reaction shows a broad scope of substrates and good functional group tolerance. Moreover, this method can be easily adapted to large-scale preparation The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Synthetic Route of 143-10-2

The Article related to phosphorotrithioate phosphorotrithioite green chem preparation occupational safety, green chem white phosphorus thiol reactivity occupational safety, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Synthetic Route of 143-10-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rima, Maya; Trognon, Jeanne; Latapie, Laure; Chbani, Asma; Roques, Christine; El Garah, Fatima published an article in 2022, the title of the article was Seaweed Extracts: A Promising Source of Antibiofilm Agents with Distinct Mechanisms of Action against Pseudomonas aeruginosa.Application In Synthesis of 2,4-Di-tert-butylphenol And the article contains the following content:

The organization of bacteria in biofilms is one of the adaptive resistance mechanisms providing increased protection against conventional treatments. Thus, the search for new antibiofilm agents for medical purposes, especially of natural origin, is currently the object of much attention. The objective of the study presented here was to explore the potential of extracts derived from three seaweeds: the green Ulva lactuca, the brown Stypocaulon scoparium, and the red Pterocladiella capillacea, in terms of their antibiofilm activity against P. aeruginosa. After preparation of extracts by successive maceration in various solvents, their antibiofilm activity was evaluated on biofilm formation and on mature biofilms. Their inhibition and eradication abilities were determined using two complementary methods: crystal violet staining and quantification of adherent bacteria. The effect of active extracts on biofilm morphol. was also investigated by epifluorescence microscopy. Results revealed a promising antibiofilm activity of two extracts (cyclohexane and Et acetate) derived from the green alga by exhibiting a distinct mechanism of action, which was supported by microscopic analyses. The Et acetate extract was further explored for its interaction with tobramycin and colistin. Interestingly, this extract showed a promising synergistic effect with tobramycin. First analyses of the chem. composition of extracts by GC-MS allowed for the identification of several mols. Their implication in the interesting antibiofilm activity is discussed. These findings suggest the ability of the green alga U. lactuca to offer a promising source of bioactive candidates that could have both a preventive and a curative effect in the treatment of biofilms. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Application In Synthesis of 2,4-Di-tert-butylphenol

The Article related to seaweed extract antibiofilm agent pseudomonas, pseudomonas aeruginosa, ulva lactuca, anti-biofilm, biofilm-matrix, seaweed extracts, synergistic activity, Microbial, Algal, and Fungal Biochemistry: Antimicrobial Sensitivity and other aspects.Application In Synthesis of 2,4-Di-tert-butylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Salerno, Anna; Fragasso, Gabriele; Montanaro, Claudia; Cera, Michela; Torlasco, Camilla; Maranta, Francesco; Margonato, Alberto published an article in 2010, the title of the article was Role of metabolic modulation in the management of chronic ischemic heart disease.SDS of cas: 32462-30-9 And the article contains the following content:

Abstract: Coronary artery disease (CAD) is a major cause of morbidity and mortality in the world. Therapy for stable CAD is currently based on conventional medical therapy, including nitrates, β-blockers and calcium-channels antagonists and, more recently, metabolic therapy, of which a pivotal therapeutic role is increasingly recognized. Under normoxic condition, the healthy heart derives 2/3 of its energy from the free fatty acid (FFA) pathway, the other source of energy being derived from glucose oxidation However, glycolysis requires less O2 per mol of ATP generated compared with FFA oxidation On this basis, shifting energy substrate utilization from fatty acid metabolism to glucose metabolism can be more efficient in terms of ATP production per mol of oxygen utilized. A number of different approaches have been used to manipulate energy metabolism in the heart. These approaches include direct agents, such as dichloroacetate, -carnitine, ribose or lipoic acid which directly increase glucose oxidation, or indirect methods, through the inhibition of free fatty acids oxidation Among these, the most important are carnitil-palmitoyl-transpherase I (CPT-I) inhibitors, which inhibit FFA mitochondrial uptake (e.g. etomoxir, perhexiline, oxphenicine), or 3-ketoacyl-coenzyme-A thiolase (3-KAT) inhibitors, such as trimetazidine, which inhibits the last enzyme involved in β-oxidation In most patients with ischemic heart disease metabolic abnormalities, if not adequately treated, will heavily contribute to the occurrence of complications, of whom severe left ventricular dysfunction is at present one of the most frequent and insidious. In this paper, all possible metabolic approaches to ischemic heart disease are reviewed and discussed. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).SDS of cas: 32462-30-9

The Article related to metabolic therapy ischemic heart disease cardioprotectant, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.SDS of cas: 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On April 30, 1978, Perchonock, Carl D.; Loev, Bernard published an article.Synthetic Route of 42900-89-0 The title of the article was Synthesis of some aromatic prostaglandin analogs. And the article contained the following:

Some aromatic prostaglandin analogs, with a benzene (I) (R = H, Me) or a dimethoxybenzene ring (II) in place of the cyclopentane moiety, were synthesized. The key intermediates in the syntheses were lactols III and IV, which were elaborated to the final products via two olefination reactions. I (R = H) was twice as potent as phenylbutazone and nine times as potent as aspirin in inhibiting prostaglandin synthetase activity. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Synthetic Route of 42900-89-0

The Article related to aromatic prostaglandin analog, benzene prostaglandin analog, Alicyclic Compounds: Cyclopentanes, Including Fulvenes and Fulvalenes and other aspects.Synthetic Route of 42900-89-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 1, 2013, Greco, M. N.; Connelly, M. A.; Leo, G. C.; Olson, M. W.; Powell, E.; Huang, Z.; Hawkins, M.; Smith, C.; Schalk-Hihi, C.; Darrow, A. L.; Xin, H.; Lang, W.; Damiano, B. P.; Hlasta, D. J. published an article.Name: (2-Fluorophenyl)methanethiol The title of the article was A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice. And the article contained the following:

By screening directed libraries of serine hydrolase inhibitors using the cell surface form of endothelial lipase (EL), the authors identified a series of carbamate-derived (EL) inhibitors. Compound (I) raised plasma HDL-C levels in the mouse, and a correlation was found between HDL-C and plasma compound levels. Spectroscopic and kinetic studies support a covalent mechanism of inhibition. The authors’ findings represent the first report of EL inhibition as an effective means for increasing HDL-C in an in vivo model. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Name: (2-Fluorophenyl)methanethiol

The Article related to thiocarbamate endothelial lipase hdl cholesterol preparation, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.Name: (2-Fluorophenyl)methanethiol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hayashi, Mikihiro; Obara, Haruna; Miwa, Yohei published an article in 2021, the title of the article was Design and basic properties of polyester vitrimers combined with an ionomer concept.Reference of Pentane-1,5-diol And the article contains the following content:

Vitrimers are a novel class of crosslinked materials containing associative bond exchange properties. Here we demonstrate the preparation of vitrimers with ionic components to investigate the effects of ion-rich domain formation on vitrimer properties. An amorphous polyester that bears COOH side groups was synthesized, and some fraction of COOH was neutralized with Zn2+. The residual non-neutralized COOH was reacted with diepoxy crosslinkers, resulting in a network with ester bonds, OH groups, and COOH groups neutralized with Zn2+. The sample was further thermally annealed to induce aggregation of Zn2+ ionic groups. The aggregated Zn2+ groups in the network remained active for trans-esterification-based bond exchange, wherein the degree of ion aggregation can be a factor in tuning the bond-exchange properties. The present study provides some important knowledge on the design of new mol. systems of vitrimers with tunable bond exchange properties. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Reference of Pentane-1,5-diol

The Article related to polyester vitrimer polycondensation michael addition reaction, Chemistry of Synthetic High Polymers: Organic Addition Polymerization and other aspects.Reference of Pentane-1,5-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On February 25, 2021, Le Manach, Claire; Dam, Jean; Woodland, John G.; Kaur, Gurminder; Khonde, Lutete P.; Brunschwig, Christel; Njoroge, Mathew; Wicht, Kathryn J.; Horatscheck, Andre; Paquet, Tanya; Boyle, Grant A.; Gibhard, Liezl; Taylor, Dale; Lawrence, Nina; Yeo, Tomas; Mok, Sachel; Eastman, Richard T.; Dorjsuren, Dorjbal; Talley, Daniel C.; Guo, Hui; Simeonov, Anton; Reader, Janette; van der Watt, Mariette; Erlank, Erica; Venter, Nelius; Zawada, Jacek W.; Aswat, Ayesha; Nardini, Luisa; Coetzer, Theresa L.; Lauterbach, Sonja B.; Bezuidenhout, Belinda C.; Theron, Anjo; Mancama, Dalu; Koekemoer, Lizette L.; Birkholtz, Lyn-Marie; Wittlin, Sergio; Delves, Michael; Ottilie, Sabine; Winzeler, Elizabeth A.; von Geldern, Thomas W.; Smith, Dennis; Fidock, David A.; Street, Leslie J.; Basarab, Gregory S.; Duffy, James; Chibale, Kelly published an article.Electric Literature of 32462-30-9 The title of the article was Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts. And the article contained the following:

A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chem. optimization and biol. profiling program. Structure-activity-relationship studies led to the identification of compounds that showed low nanomolar asexual blood-stage activity (<50 nM) together with strong gametocyte sterilizing properties that translated to transmission-blocking activity in the standard membrane feeding assay. Mechanistic studies through resistance selection with one of the analogs followed by whole-genome sequencing implicated the P. falciparum cyclic amine resistance locus in the mode of resistance. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Electric Literature of 32462-30-9

The Article related to malaria antimalarial plasmodium diazaspirooctane pharmacokinetic, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Electric Literature of 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts