Month: November 2022

On March 31, 2010, Karthikeyan, K.; Balaji, T. S.; Shanmugasundaram, P.; Chandrasekara Pillai, K. published an article.Formula: C7H16O2 The title of the article was Stability-Indicating HPLC Method for the Determination of Impurities in Meprobamate with Refractive Index Detection. And the article contained the following:

The purpose of this study is to develop and validate a simple, sensitive, and robust high-performance liquid chromatog. (HPLC) method for the determination of impurities ca. 2-methyl-2-propyl-1,3-propane diol (MP0) and 2-hydroxymethyl-2-Me pentyl carbamate (MP1) in meprobamate (MEP) drug substance with refractive index (RI) detection. This method utilizes a Zorbax Eclipse XDB C18 HPLC column, a mobile phase of 80:20 (volume/volume) 10 mM KH2PO4,-acetonitrile, resp. The stability-indicating capability of the method was established by performing stress studies under acidic, basic, oxidation, light, humidity, and thermal conditions. The major degradation products of acid and base hydrolysis are identified as MP0 and MP1. The recovery data obtained for impurities are between 96.0-109.8%. The detection and quantitation limits of this method ranges from 0.009 to 0.017 mg/mL and 0.029 to 0.055 mg/mL, resp. The relative standard deviation (RSD) for the area at QL is < 6.1%. Good linearity (r2 > 0.99) and precision (RSD < 2.2%) were obtained for MEP, MP0, and MP1. This method was applied successfully to determine the content of impurities in MEP bulk drug. (c) 2010 Preston Publications. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Formula: C7H16O2

The Article related to meprobamate impurity determination rp hplc stability refractive index, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Formula: C7H16O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 30, 2021, Carlson, Shane; Becker, Maximilian; Bruenig, Florian N.; Ataka, Kenichi; Cruz, Ruben; Yu, Leixiao; Tang, Peng; Kanduc, Matej; Haag, Rainer; Heberle, Joachim; Makki, Hesam; Netz, Roland R. published an article.Quality Control of 1-Decanethiol The title of the article was Hydrophobicity of Self-Assembled Monolayers of Alkanes: Fluorination, Density, Roughness, and Lennard-Jones Cutoffs. And the article contained the following:

The interplay of fluorination and structure of alkane self-assembled monolayers and how these affect hydrophobicity are explored via mol. dynamics simulations, contact angle goniometry, and surface-enhanced IR absorption spectroscopy. Wetting coefficients are found to grow linearly in the monolayer d. for both alkane and perfluoroalkane monolayers. The larger contact angles of monolayers of perfluorinated alkanes are shown to be primarily caused by their larger mol. volume, which leads to a larger nearest-neighbor grafting distance and smaller tilt angle. Increasing the Lennard-Jones force cutoff in simulations is found to increase hydrophilicity. Specifically, wetting coefficients scale like the inverse square of the cutoff, and when extrapolated to the infinite cutoff limit, they yield contact angles that compare favorably to exptl. values. Nanoscale roughness is also found to reliably increase monolayer hydrophobicity, mostly via the reduction of the entropic part of the work of adhesion. Anal. of depletion lengths shows that droplets on nanorough surfaces partially penetrate the surface, intermediate between Wenzel and Cassie-Baxter states. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Quality Control of 1-Decanethiol

The Article related to fluorination roughness hydrophobicity self assembled monolayer alkane, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Quality Control of 1-Decanethiol

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Alcohol – Wikipedia,
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On March 3, 2021, Han, Yunrui; Han, Lin; He, Limin; Wang, Shipeng; Luo, Xiaoming published an article.Related Products of 143-10-2 The title of the article was Universal Criterion for Critical Motion of Droplets Adhered on Surfaces with Different Wettability in Laminar Flow. And the article contained the following:

The initial motion of micro-oil droplets on substrates immersed in water is of great significance to study droplet motion. Here, microscopic experiments and mechanism anal. are used to establish a universal criterion and a math. model describing the critical conditions for the initial motion of droplets adhered on surfaces with different wettability in the laminar flow. The authors demonstrate a surface modification technique and anal. method in a microtest. Based on the force’s anal. on the 3-phase contact points of 2-dimensional oil droplets on the surfaces, the movement mechanism is also obtained when the oil droplets start to move. This work focuses on the coupling effects of oil droplet’s height, surface properties, and water flow velocity on the initial motion behaviors of oil droplets and obtains the critical shear water flow velocity required for the critical movement of oil droplets from different surfaces. The authors achieve a universal criterion and model for different application scenarios, which are of great scientific significance to improve theor. systems of multiphase separation and guide the design and optimization of surface properties and flow field velocity. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Related Products of 143-10-2

The Article related to critical motion droplet surface wettability laminar flow silicone oil, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Related Products of 143-10-2

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Alcohol – Wikipedia,
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On July 2, 2008, Kotachi, Shinji; Fukuda, Kazuyuki published a patent.Name: 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Preparation and process for purifying acetal compounds in presence of antioxidants for perfumes. And the patent contained the following:

The present invention relates to (i) a process for purifying an acetal compound having a sweet floral scent and a process for producing the acetal compound, which are inhibited from generating off-odor even when subjecting the acetal compound to distillation under a low vacuum and at a high temperature; and (ii) a perfume composition containing the acetal compound In accordance with the present invention, there is provided a process for purifying an acetal compound represented by the general formula (I; R1 = H, Me, Et; R2 = Pr, iso-Pr; R3 = H, Pr, iso-Pr), the process including the step of subjecting a raw material containing the acetal compound to distillation at a temperature of 80 to 170° in the presence of an antioxidant. Thus, reaction of 396 g of 2-methyl-2-propyl-1,3-propanediol with 300 g of 2-methylpentanal in presence of 444 g of Et formate resulted in 636 g of a raw material containing 2-(1-methylbutyl)-5-methyl-5-propyl-1,3-dioxane. The raw material (100 g) was mixed with 0.1 g of 2,2′-methylenebis(4-ethyl-6-tert-butylphenol) as an antioxidant, and the mixture was subjected to distillation under such a condition that a main distillate was distilled off under a pressure of 5 to 7 kPa and at a temperature of 138 to 143°, thereby 97 g of a fraction composed of 2-(1-methylbutyl)-5-methyl-5-propyl-1,3-dioxane (purity 98.4%). As a result of analyzing the thus obtained fraction by gas chromatog., it was confirmed that no 2,2-dimethylpentyl-2-methylpentanoate as a byproduct was detected, and no fruity green off-odor was sensed. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Name: 2-Methyl-2-propylpropane-1,3-diol

The Article related to acetal compound preparation purification distillation antioxidant perfume, Essential Oils and Cosmetics: Fragrance Preparations and other aspects.Name: 2-Methyl-2-propylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Padinjarakoot, Nandagopal; Sabikhi, Latha; Panjagari, Narender R.; Kumar, Ct manoj published an article in 2020, the title of the article was Adsorption isotherm and thermodynamic properties of high fiber reduced calorie multigrain biscuit.Quality Control of SweetPearlR P300 DC Maltitol And the article contains the following content:

A study has been conducted to evaluate the effect of addition of interesterified fat, polydextrose, maltitol, and FOS-sucralose on adsorption isotherm and thermodn. properties of multigrain high fiber reduced calorie biscuits (HFRCB). A static gravimetric method was used over a water activity range of 0.11-0.95 at three different temperatures (25°C, 35°C, and 45°C). The adsorption isotherm of HFRCB showed a slight shift from type II curve to type III. The BET and GAB models were found as the best fitted to the exptl. data. The net isosteric heat of sorption of HFRCB varied from 5.07 to 25.45 kJ/mol. The net isosteric heat of sorption of first water mol. and characteristic moisture content of HFRCB was 27.43 kJ/mol and 0.11 kg/kg dry solids, resp. The spreading pressure increased with increasing water activity and temperature Entropy-Enthalpy compensation theory was evaluated for sorption isotherm of HFRCB at studied exptl. conditions. Practical applications : The study revealed the effect of addition of selected novel ingredients on the sorption properties of biscuit. The study also gives clarity for product developers to cautiously select type and quantity of ingredients. The calculated monolayer moisture content and isosteric heat of sorption can be used for the estimation of energy required during drying, designing of driers, storage condition and shelf life prediction. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Quality Control of SweetPearlR P300 DC Maltitol

The Article related to high fiber calorie multigrain biscuit adsorption isotherm thermodn property, Food and Feed Chemistry: Cereals and Bakery Products and other aspects.Quality Control of SweetPearlR P300 DC Maltitol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On April 14, 2020, Girard, Henri-Louis; Bourrianne, Philippe; Chen, Dayong; Jaishankar, Aditya; Vreeland, Jessica L.; Cohen, Robert E.; Varanasi, Kripa K.; McKinley, Gareth H. published an article.Formula: C10H22S The title of the article was Asphaltene Adsorption on Functionalized Solids. And the article contained the following:

Asphaltenes, heavy aromatic components of crude oil, are known to adsorb on surfaces and can lead to pipe clogging or hinder oil recovery. Because of their multicomponent structure, the details of their interactions with surfaces are complex. We investigate the effect of the physicochem. properties of the substrate on the extent and mechanism of this adsorption. Using wetting measurements, we relate the initial kinetics of deposition to the interfacial energy of the surface. We then quantify the long-term adsorption dynamics using a quartz crystal microbalance and ellipsometry. Finally, we investigate the mechanism and morphol. of adsorption with force spectroscopy measurements as a function of surface chem. We determine different adsorption regimes differing in orientation, packing d., and initial kinetics on different substrate functionalizations. Specifically, we find that alkane substrates delay the initial monolayer formation, fluorinated surfaces exhibit fast adsorption but low bonding strength, and hydroxyl substrates lead to a different adsorption orientation and a high packing d. of the asphaltene layer. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Formula: C10H22S

The Article related to asphaltene adsorption solid functionalized silicon gold hydroxyl alkane fluorinated, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Formula: C10H22S

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reddy, Ambavaram Vijaya Bhaskar; Yusop, Zulkifli; Jaafar, Jafariah; Bin Aris, Azmi; Abdul Majid, Zaiton published an article in 2017, the title of the article was A simple, selective, and sensitive gas chromatography-mass spectrometry method for the analysis of five process-related impurities in atenolol bulk drug and capsule formulations.Reference of H-Phg(4-OH)-OH And the article contains the following content:

An extremely sensitive and simple gas chromatog. with mass spectrometry method was developed and completely validated for the anal. of five process-related impurities, viz., 4-hydroxy-L-phenylglycine, 4-hydroxyphenylacetonitrile, 4-hydroxyphenylacetic acid, methyl-4-hydroxyphenylacetate, and 2-[4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl]acetonitrile, in atenolol. The separation of impurities was accomplished on a BPX-5 column with dimensions of 50 m × 0.25 mm i.d. and 0.25 μm film thickness. The method validation was performed following International Conference on Harmonisation guidelines in which the method was capable to quantitate 4-hydroxy-L-phenylglycine, 4-hydroxyphenylacetonitrile, and 4-hydroxyphenylacetic acid at 0.3 ppm, and methyl-4-hydroxyphenylacetate and 2-[4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl]acetonitrile at 0.35 ppm with respect to 10 mg/mL of atenolol. The method was linear over the concentration range of 0.3-10 ppm for 4-hydroxy-L-phenylglycine, 4-hydroxyphenylacetonitrile, and 4-hydroxyphenylacetic acid, and 0.35-10 ppm for methyl-4-hydroxyphenylacetate and 2-[4-{(2RS)-2-hydroxy-3-[(1-methylethyl)amino]propoxy}phenyl]acetonitrile. The correlation coefficient in each case was found ≥0.998. The repeatability and recovery values were acceptable, and found between 89.38% and 105.60% for all five impurities under optimized operating conditions. The method developed here is simple, selective, and sensitive with apparently better resolution than the reported methods. Hence, the method is a straightforward and good quality control tool for the quantitation of selected impurities at trace concentrations in atenolol. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Reference of H-Phg(4-OH)-OH

The Article related to atenolol impurity analysis gc ms, beta-blockers, genotoxicity, mass spectrometry, method validation, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Reference of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
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On February 9, 2021, Bhadra, Pratiti; Siu, Shirley W. I. published an article.Formula: C10H22S The title of the article was Effect of Concentration, Chain Length, Hydrophobicity, and an External Electric Field on the Growth of Mixed Alkanethiol Self-Assembled Monolayers: A Molecular Dynamics Study. And the article contained the following:

Growing functionalized self-assembled monolayers (SAMs) with fewer defects and lower cost is the focus of ongoing investigations. In the present study, mol. dynamics simulations were performed to investigate the process of SAM formation on a gold substrate from mixed alkanethiolates in ethanol solution Using the mixed-SAM system of 11-mercaptoundecanoic acid (MUA) with either 1-decanethiol (C9CH3) or 6-mercaptohexanol (C6OH) in a 3:7 ratio as the standard SAM model, we systematically investigated the effects of the concentration, chain length, functional group, and an external elec. field on SAM growth. The results showed that the initial growth rate and surface coverage of the SAM are dependent on the ligand concentration At a certain high concentration (about 1.2-1.5 times the min. concentration), the final surface coverage is optimal. Reducing the chain length and increasing the proportion of hydrophobic diluting mols. are effective ways to improve the surface coverage, but the compositional ligands have to be changed, which may not be desirable for the functional requirements of SAMs. Furthermore, by investigating the behavior of the alkanethiolates and ethanol solvent under an applied external field, we find that a strong elec. field with a proper field direction can facilitate the generation of defect-free monolayers. These findings will contribute to the understanding of mixed-SAM formation and provide insight into exptl. design for efficient and effective SAM formation. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Formula: C10H22S

The Article related to hydrophobicity alkanethiol self assembled monolayer md simulation, external elec field concentration, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Formula: C10H22S

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 20, 2002, Bazylak, Grzegorz; Nagels, Luc J. published an article.Name: 2,2′-(tert-Butylazanediyl)diethanol The title of the article was Potentiometric detection of N,N’-diethylaminoethanol and lysosomotropic amino alcohols in cation-exchange high-performance liquid-chromatography systems. And the article contained the following:

Potentiometric detection of N,N’-diethylaminoethanol (DEAE) and a series of related physiol. relevant lysosomotropic amino alcs. was carried out by cation-exchange HPLC. Poly(vinyl chloride) (PVC)-based liquid membrane electrode coatings were used which contained the lipophilic cation exchanger tetrakis(p-chlorophenyl)borate (TCPB) either alone or in combination with one of the macrocyclic ionophores hexakis-(2,3,6-tri-O-octyl)-α-cyclodextrin (CDX), dibenzo-18-crown-6 (CRW) or calix[6]arene hexaethylacetate ester (CLX). With all the PVC membrane electrodes used, improved sensitivity over UV detection at 210 nm was obtained for the aliphatic amino alcs. analyzed. Especially, addition of CLX to the PVC-based membrane led to highly enhanced detection limits for the lower-mol.-weight lysosomotropic amino compounds, i.e., aminoethanol and methylamine. The performance of the proposed potentiometric detection method was demonstrated in cation-exchange HPLC modes employing two different aqueous mobile phase systems with pH 2.30 comprising H3PO4 or HOAc with MeCN as organic modifier. Detection limits of 1.1 × 10-8 and 2.4 × 10-8M (injected concentrations) were achieved for N-methylaminoethanol and hexylamine, resp., by using a CLX-based electrode. Sensitive and reliable determination of DEAE, a local anesthetic agent, after liquid-liquid or solid-phase extraction from fortified bovine serum samples was obtained with the HPLC method coupled with the proposed potentiometric detection system. A linear free-energy relationship based on a general solvation equation was used to predict detection limits of amino alcs. from their mol. structure in the potentiometric detectors employing CLX and CRW. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Name: 2,2′-(tert-Butylazanediyl)diethanol

The Article related to amino alc determination hplc potentiometry, diethylaminoethanol determination blood liquid chromatog potentiometry, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: 2,2′-(tert-Butylazanediyl)diethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 27, 2022, Soh, Eugene Jia Hao; Astier, Hippolyte P. A. G.; Daniel, Dan; Isaiah Chua, Jia Qing; Miserez, Ali; Jia, Zian; Li, Ling; O’Shea, Sean J.; Bhaskaran, Harish; Tomczak, Nikodem; Nijhuis, Christian A. published an article.Recommanded Product: 1-Decanethiol The title of the article was AFM Manipulation of EGaIn Microdroplets to Generate Controlled, On-Demand Contacts on Molecular Self-Assembled Monolayers. And the article contained the following:

Liquid metal droplets, such as eutectic gallium-indium (EGaIn), are important in many research areas, such as soft electronics, catalysis, and energy storage. Droplet contact on solid surfaces is typically achieved without control over the applied force and without optimizing the wetting properties in different environments (e.g., in air or liquid), resulting in poorly defined contact areas. In this work, we demonstrate the direct manipulation of EGaIn microdroplets using an at. force microscope (AFM) to generate repeated, on-demand making and breaking of contact on self-assembled monolayers (SAMs) of alkanethiols. The nanoscale positional control and feedback loop in an AFM allow us to control the contact force at the nanonewton level and, consequently, tune the droplet contact areas at the micrometer length scale in both air and ethanol. When submerged in ethanol, the droplets are highly nonwetting, resulting in hysteresis-free contact forces and minimal adhesion; as a result, we are able to create reproducible geometric contact areas of 0.8-4.5μm2 with the alkanethiolate SAMs in ethanol. In contrast, there is a larger hysteresis in the contact forces and larger adhesion for the same EGaIn droplet in air, which reduced the control over the contact area (4-12μm2). We demonstrate the usefulness of the technique and of the gained insights in EGaIn contact mechanics by making well-defined mol. tunneling junctions based on alkanethiolate SAMs with small geometric contact areas of between 4 and 12μm2 in air, 1 to 2 orders of magnitude smaller than previously achieved. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Recommanded Product: 1-Decanethiol

The Article related to gallium indium eutectic microdroplet afm self assembly monolayer, egain, atomic force microscopy, liquid metal, micromanipulation, molecular electronics, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Recommanded Product: 1-Decanethiol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts