Month: November 2022

On December 20, 1995, Nishinaka, Koutaro; Kawaguchi, Yasuyoshi published a patent.Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Rubber compositions for mold cleaning and method therewith. And the patent contained the following:

Title compositions comprise natural and/or synthetic rubbers, amino-alc. salts 2-30 (based on amino alc.), glycols 5-50, adsorbents 30-90, and organic peroxides 0.5-10 phr. A composition containing natural rubber 100, SiO2 (adsorbent) 60, dipropylene glycol 15, Perhexa V 2, monoethanolamine 10, and adipic acid 12 phr showed no NH3 odor at room temperature or 100°, and good cleaning ability initially and after 1 mo at room temperature The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride

The Article related to mold cleaner aminoalc salt containing rubber, storage stability rubber mold cleaner, Synthetic Elastomers and Natural Rubber: Other Uses and other aspects.Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 2, 2005, Pavan, Massimiliano; Testi, Stefano; Donetti, Raffaella; Puppi, Cristiano; Maritano, Mauro published a patent.Quality Control of 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Process for manufacturing water-resistant telecommunication cable. And the patent contained the following:

The cable comprises a solid and compact element comprising a water-soluble polymer material containing a vinyl alc./vinyl acetate copolymer (Mowiol 26/88) having hydrolysis degree 60-95% and d.p. >1800, and ≥1 solid plasticizers with high melting melt and low melt. The process comprises producing in continuous the water-soluble polymer material by sep. feeding in sequence a multi-screw extruder, in the flow direction, with the copolymer and the high melting plasticizer, melting and mixing them while transporting them through the extruder, and with the low melting plasticizer, melting and mixing it with the copolymer and the high melting plasticizer, subsequently homogenizing the copolymer and the plasticizers and finally discharging the melt, at ≤205°. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Quality Control of 2-Methyl-2-propylpropane-1,3-diol

The Article related to telecommunication cable water resistance, vinyl alc polymer plasticizer optical cable, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Quality Control of 2-Methyl-2-propylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 8, 2021, Zhou, Yaming; Ling, Yun; Deng, Mingli; Jia, Yu; Liu, Xiaofeng; Yang, Yongtai published a patent.Computed Properties of 386704-04-7 The title of the patent was Microwave synthesis method of trifluoromethyl picolinaldehyde. And the patent contained the following:

The present invention relates to a microwave synthesis method of trifluoromethyl picolinaldehyde. The preparation method comprises the following steps of reacting in a reaction tank by using a microwave irradiation technol., calculating according to a chem. equivalent ratio, adding 1 equiv of 6-trifluoromethylpicolinaldehyde methanol, adding a solvent to dissolve, adding 0.01-0.1 equiv of a catalyst and 1-1.5 equiv of an oxidant and setting microwave power and temperature to react after the feeding is finished and after the reaction is finished, carrying out rotary evaporation and concentration on the reaction solution to obtain a solid product and finally carrying out separation and purification to obtain the target 6-trifluoromethyl picolinaldehyde. The inventive method has the advantages of short reaction time, mild conditions, few side reactions and high yield, simplifies the production process, reduces the production cost and cycle and is particularly suitable for the large-scale production of the intermediate 6-trifluoromethyl nicotinaldehyde of a colony stimulating factor 1 receptor (CSF-1R) inhibitor. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Computed Properties of 386704-04-7

The Article related to trifluoromethylpyridine methanol oxidation, trifluoromethyl picolinaldehyde preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Computed Properties of 386704-04-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Su, Xiangdong; Pradaux-Caggiano, Fabienne; Vicker, Nigel; Thomas, Mark P.; Halem, Heather; Culler, Michael D.; Potter, Barry V. L. published an article in 2011, the title of the article was Adamantyl Ethanone Pyridyl Derivatives: Potent and Selective Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1.Application of 386704-04-7 And the article contains the following content:

Elevated levels of active glucocorticoids have been implicated in the development of several phenotypes of metabolic syndrome, such as type 2 diabetes and obesity. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the intracellular conversion of inactive cortisone to cortisol. Selective 11β-HSD1 inhibitors have shown beneficial effects in various conditions, including diabetes, dyslipidemia and obesity. A series of adamantyl ethanone pyridyl derivatives has been identified, providing potent and selective inhibitors of human 11β-HSD1. Lead compounds display low nanomolar inhibition against human and mouse 11β-HSD1 and are selective for this isoform, with no activity against 11β-HSD2 and 17β-HSD1. Structure-activity relationship studies reveal that an unsubstituted pyridine tethered to an adamantyl ethanone motif through an ether or sulfoxide linker provides a suitable pharmacophore for activity. The most potent inhibitors have IC50 values around 34-48 nM against human 11β-HSD1, display reasonable metabolic stability in human liver microsomes, and weak inhibition of key human CYP450 enzymes. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7

The Article related to pyridyl adamantyl ethanone derivative preparation hydroxysteroid dehydrogenase inhibitor sar, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 386704-04-7

Referemce:
Alcohol – Wikipedia,
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On June 5, 2003, Aranapakam, Venkatesan; Davis, Jamie M.; Grosu, George T.; Baker, Jannie; Ellingboe, John; Zask, Arie; Levin, Jeremy I.; Sandanayaka, Vincent P.; Du, Mila; Skotnicki, Jerauld S.; DiJoseph, John F.; Sung, Amy; Sharr, Michele A.; Killar, Loran M.; Walter, Thomas; Jin, Guixian; Cowling, Rebecca; Tillett, Jeff; Zhao, Weiguang; McDevitt, Joseph; Xu, Zhang Bao published an article.Formula: C8H19NO2 The title of the article was Synthesis and Structure-Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis. And the article contained the following:

A series of novel and orally active N-substituted 4-benzenesulfonylpiperidine-4-carboxylic acid hydroxyamide derivatives have been synthesized and their structure-activity relationships determined Among the several compounds synthesized, I turned out to be a potent, selective, and an orally active MMP inhibitor in the clin. relevant advanced rabbit osteoarthritis model. Pharmacokinetics and metabolism data are reported. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Formula: C8H19NO2

The Article related to arylsulfonylpiperidinehydroxamic acid preparation matrix metalloproteinase inhibitor structure activity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C8H19NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 22, 2015, Hirayama, Takaharu; Fujimoto, Jun; Cary, Douglas Robert; Okaniwa, Masanori; Hirata, Yasuhiro published a patent.HPLC of Formula: 428855-17-8 The title of the patent was Preparation of heterocyclic compounds as cyclin-dependent protein kinase inhibitors for prophylactic and therapeutic treatment of cancer. And the patent contained the following:

The present invention provides a heterocyclic compound having a CDK8 and/or CDK19 inhibitory effect. The present invention provides a compound represented by formula I [R1-R3, R5a, R5b, R7, R8 = H, substituent; R4 = (un)substituted heteroaryl; R5a and R5b may be bonded to form double bond or C3-4 cycloalkyl; R7 and R8 may be bonded to form N-containing heterocyclyl] or a salt thereof. Thus, (2E)-N-[4-[2-(1,3,4-oxadiazol-2-yl)ethyl]phenyl]-3-[4-(2-thienyl)pyridin-3-yl]acrylamide (preparation given) inhibited CDK8 and CDK19 activity with inhibitory rates of 101 and 100%, resp. at 1 μM and inhibited RPMI8226 cell proliferation with inhibitory rate of 59% at 1 μM. The experimental process involved the reaction of 1-[(Dibenzylamino)methyl]cyclopropanol(cas: 428855-17-8).HPLC of Formula: 428855-17-8

The Article related to preparation heterocycle cyclin dependent protein kinase inhibitor antitumor, pyridine preparation cdk8 cdk19 inhibitor antitumor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 428855-17-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Duan, Jihua; Jiang, Guichang published an article in 2022, the title of the article was Synthesis, Characterization and Properties of Antibacterial Polyurethanes †.HPLC of Formula: 4719-04-4 And the article contains the following content:

Novel phys. crosslinked polyurethane (PUII), based on isophorone diisocyanates, was prepared by a conventional two-step method. The chem. structures of the PUII were characterized by fourier transform IR, proton NMR (1H NMR), gel permeation chromatog., SEM and DSC. The PUII hydrogels were subjected to solvent-induced self-assembly in THF + water to construct a variety of morphologies. The self-assembly morphol. of the PUII was observed by SEM. The PUII films with different amounts (0.2%, 0.4%, 0.6%, 0.8%, 1.0%) of 1,3,5-Tris(2-hydroxyethyl)hexahydro-1,3,5-triazine (TNO) were challenged with Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Gray mold. The results showed that when a small amount of antibacterial agent were added, the antibacterial effect of films on Botrytis cinerea was more obvious. The mech. evaluation shows that the antimicrobial polyurethane films exhibit good mech. properties. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).HPLC of Formula: 4719-04-4

The Article related to antibacterial polyurethane synthesis self assembly morphol property, electron microscopy, morphology, polyurethanes, self-assembly, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.HPLC of Formula: 4719-04-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 22, 2022, Litak, Nicholas P.; Mawby, Lillian M.; Lear, Benjamin J. published an article.Category: alcohols-buliding-blocks The title of the article was Surface Chemistry Controls the Density of States in Metallic Nanoparticles. And the article contained the following:

Ligand-stabilized colloidal metallic nanoparticles are prized in science and technol. for their electronic properties and tunable surface chem. However, little is known about the interplay between these two aspects of the particles. A particularly glaring absence concerns the d. of electronic states, which is fundamental in explaining the electronic properties of solid-state materials. In part, this absence owes to the difficulty in the exptl. determination of the parameter for colloidal systems. Herein, we demonstrate the d. of electronic states for metallic colloidal particles can be determined from their magnetic susceptibility, measured using NMR spectroscopy. For this study, we use small alkanethiolate protected gold nanoparticles and demonstrate that changes in the surface chem., as subtle as changes in alkane chain length, can result inasmuch as a 3-fold change in the d. of states at the Fermi level for these particles. This suggests that surface chem. can be a powerful tool for controlling the electronic behavior of the materials to which they are attached, and suggests a paradigm that could be applied to other metallic systems, such as other metal nanoparticles, doped semiconductor systems, and even 2D metals. For all of these metallic systems, the Evans method can serve as a simple means to probe the d. of states near the Fermi level. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Category: alcohols-buliding-blocks

The Article related to gold nanoparticle dos surface chem, nmr, density of states, electronic bands, gold, ligands, magnetic susceptibility, nanoparticles, Surface Chemistry and Colloids: Solid-Solid Systems and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sanchez-Calderon, Ismael; Bernardo, Victoria; Santiago-Calvo, Mercedes; Naji, Haneen; Saiani, Alberto; Rodriguez-Perez, Miguel Angel published an article in 2021, the title of the article was Effect of the Molecular Structure of TPU on the Cellular Structure of Nanocellular Polymers Based on PMMA/TPU Blends.Category: alcohols-buliding-blocks And the article contains the following content:

In this work, the effects of thermoplastic polyurethane (TPU) chem. and concentration on the cellular structure of nanocellular polymers based on poly(methyl-methacrylate) (PMMA) are presented. Three grades of TPU with different fractions of hard segments (HS) (60%, 70%, and 80%) were synthesized by the prepolymer method. Nanocellular polymers based on PMMA were produced by gas dissolution foaming using TPU as a nucleating agent in different contents (0.5 wt%, 2 wt%, and 5 wt%). TPU characterization shows that as the content of HS increases, the d., hardness, and mol. weight of the TPU are higher. PMMA/TPU cellular materials show a gradient cell size distribution from the edge of the sample toward the nanocellular core. In the core region, the addition of TPU has a strong nucleating effect in PMMA. Core structure depends on the HS content and the TPU content. As the HS or TPU content increases, the cell nucleation d. increases, and the cell size is reduced. Then, the use of TPUs with different characteristics allows controlling the cellular structure. Nanocellular polymers have been obtained with a core relative d. between 0.15 and 0.20 and cell sizes between 220 and 640 nm. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Category: alcohols-buliding-blocks

The Article related to mol structure nanocellular pmma tpu blend, gas dissolution foaming, nanocellular polymer, poly(methyl-methacrylate), thermoplastic polyurethane, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bertolini, Federico A.; Soccio, Michelina; Weinberger, Simone; Guidotti, Giulia; Gazzano, Massimo; Guebitz, Georg M.; Lotti, Nadia; Pellis, Alessandro published an article in 2021, the title of the article was Unveiling the enzymatic degradation process of biobased thiophene polyesters.Application of 111-29-5 And the article contains the following content:

In the past 20 years, scientific research focused on the identification of valid alternatives to materials of fossil origin, in particular, related to biobased polymers. Recently, the efforts led to the synthesis of thiophene-based polymers (TBPs), a new class of polyesters based on 2,5-thiophenedicarboxylic acid (TPCA) that can be industrially produced using biomass-derived mols. In this study, TBPs were synthesized using diols with different chain length (from C4 to C6) leading to poly(butylene 2,5- thiophenedicarboxylate) (PBTF), poly(pentamethylene 2,5-thiophenedicarboxylate) (PPeTF), and poly(hexamethylene 2,5-thiophenedicarboxylate) (PHTF), resp., that were processed to thin films. To investigate enzymic hydrolysis of these polymer films, cutinase 1 (Thc_cut1) and cutinase 2 (Thc_cut2) from Thermobifida cellulosilytica were recombinantly expressed in the host E. coli and purified. The SEM anal. showed that tiny holes were formed on the surface of the films and after 72 h PPeTF was completely degraded. After 72 h of incubation at 65°C with 5μM Thc_cut1, weight loss and HPLC anal. indicated 9, 100, and 80% degradation of PBTF, PPeTF, and PHTG with a concomitant release of 0.12, 2.70, and 0.67 mM of TPCA. The LC-TOF/MS anal. indicated that Thc_cut2 in particular released various oligomers from the polymer during the reaction. In addition, the FTIR anal. showed the formation of novel acid and hydroxyl groups on the polymer surfaces. The results showed that the two used thermostable cutinases are promising biocatalysts for the environmentally friendly degradation of TPCA-based polyesters, in view of a possible sustainable recycling of plastic waste through resynthesis processes. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Application of 111-29-5

The Article related to thiophene polyester enzymic degradation, biodegradability, circular economy, circular materials, cutinases, polyesters, thiophene-based polymers, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Application of 111-29-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts