Month: November 2022

On September 2, 2014, Bae, Sung Jin; Yi, Han Ju; Hwang, Sun Gwan; Jeong, Mo Ses; Yoon, Yeo Jin; Chae, Sang Mi; Park, Joo Young; Ryu, Eun Ju published a patent.Formula: C7H6F3NO The title of the patent was Methylcyclohexane derivatives and uses thereof. And the patent contained the following:

A novel methylcyclohexane derivative, and a pharmaceutical composition including the same that is effective for the prevention or treatment of pain. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Formula: C7H6F3NO

The Article related to cyclohexane preparation nitric oxide production inhibitor treatment pain, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C7H6F3NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On April 5, 2012, Bae, Sung Jin; Yi, Han Ju; Hwang, Sun Gwan; Jeong, Mo Ses; Yoon, Yeo Jin; Chae, Sang Mi; Park, Joo Young; Ryu, Eun Ju published a patent.Application of 386704-04-7 The title of the patent was Cyclohexane derivatives as NO production inhibitors and their preparation and use for the treatment of pain. And the patent contained the following:

The invention relates to cyclohexane derivatives of formula I, which are inhibitors of nitric oxide production and which are useful in the treatment of pain. Compounds of formula I wherein Ar is (un)substituted Ph, (un)substituted pyridine and (un)substituted pyridine N-oxide; X is O, C(O)O, NH, etc.; Y is CH2, O and NH and derivatives; A is O and NH; Q is CH and N; m is 0 to 2; n is 0 and 1; and pharmaceutically acceptable salts, isomers, solvates and hydrates thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their NO production inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values in the range 7.5 – 9.9 μM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7

The Article related to cyclohexane preparation nitric oxide production inhibitor treatment pain, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 386704-04-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chaudhari, Shivshankar; Shin, HyeonTae; Choi, SeoungYong; Cho, KieYong; Shon, MinYoung; Nam, SeungEun; Park, YouIn published an article in 2021, the title of the article was Hydrophilic and organophilic pervaporation of industrially important α,β and α,ω-diols.Recommanded Product: 111-29-5 And the article contains the following content:

The distillation-based purification of α,β and α,ω-diols is energy and resource intensive, as well as time consuming. Pervaporation separation is considered to be a remarkable energy efficient membrane technol. for purification of diols. Thus, as a core pervaporation process, hydrophilic polyvinyl alc. (PVA) membranes for the removal of water from 1,2-hexanediol (1,2-HDO) and organophilic polydimethylsiloxane-polysulfone (PDMS-PSF) membranes for the removal of isopropanol from 1,5 pentanediol (1,5-PDO) were employed. For 1,2-HDO/water separation using a feed having a 1 : 4 weight ratio of 1,2-HDO/water, the membrane prepared using 4 vol% glutaraldehyde (GA4) showed the best performance, yielding a flux of 0.59 kg m-2 h-1 and a separation factor of 175 at 40°C. In the organophilic pervaporation separation of the 1,5-PDO/IPA feed having a 9 : 1 weight ratio of components, the PDMS membrane prepared with a molar ratio of TEOS alkoxy groups to PDMS hydroxyl groups of 70 yielded a flux of 0.12 kg m-2 h-1 and separation factor of 17 638 at 40°C. Long term stability anal. found that both hydrophilic (PVA) and organophilic (PDMS) membranes retained excellent pervaporation output over 18 days’ continuous exposure to the feed. Both the hydrophilic and organophilic membranes exhibited promising separation performance at elevated operating conditions, showing their great potential for purification of α,β and α,ω-diols. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: 111-29-5

The Article related to pva pdms polysulfone membrane diol hydrophilic organophilic pervaporation, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Recommanded Product: 111-29-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 8, 2021, Wang, Bingzhi; Yang, Xingxing; Yan, Yiyong; Xu, Wenjian; Fu, Hui; Zeng, Chuyi; Huang, Yongjian; Liu, Yunwang; Wang, Shuishu published a patent.Category: alcohols-buliding-blocks The title of the patent was Preparation of sulfoxaflor hapten, artificial antigen and antibody for immunodetection of sulfoxaflor. And the patent contained the following:

The present invention relates to the preparation of sulfoxaflor hapten, artificial antigen and antibody for immunodetection of sulfoxaflor. In particular, the sulfoxaflor hapten I (wherein, n = 1, 2, 3, 4, or 5) was prepared The inventive hapten is coupled with the carrier protein to prepare artificial antigens, and the artificial antigens are used to immunize animals to obtain sulfoxaflor antibodies, the sulfoxaflor hapten, antigen, and antibody is used in immunol. detection, the inventive method provides a gold chromatog. detection device which can quickly and accurately detect sulfoxaflor residue content in vegetables or fruits, can meet regulators, on-site supervision and law enforcement detection mechanism needs, uses easily available chem. reagents, has simple operation process, high reaction yield and low detection cost.; the inventive detection method has high degree, high specificity, low cost, simple operation, short detection time and long shelf life. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Category: alcohols-buliding-blocks

The Article related to sulfoxaflor hapten preparation artificial antigen antibody immunodetection, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 2, 2013, Bayburt, Erol K.; Clapham, Bruce; Cox, Phil B.; Daanen, Jerome F.; Gomtsyan, Arthur; Kort, Michael E.; Kym, Philip R.; Voight, Eric A.; Schmidt, Robert G.; Dart, Michael J.; Gfesser, Gregory published a patent.Application of 386704-04-7 The title of the patent was Preparation of (cyclobutyl)(pyridinyl)methanol derivatives as TRPV3 modulators. And the patent contained the following:

Title compounds I [each occurrence of Ra and Rb independently = H, (un)substituted alkyl, haloalkyl, halogen, OH, O(alkyl), or phenyl; q = 0-2; X3 = O; X4 = bond or (CH2)m; X5 = (CH2)n; m and n are each 1; each Z1 = alkyl, oxo, halogen, haloalkyl, etc.; p = 1-4; X1 = OH; X2 = H; G1 = (un)substituted aryl, heteroaryl, cycloalkyl, heterocycle, or cycloalkenyl; G2 = aryl, heteroaryl, cycloalkyl, heterocycle, or cycloalkenyl], and their pharmaceutically acceptable salts, are prepared Compounds of the invention were evaluated for ability to antagonize the activation of recombinant human TRPV3 using FLIPR Tetra cellular screening. Thus, e.g., II was prepared in a multi-step synthesis and had IC50 value of 0.19 nM as human TRPV3 antagonist. The invention compounds and combination with other therapeutic agent are useful for treating conditions such as pain and inflammation. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7

The Article related to methanol cyclobutyl pyridinyl preparation trpv3 modulator pain inflammation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 386704-04-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 30, 2022, Nobakht, Danial; Abedini, Reza published an article.Recommanded Product: SweetPearlR P300 DC Maltitol The title of the article was Improved gas separation performance of Pebax1657 membrane modified by polyalcoholic compounds. And the article contained the following:

Poly (ether-block-amide) or Pebax is one of the most promising copolymers employed for CO2 separation The existence of polyamide and polyether segments within the total matrix gives superior properties to Pebax, providing it significant CO2 permeation compared to the other light gases such as CH4 and N2. However, improving the separation performance of Pebax is one of the major concerns in developing new membranes. Compounds with hydroxyl and carboxyl groups are listed as appropriate candidates to be embedded within the Pebax matrix, finally enhancing the CO2 separation Such compounds with oxygen atoms (neg. charged) can interact with the central carbon (pos. charged) of CO2 via Lewis acid-base interactions, which contributes to further CO2 permeation. In this study, Pebax1657, which has a good performance in CO2 separation, was blended with maltitol and mannitol as multi-hydroxyl compounds Pebax/mannitol and Pebax/maltitol blend membranes were prepared by solution casting/solvent evaporation method, and their CO2 separation performance from N2 and CH4 was studied. Changes in chem. bonds, thermal properties, and cross-sectional morphol. of the membranes were investigated using FTIR, DSC, TGA, FESEM and XRD anal. The gas permeability results showed that the highest permeability of CO2 was 341.27 barrer and 228.64 barrer, which are related to Pebax/maltitol (20 wt%), and Pebax/mannitol (20 wt%) at a temperature of 30°C and feed pressure of 10 bar, resp. In addition, the highest selectivity of 66.65 (CO2/N2) and 23.95 (CO2/CH4) was obtained for Pebax/maltitol (20 wt%). Likewise, selectivity values of 67.84 for CO2/N2 and 25.49 for CO2/CH4 were obtained with Pebax/mannitol (20 wt%), at a pressure of 10 bar. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Recommanded Product: SweetPearlR P300 DC Maltitol

The Article related to caprolactam ethylene oxide rubber maltitol mannitol gas separation membrane, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Recommanded Product: SweetPearlR P300 DC Maltitol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 27, 2011, Bhavaraju, Sai; Karanjikar, Mukund; Joshi, Ashok; Hunt, Joel; Chitta, Pallavi published a patent.Recommanded Product: 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Decarboxylation cell for production of coupled radical products. And the patent contained the following:

An electrolytic cell produces coupled radical products. The method involves obtaining a carboxylic acid material from biomass and converting it into an alkali metal salt. The alkali metal salt is then used in an anolyte as part of an electrolytic cell. The electrolytic cell may include an alkali ion conducting membrane (such as a NaSICON membrane). When the cell is operated, the alkali metal salt of the carboxylic acid decarboxylates and forms radicals. Such radicals are then bonded to other radicals, thereby producing a coupled radical product such as a hydrocarbon. The produced hydrocarbon may be, for example, saturated, unsaturated, branched, or unbranched, depending upon the starting material. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Recommanded Product: 2-Methyl-2-propylpropane-1,3-diol

The Article related to alkali metal salt decarboxylation cell coupled radical formation hydrocarbon, Electrochemistry: Electrochemical Cells and Systems and other aspects.Recommanded Product: 2-Methyl-2-propylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 24, 2003, Polla, Magnus published a patent.Safety of 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Preparation of 2,5-disubstituted 3-mercaptopentanoic acids as carboxypeptidase U inhibitors. And the patent contained the following:

The title compounds R1(CH2)2CH(SH)CH(CO2H)CH2R2 [I; R1 = (un)substituted Ph, naphthyl, pyridinyl, etc.; R2 = aminopyridinyl, aminothiazolyl, 3-azabicyclo[3.2.1]octyl] which inhibit carboxypeptidase U and thus can be used in the prevention and treatment of diseases where inhibition of carboxypeptidase U is beneficial, were prepared E.g., a 4-step synthesis of 2-[(6-aminopyridin-3-yl)methyl]-5-(1,1′-biphenyl-3-yl)-3-mercaptopentanoic acid (starting from 3-iodo-1,1′-biphenyl), was given. Biol. data was given for 13 exemplified compounds I. In further aspects, the invention relates to pharmaceutical compositions containing at least one compound I. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Safety of 2-(Methylamino)ethan-1-ol hydrochloride

The Article related to mercaptopentanoate aminopyridinylmethyl preparation carboxypeptidase u inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of 2-(Methylamino)ethan-1-ol hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 8, 2014, Robl, Jeffrey A.; Wu, Shung C.; Yoon, David S. published a patent.Application In Synthesis of (2-Fluorophenyl)methanethiol The title of the patent was Preparation of pyridone/hydroxypyridine compounds as 11β-hydroxysteroid dehydrogenase h type I inhibitors. And the patent contained the following:

Title compounds I [A = (un)substituted 4- to 15-membered mono, bi- or tricyclic aliphatic or aromatic ring, X = halo, cyano, haloalkyl, etc.; Y = bond, (un)substituted alkylene or cycloalkyl, etc.; R1 = (un)substituted alkyl, heteroaryl, aryl, heterocyclyl, etc.; W = bond, alkyl, O, S, SO, SO2, etc.], and their enantiomers, diastereomers, solvates, salts, tautomers or prodrugs, are prepared as 11-beta-hydroxysteroid dehydrogenase type I inhibitors. Thus, e.g., II was prepared by reaction of cyclohexanone with malononitrile followed by reaction with 2-chlorobenzyl bromide. Compound II showed IC50 value of 2.95 nM at the in vitro inhibition of recombinant human 11β-HSD1 assay. The invention compounds are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy, such as diabetes, hyperglycemia, obesity, dislipidemia, hypertension, cognitive impairment, rheumatoid arthritis, osteoarthritis, glaucoma, Cushing’s disease and metabolic syndrome. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Application In Synthesis of (2-Fluorophenyl)methanethiol

The Article related to pyridone hydroxypyridine preparation beta hydroxysteroid dehydrogenase inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of (2-Fluorophenyl)methanethiol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 13, 2004, Linn, David Martin; Wong, Erik Ho Fong published a patent.Safety of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol The title of the patent was Preparation of azabicyclic α7 nicotinic acetylcholine agonists for the treatment of glaucoma and retinal neuropathy. And the patent contained the following:

The invention provides a use or method of treating glaucoma, diabetic retinopathy, or age-related macular degeneration by the administration of azabicycles (azabicyclo-N(R1)C(:X)W (I); X = O, S; R1 = H, alkyl, cycloalkyl, haloalkyl, substituted Ph, substituted naphthyl; W = substituted Ph, (un)substituted 5- or 6-membered heterocyclyl, etc.; addnl. details are given in the claims) that are α7 nAChR agonists (no data) to a mammal in need thereof. Although the methods of preparation are not claimed, many example preparations of intermediates are included. For example, intermediate exo-(4S)-3-amino-1-azabicyclo[2.2.1]heptane bis(p-toluenesulfonate) was prepared in 8 steps (68, 62, 76, 100, 77, 94, 46, 84 % yields, resp.) starting with reaction of benzoyl chloride with 2-nitroethanol to give 2-(benzoyloxy)-1-nitroethane, reaction of Et E-4-bromo-2-butenoate with benzylamine to give Et E-4-(benzylamino)-2-butenoate, reaction of these 2 products to give trans-4-nitro-1-(phenylmethyl)-3-pyrrolidineacetic acid Et ester, reduction to trans-4-amino-1-(phenylmethyl)-3-pyrrolidineacetic acid Et ester, N-protection, reduction to trans-3-(tert-butoxycarbonylamino)-4-(2-hydroxyethyl)-1-(phenylmethyl)pyrrolidine, chromatog. resolution, cyclization of the (+)-enantiomer to give exo-(4S)-3-(tert-butoxycarbonylamino)-1-azabicyclo[2.2.1]heptane and finally deprotection. In another example, N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-4-bromo-1H-pyrazole-1-carboxamide hydrochloride was prepared (25 %) by treating 4-bromopyrazole with phosgene followed by (R)-(+)-3-aminoquinuclidine dihydrochloride and excess Et3N, followed by NaOH. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Safety of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol

The Article related to azabicycle preparation nicotinic acetylcholine agonist glaucoma retinal neuropathy, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts